-
公开(公告)号：US20240359009A1
公开(公告)日：2024-10-31
申请号：US18646450
申请日：2024-04-25
CPC分类号： A61N1/36046 , A61N1/0543
摘要： Systems and methods for calibration of retinal prosthetics in accordance with embodiments of the invention are illustrated. A closed loop calibration process is described whereby a multi-electrode stimulation regime can be calibrated to a given user's retina. Multi-electrode stimulation can provide increased stimulation selectivity, but significantly increases complexity. Systems and methods described herein provide computational steps that significantly reduce the amount of trials and computation required in order to achieve clinically viable selectivity, making closed-loop calibration of retinal prosthetics possible in significantly less time than open-loop calibration.
-
公开(公告)号：US20240353302A1
公开(公告)日：2024-10-24
申请号：US18681312
申请日：2022-08-08
IPC分类号： G01N11/14
CPC分类号： G01N11/14
摘要： Improved rheometry is provided using an autonomous swimming robot that can be driven at least in an angular velocity mode and in a torque mode. The resulting improved capability can enable measurement of multiple rheological parameters, such as both normal stress components ψ1 and ψ2, by observing motion of the robot in the fluid. The robot is preferably rotationally symmetric. but with a fore-aft head-tail asymmetry that enables propulsion in complex fluids when the head and tail are driven to rotate opposite each other about the rotational axis of symmetry.
-
公开(公告)号：US20240351996A1
公开(公告)日：2024-10-24
申请号：US18577851
申请日：2022-07-11
IPC分类号： C07D401/12 , A61K31/444 , A61K31/506 , C07D213/74 , C07D239/42 , C07D239/48 , C07D401/06 , C07D401/14 , C07D405/14
CPC分类号： C07D401/12 , A61K31/444 , A61K31/506 , C07D213/74 , C07D239/42 , C07D239/48 , C07D401/06 , C07D401/14 , C07D405/14
摘要： Provided herein are compounds, tautomers, or pharmaceutically acceptable salts thereof, having a structure of formula (I): wherein X1, Y, Z1, Z2, (R1)n, (R2)m, and ring A are as described herein. Also provided are pharmaceutical compositions comprising compounds, tautomers, or pharmaceutically acceptable salts having a structure of formula (I). Further provided are a method of inhibiting cyclin dependent kinase 19 (CDK19) a method of treating breast cancer with the disclosed compounds.
-
公开(公告)号：US20240350307A1
公开(公告)日：2024-10-24
申请号：US18642416
申请日：2024-04-22
发明人： Eduardo Jose Chichilnisky , Ruwan Amila Silva , Martin Breidenbach , Knut Skarpaas, VIII , Marco Oriunno
IPC分类号： A61F9/007
CPC分类号： A61F9/00727 , A61F2220/0033
摘要： A retina clip in accordance with embodiments of the invention are illustrated. One embodiment includes a retina clip including an outer ring having a means of retention against the retina, and an inner platform configured to hold a payload against the retina of an eye, where the inner platform is suspended from the inner ring via several springs. In many embodiments, the springs are flexures. The springs can be modified to generate a desired deflection based on a given payload attached to the inner platform. In numerous embodiments, the payload is a microelectrode array used as part of a retinal prosthetic.
-
5.发明公开公开(公告)号：US20240348228A1
公开(公告)日：2024-10-17
申请号：US18631914
申请日：2024-04-10
申请人： The Board of Trustees of the Leland Stanford Junior University , Board of Regents, The University of Texas System
发明人： Eric Stolt , Juan Rivas-Davila , Weston Braun , Ruochen Lu , Kristi Nguyen
IPC分类号： H03H9/02 , H03H9/17 , H10N30/853
CPC分类号： H03H9/02086 , H03H9/17 , H10N30/8542
摘要： In certain examples, methods and apparatus are directed to a resonator-based circuit which, in operation, has an electrically-conductive band (“band”) at least partially surrounding a center electrode which includes the piezoelectric material of the circuit's resonator. In particular examples, the band acts to electrically load vibrations near resonance and consequently, spurious mode suppression is realized. In more particular example embodiments, the band maintains TE mode while eliminating lateral spurious tones, and in one application-specific example, the resonator-based circuitry and the electrical-conductive band are to provide of facilitate piezoelectric power conversion.
-
公开(公告)号：US20240341607A1
公开(公告)日：2024-10-17
申请号：US18643950
申请日：2024-04-23
发明人： Nolan R. Williams , Keith Sudheimer
IPC分类号： A61B5/024 , A61B5/00 , A61B5/16 , A61N2/00 , A61N2/02 , G01R33/48 , G01R33/565 , G16H20/30 , G16H50/30
CPC分类号： A61B5/02405 , A61B5/165 , A61B5/4836 , A61N2/004 , A61N2/006 , A61N2/02 , G01R33/4806 , G01R33/4808 , G01R33/565 , G16H20/30 , A61B5/681 , A61B2576/026 , G16H50/30
摘要： Systems and methods for predicting and treating relapses for neurological conditions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting and treating a clinical neurological condition relapse. The method includes steps for selecting a threshold heart rate variability value for a patient suffering from a clinical neurological condition, monitoring, using a cardiac monitor, the heart rate variability of the patient over time, providing an indicator that a relapse is imminent when the heart rate variability of the patient falls below the threshold heart rate variability value, and treating the patient using a transcranial magnetic stimulation device by applying an accelerated theta burst stimulation protocol where the transcranial magnetic stimulation target is the left prefrontal dorsolateral cortex.
-
公开(公告)号：US12110504B2
公开(公告)日：2024-10-08
申请号：US18501837
申请日：2023-11-03
申请人： The Board of Trustees of the Leland Stanford Junior University , The United States Government as represented by the Department of Veterans Affairs
发明人： Zurab Siprashvili , Ngon T. Nguyen , M. Peter Marinkovich , Jean Tang , Alfred T. Lane , Paul A. Khavari
CPC分类号： C12N5/0629 , A61K48/0058 , A61K48/0075 , A61K48/0091 , C12N2510/00 , C12N2760/16043
摘要： Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.
-
公开(公告)号：US12102663B2
公开(公告)日：2024-10-01
申请号：US18172546
申请日：2023-02-22
IPC分类号： A61K38/17 , A61K9/00 , A61K9/08 , A61K9/10 , A61K38/22 , A61K38/26 , A61K45/06 , A61P3/08 , A61P3/10
CPC分类号： A61K38/2278 , A61K9/0019 , A61K9/08 , A61K9/10 , A61K38/17 , A61K38/22 , A61K38/26 , A61K45/06 , A61P3/08
摘要： Compositions and methods for treating hyperinsulinemic hypoglycemia, such as hyperinsulinemic hypoglycemia after bariatric surgery, are provided. In some embodiments, an effective amount of the glucagon-like peptide-1 receptor antagonist exendin(9-39) is subcutaneously administered twice per day.
-
公开(公告)号：US12100480B2
公开(公告)日：2024-09-24
申请号：US17005241
申请日：2020-08-27
IPC分类号： G16B20/20 , C12Q1/6883
CPC分类号： G16B20/20 , C12Q1/6883 , C12Q2600/156
摘要： Methods to determine an individual's propensity or risk for a trait and applications thereof are described. Generally, systems and methods utilize genetic data acquired from an individual to determine their propensity or risk for a set of components that contribute to a trait. Propensity or risk of a trait is determined by assessing propensity or risk for each component of a set of components and the weighted contribution of each component to the trait.
-
公开(公告)号：US12098418B2
公开(公告)日：2024-09-24
申请号：US17570111
申请日：2022-01-06
IPC分类号： C12Q1/6841 , C12Q1/68 , C12Q1/6806 , C12Q1/6837 , G01N1/30 , G02B21/06 , G02B21/00
CPC分类号： C12Q1/6841 , C12Q1/68 , C12Q1/6806 , C12Q1/6837 , G01N1/30 , G02B21/06 , G01N2001/305 , G02B21/0024 , C12Q1/6806 , C12Q2523/101 , C12Q2543/10 , C12Q2565/601 , C12Q1/6841 , C12Q2523/101 , C12Q2565/601
摘要： Methods, kits, and systems for fixation of RNA permitting its detection in intact tissue, such as, large volume of mammalian tissue are disclosed. The methods, kits, and systems util-ize carbodiimide-based chemistry to stably retain RNAs in tissue clarified using CLARITY. Also provided herein are methods, kits, and systems for detection of RNAs ire clarified tissue.
-
-
-
-
-
-
-
-
-
搜索结果
5184 条记录 (耗时 0.048 秒)
