Flow resistance modulated aerosolized active agent delivery
    3.
    发明授权
    Flow resistance modulated aerosolized active agent delivery 失效
    阻流调制气雾剂活性剂输送

    公开(公告)号:US08408200B2

    公开(公告)日:2013-04-02

    申请号:US09414384

    申请日:1999-10-07

    IPC分类号: A61M16/00 A61M15/00 A62B9/02

    摘要: The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.

    摘要翻译: 本发明涉及用于将活性剂制剂递送到人类患者的肺的方法和装置。 活性剂制剂可以是干粉形式,它可以是雾化的,或者它可以与推进剂混合。 活性剂制剂以低吸入流速在初始时期递送给患者,以提高活性剂的生物利用度。

    Increased dosage metered dose inhaler
    6.
    发明申请
    Increased dosage metered dose inhaler 有权
    增加剂量计量剂量吸入器

    公开(公告)号:US20050051162A1

    公开(公告)日:2005-03-10

    申请号:US10698025

    申请日:2003-10-30

    IPC分类号: A61M15/00 B65D83/14 A61M11/00

    CPC分类号: B65D83/54 A61M15/009

    摘要: An aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus further comprises a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation, a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated, and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber. In one version, the metering chamber is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.

    摘要翻译: 雾化装置包括容纳药物制剂的容器,药物制剂包含活性剂和推进剂。 雾化装置还包括与容器连通的计量室,计量室适于容纳计量量的药物制剂,阀,以允许计量量的药物制剂在计量室内从计量腔室释放时,阀门为 以及当药物制剂从计量室释放时向计量室中的药物制剂施加压力的加压器。 在一个版本中,计量室的尺寸设定为使得至少2mg,优选至少5mg的活性剂被雾化以在吸入期间输送给使用者。

    III-N EPITAXY ON MULTILAYER BUFFER WITH PROTECTIVE TOP LAYER
    7.
    发明申请
    III-N EPITAXY ON MULTILAYER BUFFER WITH PROTECTIVE TOP LAYER 审中-公开
    具有保护顶层的多层缓冲层的III-N外延

    公开(公告)号:US20160181093A1

    公开(公告)日:2016-06-23

    申请号:US14576500

    申请日:2014-12-19

    IPC分类号: H01L21/02

    摘要: A method of growing III-N material on a silicon substrate including the steps of epitaxially growing a buffer layer of REO material on a silicon substrate, epitaxially growing a layer of REN material on the surface of the buffer, and epitaxially growing a thin protective layer of REO on the surface of the REN material layer. The substrate and structure can then be conveniently transferred to another growth machine in which are performed the steps of transforming or modifying in-situ the REO protective layer to a REN layer with a nitrogen treatment and epitaxially growing a layer of III-N material on the modified protective layer.

    摘要翻译: 一种在硅衬底上生长III-N材料的方法,包括以下步骤:在硅衬底上外延生长REO材料的缓冲层,在衬底的表面上外延生长REN材料层,并外延生长薄的保护层 的REO在REN材料层的表面上。 底物和结构可以方便地转移到另一种生长机器中,其中进行以下步骤:将REO保护层原位转化或修饰为具有氮处理的REN层,并在其上外延生长III-N材料层 改性保护层。

    Low profile distractor apparatuses
    8.
    发明授权
    Low profile distractor apparatuses 有权
    低调牵引器装置

    公开(公告)号:US09173649B2

    公开(公告)日:2015-11-03

    申请号:US13435022

    申请日:2012-03-30

    摘要: Embodiments of low profile distractor apparatuses are disclosed. The distractor apparatuses generally comprise a mounting body, a tensioning mechanism coupled to the mounting body and a distractor arm coupled to the tensioning mechanism and pivotally coupled to the mounting body for rotation relative to the mounting body. The tensioning axis of the tensioning mechanism is non-coaxial with an effector axis of the distractor arm and a distraction force applied with the distractor arm is translated to the effector axis. This enables the distractor apparatus to be positioned relative to a patient such that the tensioning mechanism is offset from the long axis of the limb of the patient thereby facilitating improved access to the distal portions of the limb.

    摘要翻译: 公开了低剖面牵引装置的实施例。 牵引装置通常包括安装体,联接到安装体的张紧机构和联接到张紧机构的牵引臂,枢转地联接到安装体以相对于安装体旋转。 张紧机构的张紧轴线与牵引臂的效应器轴线不同轴,并且用牵引臂施加的牵引力平移到效应器轴线。 这使得牵引器装置能够相对于患者定位,使得张紧机构偏离患者肢体的长轴线,从而便于改善对肢体的远端部分的接近。

    AlN CAP GROWN ON GaN/REO/SILICON SUBSTRATE STRUCTURE
    10.
    发明申请
    AlN CAP GROWN ON GaN/REO/SILICON SUBSTRATE STRUCTURE 有权
    GaN / REO /硅衬底结构上的AlN电极

    公开(公告)号:US20140231818A1

    公开(公告)日:2014-08-21

    申请号:US13772169

    申请日:2013-02-20

    IPC分类号: H01L21/02 H01L29/20

    摘要: III-N material grown on a silicon substrate includes a single crystal rare earth oxide layer positioned on a silicon substrate. The rare earth oxide is substantially crystal lattice matched to the surface of the silicon substrate. A first layer of III-N material is positioned on the surface of the rare earth oxide layer. An inter-layer of aluminum nitride (AlN) is positioned on the surface of the first layer of III-N material and an additional layer of III-N material is positioned on the surface of the inter-layer of aluminum nitride. The inter-layer of aluminum nitride and the additional layer of III-N material are repeated n-times to reduce or engineer strain in a final III-N layer. A cap layer of AlN is grown on the final III-N layer and a III-N layer of material with one of an LED structure and an HEMT structure is grown on the AlN cap layer.

    摘要翻译: 在硅衬底上生长的III-N材料包括位于硅衬底上的单晶稀土氧化物层。 稀土氧化物与硅衬底的表面基本上晶格匹配。 第一层III-N材料位于稀土氧化物层的表面上。 氮化铝(AlN)的层间位于III-N材料的第一层的表面上,并且在氮化铝层间的表面上设置附加的III-N层。 氮化铝层和III-N材料的附加层重复n次,以减少或设计最终III-N层的应变。 在最终的III-N层上生长AlN的覆盖层,并且在AlN覆盖层上生长具有LED结构和HEMT结构之一的III-N层材料。