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公开(公告)号：US10197500B2
公开(公告)日：2019-02-05
申请号：US15544176
申请日：2016-01-19
申请人： ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. , THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
IPC分类号： G01N21/75 , G01N21/27 , G01N21/84 , G01N35/00 , B01J8/00 , B01J19/00 , B01J19/18 , B01J8/22 , G01N21/19 , G01N21/21 , G01N21/23 , G01N21/33 , G01N21/35 , G01N21/47 , G01N21/64 , G01N21/65 , G01N11/08
摘要： Devices and methods for controlling the properties of chemical species during time-dependent processes. A device includes a reactor for containing one or more chemical species of a time-dependent process, an extraction pump for automatically and continuously extracting an amount of the one or more chemical species from the reactor, one or more detectors for measuring property changes of the one or more extracted chemical species and generating a continuous stream of data related to the one or more property changes to the one or more chemical species during a time interval, and a process controller configured to fit the continuous stream of data to a mathematical function to predict one or more properties of the one or more chemical species at a future time point and make one or more process decisions based on the prediction of one or more properties at the future time point.
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公开(公告)号：US09664608B2
公开(公告)日：2017-05-30
申请号：US14464658
申请日：2014-08-20
CPC分类号： G01N15/0211 , G01N21/51 , G01N21/53 , G01N33/6803 , G01N2021/4711 , G01N2021/4719 , G01N2021/4726 , G01N2021/4792 , G01N2201/0612 , G01N2201/08 , G01N2201/1224
摘要： Simultaneous Multiple Sample Light Scattering systems and methods can be used for polymer stability testing and for applying stressors to polymer or colloid solutions including heat stress, ultrasound, freeze/thaw cycles, shear stress and exposure to different substances and surfaces, among others, that create a polymer stress response used to characterize the polymer solution and stability.
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3.发明申请公开(公告)号：US20190154588A1
公开(公告)日：2019-05-23
申请号：US16254532
申请日：2019-01-22
申请人： ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. , THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
摘要： Devices and methods for controlling the properties of chemical species during time-dependent processes. A device includes a reactor for containing one or more chemical species of a time-dependent process, an extraction pump for automatically and continuously extracting an amount of the one or more chemical species from the reactor, one or more detectors for measuring property changes of the one or more extracted chemical species and generating a continuous stream of data related to the one or more property changes to the one or more chemical species during a time interval, and a process controller configured to fit the continuous stream of data to a mathematical function to predict one or more properties of the one or more chemical species at a future time point and make one or more process decisions based on the prediction of one or more properties at the future time point.
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公开(公告)号：US20190025178A1
公开(公告)日：2019-01-24
申请号：US16070117
申请日：2017-01-12
申请人： ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. , THE ADMINISTRATORS OF THE TULANE EDUCATION FUND
摘要： Method, device, and system for identifying a model-based time dependent light scattering signature that includes receiving an experimental time dependent light scattering signature comprising experimental data descriptive of an average molecular weight of protein components in a solution over time. The method further includes identifying an Ansatz for evaluating the experimental time dependent light scattering signature, the Ansatz being an initial model-based time dependent light scattering signature, the initial model-based time dependent light scattering signature identifying at least one key variable. The method also includes adjusting the at least one key variable in the initial model-based time dependent light scattering signature until a final model-based time dependent light scattering signature is identified. In some instances, the final model-based time dependent light scattering signature identifies at least one protein aggregation mechanism.
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公开(公告)号：US20180224473A1
公开(公告)日：2018-08-09
申请号：US15746268
申请日：2016-07-21
发明人： Wayne Frederick Reed
CPC分类号： G01N35/0092 , G01N21/253 , G01N21/53 , G01N35/10 , G01N2021/4711 , G01N2021/4726 , G01N2035/1062
摘要： A device, method, and system for scheduling the analytical testing and throughput of macromolecular solutions based on light scattering measurements of one or more time dependent macromolecular solution characteristics. A device that includes a plurality of monitoring reservoirs, each configured to receive a macromolecular solution sample, coupled to a light scattering detection instrument configured to monitor light scattering from the plurality of macromolecular solution samples. The device further includes a computing device configured to measure a predetermined time dependent solution characteristic based on the monitored light scattering data and further configured to determine a time for performing an operation on one or more of the macromolecular solution samples based on the predetermined time dependent characteristic measurement.
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公开(公告)号：US11532381B2
公开(公告)日：2022-12-20
申请号：US16070117
申请日：2017-01-12
申请人： ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. , THE ADMINISTRATORS OF THE TULANE EDUCATION FUND
摘要： Method, device, and system for identifying a model-based time dependent light scattering signature that includes receiving an experimental time dependent light scattering signature comprising experimental data descriptive of an average molecular weight of protein components in a solution over time. The method further includes identifying an Ansatz for evaluating the experimental time dependent light scattering signature, the Ansatz being an initial model-based time dependent light scattering signature, the initial model-based time dependent light scattering signature identifying at least one key variable. The method also includes adjusting the at least one key variable in the initial model-based time dependent light scattering signature until a final model-based time dependent light scattering signature is identified. In some instances, the final model-based time dependent light scattering signature identifies at least one protein aggregation mechanism.
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7.发明申请公开(公告)号：US20180011024A1
公开(公告)日：2018-01-11
申请号：US15544176
申请日：2016-01-19
申请人： ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. , THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
CPC分类号： E21B41/00 , B01J8/001 , B01J8/006 , B01J8/222 , B01J8/228 , B01J19/0006 , B01J19/18 , B01J19/1881 , B01J2208/00061 , B01J2208/00212 , B01J2208/00362 , B01J2208/00539 , B01J2208/00548 , B01J2208/00575 , B01J2208/00628 , B01J2208/00637 , B01J2208/00725 , B01J2208/00973 , B01J2219/0004 , B01J2219/00063 , B01J2219/00069 , B01J2219/00072 , B01J2219/00094 , B01J2219/00123 , B01J2219/00164 , B01J2219/00168 , B01J2219/00186 , B01J2219/002 , B01J2219/00216 , B01J2219/00218 , B01J2219/00225 , B01J2219/00231 , B01J2219/00236 , B01J2219/00238 , B01J2219/0024 , B01J2219/00243 , B01J2219/00272 , G01N11/08 , G01N21/19 , G01N21/21 , G01N21/23 , G01N21/272 , G01N21/33 , G01N21/35 , G01N21/47 , G01N21/64 , G01N21/65 , G01N21/75 , G01N21/84 , G01N2021/8416 , G01N2201/12
摘要： Devices and methods for controlling the properties of chemical species during time-dependent processes. A device includes a reactor for containing one or more chemical species of a time-dependent process, an extraction pump for automatically and continuously extracting an amount of the one or more chemical species from the reactor, one or more detectors for measuring property changes of the one or more extracted chemical species and generating a continuous stream of data related to the one or more property changes to the one or more chemical species during a time interval, and a process controller configured to fit the continuous stream of data to a mathematical function to predict one or more properties of the one or more chemical species at a future time point and make one or more process decisions based on the prediction of one or more properties at the future time point.
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公开(公告)号：US20150056710A1
公开(公告)日：2015-02-26
申请号：US14464658
申请日：2014-08-20
CPC分类号： G01N15/0211 , G01N21/51 , G01N21/53 , G01N33/6803 , G01N2021/4711 , G01N2021/4719 , G01N2021/4726 , G01N2021/4792 , G01N2201/0612 , G01N2201/08 , G01N2201/1224
摘要： Simultaneous Multiple Sample Light Scattering systems and methods can be used to for polymer stability testing and for applying stressors to polymer or colloid solutions including heat stress, ultrasound, freeze/thaw cycles, shear stress and exposure to different substances and surfaces. among others, that create a polymer stress response used to characterize the polymer solution and stability.
摘要翻译： 同时多重样品光散射系统和方法可用于聚合物稳定性测试和将应激物施加到聚合物或胶体溶液，包括热应力，超声波，冻融循环，剪切应力和暴露于不同物质和表面。 其中，产生用于表征聚合物溶液和稳定性的聚合物应力响应。
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公开(公告)号：US11474044B2
公开(公告)日：2022-10-18
申请号：US16094542
申请日：2017-04-21
申请人： ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. , THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
摘要： Devices and methods for determining the cumulative distribution of a polymer property in a reactor without physical separation of reaction subcomponents. The device includes a means of measuring an instantaneous property of the polymers being produced in a reaction vessel a plurality of times during a polymerization reaction as well as a means of determining the corresponding change in polymer concentration in the reaction vessel between measurements of the instantaneous polymer property The device also includes a means of computing a statistical distribution appropriate to the polymer characteristic and applying the statistical distribution to a recently measured instantaneous value of the polymer property so as to have an instantaneous distribution of the polymer property and a means of adding together the instantaneous distributions of the polymer property in order to obtain the cumulative distribution of the polymer property in the reactor.
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10.发明申请公开(公告)号：US20170212054A1
公开(公告)日：2017-07-27
申请号：US15515119
申请日：2015-09-30
申请人： ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. , THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
CPC分类号： G01N21/75 , B01J8/1809 , G01N11/02 , G01N15/06 , G01N2015/0693 , G05B13/04
摘要： Manual and automatic methods and devices using a ACOMP system for active control of polymerization reaction processes. An ideal desired trajectory of one or more reaction and polymer characteristics can be established to produce a desired fmal polymer product with specified characteristics from a polymerization reaction process. A current reaction trajectory of a polymerization reaction process can be driven to an ideal or desired reaction trajectory. In a manual embodiment an operator can use ACOMP data to adjust process variables in order to drive the current reaction trajectory toward the ideal or desired reaction trajectory. In an automated mode a control program can use ACOMP data to make adjustments to process variables to drive the polymerization reaction process toward the desired trajectory as closely as possible either empirically or by solving the governing equations for the polymerization reaction process.
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