公开(公告)号：US20130041241A1

公开(公告)日：2013-02-14

申请号：US13651299

申请日：2012-10-12

申请人： John T. Felts ,  Thomas E. Fisk ,  Shawn Kinney ,  Christopher Weikart ,  Benjamin Hunt ,  Adrian Raiche ,  Brian Fitzpatrick ,  Peter J. Sagona ,  Adam Stevenson

发明人： John T. Felts ,  Thomas E. Fisk ,  Shawn Kinney ,  Christopher Weikart ,  Benjamin Hunt ,  Adrian Raiche ,  Brian Fitzpatrick ,  Peter J. Sagona ,  Adam Stevenson

IPC分类号： A61M5/31 ,  A61M5/178 ,  A61M5/30 ,  A61B5/145 ,  A61J7/00 ,  A61M15/00 ,  A61B6/00 ,  A61M35/00 ,  B05D7/22 ,  A61M5/315

CPC分类号： C23C16/401 ,  A61B5/1405 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150274 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/150595 ,  A61B5/150717 ,  A61B5/150755 ,  A61B5/153 ,  A61B5/154 ,  A61L31/08 ,  A61M5/3202 ,  B05D7/22 ,  C23C16/045 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01M3/329 ,  G01N2033/0096

摘要： A method is disclosed in which a vapor-deposited coating or layer is directly or indirectly applied to at least a portion of the internal wall of the barrel of a capped pre-assembly comprising a barrel, optionally a dispensing portion, and a cap. The cap is secured to the barrel and at least substantially isolates the distal opening of the dispensing portion from pressure conditions outside the cap. A vapor-deposited coating or layer is applied directly or indirectly to at least a portion of the internal wall of the barrel while the pre-assembly is capped. The coating or layer is applied under conditions effective to maintain communication from the barrel lumen to the exterior via the front opening, optionally further via the dispensing portion lumen if present, at the end of the applying step. The capped pre-assembly can be pressure tested easily and rapidly, for example with a test duration between 1 and 60 seconds, to determine whether it has container closure integrity.

摘要翻译： 公开了一种方法，其中气相沉积的涂层或层直接或间接地施加到包括桶，任选地分配部分和盖的封盖预组件的筒的内壁的至少一部分上。 盖被固定到筒体上，并且至少基本上将分配部分的远端开口与帽外的压力条件隔离。 当预组件被盖住时，气相沉积的涂层或层直接或间接施加到筒的内壁的至少一部分。 在施加步骤结束时，有效地保持通过前开口保持从筒内腔到外部的通信，任选地进一步经由分配部分腔（如果存在）进一步施加涂层或层。 封盖预组件可以容易且快速地进行压力测试，例如在1至60秒之间的测试持续时间，以确定其是否具有容器封闭完整性。

公开(公告)号：US09458536B2

公开(公告)日：2016-10-04

申请号：US13651299

申请日：2012-10-12

申请人： John T. Felts ,  Thomas E. Fisk ,  Shawn Kinney ,  Christopher Weikart ,  Benjamin Hunt ,  Adrian Raiche ,  Brian Fitzpatrick ,  Peter J. Sagona ,  Adam Stevenson

发明人： John T. Felts ,  Thomas E. Fisk ,  Shawn Kinney ,  Christopher Weikart ,  Benjamin Hunt ,  Adrian Raiche ,  Brian Fitzpatrick ,  Peter J. Sagona ,  Adam Stevenson

IPC分类号： A61M25/00 ,  B05D3/00 ,  C23C16/40 ,  C23C16/04 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  A61B5/15 ,  A61B5/153 ,  A61B5/154 ,  A61M5/32 ,  G01M3/32 ,  B05D7/22 ,  A61L31/08 ,  G01N33/00

CPC分类号： C23C16/401 ,  A61B5/1405 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150274 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/150595 ,  A61B5/150717 ,  A61B5/150755 ,  A61B5/153 ,  A61B5/154 ,  A61L31/08 ,  A61M5/3202 ,  B05D7/22 ,  C23C16/045 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01M3/329 ,  G01N2033/0096

摘要： A method is disclosed in which a vapor-deposited coating or layer is directly or indirectly applied to at least a portion of the internal wall of the barrel of a capped pre-assembly comprising a barrel, optionally a dispensing portion, and a cap. The cap is secured to the barrel and at least substantially isolates the distal opening of the dispensing portion from pressure conditions outside the cap. A vapor-deposited coating or layer is applied directly or indirectly to at least a portion of the internal wall of the barrel while the pre-assembly is capped. The coating or layer is applied under conditions effective to maintain communication from the barrel lumen to the exterior via the front opening, optionally further via the dispensing portion lumen if present, at the end of the applying step. The capped pre-assembly can be pressure tested easily and rapidly, for example with a test duration between 1 and 60 seconds, to determine whether it has container closure integrity.

摘要翻译： 公开了一种方法，其中气相沉积的涂层或层直接或间接地施加到包括桶，任选地分配部分和盖的封盖预组件的筒的内壁的至少一部分上。 盖被固定到筒体上，并且至少基本上将分配部分的远端开口与帽外的压力条件隔离。 当预组件被盖住时，气相沉积的涂层或层直接或间接施加到筒的内壁的至少一部分。 在施加步骤结束时，有效地保持通过前开口保持从筒内腔到外部的通信，任选地进一步经由分配部分腔（如果存在）进一步施加涂层或层。 封盖预组件可以容易且快速地进行压力测试，例如在1至60秒之间的测试持续时间，以确定其是否具有容器封闭完整性。

公开(公告)号：US20150021339A1

公开(公告)日：2015-01-22

申请号：US14357418

申请日：2012-11-09

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona ,  Christopher Weikart

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona ,  Christopher Weikart

IPC分类号： B65D25/14

CPC分类号： B65D25/14 ,  A61J1/05 ,  A61M5/3129 ,  A61M2005/3109 ,  A61M2005/3131 ,  C23C16/045 ,  C23C16/30 ,  C23C16/36 ,  C23C16/401 ,  C23C16/507

摘要： A method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by setting the ratio of the O2 to the organosilicon precursor in the precursor feed, and/or by setting the electric power used for generating the plasma. In particular, a passivation layer or pH protective coating made by the method is provided. Pharmaceutical packages coated by the method and the use of such packages protecting a composition contained in the vessel against mechanical and/or chemical effects of the surface of the package without a passivation layer or pH protective coating material are also provided.

摘要翻译： 提供了一种通过PECVD在衬底表面上提供钝化层或pH保护涂层的方法，该方法包括从包含聚合气体的气态反应物产生等离子体。 钝化层或pH保护涂层的润滑性，钝化性，pH保护性，疏水性和/或阻隔性能通过设定前体进料中O 2与有机硅前体的比例和/或通过设定所用的功率来设定 用于产生等离子体。 特别地，提供了由该方法制成的钝化层或pH保护涂层。 还提供了通过该方法涂覆的药物包装，并且使用这种包装保护容器中包含的组合物免受包装表面的机械和/或化学作用而没有钝化层或pH保护涂层材料。

公开(公告)号：US20150126941A1

公开(公告)日：2015-05-07

申请号：US14399678

申请日：2013-05-09

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter Sagona ,  Christopher Weikart ,  Jacob Israelachvili

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter Sagona ,  Christopher Weikart ,  Jacob Israelachvili

IPC分类号： A61L31/08 ,  A61L31/10

CPC分类号： A61J1/1468 ,  A61J1/00 ,  A61J1/05 ,  A61J1/2096 ,  A61J2200/50 ,  A61L31/10 ,  A61L2400/10 ,  A61L2420/08 ,  A61M3/0262 ,  Y10T428/1383

摘要： A method for providing a saccharide based lubricating or protective coating or layer on a substrate surface is provided. In particular, a lubricity and/or protective coating or layer made by said method is provided. Pharmaceutical packages or other vessels coated by said method and the use of such pharmaceutical packages or other vessels protecting a compound or composition contained or received in said vessel with a protective coating against mechanical and/or chemical effects of the surface of the vessel without a protective coating material are also provided.

摘要翻译： 提供了一种在基材表面上提供基于糖的润滑或保护涂层或层的方法。 特别地，提供了由所述方法制成的润滑性和/或保护性涂层或层。 通过所述方法涂覆的药物包装或其他容器以及使用这种药物包装或其他容器保护在所述容器中包含或接收的化​​合物或组合物的保护涂层，以防止容器表面的机械和/或化学作用而没有保护 还提供涂料。

公开(公告)号：US20180221243A1

公开(公告)日：2018-08-09

申请号：US15904018

申请日：2018-02-23

申请人： Christopher Weikart ,  Becky L. Clark ,  Adam Stevenson ,  John T. Felts

发明人： Christopher Weikart ,  Becky L. Clark ,  Adam Stevenson ,  John T. Felts

IPC分类号： A61J1/14 ,  C23C16/455 ,  A61M3/02 ,  C23C16/04 ,  C23C16/02 ,  B32B1/02 ,  C23C16/40 ,  A61J1/00 ,  A61M3/00 ,  A61J1/06 ,  A61J1/05 ,  A61J1/20 ,  A61M5/31

摘要： An article is described including an article surface and a coating set comprising an optional tie coating or layer, a barrier coating or layer, and a pH protective layer. The respective coatings or layers can be applied by chemical vapor deposition of a polysiloxane or polysilazane precursor in the presence of oxygen. Examples of such an article are a thermoplastic syringe, vial, or blood collection tube with a coated interior portion containing a pharmaceutical preparation or other fluid with a pH of 4 to 8, alternatively 5 to 9. The barrier coating or layer prevents oxygen from penetrating into the thermoplastic syringe, vial, or blood collection tube. The tie coating or layer, if present, and the pH protective coating or layer protect the barrier layer from the contents of the syringe, vial, or blood collection tube.

公开(公告)号：US20070281108A1

公开(公告)日：2007-12-06

申请号：US11662379

申请日：2005-10-05

申请人： Christopher Weikart ,  Todd Smith

发明人： Christopher Weikart ,  Todd Smith

IPC分类号： C08J7/04 ,  C23C16/04

CPC分类号： C23C16/511 ,  C08J7/123 ,  C08J2323/12 ,  C08J2367/04 ,  C23C16/0245 ,  C23C16/045 ,  H01J37/32192

摘要： The present invention describes a method for plasma coating the inside surface of a polyolefin or a polylactic acid container to provide an effective barrier against gas transmission. The method provides a way to deposit rapidly and uniformly very thin, adherent and nearly defect-free layers of polyorganosiloxane and silicon oxide (or amorphous carbon) on the inner surface of the container to achieve more than an order of magnitude increase in barrier properties.

摘要翻译： 本发明描述了一种用于等离子体涂覆聚烯烃或聚乳酸容器的内表面以提供有效阻挡气体传输的方法。 该方法提供了在容器的内表面上快速且均匀地沉积非常薄，粘附和几乎无缺陷的聚有机硅氧烷和氧化硅（或无定形碳）层以达到阻挡性能提高一个数量级以上的方式。

公开(公告)号：US20070212486A1

公开(公告)日：2007-09-13

申请号：US11547461

申请日：2005-05-20

申请人： Dmitry Dinega ,  Christopher Weikart

发明人： Dmitry Dinega ,  Christopher Weikart

IPC分类号： C23C16/40

CPC分类号： C23C16/401 ,  C23C16/405 ,  C23C16/407 ,  C23C16/50

摘要： A metal oxide coating can be applied to a substrate at a relatively low temperature and at or near atmospheric pressure by carrying a metal oxide precursor and an oxidizing agent through a corona discharge or a dielectric barrier discharge to form the metal oxide and deposit it onto to the substrate.

摘要翻译： 金属氧化物涂层可以在相对较低的温度和大气压附近的基底上，通过电晕放电或电介质阻挡放电载入金属氧化物前体和氧化剂，形成金属氧化物并将其沉积到 底物。