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1.发明申请公开(公告)号：US20110223205A1
公开(公告)日：2011-09-15
申请号：US13026995
申请日：2011-02-14
CPC分类号： C12N5/0605 , A61K35/12 , C12N5/0607 , C12N5/0622 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/12 , C12N2501/13 , C12N2501/21 , C12N2501/23 , C12N2501/385 , C12N2501/41 , C12N2502/02 , C12N2502/03 , C12N2506/02 , C12N2506/025 , C12N2506/03 , C12N2509/00 , C12N2533/50
摘要： This invention relates to methods of treating amyotrophic lateral sclerosis. In particular, the invention provides for methods of treating amyotrophic lateral sclerosis by administering umbilical cord tissue-derived cells, an effective amount of a substantially homogenous population of umbilical cord tissue-derived cells or a pharmaceutical composition comprising umbilical cord tissue-derived cells to a patient.
摘要翻译： 本发明涉及治疗肌萎缩性侧索硬化症的方法。 特别地，本发明提供了通过施用脐带组织来源的细胞，有效量的基本上均匀的脐带组织来源的细胞群或包含脐带组织来源的细胞的药物组合物来治疗肌萎缩性侧索硬化的方法 患者。
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公开(公告)号：US20090275129A1
公开(公告)日：2009-11-05
申请号：US12432994
申请日：2009-04-30
申请人： Kevin Cooper , Iksoo Chun , David C. Colter , Sridevi Dhanaraj , Anna Gosiewska , Agnieszka Seyda , Carrie H. Fang , Chunlin Yang
发明人： Kevin Cooper , Iksoo Chun , David C. Colter , Sridevi Dhanaraj , Anna Gosiewska , Agnieszka Seyda , Carrie H. Fang , Chunlin Yang
CPC分类号： C12N5/0691 , A61L27/18 , A61L27/3604 , A61L27/38 , A61L27/507 , C12M21/08 , C12M25/14 , C08L67/04
摘要： Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.
摘要翻译： 公开了使用组织工程化血管修复和再生血管疾病患者血管的组合物和方法。
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3.发明申请公开(公告)号：US20090155245A1
公开(公告)日：2009-06-18
申请号：US12330704
申请日：2008-12-09
IPC分类号： A61K35/12 , A61K35/28 , A61K39/395 , A61P13/12
CPC分类号： A61K45/06 , A61K35/22 , A61K35/28 , A61K38/1841 , A61K38/553 , A61K38/556 , A61K2300/00
摘要： Combination therapies of drugs and biologics for treatment of acute and chronic organ degeneration are disclosed. More specifically, the use of morphogens, stem cells, and anti-inflammatories or inhibitors for the renin-angiotensin-aldosterone system (RAAS) for the treatment of acute and chronic renal disease is disclosed.
摘要翻译： 公开了用于治疗急性和慢性器官退行性疾病的药物和生物制剂的组合疗法。 更具体地，公开了用于治疗急性和慢性肾脏疾病的肾素 - 血管紧张素 - 醛固酮系统（RAAS）的形态发生剂，干细胞和抗炎剂或抑制剂的用途。
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公开(公告)号：US08071137B2
公开(公告)日：2011-12-06
申请号：US12059915
申请日：2008-03-31
申请人： Sridevi Dhanaraj , Carrie H. Fang
发明人： Sridevi Dhanaraj , Carrie H. Fang
IPC分类号： A61K36/00
CPC分类号： A61K36/23 , A61K9/0019
摘要： The invention is a method for the treatment of mammalian articular cartilage disorders, inflammatory joint disease, trauma-related cartilage injuries, and degenerative disc disease. The method involves treating the affected area with a composition containing a therapeutically effective dose of Centella extract. The composition is delivered locally by parenteral administration to the affected site.
摘要翻译： 本发明是一种治疗哺乳动物关节软骨疾病，炎性关节疾病，创伤相关软骨损伤和退行性椎间盘疾病的方法。 该方法包括用含有治疗有效剂量的Centella提取物的组合物治疗受影响的区域。 组合物通过肠胃外给药局部递送至受影响部位。
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公开(公告)号：US20080226754A1
公开(公告)日：2008-09-18
申请号：US12059915
申请日：2008-03-31
申请人： Sridevi DHANARAJ , Carrie H. Fang
发明人： Sridevi DHANARAJ , Carrie H. Fang
CPC分类号： A61K36/23 , A61K9/0019
摘要： The invention is a method for the treatment of mammalian articular cartilage disorders, inflammatory joint disease, trauma-related cartilage injuries, and degenerative disc disease. The method involves treating the affected area with a composition containing a therapeutically effective dose of Centella extract. The composition is delivered locally by parenteral administration to the affected site.
摘要翻译： 本发明是一种治疗哺乳动物关节软骨疾病，炎性关节疾病，创伤相关软骨损伤和退行性椎间盘疾病的方法。 该方法包括用含有治疗有效剂量的Centella提取物的组合物治疗受影响的区域。 组合物通过肠胃外给药局部递送至受影响部位。
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公开(公告)号：US20080268016A1
公开(公告)日：2008-10-30
申请号：US12107290
申请日：2008-04-22
CPC分类号： A61K35/22 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3804 , A61L27/48 , A61L2430/26
摘要： Biocompatible tissue repair implant devices and their methods of use are provided for repairing a diseased kidney tissue. The present invention relates to methods of removing a portion of kidney tissue from a host or donor, mincing it, placing it on a bioresorbable scaffold, and implanting the scaffold into a defect site in a kidney of a host or patient for use in the treatment of degenerative kidney diseases. The compositions and methods provide a pluripotent milieu for the de-novo generation of renal tubular structures in the replacement of diseased kidney tissue. The processes and devices are useful in the treatment of medical conditions and diseases relating to the kidneys such as trauma, necrosis, and both acute and chronic forms of renal failure.
摘要翻译： 生物相容性组织修复植入装置及其使用方法被提供用于修复患病的肾组织。 本发明涉及从宿主或供体去除一部分肾组织的方法，将其切碎，将其置于生物可再吸收的支架上，以及将支架植入宿主或患者的肾脏中的缺陷部位用于治疗 的退行性肾脏疾病。 组合物和方法提供用于替代患病肾组织的肾小管结构的新生代的多功能环境。 方法和装置可用于治疗与肾脏相关的医学病症和疾病，例如创伤，坏死，以及急性和慢性肾衰竭形式。
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公开(公告)号：US20090162351A1
公开(公告)日：2009-06-25
申请号：US12005060
申请日：2007-12-21
IPC分类号： A61K39/395 , A61K31/496 , A61K31/4439 , A61P19/00 , A61K35/12 , A61K31/519
CPC分类号： A61K31/4439 , A61K31/496 , A61K31/519
摘要： The present invention relates to methods, formulations and kits for administering a p38 MAP kinase inhibitor or other therapeutic agent into an intervertebral disc, such as a diseased disc, for example, for purposes of prevention and treatment of degenerative and other disorders.
摘要翻译： 本发明涉及用于将p38MAP激酶抑制剂或其它治疗剂施用于椎间盘例如患病椎间盘的方法，制剂和试剂盒，例如用于预防和治疗退行性疾病和其他疾病。
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公开(公告)号：US20110230406A1
公开(公告)日：2011-09-22
申请号：US13044607
申请日：2011-03-10
申请人： John Kehoe , Daphne A. Salick , Carrie H. Fang , Chunlin Yang , Abla Creasey
发明人： John Kehoe , Daphne A. Salick , Carrie H. Fang , Chunlin Yang , Abla Creasey
CPC分类号： B82Y5/00 , A61K47/6435 , A61K47/66 , C07K7/08
摘要： We have disclosed affinity peptides toward BMP-2. More specifically we have disclosed an affinity biomatrix where the affinity peptide is covalently attached to a biocompatible, biodegradable polymer. The affinity biomatrix is useful in preparing controlled release devices for BMP-2.
摘要翻译： 我们已经公开了针对BMP-2的亲和肽。 更具体地，我们已经公开了一种亲和力生物基质，其中亲和肽共价连接到生物相容的可生物降解的聚合物上。 亲和力生物基质可用于制备BMP-2的受控释放装置。
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公开(公告)号：US20120089232A1
公开(公告)日：2012-04-12
申请号：US13207398
申请日：2011-08-10
申请人： Jennifer Hagyoung Kang Choi , Chunlin Yang , Ying Sun , Carrie H. Fang , James E. Hauschild , Abla A. Creasey
发明人： Jennifer Hagyoung Kang Choi , Chunlin Yang , Ying Sun , Carrie H. Fang , James E. Hauschild , Abla A. Creasey
CPC分类号： A61K9/143 , A61K33/06 , A61K33/30 , A61K33/34 , A61K33/38 , A61L15/18 , A61L15/42 , A61L26/0004 , A61L26/0066 , A61L27/24 , A61L27/30 , A61L27/306 , A61L27/50 , A61L27/54 , A61L29/106 , A61L29/14 , A61L31/088 , A61L31/14 , A61L2300/102 , A61L2300/104 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/45 , A61L2300/622
摘要： Implantable medical devices having galvanic particulates are disclosed. The particulates may be coated onto at least part of a surface of the medical device. In addition, the galvanic particulates may be contained in the material used to manufacture the antimicrobial medical devices, or may be embedded into the surface of the medical devices. The present invention also provides novel coating methods and processing methods. The present invention further provides a combination of galvanic particulates with an aqueous gel, a method of making this combination, and a method of treatment using this combination. The devices and compositions may have advantageous characteristics and effects including anti-microbial, anti-inflammatory, tissue regeneration promoting, and pain reduction or elimination.
摘要翻译： 公开了具有电偶颗粒的可植入医疗装置。 颗粒可以涂覆在医疗装置的表面的至少一部分上。 此外，电化学颗粒可以包含在用于制造抗微生物医疗装置的材料中，或者可以嵌入医疗装置的表面中。 本发明还提供了新的涂布方法和加工方法。 本发明还提供电偶粒子与水性凝胶的组合，制造该组合的方法以及使用该组合的治疗方法。 所述装置和组合物可以具有有利的特征和效果，包括抗微生物，抗炎，组织再生促进和疼痛减轻或消除。
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公开(公告)号：US20110143429A1
公开(公告)日：2011-06-16
申请号：US12971116
申请日：2010-12-17
申请人： Iksoo Chun , Kevin Cooper , Carrie H. Fang
发明人： Iksoo Chun , Kevin Cooper , Carrie H. Fang
CPC分类号： A61L27/18 , A61L27/3804 , A61L27/507 , C12M21/08 , C12M25/14 , Y10T156/1038 , C08L67/04
摘要： Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.
摘要翻译： 公开了使用组织工程化血管修复和再生血管疾病患者血管的组合物和方法。
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