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    Methods for amplification and detection of nucleic acids
    1.
    发明申请
    Methods for amplification and detection of nucleic acids 审中-公开
    扩增和检测核酸的方法

    公开(公告)号：US20060240462A1

    公开(公告)日：2006-10-26

    申请号：US11409369

    申请日：2006-04-21

    申请人： Alison Todd ,  Tanya Applegate ,  Tram Doan ,  Paul Young

    发明人： Alison Todd ,  Tanya Applegate ,  Tram Doan ,  Paul Young

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6816 ,  C12Q2531/119

    摘要： Provided herein are methods for the combined amplification and detection of one or a plurality of target nucleic acid molecules. The methods encompass the use of an antisense strand of a catalytic nucleic acid in a primer for amplification such that an amplicon produced thereby includes an active catalytic nucleic acid capable of indicating the presence of the target sequences through the modification of a reporter substrate. Devices and kits are also provided. DNA molecules for practicing the methods are also provided. The DNA molecules comprise at least a first portion complementary to at least a first portion of a target nucleic acid sequence, a second portion complementary to an antisense sequence of a second portion of the target nucleic acid sequence, and a third portion comprising an antisense sequence of a catalytic nucleic acid; the third portion positioned between the first and second portions of said DNA molecule.

    摘要翻译： 本文提供了用于组合扩增和检测一个或多个靶核酸分子的方法。 所述方法包括在引物中使用催化核酸的反义链进行扩增，使得由此产生的扩增子包含能够通过报道底物修饰来指示靶序列存在的活性催化核酸。 还提供设备和套件。 还提供了用于实践该方法的DNA分子。 DNA分子包含至少与靶核酸序列的至少第一部分互补的第一部分，与靶核酸序列的第二部分的反义序列互补的第二部分和包含反义序列的第三部分 的催化核酸; 位于所述DNA分子的第一和第二部分之间的第三部分。

    Automated Online Sales Risk Management
    2.
    发明申请
    Automated Online Sales Risk Management 审中-公开
    自动在线销售风险管理

    公开(公告)号：US20120150568A1

    公开(公告)日：2012-06-14

    申请号：US13153557

    申请日：2011-06-06

    申请人： Sharon Greener ,  Mark Higgins ,  Effie Konstantine Anagnostopoulos ,  Paul Young ,  Dan Rothman ,  John Godfrey ,  Mel Gunewardena

    发明人： Sharon Greener ,  Mark Higgins ,  Effie Konstantine Anagnostopoulos ,  Paul Young ,  Dan Rothman ,  John Godfrey ,  Mel Gunewardena

    IPC分类号： G06Q40/08 ,  G06Q30/06 ,  G06Q40/02

    CPC分类号： G06Q40/08 ,  G06Q20/10 ,  G06Q20/381 ,  G06Q20/4016

    摘要： The present invention contemplates a risk management system for facilitating an e-commerce transaction wherein the participants to the transaction engage in commerce using different currencies. An automated sales risk management system facilitates a transaction by providing a price of a transaction which incorporates aggregated costs related to the transaction into a price made available to the participants. A currency risk management system can receive an amount relating to a deliverable involved in a transaction and determines an aggregated cost of the transaction. Aggregated cost can include a cost of credit, a cost for exchange of currency, a cost of insurance, processing fees, or other associated costs. Insurance can be monitored and a determination can be made regarding whether a participant has adequate insurance to cover a proposed transaction. The present invention also provides for risk associated with online transactions to be categorized and transferred.

    摘要翻译： 本发明考虑了一种用于促进电子商务交易的风险管理系统，其中交易的参与者使用不同的货币进行商务。 自动销售风险管理系统通过提供交易的价格来促成交易，该交易将与交易相关的综合成本纳入参与者可用的价格。 货币风险管理系统可以收到与交易中涉及的交付品相关的金额，并确定交易的合计成本。 总成本可以包括信用成本，货币兑换成本，保险成本，处理费用或其他相关费用。 可以监控保险，并且可以确定参与者是否有足够的保险来支付拟议的交易。 本发明还提供与要分类和转移的在线交易相关联的风险。

    METHOD FOR DETERMINING ADEQUACY OF SEISMIC DATA COVERAGE OF A SUBSURFACE AREA BEING SURVEYED AND ITS APPLICATION TO SELECTING SENSOR ARRAY GEOMETRY
    3.
    发明申请
    METHOD FOR DETERMINING ADEQUACY OF SEISMIC DATA COVERAGE OF A SUBSURFACE AREA BEING SURVEYED AND ITS APPLICATION TO SELECTING SENSOR ARRAY GEOMETRY 有权
    用于确定测量的地表区域的地震数据覆盖的适应性的方法及其在选择传感器阵列几何中的应用

    公开(公告)号：US20090279388A1

    公开(公告)日：2009-11-12

    申请号：US12409577

    申请日：2009-03-24

    申请人： David Monk ,  Paul Young

    发明人： David Monk ,  Paul Young

    IPC分类号： G01V1/38

    CPC分类号： G01V1/3808

    摘要： A method for marine seismic surveying includes towing a seismic sensors in a plurality of streamers in the water, actuating a seismic energy source in the water at selected times and detecting seismic signals at the sensors resulting from the actuation of the source. A data trace is created for each of the detected signals. At least one Fresnel zone is determined for at least some of the seismic data traces. A contribution of each of the traces to each one of a plurality of bins defined in a predetermined pattern is computed, based on the Fresnel zone associated with each trace. Based on the computed contributions, a maximum lateral distance between corresponding seismic sensors is determined that will result in a contribution sum above a selected threshold.

    摘要翻译： 一种用于海洋地震测量的方法包括在水中的多个拖缆中牵引地震传感器，在选定的时间致动水中的地震能量源，并检测由于源的致动而导致的传感器的地震信号。 为每个检测到的信号创建数据跟踪。 为至少一些地震数据轨迹确定至少一个菲涅尔区域。 基于与每个迹线相关联的菲涅耳区域，计算每个轨迹对以预定图案定义的多个箱体中的每一个的贡献。 基于计算的贡献，确定相应地震传感器之间的最大横向距离，其将导致高于所选阈值的贡献和。

    Peptidoglycan recognition proteins
    6.
    发明申请
    Peptidoglycan recognition proteins 失效
    肽聚糖识别蛋白

    公开(公告)号：US20060003378A1

    公开(公告)日：2006-01-05

    申请号：US11214796

    申请日：2005-08-31

    申请人： Paul Young ,  Steven Ruben ,  Craig Rosen ,  Henrik Olsen

    发明人： Paul Young ,  Steven Ruben ,  Craig Rosen ,  Henrik Olsen

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention related to three novel recognition protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-C polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

    摘要翻译： 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型识别蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-C多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

    Enhanced online sales risk management system
    9.
    发明授权
    Enhanced online sales risk management system 有权
    增强在线销售风险管理系统

    公开(公告)号：US06829590B1

    公开(公告)日：2004-12-07

    申请号：US09702956

    申请日：2000-10-31

    申请人： Sharon Greener ,  Mark Higgins ,  Effie Konstantine Anagnostopoulos ,  Paul Young ,  Dan Rothman ,  John Godfrey ,  Mel Gunewardena

    发明人： Sharon Greener ,  Mark Higgins ,  Effie Konstantine Anagnostopoulos ,  Paul Young ,  Dan Rothman ,  John Godfrey ,  Mel Gunewardena

    IPC分类号： G06F1760

    CPC分类号： G06Q40/04 ,  G06Q40/025 ,  G06Q40/123

    摘要： The present invention provides a method and system to implement risk management of foreign exchange of currency related to an online transaction. According to the present invention an exchange price and a tolerance parameter can be determined for a foreign currency as the foreign currency relates to a base currency. A computer system can receive a spot price relating to a market price for exchange of a foreign currency and compare the spot price with the tolerance parameter. The system can modify the exchange price if spot price exceeds the tolerance parameter. In addition, the system can receive information including the base currency amount involved in an online transaction and transmit the base currency amount and the foreign currency amount, wherein the foreign currency amount is derived according to the exchange price. If desired, a first tolerance parameter and a second tolerance parameter can be utilized, wherein a rise in the spot price is compared to the first tolerance parameter and a fall in the spot price is compared to the second tolerance parameter. In addition, the magnitude of the first tolerance parameter does not need to be equal to the magnitude of the second tolerance parameter. A rise in the spot price can be compared to the tolerance parameter such that the exchange price is modified if the spot price is higher than the tolerance parameter. Similarly, only a fall of the spot price can be compared to the tolerance parameter such that the exchange price is modified if the spot price is lower than the tolerance parameter. Additionally, a spot price can be determined and compared to the tolerance level at predetermined periods of time. An original tolerance level can be modified to create a new tolerance level, if the spot price exceeds the original tolerance level.

    摘要翻译： 本发明提供了一种实现与在线交易相关的货币外汇风险管理的方法和系统。 根据本发明，由于外币与基本货币有关，因此可以为外币确定兑换价格和公差参数。 计算机系统可以接收与市场价格相关的现货价格以交换外币，并将现货价格与公差参数进行比较。 如果现货价格超过公差参数，系统可以修改汇价。 此外，系统可以接收包括在线交易中涉及的基本货币金额的信息，并且传送基础货币金额和外币金额，其中根据交换价格导出外币金额。 如果需要，可以使用第一公差参数和第二公差参数，其中将现货价格的上升与第一公差参数进行比较，并将现货价格的下降与第二公差参数进行比较。 此外，第一公差参数的大小不需要等于第二公差参数的大小。 可以将现货价格上涨与公差参数进行比较，如果现货价格高于公差参数，交易价格将被修改。 同样，只有现货价格的下降可以与公差参数进行比较，以便如果现货价格低于公差参数，则交易价格将被修改。 此外，可以确定现货价格并将其与预定时间段的容限水平进行比较。 如果现货价格超过原始公差水平，则可以修改原始公差水平以创建新的公差水平。