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7 条记录 (耗时 0.02 秒)

    Flow resistance modulated aerosolized active agent delivery
    2.
    发明授权
    Flow resistance modulated aerosolized active agent delivery 失效
    阻流调制气雾剂活性剂输送

    公开(公告)号：US08408200B2

    公开(公告)日：2013-04-02

    申请号：US09414384

    申请日：1999-10-07

    申请人： Andrew Clark ,  Carlos Schuler ,  Steve Paboojian

    发明人： Andrew Clark ,  Carlos Schuler ,  Steve Paboojian

    IPC分类号： A61M16/00 ,  A61M15/00 ,  A62B9/02

    CPC分类号： A61M15/00 ,  A61M2016/0021 ,  A61M2202/064

    摘要： The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.

    摘要翻译： 本发明涉及用于将活性剂制剂递送到人类患者的肺的方法和装置。 活性剂制剂可以是干粉形式，它可以是雾化的，或者它可以与推进剂混合。 活性剂制剂以低吸入流速在初始时期递送给患者，以提高活性剂的生物利用度。

    Aerosolization apparatus with capsule puncture alignment guide
    6.
    发明授权
    Aerosolization apparatus with capsule puncture alignment guide 有权

    公开(公告)号：US10207066B2

    公开(公告)日：2019-02-19

    申请号：US10821624

    申请日：2004-04-09

    申请人： Michael John Dunkley ,  Jon David Tuckwell ,  Edward William Vernon-Harcourt ,  Mark Glusker ,  Steve Paboojian

    发明人： Michael John Dunkley ,  Jon David Tuckwell ,  Edward William Vernon-Harcourt ,  Mark Glusker ,  Steve Paboojian

    IPC分类号： A61M15/00

    摘要： An aerosolization apparatus comprises a housing defining a chamber having one or more air inlets. The chamber is sized to receive a capsule which contains an aerosolizable pharmaceutical formulation. The aerosolization apparatus further comprises a puncturing mechanism within the housing. The puncturing mechanism comprises an alignment guide and a puncture member, wherein the alignment guide comprises a surface adapted to contact the capsule while the puncture member is advanced into the capsule to create an opening in the capsule. At least a portion of the surface is sloped relative to the longitudinal axis of the capsule. Alternatively or additionally, the surface may comprise one or more protrusions. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule. The alignment guide allows for more consistent puncturing of the capsule and a longer lifetime of the apparatus.

    Aerosolization apparatus with capsule puncture alignment guide
    7.
    发明申请
    Aerosolization apparatus with capsule puncture alignment guide 审中-公开
    胶囊穿刺对准导管的气雾化装置

    公开(公告)号：US20050000518A1

    公开(公告)日：2005-01-06

    申请号：US10821624

    申请日：2004-04-09

    申请人： Michael Dunkley ,  Jon Tuckwell ,  Edward Vernon-Harcourt ,  Mark Glusker ,  Steve Paboojian

    发明人： Michael Dunkley ,  Jon Tuckwell ,  Edward Vernon-Harcourt ,  Mark Glusker ,  Steve Paboojian

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0028 ,  A61M15/0033 ,  A61M2202/064

    摘要： An aerosolization apparatus comprises a housing defining a chamber having one or more air inlets. The chamber is sized to receive a capsule which contains an aerosolizable pharmaceutical formulation. The aerosolization apparatus further comprises a puncturing mechanism within the housing. The puncturing mechanism comprises an alignment guide and a puncture member, wherein the alignment guide comprises a surface adapted to contact the capsule while the puncture member is advanced into the capsule to create an opening in the capsule. At least a portion of the surface is sloped relative to the longitudinal axis of the capsule. Alternatively or additionally, the surface may comprise one or more protrusions. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule. The alignment guide allows for more consistent puncturing of the capsule and a longer lifetime of the apparatus.

    摘要翻译： 雾化装置包括限定具有一个或多个空气入口的室的壳体。 该腔室的大小适于接收含有可雾化药物制剂的胶囊。 雾化装置还包括在壳体内的穿刺机构。 穿刺机构包括对准引导件和穿刺构件，其中对齐引导件包括适于在穿刺构件前进到胶囊中以接触胶囊的表面以在胶囊中形成开口。 表面的至少一部分相对于胶囊的纵向轴线倾斜。 或者或另外，表面可以包括一个或多个突起。 端部与壳体相关联。 端部的尺寸和形状被容纳在使用者的嘴或鼻中，使得使用者可以通过端部部分吸入，以吸入通过在胶囊中形成的开口离开胶囊的雾化药物制剂。 对准引导件允许胶囊的更一致的穿刺和装置的更长的使用寿命。