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公开(公告)号：US20220314223A1
公开(公告)日：2022-10-06
申请号：US17419970
申请日：2020-09-25
发明人： Qiuxu WEI , Yingying ZHAO , Wenliang YAO , Bolin FAN , Le GU , Yongjia GAO
IPC分类号： B01L3/00
摘要： An embodiment of the present disclosure provides a microfluidic chip, including: a first substrate; wherein the first substrate includes a first base, a first electrode layer on the first base; the first electrode layer includes a plurality of first electrodes at intervals along a first direction, wherein a cross-sectional shape of the first electrode parallel to the first base is a centrosymmetric shape, and the cross-sectional shape includes: a first boundary and a second boundary opposite to each other in the first direction; a shape of the first boundary is a centrosymmetric curve, a distance between two end points of the first boundary in a second direction perpendicular to the first direction is less than a length of the first boundary; the second boundary has a same shape and length as the first boundary, and the first and second boundaries are parallel to each other in the first direction.
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公开(公告)号：US20220126287A1
公开(公告)日：2022-04-28
申请号：US17271297
申请日：2020-05-13
发明人： Yue LI , Wenliang YAO , Nan ZHAO , Yongjia GAO , Le GU , Hui LIAO , Bolin FAN , Yingying ZHAO
摘要： Provided is a micro-fluidic chip, including a first substrate and a second substrate opposite to each other. A liquid storage cavity is formed between the first substrate and the second substrate, and a liquid inlet hole penetrating through the first substrate in a thickness direction is formed in the first substrate. The first substrate includes a first electrode layer and a hydrophobic layer that are sequentially disposed in the thickness direction of the first substrate, and the first electrode layer is on a surface of the hydrophobic layer away from the second substrate. The second substrate includes an adjustment layer and a second electrode layer that are sequentially disposed in a thickness direction of the second substrate, and the second electrode layer is on a surface of the adjustment layer away from the first substrate. A micro-fluidic system and a control method of the micro-fluidic chip are also provided.
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公开(公告)号：US20240207852A1
公开(公告)日：2024-06-27
申请号：US17908067
申请日：2021-09-02
发明人： Bolin FAN , Wenliang YAO , Yingying ZHAO , Le GU , Yongjia GAO , Qiuxu WEI , Li YANG
IPC分类号： B01L3/00
CPC分类号： B01L3/502792 , B01L3/502715 , B01L2300/0645 , B01L2300/087 , B01L2300/088 , B01L2400/0427
摘要： A microfluidic substrate has a first straight region, a second straight region, and a first turning region, which is substantially of a ring sector and includes a first arc edge and a second arc edge that are opposite. The microfluidic substrate includes first straight driving electrodes in the first straight region, second straight driving electrodes in the second straight region, and turning driving electrodes the first turning region. A border of each turning driving electrode includes at least one first reference point coinciding with the first arc edge and at least one second reference point coinciding with the second arc edge. A radius of the first arc edge is greater than or equal to (√{square root over (3)}−1) times of a first dimension of a reference electrode, and a radius of the second arc edge is greater than or equal to 3/2 times of the first dimension of the reference electrode.
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4.发明申请公开(公告)号：US20220341925A1
公开(公告)日：2022-10-27
申请号：US17434408
申请日：2021-02-07
发明人： Yue LI , Wenliang YAO , Nan ZHAO , Yongjia GAO , Bolin FAN , Le GU , Hui LIAO , Yingying ZHAO
IPC分类号： G01N33/543 , G01N21/76
摘要： The present disclosure relates to a digital microfluidic chemiluminescence detection chip, a detection method and a detection device. The digital microfluidic chemiluminescence detection chip includes a first baseplate and a second baseplate disposed oppositely. A cavity formed by the first and second baseplate includes a mixing and incubating area for combining an antigen, a magnetic particle antibody and an antibody, a luminescence detection area for chemiluminescence and detecting an optical signal, and a communication path for communicating the mixing and incubating area and the luminescence detection area. The first baseplate is provided with a drive array for driving sample solution to move and an optical sensing array for acquiring a luminescence signal of the sample solution. The drive array corresponds to positions of the mixing and incubating area, the luminescence detection area and the communication path. The optical sensing array corresponds to a position of the luminescence detection area.
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公开(公告)号：US20210268499A1
公开(公告)日：2021-09-02
申请号：US17186186
申请日：2021-02-26
发明人： Hui LIAO , Yingying ZHAO , Bolin FAN , Wenliang YAO , Nan ZHAO , Le GU , Yongjia GAO
IPC分类号： B01L3/00 , G01N33/577 , G01N27/22
摘要： The present disclosure discloses a microfluidic structure, a microfluidic chip and a detection method. The microfluidic structure includes: a first base substrate and a second base substrate opposite to each other, an antibody area located between the first base substrate and the second base substrate and storing an enzyme-labeled first antibody, a cleaning area storing cleaning liquid, a signal substrate area storing a signal substrate solution and a detection area with a second antibody and an ion sensitive film fixed thereon, wherein all channel areas from the antibody area, the cleaning area and the signal substrate area to the detection area each have a driving electrode structure driving liquid drops to move; and the detection area has a thin film transistor connected with the ion sensitive film.
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公开(公告)号：US20220403306A1
公开(公告)日：2022-12-22
申请号：US17598928
申请日：2020-12-25
发明人： Bolin FAN , Le GU , Yingying ZHAO , Wenliang YAO , Yongjia GAO , Qiuxu WEI
摘要： Disclosed are a substrate for a microfluidic device, a microfluidic device, a driving method of the microfluidic device, and a method of manufacturing a substrate for the microfluidic device. The substrate includes: a first base substrate; a first electrode layer on the first base substrate, the first electrode layer including a plurality of drive electrodes. The plurality of drive electrodes define at least one flow channel and at least one functional area in the first substrate, the at least one functional area includes a reagent area, the at least one flow channel includes a reagent area flow channel, the reagent area includes a reagent area liquid storage portion and a droplet shape changing portion, the droplet shape changing portion is adjacent to the reagent area flow channel, and the reagent liquid storage portion is on a side of the droplet shape changing portion away from the reagent area flow channel.
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公开(公告)号：US20220395826A1
公开(公告)日：2022-12-15
申请号：US17606716
申请日：2020-12-25
发明人： Bolin FAN , Yongjia GAO , Yingying ZHAO , Le GU , Wenliang YAO , Qiuxu WEI
IPC分类号： B01L3/00
摘要： The present disclosure relates to a microfluidic substrate, a microfluidic device and a driving method thereof. The microfluidic substrate includes a first area, the first area includes a first module for generating droplets, the first module includes a first electrode pair and a second electrode pair, and the first electrode pair and the second electrode pair are arranged in a crisscross pattern. The first electrode pair includes a first electrode and a second electrode, and the second electrode pair includes a third electrode and a fourth electrode.
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公开(公告)号：US20210162409A1
公开(公告)日：2021-06-03
申请号：US16757902
申请日：2019-03-27
发明人： Wenliang YAO , Nan ZHAO , Peizhi CAI , Fengchun PANG , Yue GENG , Le GU , Yuelei XIAO , Hui LIAO , Yingying ZHAO , Bolin FAN
IPC分类号： B01L3/00 , G01N33/487
摘要： A biological detection chip, a biological detection device, and a detection method thereof are disclosed. The biological detection chip includes a first base substrate and a plurality of detection units arranged in an array along a row direction and a column direction on the first base substrate. Each of the plurality of detection units includes a thin film transistor and an electrode, the thin film transistor is on the first base substrate and includes a gate electrode, a source electrode, and a drain electrode, and the electrode is on a side of the thin film transistor away from the first base substrate and is connected to the drain electrode, and the electrode is configured to carry a biological material to be detected.
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9.发明公开公开(公告)号：US20240238781A1
公开(公告)日：2024-07-18
申请号：US17921637
申请日：2021-10-27
发明人： Yingying ZHAO , Le GU , Bolin FAN , Wenliang YAO , Qiuxu WEI , Yongjia GAO , Li YANG
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502784 , B01L2300/18
摘要： A digital microfluidics chip and a drive method thereof, and a digital microfluidics apparatus are provided. The digital microfluidics chip includes a first substrate (1) and a second substrate (2) which are oppositely disposed, the first substrate (1) is provided with a plurality of drive regions for driving a droplet to move, at least one drive region includes a drive transistor (50), a drive electrode (60), and a storage capacitor, the drive electrode (60) is connected with the drive transistor (50) and the storage capacitor respectively, and the storage capacitor is configured to be charged when the drive transistor (50) is turned on, and to maintain a voltage signal on the drive electrode (60) when the drive transistor (50) is turned off.
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公开(公告)号：US20240084369A1
公开(公告)日：2024-03-14
申请号：US18273558
申请日：2022-07-21
发明人： Qiuxu WEI , Wenliang YAO , Yongjia GAO , Bolin FAN , Yingying ZHAO , Le GU , Li YANG
IPC分类号： C12Q1/6844 , B01L3/00 , B01L7/00
CPC分类号： C12Q1/6844 , B01L3/50273 , B01L7/52 , B01L2200/0642 , B01L2200/16 , B01L2300/027 , B01L2300/0645 , B01L2300/18 , B01L2400/0415
摘要： A digital microfluidic apparatus and a driving method therefor. The digital microfluidic apparatus comprises a digital microfluidic chip (10), a thermal control apparatus (20), and an elastic support apparatus (30). The digital microfluidic chip (10) is provided with a droplet channel (91), and the droplet channel (91) is configured to allow droplets (90) to move therein; the thermal control apparatus (20) is disposed on one side of the digital microfluidic chip (10), and is configured to generate at least two independent and non-interference hot zones in the droplet channel (91), and control the temperature of each hot zone; and the elastic support apparatus (30) is disposed on the side of the thermal control apparatus (20) away from the digital microfluidic chip (10), and is configured to drive the thermal control apparatus (20) to be pasted on the surface of the digital microfluidic chip (10).
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