Amorphous silibinin for the treatment of viral hepatitis
    1.
    发明授权
    Amorphous silibinin for the treatment of viral hepatitis 有权
    用于治疗病毒性肝炎的无定形水飞蓟宾

    公开(公告)号:US08614341B2

    公开(公告)日:2013-12-24

    申请号:US13320176

    申请日:2010-05-14

    CPC classification number: C07D407/04 A61K31/357

    Abstract: The invention relates to a method for the preparation of amorphous silibinin (or its synonyms: silybin or silibin) derived from a milk thistle fruit extract having an increased release rate and improved absorbability or bioavailability, and to the use of amorphous silibinin for the treatment or prevention of liver diseases, preferably for the treatment of viral hepatitis, e.g. hepatitis B or C, in particular in a patient who will undergo or has undergone liver transplantation. Preferably, the amorphous silibinin is adapted for oral administration.

    Abstract translation: 本发明涉及一种制备来源于具有增加的释放速率和改善的吸收性或生物利用度的乳蓟果提取物的无定形水蛭素(或其同义词:水飞蓟宾或水蛭素)的方法,以及使用无定形水飞蓟宾进行处理或 预防肝病,优选用于治疗病毒性肝炎,例如 乙型肝炎或丙型肝炎,特别是在接受或已经接受肝移植的患者中。 优选地,非晶硅藻蛋白适于口服给药。

    Aqueous PU dispersions with improved adhesion
    8.
    发明申请
    Aqueous PU dispersions with improved adhesion 审中-公开
    水性PU分散体具有改善的附着力

    公开(公告)号:US20050209399A1

    公开(公告)日:2005-09-22

    申请号:US11080278

    申请日:2005-03-14

    Abstract: A process for preparing polyester-polyurethane resin dispersions that includes: A) reacting one or more polyol components i) having an average molecular weight of at least 300, at least one of the components being a polyester polyol and the fraction of polyester polyol based on aromatic polycarboxylic acids being more than 50% by weight with a polyisocyanate to form a prepolymer, B) dissolving the prepolymer in an organic solvent; C) reacting the prepolymer with aliphatic polyamines having a molecular weight of 60 to 300 or hydrazine and a hydrophilicized aliphatic diamine, D) precipitating the product from C) by adding water to form a dispersion, and E) removing the organic solvent. The resulting polyester-polyurethane resin dispersions can be used in coating compositions and in coating systems that include a substrate and one or more coating films, at least one of which includes the polyester-polyurethane resin dispersion.

    Abstract translation: 一种制备聚酯 - 聚氨酯树脂分散体的方法,其包括:A)使一种或多种平均分子量为至少300的多元醇组分i),至少一种组分为聚酯多元醇和聚酯多元醇的分数基于 芳族多羧酸与多异氰酸酯重量多于50重量%以形成预聚物,B)将预聚物溶解在有机溶剂中; C)使预聚物与分子量为60至300的脂族多胺或肼和亲水化的脂族二胺反应,D)通过加入水使C)沉淀形成分散体,和E)除去有机溶剂。 所得到的聚酯 - 聚氨酯树脂分散体可用于涂料组合物和包括基材和一种或多种涂膜的涂料体系中,其中至少一种包括聚酯 - 聚氨酯树脂分散体。

    AMORPHOUS SILIBININ FOR THE TREATMENT OF VIRAL HEPATITIS
    10.
    发明申请
    AMORPHOUS SILIBININ FOR THE TREATMENT OF VIRAL HEPATITIS 有权
    用于治疗病毒性肝炎的非晶SILILININ

    公开(公告)号:US20120108825A1

    公开(公告)日:2012-05-03

    申请号:US13320176

    申请日:2010-05-14

    CPC classification number: C07D407/04 A61K31/357

    Abstract: The invention relates to a method for the preparation of amorphous silibinin (or its synonyms: silybin or silibin) derived from a milk thistle fruit extract having an increased release rate and improved absorbability or bioavailability, and to the use of amorphous silibinin for the treatment or prevention of liver diseases, preferably for the treatment of viral hepatitis, e.g. hepatitis B or C, in particular in a patient who will undergo or has undergone liver transplantation. Preferably, the amorphous silibinin is adapted for oral administration.

    Abstract translation: 本发明涉及一种制备来源于具有增加的释放速率和改善的吸收性或生物利用度的乳蓟果提取物的无定形水蛭素(或其同义词:水飞蓟宾或水蛭素)的方法,以及使用无定形水飞蓟宾进行处理或 预防肝病,优选用于治疗病毒性肝炎,例如 乙型肝炎或丙型肝炎,特别是在接受或已经接受肝移植的患者中。 优选地,非晶硅藻蛋白适于口服给药。

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