公开(公告)号：US09878101B2

公开(公告)日：2018-01-30

申请号：US13240797

申请日：2011-09-22

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： A61M5/00 ,  A61M5/31 ,  A61M5/315

CPC分类号： A61M5/3129 ,  A61M5/31513 ,  A61M2005/3131

摘要： A package including a vessel made of cyclic olefin polymer (COP) resin, a CVD coating on a vessel, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.

公开(公告)号：US09458536B2

公开(公告)日：2016-10-04

申请号：US13651299

申请日：2012-10-12

申请人： John T. Felts ,  Thomas E. Fisk ,  Shawn Kinney ,  Christopher Weikart ,  Benjamin Hunt ,  Adrian Raiche ,  Brian Fitzpatrick ,  Peter J. Sagona ,  Adam Stevenson

发明人： John T. Felts ,  Thomas E. Fisk ,  Shawn Kinney ,  Christopher Weikart ,  Benjamin Hunt ,  Adrian Raiche ,  Brian Fitzpatrick ,  Peter J. Sagona ,  Adam Stevenson

IPC分类号： A61M25/00 ,  B05D3/00 ,  C23C16/40 ,  C23C16/04 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  A61B5/15 ,  A61B5/153 ,  A61B5/154 ,  A61M5/32 ,  G01M3/32 ,  B05D7/22 ,  A61L31/08 ,  G01N33/00

CPC分类号： C23C16/401 ,  A61B5/1405 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150274 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/150595 ,  A61B5/150717 ,  A61B5/150755 ,  A61B5/153 ,  A61B5/154 ,  A61L31/08 ,  A61M5/3202 ,  B05D7/22 ,  C23C16/045 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01M3/329 ,  G01N2033/0096

摘要： A method is disclosed in which a vapor-deposited coating or layer is directly or indirectly applied to at least a portion of the internal wall of the barrel of a capped pre-assembly comprising a barrel, optionally a dispensing portion, and a cap. The cap is secured to the barrel and at least substantially isolates the distal opening of the dispensing portion from pressure conditions outside the cap. A vapor-deposited coating or layer is applied directly or indirectly to at least a portion of the internal wall of the barrel while the pre-assembly is capped. The coating or layer is applied under conditions effective to maintain communication from the barrel lumen to the exterior via the front opening, optionally further via the dispensing portion lumen if present, at the end of the applying step. The capped pre-assembly can be pressure tested easily and rapidly, for example with a test duration between 1 and 60 seconds, to determine whether it has container closure integrity.

摘要翻译： 公开了一种方法，其中气相沉积的涂层或层直接或间接地施加到包括桶，任选地分配部分和盖的封盖预组件的筒的内壁的至少一部分上。 盖被固定到筒体上，并且至少基本上将分配部分的远端开口与帽外的压力条件隔离。 当预组件被盖住时，气相沉积的涂层或层直接或间接施加到筒的内壁的至少一部分。 在施加步骤结束时，有效地保持通过前开口保持从筒内腔到外部的通信，任选地进一步经由分配部分腔（如果存在）进一步施加涂层或层。 封盖预组件可以容易且快速地进行压力测试，例如在1至60秒之间的测试持续时间，以确定其是否具有容器封闭完整性。

公开(公告)号：US08512796B2

公开(公告)日：2013-08-20

申请号：US13169811

申请日：2011-06-27

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： G01N15/08 ,  G01N31/00 ,  G01N33/44 ,  G01M3/04 ,  B29D22/00 ,  B32B27/08

CPC分类号： A61B5/150206 ,  A61B5/154 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/08 ,  B05C13/00 ,  B05C13/025 ,  B23Q7/04 ,  B23Q7/1494 ,  C23C16/045 ,  C23C16/401 ,  C23C16/458 ,  C23C16/50 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01N15/082 ,  G01N23/2273 ,  G01N30/7206 ,  G01N33/00 ,  G01N2033/0096 ,  Y10T428/13 ,  Y10T428/1383

摘要： Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed, for example using material outgassed from a surface to inspect the properties of a surface coating.

摘要翻译： 公开了处理容器的方法，例如提供阻气或润滑性。 提供第一和第二PECVD或其他容器加工站或装置以及包括容器端口的容器保持器。 船只的开口可以坐在船只港口上。 坐便器的内表面可以通过第一和第二处理站或设备经容器端口处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。 还公开了容器处理系统和容器检查装置和方法，例如使用从表面去除的材料来检查表面涂层的性质。

公开(公告)号：US5391634A

公开(公告)日：1995-02-21

申请号：US184802

申请日：1994-01-21

申请人： Mladen Ladika ,  Thomas E. Fisk

发明人： Mladen Ladika ,  Thomas E. Fisk

IPC分类号： C07B57/00 ,  C08F246/00 ,  C08F278/02

CPC分类号： C07B57/00 ,  C08F246/00

摘要： Optically-active, amphiphilic, free-radical addition copolymers having an optically-active hydrophobic portion and an ionic hydrophilic portion are effective resolving agents. This utility is based on a unique combination of properties, viz., water solubility, chirality and amphiphilicity, i.e., having a dual hydrophobic and hydrophilic nature.

摘要翻译： 具有光学活性疏水部分和离子亲水部分的光学活性，两亲性，自由基加成共聚物是有效的拆分剂。 该实用性基于特性的独特组合，即水溶性，手性和两亲性，即具有双重疏水性和亲水性。

公开(公告)号：US4500675A

公开(公告)日：1985-02-19

申请号：US472533

申请日：1983-03-07

申请人： Thomas E. Fisk

发明人： Thomas E. Fisk

IPC分类号： C08F220/36 ,  C08F283/06 ,  C08K5/05 ,  C08J3/08 ,  C08K5/06 ,  C08L75/04

CPC分类号： C08F220/36 ,  C08F283/06

摘要： A stable copolymer dispersion is prepared by addition copolymerization of (1) a monomeric adduct of an active hydrogen compound, e.g., a polyether polyol or polyether monool, and an ethylenically unsaturated N-chlorosulfonyl carbamyl compound such as acryloxyethylchlorosulfonylcarbamate or an unsaturated N-chlorocarbonyl carbamyl compound with (2) ethylenically unsaturated monomer(s), e.g., styrene or a mixture thereof with acrylonitrile, while (1) and (2) are dispersed or dissolved in an excess of an active hydrogen polyfunctional compound such as a polyether polyol. The molar ratio of carbamyl moiety to active hydrogen compound is preferably less than about 0.1:1. The resulting dispersion has a controlled particle size and a viscosity such that it is suitably employed in the production of polyurethane foams.

摘要翻译： 通过（1）活性氢化合物的单体加合物例如聚醚多元醇或聚醚一元醇和烯属不饱和的N-氯磺酰基氨基甲酰基化合物如丙烯酰氧基乙基氯磺酰氨基甲酸酯或不饱和N-氯羰基氨基甲酰基 与（2）烯键式不饱和单体（例如苯乙烯或其与丙烯腈的混合物）的化合物，而（1）和（2）分散或溶解于过量的活性氢多官能化合物如聚醚多元醇中。 氨基甲酰部分与活性氢化合物的摩尔比优选小于约0.1:1。 所得到的分散体具有受控的粒度和粘度，使得它适合用于生产聚氨酯泡沫体。

公开(公告)号：US20120123345A1

公开(公告)日：2012-05-17

申请号：US13240797

申请日：2011-09-22

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： A61M5/31 ,  A61J1/14

CPC分类号： A61M5/3129 ,  A61M5/31513 ,  A61M2005/3131

摘要： A package including a vessel made of cyclic olefin polymer (COP) resin, a CVD coating on a vessel, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.

摘要翻译： 公开了一种包括由环烯烃聚合物（COP）树脂制成的容器，容器上的CVD涂层和包含至少一种蛋白质，肽和/或DNA序列的药物的包装。 还公开了处理容器的方法，例如提供润滑性或疏水性。 坐便器的内表面可以通过PECVD通过容器端口进行处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。

公开(公告)号：US20110252899A1

公开(公告)日：2011-10-20

申请号：US13169811

申请日：2011-06-27

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： G01N33/00 ,  B05C11/00 ,  A61M5/315

CPC分类号： A61B5/150206 ,  A61B5/154 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/08 ,  B05C13/00 ,  B05C13/025 ,  B23Q7/04 ,  B23Q7/1494 ,  C23C16/045 ,  C23C16/401 ,  C23C16/458 ,  C23C16/50 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01N15/082 ,  G01N23/2273 ,  G01N30/7206 ,  G01N33/00 ,  G01N2033/0096 ,  Y10T428/13 ,  Y10T428/1383

摘要： Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed, for example using material outgassed from a surface to inspect the properties of a surface coating.

摘要翻译： 公开了处理容器的方法，例如提供阻气或润滑性。 提供第一和第二PECVD或其他容器加工站或装置以及包括容器端口的容器保持器。 船只的开口可以坐在船只港口上。 坐便器的内表面可以通过第一和第二处理站或设备经容器端口处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。 还公开了容器处理系统和容器检查装置和方法，例如使用从表面去除的材料来检查表面涂层的性质。

公开(公告)号：US5000873A

公开(公告)日：1991-03-19

申请号：US361619

申请日：1989-06-05

申请人： Thomas E. Fisk ,  Christopher J. Tucker

发明人： Thomas E. Fisk ,  Christopher J. Tucker

IPC分类号： C07D213/20 ,  C23F11/04

CPC分类号： C07D213/20 ,  C23F11/04 ,  Y10S507/939

摘要： Corrosion of metal surfaces in contact with an aqueous medium is inhibited by incorporating a N-(hydrophobe aromatic)pyridinium compound such as N-(p-dodecylphenyl-2,4,6-trimethylpyridinium sulfoacetate into the aqueous medium.

摘要翻译： 通过将N-（疏水基芳族）吡啶鎓化合物如N-（对十二烷基苯基-2,4,6-三甲基吡啶鎓磺基乙酸酯）加入到水性介质中来抑制与水性介质接触的金属表面的腐蚀。

公开(公告)号：US4672118A

公开(公告)日：1987-06-09

申请号：US569099

申请日：1984-01-09

申请人： Thomas E. Fisk ,  Christopher J. Tucker

发明人： Thomas E. Fisk ,  Christopher J. Tucker

IPC分类号： C07D213/20 ,  C23F11/04 ,  C07F5/02 ,  C07D211/72 ,  C07D213/22 ,  C07F7/02

CPC分类号： C07D213/20 ,  C23F11/04

摘要： Corrosion of metal surfaces in contact with an aqueous medium is inhibited by incorporating a N-(hydrophobe aromatic)pyridinium compound such as N-(p-dodecylphenyl)-2,4,6-trimethylpyridinium sulfoacetate into the aqueous medium.

摘要翻译： 通过在水性介质中加入N-（对 - 十二烷基苯基）-2,4,6-三甲基吡啶磺酰乙酸盐等N-（疏水性芳香族）吡啶鎓化合物来抑制与水性介质接触的金属表面的腐蚀。

公开(公告)号：US4588830A

公开(公告)日：1986-05-13

申请号：US448082

申请日：1982-12-09

申请人： Thomas E. Fisk ,  Dwight K. Hoffman

发明人： Thomas E. Fisk ,  Dwight K. Hoffman

IPC分类号： C08F299/02 ,  C08G18/63 ,  C08G65/336 ,  C07F7/28

CPC分类号： C08G65/336 ,  C08F299/024 ,  C08F299/028 ,  C08G18/635

摘要： An adduct of a heteroatomic monomer, e.g., gamma-methacryloxypropyl trimethoxysilane and a monoahl, e.g., a monohydroxyl polyalkylene oxide or a polyahl, e.g., a polypropylene glycol, is usefully employed in the preparation of stable copolymer dispersions of the type used in the production of polyurethane foams and polyurethane elastomers.The copolymer dispersion is prepared by addition copolymerization of (1) the adduct with (2) ethylenically unsaturated monomer(s), e.g., styrene or mixture thereof with acrylonitrile, while (1) and (2) are dispersed or dissolved in an excess of a polyahl, i.e., an active hydrogen polyfunctional compound.