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    Osteoimplant and Method for Making Same
    5.
    发明申请
    Osteoimplant and Method for Making Same 有权
    植骨及其制作方法

    公开(公告)号：US20070168030A1

    公开(公告)日：2007-07-19

    申请号：US11676429

    申请日：2007-02-19

    申请人： Jean Edwards ,  Lawrence Shimp ,  Michele Diegmann ,  Todd Boyce ,  Nelson Scarborough ,  James Russell

    发明人： Jean Edwards ,  Lawrence Shimp ,  Michele Diegmann ,  Todd Boyce ,  Nelson Scarborough ,  James Russell

    IPC分类号： A61F2/28 ,  A61F2/44

    CPC分类号： A61L27/3683 ,  A61L27/3608 ,  A61L27/365 ,  A61L2430/02

    摘要： A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.

    摘要翻译： 提供了一种制造骨诱导性骨植入物的方法，其包括以下步骤：将至少一个皮质骨整体部分的至少一个表面的部分或全部软化至至少约100微米的深度; 以及配置皮质骨的整体部分以提供具有外表面的骨植入物，所述外表面具有至少一个脱矿质区和非脱矿质区。 根据上述方法制备的植入物表现出改善的骨诱导，而不会在骨植入物的临界区域中产生任何临床显着的强度降低。

    Process for selecting bone for transplantation
    7.
    发明申请
    Process for selecting bone for transplantation 有权
    选择骨移植的方法

    公开(公告)号：US20060100498A1

    公开(公告)日：2006-05-11

    申请号：US10519202

    申请日：2003-07-17

    申请人： Todd Boyce ,  Stephen Mercadante

    发明人： Todd Boyce ,  Stephen Mercadante

    IPC分类号： A61B5/05

    CPC分类号： A61B6/505 ,  A61B34/10 ,  A61F2002/2835 ,  A61F2002/30948

    摘要： A procedure for determining a plan for cutting a bone sample for use as an implant provides scanning the bone with a CT scanning system to provide slice images of the bone. The scanning system then determines the cortical or cancellous bone dimensions and density of the bone. Determining such dimensions and density permits accurate planning and preparation of an implant graft that is correlated to the predetermined plan without waste of bone through cutting test specimens to determine the bone parameters. Other images techniques that provide slice images are also disclosed.

    摘要翻译： 用于确定切割用作植入物的骨样品的计划的步骤提供用CT扫描系统扫描骨骼以提供骨的切片图像。 然后扫描系统确定皮质或松质骨的尺寸和骨密度。 确定这种尺寸和密度允许准确地规划和准备与预定计划相关的植入物移植物，而不会通过切割试样来浪费骨骼以确定骨骼参数。 还公开了提供切片图像的其它图像技术。

    Osteoinductive demineralized cancellous bone
    8.
    发明授权
    Osteoinductive demineralized cancellous bone 有权
    骨诱导软骨松质骨

    公开(公告)号：US08734525B2

    公开(公告)日：2014-05-27

    申请号：US12140025

    申请日：2008-06-16

    申请人： Keyvan Behnam ,  Nanette Forsyth ,  James Russell ,  John Winterbottom ,  Todd Boyce

    发明人： Keyvan Behnam ,  Nanette Forsyth ,  James Russell ,  John Winterbottom ,  Todd Boyce

    IPC分类号： A61K35/32

    CPC分类号： A61K35/32 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2002/30059 ,  A61F2310/00359 ,  A61L27/3608 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/3878 ,  A61L2430/02

    摘要： An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.

    摘要翻译： 公开了一种骨诱导的软骨骨架，相应的骨关节植入物以及用于制造骨诱导性软骨骨架的方法。 可以通过提供软化骨和改变骨的胶原结构来制备骨诱导的软骨骨架。 还可以通过提供脱矿质骨和压实骨，例如通过机械压实，研磨成颗粒或用化学品处理来制备骨诱导的软化骨基质。 添加剂如生长因子或生物活性剂可以加入到骨诱导的软化骨基质中。 骨诱导的骨质疏松骨质可形成成骨植骨。 当植入植入哺乳动物体内的植骨植入物可能在植入物的位置诱导软骨内骨形成的完全发育级联，包括血管化，矿化和骨髓分化。 骨诱导的软化骨基质也可以用作施用生物活性剂的递送装置。