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公开(公告)号：US20240035071A1
公开(公告)日：2024-02-01
申请号：US18336866
申请日：2023-06-16
Applicant: 10X Genomics, Inc.
Inventor： Joshua DELANEY , Shalini Gohil , Veronica Emelina Gonzalez Muñoz , Joshua Gu , Albert Dale Kim , Yi Luo , Tathagata Mukherjee , Monica Nagendran , James Francis Perna, III , Kristen Nguyen Pham , Meiliana Tjandra
IPC: C12Q1/6841 , C12Q1/6816 , C12Q1/6806 , C12Q1/6876
CPC classification number: C12Q1/6841 , C12Q1/6816 , C12Q1/6806 , C12Q1/6876
Abstract: The present disclosure relates in some aspects to methods and compositions for in situ analysis involving catalytic de-crosslinking of biological samples.
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公开(公告)号：US20230295556A1
公开(公告)日：2023-09-21
申请号：US18188164
申请日：2023-03-22
Applicant: 10x Genomics, Inc.
Inventor： Shalini GOHIL , Joshua DELANEY , Yi LUO , Adam LOWE , Jason C. BELL , Michael John Terry STUBBINGTON , Wyatt James MCDONNELL
CPC classification number: C12M47/04 , B01L3/0241 , B01L3/502715 , B01L3/502761 , B01L2200/027 , B01L2200/0652
Abstract: The present disclosure provides methods, compositions, and systems for selective enzymatic gelation of cells, e.g., immune cells, contained in partitions.
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Patent Agency Ranking
公开(公告)号：US20190233878A1
公开(公告)日：2019-08-01
申请号：US16374112
申请日：2019-04-03
Applicant: 10X Genomics, Inc.
Inventor： Joshua DELANEY , Shalini GOHIL , Christopher HINDSON , Adam LOWE , Andrew D. PRICE , Joseph Francis SHUGA
IPC: C12Q1/6806 , B01J13/00 , B01J13/18
Abstract: The present disclosure provides systems and methods for making a hydrogel comprising a cell, cell nucleus, or one or more components derived from a cell or cell nucleus. A method for making a hydrogel may comprise providing a cell or cell nucleus, a first polymer, wherein the first polymer comprises a plurality of first crosslink precursors, each of the plurality of first crosslink precursors comprising an azide group; providing a second polymer, wherein the second polymer comprises a plurality of second crosslink precursors, each of the plurality of second crosslink precursors comprising an alkyne group; and crosslinking the first polymer and the second polymer via a reaction between a first section of the first crosslink precursors and a second section of the second crosslink precursors, thereby providing the hydrogel comprising the cell or cell nucleus.
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公开(公告)号：US20240271183A1
公开(公告)日：2024-08-15
申请号：US18542404
申请日：2023-12-15
Applicant: 10X Genomics, Inc.
Inventor： Joshua DELANEY , Shalini GOHIL , Christopher HINDSON , Adam LOWE , Andrew D. PRICE , Joseph Francis SHUGA
IPC: C12Q1/6806 , B01J13/00 , B01J13/18 , C08J3/075 , C12Q1/6869
CPC classification number: C12Q1/6806 , B01J13/0065 , B01J13/18 , C08J3/075 , C08J2333/00 , C12Q1/6869
Abstract: The present disclosure provides systems and methods for making a hydrogel comprising a cell, cell nucleus, or one or more components derived from a cell or cell nucleus. A method for making a hydrogel may comprise providing a cell or cell nucleus, a first polymer, wherein the first polymer comprises a plurality of first crosslink precursors, each of the plurality of first crosslink precursors comprising an azide group; providing a second polymer, wherein the second polymer comprises a plurality of second crosslink precursors, each of the plurality of second crosslink precursors comprising an alkyne group; and crosslinking the first polymer and the second polymer via a reaction between a first section of the first crosslink precursors and a second section of the second crosslink precursors, thereby providing the hydrogel comprising the cell or cell nucleus.
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公开(公告)号：US20240117410A1
公开(公告)日：2024-04-11
申请号：US18499129
申请日：2023-10-31
Applicant: 10X Genomics, Inc.
Inventor： Joshua DELANEY , Shalini Gohil , Veronica Emelina Gonzalez Munoz , Joshua Gu , Albert Dale Kim , Yi Luo , Tathagata Mukherjee , Monica Nagendran , James Francis Perna, III , Kristen Nguyen Pham , Meiliana Tjandra
IPC: C12Q1/6806 , C12Q1/6823
CPC classification number: C12Q1/6806 , C12Q1/6823
Abstract: The present disclosure relates in some aspects to methods and compositions for in situ analysis involving catalytic de-crosslinking of biological samples.
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公开(公告)号：US20220364150A1
公开(公告)日：2022-11-17
申请号：US17861503
申请日：2022-07-11
Applicant: 10x Genomics, Inc.
Inventor： Joshua DELANEY , Shalini GOHIL , Christopher HINDSON , Adam LOWE , Andrew D. PRICE , Joseph Francis SHUGA
IPC: C12Q1/6806 , B01J13/18 , B01J13/00 , C08J3/075
Abstract: The present disclosure provides systems and methods for making a hydrogel comprising a cell, cell nucleus, or one or more components derived from a cell or cell nucleus. A method for making a hydrogel may comprise providing a cell or cell nucleus, a first polymer, wherein the first polymer comprises a plurality of first crosslink precursors, each of the plurality of first crosslink precursors comprising an azide group; providing a second polymer, wherein the second polymer comprises a plurality of second crosslink precursors, each of the plurality of second crosslink precursors comprising an alkyne group; and crosslinking the first polymer and the second polymer via a reaction between a first section of the first crosslink precursors and a second section of the second crosslink precursors, thereby providing the hydrogel comprising the cell or cell nucleus.
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公开(公告)号：US20210190770A1
公开(公告)日：2021-06-24
申请号：US17131174
申请日：2020-12-22
Applicant: 10X Genomics, Inc.
Inventor： Joshua DELANEY , Shalini GOHIL , Jill HERSCHLEB , Adam LOWE , Albert KIM , Meiliana TJANDRA
IPC: G01N33/53 , C12N9/48 , C07D239/24 , C07D213/04
Abstract: The present disclosure provides compositions and methods for using fixed biological samples in partition-based assays. In at least one embodiment, the disclosure provides a composition comprising a fixed biological sample and an un-fixing agent contained in a partition, such as a discrete droplet. In some embodiments, the disclosure provides un-fixing agent compounds capable of catalytically cleaving crosslinks in fixed biological samples, particularly crosslinked nucleic acids, such as RNA.
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