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18 条记录 (耗时 0.022 秒)

    Flow resistance modulated aerosolized active agent delivery
    3.
    发明授权
    Flow resistance modulated aerosolized active agent delivery 失效
    阻流调制气雾剂活性剂输送

    公开(公告)号：US08408200B2

    公开(公告)日：2013-04-02

    申请号：US09414384

    申请日：1999-10-07

    申请人： Andrew Clark ,  Carlos Schuler ,  Steve Paboojian

    发明人： Andrew Clark ,  Carlos Schuler ,  Steve Paboojian

    IPC分类号： A61M16/00 ,  A61M15/00 ,  A62B9/02

    CPC分类号： A61M15/00 ,  A61M2016/0021 ,  A61M2202/064

    摘要： The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.

    摘要翻译： 本发明涉及用于将活性剂制剂递送到人类患者的肺的方法和装置。 活性剂制剂可以是干粉形式，它可以是雾化的，或者它可以与推进剂混合。 活性剂制剂以低吸入流速在初始时期递送给患者，以提高活性剂的生物利用度。

    Increased dosage metered dose inhaler
    6.
    发明申请
    Increased dosage metered dose inhaler 有权
    增加剂量计量剂量吸入器

    公开(公告)号：US20050051162A1

    公开(公告)日：2005-03-10

    申请号：US10698025

    申请日：2003-10-30

    申请人： Carlos Schuler ,  Andrew Clark ,  Kevin Walsh ,  William Alston

    发明人： Carlos Schuler ,  Andrew Clark ,  Kevin Walsh ,  William Alston

    IPC分类号： A61M15/00 ,  B65D83/14 ,  A61M11/00

    CPC分类号： B65D83/54 ,  A61M15/009

    摘要： An aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus further comprises a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation, a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated, and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber. In one version, the metering chamber is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.

    摘要翻译： 雾化装置包括容纳药物制剂的容器，药物制剂包含活性剂和推进剂。 雾化装置还包括与容器连通的计量室，计量室适于容纳计量量的药物制剂，阀，以允许计量量的药物制剂在计量室内从计量腔室释放时，阀门为 以及当药物制剂从计量室释放时向计量室中的药物制剂施加压力的加压器。 在一个版本中，计量室的尺寸设定为使得至少2mg，优选至少5mg的活性剂被雾化以在吸入期间输送给使用者。

    Increased dosage metered dose inhaler
    8.
    发明授权
    Increased dosage metered dose inhaler 有权
    增加剂量计量剂量吸入器

    公开(公告)号：US07481212B2

    公开(公告)日：2009-01-27

    申请号：US10698025

    申请日：2003-10-30

    申请人： Carlos Schuler ,  Andrew R. Clark ,  Kevin R. Walsh ,  William Alston

    发明人： Carlos Schuler ,  Andrew R. Clark ,  Kevin R. Walsh ,  William Alston

    IPC分类号： A61M11/00

    CPC分类号： B65D83/54 ,  A61M15/009

    摘要： An aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus further comprises a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation, a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated, and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber. In one version, the metering chamber is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.

    摘要翻译： 雾化装置包括容纳药物制剂的容器，药物制剂包含活性剂和推进剂。 雾化装置还包括与容器连通的计量室，计量室适于容纳计量量的药物制剂，阀，以允许计量量的药物制剂在计量室内从计量腔室释放时，阀门为 以及当药物制剂从计量室释放时向计量室中的药物制剂施加压力的加压器。 在一个版本中，计量室的尺寸设定为使得至少2mg，优选至少5mg的活性剂被雾化以在吸入期间输送给使用者。

    Metered dose inhaler with lockout
    10.
    发明申请
    Metered dose inhaler with lockout 有权
    计量吸入器锁定

    公开(公告)号：US20050056276A1

    公开(公告)日：2005-03-17

    申请号：US10734076

    申请日：2003-12-10

    申请人： Carlos Schuler ,  William Alston

    发明人： Carlos Schuler ,  William Alston

    IPC分类号： A61M15/00 ,  A61M11/00

    CPC分类号： A61M15/00 ,  A61M15/0096 ,  A61M2205/3306

    摘要： An aerosolization device comprises a housing, a container comprising a reservoir storing a pharmaceutical formulation which comprises a propellant, and a metering valve. The metering valve is in communication with the reservoir and is moveable into the container to an actuated position where a predetermined amount of the pharmaceutical formulation is released. A contact member is provided in the housing. In one version, the contact member is moveable between a first position and a second position to allow for selective actuation of the metering valve. In another version, the contact member's configuration may be changed to allow for selective actuation of the metering valve.

    摘要翻译： 雾化装置包括壳体，容器，其包含储存包含推进剂的药物制剂的储存器和计量阀。 计量阀与储存器连通并且可移动到容器中到达预定量的药物制剂被释放的致动位置。 接触构件设置在壳体中。 在一个版本中，接触构件可在第一位置和第二位置之间移动，以允许选择性地致动计量阀。 在另一个版本中，可以改变接触构件的构造以允许选择性地致动计量阀。