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    METHOD AND APPARATUS FOR PRODUCING AN IMAGE OF UNDILUTED WHOLE BLOOD SAMPLE HAVING WRIGHT STAIN COLORATION
    1.
    发明申请
    METHOD AND APPARATUS FOR PRODUCING AN IMAGE OF UNDILUTED WHOLE BLOOD SAMPLE HAVING WRIGHT STAIN COLORATION 审中-公开
    用于生产不完整的血清样品的图像的方法和装置

    公开(公告)号：US20150030215A1

    公开(公告)日：2015-01-29

    申请号：US14341117

    申请日：2014-07-25

    申请人： Abbott Point of Care, Inc.

    发明人： Niaz L. Khan ,  Darryn W. Unfricht ,  Robert A. Levine ,  Niten V. Lalpuria

    IPC分类号： G06T7/00

    CPC分类号： G06T7/0012 ,  G01N15/1429 ,  G01N15/147 ,  G01N2015/1006 ,  G01N2015/1472

    摘要： An apparatus and method for imaging a sample of substantially undiluted whole blood is provided. The method includes the steps of: providing a substantially undiluted whole blood sample admixed with at least one non-Wright stain colorant, which colorant is operable to differentially identify constituents containing cytoplasmic material; providing an analysis device having an analyzer with at least one processor, at least one sample illuminator, and at least one image sensor; creating an image of the sample using the analysis device; and using the analysis device to transform the image to a transformed image having a coloration recognizable as a Wright stained sample.

    摘要翻译： 提供了用于对基本上未稀释的全血的样品进行成像的装置和方法。 该方法包括以下步骤：提供与至少一种非赖特染色剂混合的基本上未稀释的全血样品，该着色剂可操作以差异鉴定含有细胞质材料的成分; 提供具有分析器的分析装置，所述分析器具有至少一个处理器，至少一个采样照明器和至少一个图像传感器; 使用分析装置创建样品的图像; 并且使用分析装置将图像变换为具有可识别为Wright染色样本的着色的变换图像。

    METHOD AND APPARATUS FOR IDENTIFYING RETICULOCYTES WITHIN A BLOOD SAMPLE
    2.
    发明申请
    METHOD AND APPARATUS FOR IDENTIFYING RETICULOCYTES WITHIN A BLOOD SAMPLE 有权
    用于在血液样品中鉴定细胞因子的方法和装置

    公开(公告)号：US20130170729A1

    公开(公告)日：2013-07-04

    申请号：US13673644

    申请日：2012-11-09

    申请人： Abbott Point of Care, Inc.

    发明人： Stephen C. Wardlaw ,  Robert A. Levine ,  Darryn W. Unfricht ,  Niten V. Lalpuria ,  Jeremy R. Hill

    IPC分类号： G06T7/00

    CPC分类号： G06T7/0012 ,  G01N15/05 ,  G01N33/49 ,  G01N2015/055

    摘要： A method and apparatus for identifying reticulocytes within a blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, and the chamber has a known or determinable height extending between the interior surfaces of panels, which height is such that at least one red blood cell, or an aggregate of red blood cells, within the sample contacts both of the interior surfaces; b) admixing a supravital dye with the sample, which dye is operable to cause reticulin to fluoresce when excited by light of one or more predetermined wavelengths; c) imaging the sample using light that includes the one or more predetermined wavelengths that cause reticulin to fluoresce; d) imaging the sample using light that is absorbed by hemoglobin to produce values of optical density on a per image unit basis; and e) identifying reticulocytes within the sample using the image of the sample created with light that causes the dyed reticulin to fluoresce, and using the per image unit optical density values.

    摘要翻译： 提供了一种用于鉴定血液样本内的网织红细胞的方法和装置。 该方法包括以下步骤：a）将样品沉积到适于静态保持样品进行分析的分析室中，并且室具有在面板的内表面之间延伸的已知或可确定的高度，其高度使得至少一个 样品内的红血细胞或红细胞聚集体接触两个内表面; b）将supravital染料与样品混合，该染料可操作以在由一种或多种预定波长的光激发时使网状蛋白发荧光; c）使用包括导致网状蛋白发荧光的一个或多个预定波长的光成像样品; d）使用被血红蛋白吸收的光进行成像，以产生基于每个图像单位的光密度值; 以及e）使用由导致染色的网状蛋白发荧光的光产生的样品的图像，以及使用每个图像单位的光密度值来鉴定样品内的网织红细胞。

    METHOD AND APPARATUS FOR DETERMINING HEMOGLOBIN BASED PARAMETERS IN AN UNLYSED BLOOD SAMPLE
    6.
    发明申请
    METHOD AND APPARATUS FOR DETERMINING HEMOGLOBIN BASED PARAMETERS IN AN UNLYSED BLOOD SAMPLE 审中-公开
    用于在不合理血液样品中测定基于HEMOGLOBIN的参数的方法和装置

    公开(公告)号：US20170059588A1

    公开(公告)日：2017-03-02

    申请号：US15348412

    申请日：2016-11-10

    申请人： Abbott Point of Care, Inc.

    发明人： Cord Mueller ,  Stephen C. Wardlaw ,  Darryn W. Unfricht

    IPC分类号： G01N33/72 ,  G01N33/80 ,  G01N33/49 ,  G01N21/59

    CPC分类号： G01N33/721 ,  G01N15/06 ,  G01N21/03 ,  G01N21/5907 ,  G01N33/49 ,  G01N33/726 ,  G01N33/80 ,  G01N2015/0065 ,  G01N2021/0346 ,  G01N2021/3144 ,  G01N2021/5934 ,  G01N2021/5957 ,  G01N2021/5988 ,  G01N2333/805 ,  G06K9/00134

    摘要： A method and apparatus for determining hemoglobin concentration is provided. A method aspect includes the steps of: a) depositing an unlysed, substantially undiluted blood sample into an analysis chamber adapted to quiescently hold the sample for analysis; b) imaging the sample in a region of the analysis chamber where the height of the chamber is no more than about twenty microns (20μ) or no less than about two microns (2μ), to produce image signals representative of the optical density of the imaged region; c) determining a sample representative optical density value using the image signals representative of the optical density of the imaged region; and d) determining the hemoglobin concentration of the sample using the sample representative optical density value.

    摘要翻译： 提供了一种用于测定血红蛋白浓度的方法和装置。 方法方面包括以下步骤：a）将未抽提的，基本上未稀释的血液样品沉积到适于静止保持样品进行分析的分析室中; b）在分析室的区域中对样品进行成像，其中室的高度不超过约20微米（20μ）或不小于约2微米（2μ），以产生表示所述腔的光密度的图像信号 成像区域 c）使用表示成像区域的光密度的图像信号来确定样品代表性光密度值; 和d）使用样品代表光密度值确定样品的血红蛋白浓度。

    Method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample
    7.
    发明授权
    Method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample 有权
    用于确定全血样品的至少一种血红蛋白相关参数的方法和装置

    公开(公告)号：US08781203B2

    公开(公告)日：2014-07-15

    申请号：US13925295

    申请日：2013-06-24

    申请人： Abbott Point of Care, Inc.

    发明人： Graham Davis ,  Stephen C. Wardlaw ,  Robert A. Levine ,  Darryn W. Unfricht ,  Niten Lalpuria ,  Paul G. Mitsis

    IPC分类号： G06K9/00

    CPC分类号： G01N33/726 ,  G01N15/1475 ,  G01N2015/0073

    摘要： A method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by an interior surface of a first panel, and an interior surface of a second panel, and the chamber has a height extending between the interior surfaces of the panels, wherein the chamber is configured to increase the oxygenation state of the sample to a substantially oxygenated state within a predetermined amount of time after entry into the chamber; b) imaging the at least one red blood cell contacting the interior surfaces, and producing image signals; c) determining an optical density of at least a portion of the imaged red blood cell contacting both interior surfaces; and d) determining the at least one hemoglobin related parameter of the red blood cell contacting the interior surfaces, using the determined optical density and a molar extinction coefficient for oxygenated hemoglobin.

    摘要翻译： 提供了一种用于确定全血样品的至少一种血红蛋白相关参数的方法和装置。 该方法包括以下步骤：a）将样品沉积到适于静态保持样品进行分析的分析室中，所述室由第一面板的内表面和第二面板的内表面限定，并且所述室具有 在所述面板的内表面之间延伸的高度，其中所述腔被配置为在进入所述腔室之后的预定量的时间内将所述样品的氧合状态增加到基本上氧合状态; b）对与内表面接触的至少一个红细胞进行成像，并产生图像信号; c）确定接触两个内表面的成像红细胞的至少一部分的光密度; 以及d）使用确定的光密度和氧合血红蛋白的摩尔消光系数来确定与内表面接触的红细胞的至少一种血红蛋白相关参数。

    Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample
    8.
    发明授权
    Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample 有权

    公开(公告)号：US09638912B2

    公开(公告)日：2017-05-02

    申请号：US13919666

    申请日：2013-06-17

    申请人： Abbott Point of Care, Inc.

    发明人： Stephen C. Wardlaw ,  Niten V. Lalpuria ,  Darryn W. Unfricht

    IPC分类号： G02B21/36 ,  G02B21/24

    CPC分类号： G02B21/365 ,  G02B21/244

    摘要： A method and apparatus for focusing a device for imaging a biologic sample is provided. A method aspect includes the steps of: disposing lenslets within a biologic sample, which lenslets have a height and a refractive index, which refractive index is different from that of the sample, wherein one or both of the imaging device and the sample are relatively locatable so a focal position of the imaging device can be moved along the height of the lenslets; imaging a portion of the sample including lenslets using transmittance at one or more wavelengths; determining an average light transmittance intensity of the sample at the wavelengths; determining an average light transmittance intensity of a region of each lenslet at the wavelengths; and determining the focal position of the imaging device using the average light transmittance intensity of the sample and the average light transmittance intensity of the region of the lenslets.