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公开(公告)号:US06428780B2
公开(公告)日:2002-08-06
申请号:US09305506
申请日:1999-05-05
IPC分类号: A61K3800
CPC分类号: C07D333/38 , A61K9/0019 , A61K9/0043 , A61K9/0056 , A61K9/1617 , A61K9/4858 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/541 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68
摘要: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration are provided, and methods of preparation of the modified amino acid compound are provided.
摘要翻译: 提供了可用于递送活性剂的改性氨基酸化合物。 活性剂可以是肽。 提供口服,皮下,舌下和鼻内给药的给药方法,提供修饰氨基酸化合物的制备方法。
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公开(公告)号:US6099856A
公开(公告)日:2000-08-08
申请号:US763183
申请日:1996-12-10
申请人: Sam J. Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Fang Wang , Donald J. Sarubbi , Noemi B Santiago
发明人: Sam J. Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Fang Wang , Donald J. Sarubbi , Noemi B Santiago
IPC分类号: A61K8/04 , A61K8/64 , A61K9/16 , A61K9/20 , A61K31/16 , A61K31/28 , A61K31/35 , A61K31/352 , A61K31/727 , A61K38/00 , A61K38/21 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K47/12 , A61K47/18 , A61K47/48 , A61Q13/00 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/54 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/107 , C07K5/06 , A61K9/127
CPC分类号: A61K8/64 , A61K31/16 , A61K31/28 , A61K31/35 , A61K31/352 , A61K31/715 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/48238 , A61K8/0204 , A61K9/1617 , A61K9/1641 , A61K9/167 , A61K9/2013 , A61Q13/00 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/54 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/1077 , C07K5/06043 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of:(a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states;(b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and(c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety. The supramolecular complex comprises the perturbant non-covalently bound or complexed with the biologically active agent. In the present invention, the biologically active agent does not form a microsphere after interacting with the perturbant. A method for preparing an orally administrable biologically active agent comprising steps (a) and (b) above is also provided as are oral delivery compositions. Additionally, mimetics and methods for preparing mimetics are contemplated.
摘要翻译: 运输生物活性剂穿过细胞膜或脂质双层的方法。 第一种方法包括以下步骤:(a)提供可以以天然构象状态,变性构象状态和中和构象状态存在的生物活性剂,其可天然状态是可逆的,并且在天然和/或 变性状态 (b)将生物活性剂暴露于络合扰动剂以将生物活性剂可逆地转化为中间状态并形成可运输的超分子复合物; 和(c)将膜或双层暴露于超分子复合物,以将生物活性剂转运穿过膜或双层。 扰动剂具有约150至约600道尔顿之间的分子量,并且含有至少一个亲水部分和至少一个疏水部分。 超分子复合物包括与生物活性剂非共价结合或络合的扰动剂。 在本发明中,生物活性剂在与扰动剂相互作用后不形成微球体。 还提供了包含上述步骤(a)和(b)的可口服给药的生物活性剂的制备方法,口服递送组合物也是如此。 另外,可以考虑用于制备模拟物的模拟物和方法。
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公开(公告)号:US06916489B2
公开(公告)日:2005-07-12
申请号:US10255237
申请日:2002-09-25
申请人: Sam J. Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Fang Wang , Donald J. Sarubbi , Noemi B Santiago
发明人: Sam J. Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Fang Wang , Donald J. Sarubbi , Noemi B Santiago
IPC分类号: A61K8/04 , A61K8/64 , A61K9/16 , A61K9/20 , A61K31/16 , A61K31/28 , A61K31/35 , A61K31/352 , A61K31/727 , A61K38/00 , A61K38/21 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K39/395 , A61K47/12 , A61K47/18 , A61K47/48 , A61Q13/00 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/107 , C07K5/06 , A61K9/27 , A61K9/48
CPC分类号: A61K31/715 , A61K8/0241 , A61K8/64 , A61K9/1617 , A61K9/1641 , A61K9/167 , A61K9/2013 , A61K31/16 , A61K31/28 , A61K31/35 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/62 , A61K2800/56 , A61Q13/00 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07K1/1077 , C07K5/06043
摘要: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety. The supramolecular complex comprises the perturbant non-covalently bound or complexed with the biologically active agent. In the present invention, the biologically active agent does not form a microsphere after interacting with the perturbant. A method for preparing an orally administrable biologically active agent comprising steps (a) and (b) above is also provided as are oral delivery compositions. Additionally, mimetics and methods for preparing mimetics are contemplated.
摘要翻译: 运输生物活性剂穿过细胞膜或脂质双层的方法。 第一种方法包括以下步骤:(a)提供可以以天然构象状态,变性构象状态和中和构象状态存在的生物活性剂,其可天然状态是可逆的,并且在天然和/或 变性状态 (b)将生物活性剂暴露于络合扰动剂以将生物活性剂可逆地转化为中间状态并形成可运输的超分子复合物; 和(c)将膜或双层暴露于超分子复合物,以将生物活性剂转运穿过膜或双层。 扰动剂具有约150至约600道尔顿之间的分子量,并且含有至少一个亲水部分和至少一个疏水部分。 超分子复合物包括与生物活性剂非共价结合或络合的扰动剂。 在本发明中,生物活性剂在与扰动剂相互作用后不形成微球体。 还提供了包含上述步骤(a)和(b)的可口服给药的生物活性剂的制备方法,口服递送组合物也是如此。 另外,可以考虑用于制备模拟物的模拟物和方法。
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公开(公告)号:US06245359B1
公开(公告)日:2001-06-12
申请号:US08941616
申请日:1997-09-30
申请人: Sam J. Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Fang Wang , Donald J. Sarubbi , Noemi B Santiago
发明人: Sam J. Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Fang Wang , Donald J. Sarubbi , Noemi B Santiago
IPC分类号: A61K916
CPC分类号: A61K8/64 , A61K9/1617 , A61K9/1641 , A61K9/167 , A61K9/2013 , A61K31/16 , A61K31/28 , A61K31/35 , A61K31/352 , A61K31/715 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/62 , A61Q13/00 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/54 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07K1/1077 , C07K5/06043
摘要: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety. The supramolecular complex comprises the perturbant non-covalently bound or complexed with the biologically active agent. In the present invention, the biologically active agent does not form a microsphere after interacting with the perturbant. A method for preparing an orally administrable biologically active agent comprising steps (a) and (b) above is also provided as are oral delivery compositions. Additionally, mimetics and methods for preparing mimetics are contemplated.
摘要翻译: 运输生物活性剂穿过细胞膜或脂质双层的方法。 第一种方法包括以下步骤:(a)提供可以以天然构象状态,变性构象状态和中和构象状态存在的生物活性剂,其可天然状态是可逆的,并且在天然和/或 变性状态;(b)将生物活性剂暴露于络合扰动剂以将生物活性剂可逆地转化为中间状态并形成可运输的超分子复合物; 和(c)将膜或双层暴露于超分子复合物,以将生物活性剂转运穿过膜或双层。 扰动剂具有约150至约600道尔顿之间的分子量,并且含有至少一个亲水部分和至少一个疏水部分。 超分子复合物包括与生物活性剂非共价结合或络合的扰动剂。 在本发明中,生物活性剂在与扰动剂相互作用后不形成微球体。 还提供了包含上述步骤(a)和(b)的可口服给药的生物活性剂的方法,口服递送组合物也是如此。另外,可以设想模拟物和制备模拟物的方法。
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公开(公告)号:US6071538A
公开(公告)日:2000-06-06
申请号:US940056
申请日:1997-09-30
申请人: Sam J. Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Fang Wang , Donald J. Sarubbi , Noemi B Santiago
发明人: Sam J. Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Fang Wang , Donald J. Sarubbi , Noemi B Santiago
IPC分类号: A61K9/00 , A61K8/04 , A61K8/64 , A61K9/16 , A61K9/20 , A61K31/16 , A61K31/28 , A61K31/35 , A61K31/352 , A61K31/70 , A61K31/715 , A61K31/727 , A61K38/00 , A61K38/21 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/18 , A61K47/48 , A61Q13/00 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/54 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/107 , C07K5/06 , A61K9/50
CPC分类号: A61K8/64 , A61K31/16 , A61K31/28 , A61K31/35 , A61K31/352 , A61K31/715 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/48238 , A61K9/1617 , A61K9/1641 , A61K9/167 , A61K9/2013 , A61Q13/00 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/54 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/1077 , C07K5/06043 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of:(a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states;(b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and(c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety. The supramolecular complex comprises the perturbant non-covalently bound or complexed with the biologically active agent. In the present invention, the biologically active agent does not form a microsphere after interacting with the perturbant. A method for preparing an orally administrable biologically active agent comprising steps (a) and (b) above is also provided as are oral delivery compositions.Additionally, mimetics and methods for preparing mimetics are contemplated.
摘要翻译: 运输生物活性剂穿过细胞膜或脂质双层的方法。 第一种方法包括以下步骤:(a)提供可以以天然构象状态,变性构象状态和中和构象状态存在的生物活性剂,其可天然状态是可逆的,并且在天然和/或 变性状态 (b)将生物活性剂暴露于络合扰动剂以将生物活性剂可逆地转化为中间状态并形成可运输的超分子复合物; 和(c)将膜或双层暴露于超分子复合物,以将生物活性剂转运穿过膜或双层。 扰动剂具有约150至约600道尔顿之间的分子量,并且含有至少一个亲水部分和至少一个疏水部分。 超分子复合物包括与生物活性剂非共价结合或络合的扰动剂。 在本发明中,生物活性剂在与扰动剂相互作用后不形成微球体。 还提供了包含上述步骤(a)和(b)的可口服给药的生物活性剂的制备方法,口服递送组合物也是如此。 另外,可以考虑用于制备模拟物的模拟物和方法。
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公开(公告)号:US5714167A
公开(公告)日:1998-02-03
申请号:US328932
申请日:1994-10-25
申请人: Sam J. Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Fang Wang , Donald J. Sarubbi , Noemi B. Santiago
发明人: Sam J. Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Fang Wang , Donald J. Sarubbi , Noemi B. Santiago
IPC分类号: A61K9/00 , A61K8/04 , A61K8/64 , A61K9/16 , A61K9/20 , A61K31/16 , A61K31/28 , A61K31/35 , A61K31/352 , A61K31/70 , A61K31/715 , A61K31/727 , A61K38/00 , A61K38/21 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/18 , A61K47/48 , A61Q13/00 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/54 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/107 , C07K5/06 , A61K9/50
CPC分类号: A61K8/64 , A61K31/16 , A61K31/28 , A61K31/35 , A61K31/352 , A61K31/715 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/48238 , A61K9/1617 , A61K9/1641 , A61K9/167 , A61K9/2013 , A61Q13/00 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/54 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/1077 , C07K5/06043 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety. The supramolecular complex comprises the perturbant non-covalently bound or complexed with the biologically active agent. In the present invention, the biologically active agent does not form a microsphere after interacting with the perturbant. A method for preparing an orally administrable biologically active agent comprising steps (a) and (b) above is also provided as are oral delivery compositions. Additionally, mimetics and methods for preparing mimetics are contemplated.
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公开(公告)号:US06348207B1
公开(公告)日:2002-02-19
申请号:US08941609
申请日:1997-09-30
申请人: Sam J. Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Fang Wang , Donald J. Sarubbi , Noemi B Santiago
发明人: Sam J. Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Fang Wang , Donald J. Sarubbi , Noemi B Santiago
IPC分类号: A01N2512
CPC分类号: A61K8/64 , A61K9/1617 , A61K9/1641 , A61K9/167 , A61K9/2013 , A61K31/16 , A61K31/28 , A61K31/35 , A61K31/352 , A61K31/715 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/62 , A61Q13/00 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/54 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07K1/1077 , C07K5/06043
摘要: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety. The supramolecular complex comprises the perturbant non-covalently bound or complexed with the biologically active agent. In the present invention, the biologically active agent does not form a microsphere after interacting with the perturbant. A method for preparing an orally administrable biologically active agent comprising steps (a) and (b) above is also provided as are oral delivery compositions. Additionally, mimetics and methods for preparing mimetics are contemplated.
摘要翻译: 运输生物活性剂穿过细胞膜或脂质双层的方法。 第一种方法包括以下步骤:(a)提供可以以天然构象状态,变性构象状态和中和构象状态存在的生物活性剂,其可天然状态是可逆的,并且在天然和/或 变性状态;(b)将生物活性剂暴露于络合扰动剂以将生物活性剂可逆地转化为中间状态并形成可运输的超分子复合物; 和(c)将膜或双层暴露于超分子复合物,以将生物活性剂转运穿过膜或双层。 扰动剂具有约150至约600道尔顿之间的分子量,并且含有至少一个亲水部分和至少一个疏水部分。 超分子复合物包括与生物活性剂非共价结合或络合的扰动剂。 在本发明中,生物活性剂在与扰动剂相互作用后不形成微球体。 还提供了包含上述步骤(a)和(b)的可口服给药的生物活性剂的制备方法,口服递送组合物也是如此。 另外,可以考虑用于制备模拟物的模拟物和方法。
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公开(公告)号:US07186414B2
公开(公告)日:2007-03-06
申请号:US11173075
申请日:2005-06-30
申请人: David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Bruce Press , Nai Fang Wang , Pingwah Tang
发明人: David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Bruce Press , Nai Fang Wang , Pingwah Tang
CPC分类号: C07C233/83 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K38/00 , A61K47/18 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/60 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68
摘要: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译: 提供用于递送活性剂的化合物和组合物。 也提供给药和制备方法。
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公开(公告)号:US07744910B2
公开(公告)日:2010-06-29
申请号:US11531602
申请日:2006-09-13
申请人: David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Bruce Press , Nai Fang Wang , Pingwah Tang
发明人: David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Bruce Press , Nai Fang Wang , Pingwah Tang
CPC分类号: C07C233/83 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K38/00 , A61K47/18 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/60 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68
摘要: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号:US06991798B1
公开(公告)日:2006-01-31
申请号:US09762067
申请日:1999-08-06
申请人: David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Bruce Press , Nai Fang Wang , Pingwah Tang
发明人: David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Bruce Press , Nai Fang Wang , Pingwah Tang
IPC分类号: A61K38/00
CPC分类号: A61K45/06 , A61K9/0095 , A61K9/08 , A61K31/166 , A61K38/1816 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/22 , A61K2039/60 , A61K2300/00
摘要: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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