公开(公告)号：US20050247564A1

公开(公告)日：2005-11-10

申请号：US10838570

申请日：2004-05-04

申请人： Armin Volkel ,  Meng Lean ,  H. Hsieh ,  Jurgen Daniel

发明人： Armin Volkel ,  Meng Lean ,  H. Hsieh ,  Jurgen Daniel

IPC分类号： B03C5/02 ,  G01N27/27 ,  G01N27/453 ,  G01N30/00 ,  G01N33/487

CPC分类号： B03C5/028 ,  G01N2030/0035

摘要： An apparatus for extracting and concentrating bioagents within a continuously flowing fluid medium includes a flow channel fluid inlet, in which bioagents are concentrated from three dimensions to a two-dimensional transport layer in a preconcentration area. Traveling wave grids cause the preconcentrated bioagents to migrate to one side of the flow channel and then to an extraction port. Each of the traveling wave grids includes a substrate, a collection of closely spaced and parallel electrically conductive electrodes extending across said substrate, and a collection of buses providing electrical communication with the collection of conductive electrodes. A voltage controller provides a multiphase electrical signal to the collection of buses and electrodes of the traveling wave grids. Fluid exits through an outlet port.

摘要翻译： 用于在连续流动的流体介质中提取和浓缩生物体的装置包括流动通道流体入口，其中生物体从三维集中到预浓缩区域中的二维输送层。 旅行波谷使预浓缩的生物标签迁移到流动通道的一侧，然后迁移到提取口。 每个行波波谷包括基板，跨越所述基板的紧密间隔且平行的导电电极的集合，以及提供与导电电极集合电连通的总线的集合。 电压控制器提供多相电信号，用于收集行波网格的总线和电极。 流体通过出口排出。

公开(公告)号：US20050123930A1

公开(公告)日：2005-06-09

申请号：US10727301

申请日：2003-12-03

申请人： Meng Lean ,  Jeng Lu ,  Jackson Ho ,  Chinwen Shih ,  Armin Volkel ,  Huangpin Hsieh ,  Jurgen Daniel

发明人： Meng Lean ,  Jeng Lu ,  Jackson Ho ,  Chinwen Shih ,  Armin Volkel ,  Huangpin Hsieh ,  Jurgen Daniel

IPC分类号： B03C5/02 ,  G01N27/447 ,  G01N30/02 ,  C12Q1/68 ,  G01N33/53

CPC分类号： G01N27/44773 ,  B03C5/028 ,  G01N27/44713 ,  G01N30/02

摘要： Various traveling wave grids and related systems are disclosed that are particularly beneficial for the separation, transport, and focusing of biomolecules or other charged species. An implementation of a vertically integrated traveling wave module is described which allows for scalability to arbitrary gel dimensions through tiling. In addition, several unique traveling wave algorithms are also described which when used in conjunction with the traveling wave grids, impart selective motion to biomolecules or other charged species.

摘要翻译： 公开了对生物分子或其他带电物质的分离，运输和聚焦特别有利的各种行波网格和相关系统。 描述了垂直集成的行波模块的实现，其允许通过平铺来扩展任意的凝胶尺寸。 此外，还描述了当与行波网格结合使用时，对生物分子或其他带电物质赋予选择性运动的几种独特的行波算法。

公开(公告)号：US20070057748A1

公开(公告)日：2007-03-15

申请号：US11224347

申请日：2005-09-12

申请人： Meng Lean ,  Jeng Lu ,  Scott Limb ,  Jurgen Daniel ,  Armin Volkel ,  Huangpin Hsieh ,  Scott Solberg ,  Bryan Preas

发明人： Meng Lean ,  Jeng Lu ,  Scott Limb ,  Jurgen Daniel ,  Armin Volkel ,  Huangpin Hsieh ,  Scott Solberg ,  Bryan Preas

IPC分类号： H01P1/18

CPC分类号： B03C5/028

摘要： Various traveling wave grid configurations are disclosed. The grids and systems are well suited for transporting, separating, and classifying small particles dispersed in liquid or gaseous media. Also disclosed are various separation strategies and purification cells utilizing such traveling wave arrays and strategies.

摘要翻译： 公开了各种行波网格结构。 网格和系统非常适用于分散在液体或气体介质中的小粒子的运输，分离和分类。 还公开了利用这种行波阵列和策略的各种分离策略和纯化单元。

公开(公告)号：US20050123992A1

公开(公告)日：2005-06-09

申请号：US10727289

申请日：2003-12-03

申请人： Armin Volkel ,  Meng Lean ,  Huangpin Hsieh ,  Jurgen Daniel

发明人： Armin Volkel ,  Meng Lean ,  Huangpin Hsieh ,  Jurgen Daniel

IPC分类号： C12M1/34 ,  G01N33/53 ,  G01N33/543

CPC分类号： G01N33/5438

摘要： Several traveling wave grid systems are disclosed that may be used to concentrate and form highly localized regions of bio-agents or other charged species. In addition, specific detection systems are described that enable currently available detectors and sensors, including those to be developed in the future, to be used for measuring the presence and concentration of certain bio-agents or charged particles, which otherwise are present at concentrations too low to readily detect or measure.

摘要翻译： 公开了几种可以用于浓缩和形成高度局部化的生物剂或其他带电物质区域的行波系统。 此外，描述了使得目前可用的检测器和传感器（包括将来要开发的检测器和传感器）能够用于测量某些生物试剂或带电粒子的存在和浓度的具体检测系统，否则其浓度也是以浓度存在 低易于检测或测量。

公开(公告)号：US20050247565A1

公开(公告)日：2005-11-10

申请号：US10838937

申请日：2004-05-04

申请人： H. Hsieh ,  Meng Lean ,  Bryan Preas ,  Armin Volkel

发明人： H. Hsieh ,  Meng Lean ,  Bryan Preas ,  Armin Volkel

IPC分类号： G01N27/27 ,  G01N27/453

CPC分类号： G01N27/453

摘要： A portable apparatus for extracting and concentrating bioagents within a fluid medium includes a container with sample solution inlet port and traveling wave grids patterned on surfaces of the container. The traveling wave grids cause bioagents to migrate to a specified surface within the container and then to an extraction port. The traveling wave grids include a substrate, across which extend a collection of closely spaced and parallel electrically conductive electrodes, and a collection of buses providing electrical communication with the collection of conductive electrodes. A voltage controller provides a multiphase electrical signal to the collection of buses and electrodes of the traveling wave grids.

摘要翻译： 用于在流体介质中提取和浓缩生物体的便携式设备包括具有样品溶液入口的容器和在容器表面上图案化的行波网格。 行波网格使生物体迁移到容器内的指定表面，然后迁移到提取口。 行波网格包括基板，跨越其延伸紧密间隔且平行的导电电极的集合，以及提供与导电电极集合电连通的总线的集合。 电压控制器提供多相电信号，用于收集行波网格的总线和电极。

公开(公告)号：US20060121555A1

公开(公告)日：2006-06-08

申请号：US11007121

申请日：2004-12-08

申请人： Meng Lean ,  Armin Volkel ,  Peter Kiesel ,  Oliver Schmidt ,  Noble Johnson ,  H. Hsieh

发明人： Meng Lean ,  Armin Volkel ,  Peter Kiesel ,  Oliver Schmidt ,  Noble Johnson ,  H. Hsieh

IPC分类号： C12M1/34 ,  C12Q1/24

CPC分类号： G01N30/0005 ,  B03C5/028 ,  G01N30/08

摘要： A flow cell is disclosed for collecting and concentrating a sample dispersed in a flowing medium. The collected sample can be selectively manipulated within the cell by the use of one or more traveling wave grids. The cells are particularly useful as bio-enrichment devices and can be utilized upstream of conventional analytical or detection instruments.

摘要翻译： 公开了用于收集和浓缩分散在流动介质中的样品的流动池。 收集的样品可以通过使用一个或多个行波网格在单元内选择性地操纵。 细胞特别可用作生物富集装置，并可用于常规分析或检测仪器的上游。

公开(公告)号：US20050136703A1

公开(公告)日：2005-06-23

申请号：US10742501

申请日：2003-12-19

申请人： Koenraad Van Schuylenbergh ,  Armin Volkel ,  Thomas DiStefano ,  Michel Rosa ,  David Fork ,  Eugene Chow ,  Meng Lean

发明人： Koenraad Van Schuylenbergh ,  Armin Volkel ,  Thomas DiStefano ,  Michel Rosa ,  David Fork ,  Eugene Chow ,  Meng Lean

IPC分类号： H05K1/14 ,  H01B11/00 ,  H01R12/00 ,  H01R12/04 ,  H05K3/32 ,  H05K3/36

CPC分类号： H01R12/78 ,  H05K1/147 ,  H05K3/323 ,  H05K3/361 ,  H05K3/365 ,  H05K2201/044 ,  H05K2201/09845

摘要： A data transmission interconnect assembly (e.g., a router) capable of transmission speeds in excess of 40 Gbps in which a line-card is detachably coupled to a backplane using flexible flat cables that are bent to provide a continuous, smooth curve between the connected boards, and connected by a connection apparatus that employs cable-to-cable interface members that are transparent to the transmitted signal waves. Microspring contact structures are formed on the cables, or on a contact structure pressed against the cables, to provide interface arrangements that are smaller than a wavelength of the transmitted signal. A connector apparatus uses a cam mechanism to align the cables, and then to press a contact structure, having micro spring interface members formed thereon, against the cables. An alterative contact structure uses anisotropic conductive film.

公开(公告)号：US20060038120A1

公开(公告)日：2006-02-23

申请号：US10921556

申请日：2004-08-19

申请人： Meng Lean ,  Francisco Torres ,  Huangpin Hsieh ,  Armin Volkel ,  Bryan Preas ,  Scott Elrod ,  John Fitch ,  Richard Bruce

发明人： Meng Lean ,  Francisco Torres ,  Huangpin Hsieh ,  Armin Volkel ,  Bryan Preas ,  Scott Elrod ,  John Fitch ,  Richard Bruce

IPC分类号： H01J49/00

CPC分类号： B03C1/253

摘要： A sample manipulator that utilizes electrostatic traveling waves to selectively displace one or more samples deposited on its face is disclosed. The sample manipulator enables an operator to perform a wide variety of processes upon the deposited samples. Also disclosed are strategies for separating two or more samples, focusing a sample, and passing a reagent through a sample, all conducted on the face of the sample manipulator.

摘要翻译： 公开了一种使用静电行波选择性地移动沉积在其表面上的一个或多个样品的样品操纵器。 样品操纵器使得操作者能够在沉积的样品上执行各种各样的处理。 还公开了用于分离两个或更多个样品，聚焦样品并使试剂通过样品的策略，全部在样品操纵器的表面上进行。

公开(公告)号：US20060027034A1

公开(公告)日：2006-02-09

申请号：US10913940

申请日：2004-08-06

申请人： Meng Lean ,  Huangpin Hsieh ,  Armin Volkel ,  Peter Kiesel ,  Noble Johnson

发明人： Meng Lean ,  Huangpin Hsieh ,  Armin Volkel ,  Peter Kiesel ,  Noble Johnson

IPC分类号： G01G19/32

CPC分类号： G01N1/08

摘要： Disclosed is a compact, non-contacting device for collecting samples, and particularly minute quantities of bio-agents or particulates, from a surface. The device vibrates a region of a target surface containing the sample and collects the sample on an electrically charged pin array. The sample can be later released to a detector or other instrumentation for subsequent analysis.

公开(公告)号：US20070145249A1

公开(公告)日：2007-06-28

申请号：US11315992

申请日：2005-12-22

申请人： Peter Kiesel ,  Meng Lean ,  Oliver Schmidt ,  Armin Volkel ,  Noble Johnson

发明人： Peter Kiesel ,  Meng Lean ,  Oliver Schmidt ,  Armin Volkel ,  Noble Johnson

IPC分类号： H01J40/14

CPC分类号： G01N21/05 ,  G01N21/645 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/0346 ,  G01N2021/1734 ,  G01N2021/6421 ,  G01N2021/6482

摘要： A fluidic structure includes a channel and along the channel is a series of sensing components to obtain information about objects traveling within the channel, such as droplets or other objects carried by fluid. At least one sensing component includes a set of cells of a photosensor array. The set of cells photosense a range of photon energies that emanate from objects, and include a subset of cells that photosense within subranges. A processor can receive information about objects from the sensing components and use it to obtain spectral information. The processor can perform an initial analysis using information from one set of sensing components and, based on the results, control a fluidic device in the channel, such as a gate, to retain objects, such as for concentration and more detailed analysis by other sensing components, or to purge objects from the channel.

摘要翻译： 流体结构包括通道，并且沿着通道是一系列感测部件，以获得关于在通道内行进的物体的信息，例如由流体携带的液滴或其它物体。 至少一个感测组件包括一组光电传感器阵列的单元。 该组细胞照射从物体发出的一系列光子能量，并且包括在子范围内的光密度的子集。 处理器可以从感测组件接收关于对象的信息，并使用它来获得光谱信息。 处理器可以使用来自一组感测组件的信息来执行初始分析，并且基于该结果，控制通道（例如门）中的流体装置以保持对象，例如通过其他感测的浓度和更详细的分析 组件，或从通道清除对象。