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    SINGLE CELL ANALYSIS OF TRANSPOSASE ACCESSIBLE CHROMATIN
    1.
    发明申请
    SINGLE CELL ANALYSIS OF TRANSPOSASE ACCESSIBLE CHROMATIN 审中-公开

    公开(公告)号：US20200248176A1

    公开(公告)日：2020-08-06

    申请号：US16841411

    申请日：2020-04-06

    Applicant: 10X GENOMICS, INC.

    Inventor： Zahra Kamila Belhocine ,  Geoffrey MCDERMOTT ,  Francesca MESCHI ,  Xinying ZHENG

    IPC: C12N15/10

    Abstract: Methods and systems for sample preparation techniques that allow amplification (e.g., whole genome amplification) and sequencing of chromatin accessible regions of single cells are provided. The methods and systems generally operate by forming or providing partitions (e.g., droplets) including a single biological particle and a single bead comprising a barcoded oligonucleotide. The preparation of barcoded next-generation sequencing libraries prepared from a single cell is facilitated by the transposon-mediated transposition and fragmentation of a target nucleic acid sequence. The methods and systems may be configured to allow the implementation of single-operation or multi-operation chemical and/or biochemical processing within the partitions.

    METHOD AND SYSTEMS FOR HIGH THROUGHPUT SINGLE CELL GENETIC MANIPULATION
    3.
    发明申请
    METHOD AND SYSTEMS FOR HIGH THROUGHPUT SINGLE CELL GENETIC MANIPULATION 审中-公开

    公开(公告)号：US20180312873A1

    公开(公告)日：2018-11-01

    申请号：US15769609

    申请日：2016-10-17

    Applicant: 10X Genomics, Inc.

    Inventor： Xinying ZHENG

    IPC: C12N15/88

    CPC classification number: C12N15/88

    Abstract: Provided herein are methods and systems for introducing nucleic acid manipulation agents into single cells. Such high throughput delivery of nucleic acid manipulation reagents into single cells and subsequent genetic manipulation of such cells allow for large scale genetic analysis that can be useful, for example, for the study of biological pathways and drug target discovery.

    METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES
    5.
    发明申请
    METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES 有权

    公开(公告)号：US20220333191A1

    公开(公告)日：2022-10-20

    申请号：US17692792

    申请日：2022-03-11

    Applicant: 10x Genomics, Inc.

    Inventor： Tarjei Sigurd MIKKELSEN ,  Phillip BELGRADER ,  Xinying ZHENG

    IPC: C12Q1/6874

    Abstract: The present disclosure provides methods, compositions and systems for analyzing individual cells or cell populations through a partitioned analysis of contents of individual cells or cell populations, such as cancer cells and cells of the immune system. Individual cells or cell populations may be co-partitioned with processing reagents for accessing cellular contents, and for uniquely identifying the content of a given cell or cell population, and subsequently analyzing the content of the cell and characterizing it as having derived from an individual cell or cell population, including analysis and characterization of nucleic acid(s) from the cell through sequencing.

    METHODS FOR PROCESSING NUCLEIC ACID SAMPLES
    6.
    发明公开
    METHODS FOR PROCESSING NUCLEIC ACID SAMPLES 审中-公开

    公开(公告)号：US20240301459A1

    公开(公告)日：2024-09-12

    申请号：US18655106

    申请日：2024-05-03

    Applicant: 10x Genomics, Inc.

    Inventor： Xinying ZHENG

    IPC: C12P19/34 ,  C12N15/10 ,  C12Q1/6806

    CPC classification number: C12P19/34 ,  C12N15/1065 ,  C12Q1/6806

    Abstract: Provided are systems and methods for analyzing a single cell application or experiment. A set of control beads may be introduced to a biological sample and subjected to the single cell application. The control beads may be configured to mimic analytes in the biological sample, such as a cell or other analyte, and comprise one or more known sequences. The one or more known sequences may be identified to analyze the single cell application.

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