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22 条记录 (耗时 0.016 秒)

    Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
    1.
    发明授权
    Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent 失效
    通过从喷射到压缩抗溶剂中的有机溶液重结晶进行颗粒微粉化和纳米化的方法

    公开(公告)号：US5874029A

    公开(公告)日：1999-02-23

    申请号：US723463

    申请日：1996-10-09

    申请人： Bala Subramaniam ,  Said Saim ,  Roger A. Rajewski ,  Valentino Stella

    发明人： Bala Subramaniam ,  Said Saim ,  Roger A. Rajewski ,  Valentino Stella

    IPC分类号： A61K9/16 ,  A61K9/50 ,  B01J2/04 ,  B05D1/02 ,  B29B9/00

    CPC分类号： B05D1/025 ,  A61K9/1676 ,  A61K9/1688 ,  B01J2/04 ,  A61K9/1694 ,  A61K9/5089 ,  B05D2401/90 ,  Y10S977/773

    摘要： A method and an apparatus useful for the production of microparticles and nanoparticles are disclosed in which a compressed fluid and a solution including a solvent and a solute are introduced into a nozzle to produce a mixture. The mixture is then passed out of the nozzle to produce a spray of atomized droplets. The atomized droplets are contacted with a supercritical antisolvent to cause depletion of the solvent in the droplets so that particles are produced from the solute. Preferably, these particles have an average diameter of 0.6 .mu.m or less. The invention can be used in the pharmaceutical, food, chemical, electronics, catalyst, polymer, pesticide, explosives, and coating industries, all of which have a need for small-diameter particles.

    摘要翻译： 公开了一种用于生产微粒和纳米颗粒的方法和装置，其中将压缩流体和包含溶剂和溶质的溶液引入喷嘴中以产生混合物。 然后将混合物从喷嘴中排出以产生雾化液滴的喷雾。 雾化的液滴与超临界反溶剂接触以引起液滴中溶剂的消耗，使得从溶质中产生颗粒。 优选地，这些颗粒的平均直径为0.6μm以下。 本发明可用于制药，食品，化工，电子，催化剂，聚合物，农药，爆炸物和涂料工业，所有这些都需要小直径颗粒。

    In situ mitigation of coke buildup in porous catalysts with supercritical reaction media
    2.
    发明授权
    In situ mitigation of coke buildup in porous catalysts with supercritical reaction media 失效
    用超临界反应介质原位缓解多孔催化剂中的焦炭积累

    公开(公告)号：US5725756A

    公开(公告)日：1998-03-10

    申请号：US424872

    申请日：1995-04-18

    申请人： Bala Subramaniam ,  Said Saim

    发明人： Bala Subramaniam ,  Said Saim

    IPC分类号： B01J3/00 ,  C07C2/54 ,  C07C5/22 ,  C07C6/12 ,  C10G25/00 ,  C10G9/16

    CPC分类号： C07C6/12 ,  B01J3/008 ,  C07C2/54 ,  C07C5/2206 ,  C07C5/226 ,  C10G25/00 ,  C07C2521/04 ,  C07C2523/42 ,  Y02P20/544 ,  Y10S585/95

    摘要： A method to minimize catalyst deactivation rate and coke laydown, and maximize desired reaction rate in processing of industrially significant reactions under supercritical conditions to generate a reaction mixture stream including formed reaction products and reactants, said contacting at a desired catalyst temperature of about 1-1.2 critical temperature of the resulting reaction mixture and at a pressure between the critical pressure of the reaction mixture and a pressure necessary to establish said reaction mixture fluid density of greater than 0.65 gm/cc.

    摘要翻译： 一种使催化剂失活速率和焦炭沉积最小化的方法，并且在超临界条件下加工工业上显着反应的期望反应速率最大化以产生包含形成的反应产物和反应物的反应混合物流，所述反应混合物流在所需的催化剂温度下为约1-1.2 所得反应混合物的临界温度和反应混合物的临界压力和建立所述反应混合物所需的压力之间的压力流体密度大于0.65gm / cc。

    Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
    3.
    发明授权
    Methods for a particle precipitation and coating using near-critical and supercritical antisolvents 失效
    使用近临界和超临界反溶剂进行颗粒沉淀和涂层的方法

    公开(公告)号：US5833891A

    公开(公告)日：1998-11-10

    申请号：US805215

    申请日：1997-02-27

    申请人： Bala Subramaniam ,  Said Saim ,  Roger A. Rajewski ,  Valentino Stella

    发明人： Bala Subramaniam ,  Said Saim ,  Roger A. Rajewski ,  Valentino Stella

    IPC分类号： A61K9/16 ,  A61K9/50 ,  B01J2/04 ,  B05D1/02 ,  B01D11/00

    CPC分类号： A61K9/1676 ,  A61K9/1688 ,  B01J2/04 ,  B05D1/025 ,  A61K9/1694 ,  A61K9/5089 ,  B05D2401/90

    摘要： Improved methods and apparatus for particle precipitation and coating using near- or supercritical fluid conditions are described. A fluid dispersion having a continuous phase dispersant and at least one precipitatable substance therein is contacted with a supercritical fluid (SCF) antisolvent so as to generate focused high frequency antisolvent sonic waves, breaking up the dispersion into extremely small droplets; the enhanced mass transfer rates between the droplets and the antisolvent causes precipitation of very small particles on the order of 0.1-10 .mu.m. In coating processes, a turbulent fluidized flow of core particles is created using an SCF antisolvent in an enclosed zone. The core particles are contacted therein at near- or supercritical conditions by a fluid dispersion containing a dispersant together with a precipitatable substance. The antisolvent depletes the dispersant and the substance is precipitated onto the fluidized core particles. In another aspect of the invention, a process for preparing and administering a medicament using only a single container is provided. In such method, a fluid dispersion having a dispersant with the medicament therein is contacted with an antisolvent at near- or supercritical conditions within a use container, so as to directly precipitate small particles of the medicament in the container. The antisolvent is then removed and the use container is sealed with the medicament particles therein. Thereafter, dose(s) of the medicament can be withdrawn from the use container and administered to a patient.

    摘要翻译： 描述了使用近或超临界流体条件改进颗粒沉淀和涂层的方法和装置。 具有连续相分散剂和至少一种可沉淀物质的流体分散体与超临界流体（SCF）反溶剂接触，以产生聚焦的高频反溶剂声波，将分散体分解成极小的液滴; 液滴和抗溶剂之间的增强的传质速率导致非常小的颗粒的沉淀约0.1-10μm。 在涂覆过程中，使用封闭区域中的SCF反溶剂产生核心颗粒的湍流流化流。 核心颗粒在近或超临界条件下通过含有分散剂和可沉淀物质的流体分散体接触。 反溶剂消耗分散剂，物质沉淀在流化核心颗粒上。 在本发明的另一方面，提供了仅使用单一容器制备和施用药物的方法。 在这种方法中，将具有药物的分散剂的流体分散体与使用容器内的近临界或超临界条件下的反溶剂接触，从而将药物的小颗粒直接沉淀在容器中。 然后将抗溶剂除去，并将使用容器用其中的药物颗粒密封。 此后，药物的剂量可以从使用容器中取出并给予患者。

    Powder processing with pressurized gaseous fluids
    6.
    发明授权
    Powder processing with pressurized gaseous fluids 有权
    用加压气态流体进行粉末处理

    公开(公告)号：US06858166B2

    公开(公告)日：2005-02-22

    申请号：US10268879

    申请日：2002-10-10

    申请人： Said Saim ,  Stephen Horhota ,  Kenneth James Koenig ,  David Joseph Bochniak

    发明人： Said Saim ,  Stephen Horhota ,  Kenneth James Koenig ,  David Joseph Bochniak

    IPC分类号： A61J3/02 ,  A61J3/06 ,  A61K9/14 ,  A61K9/16 ,  A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  A61K9/51 ,  A61K31/46 ,  A61K47/26 ,  B29B9/00 ,  B01J2/00 ,  B01J3/00

    CPC分类号： A61K9/1694 ,  A61K9/1623

    摘要： Disclosed is a method of small particle precipitation, retention and dispersion of a solid or semi-solid material onto or into a carrier material. In this method, solute particles are precipitated from a pressurized gaseous fluid solution or a liquid solution and effectively retained and dispersed within a carrier material. This technique can be advantageously used in pharmaceutical processing to produce a blend of solid or semi-solid material particles and carrier material, a granulation of the solid or semi-solid material particles with carrier material, carrier material partially or fully coated with the solid or semi-solid material particles, or mixtures thereof.

    摘要翻译： 公开了一种将固体或半固体材料小颗粒沉淀，保留和分散在载体材料上或其中的方法。 在该方法中，溶质颗粒从加压的气态流体溶液或液体溶液中沉淀出来并有效地保留并分散在载体材料中。 该技术可有利地用于药物加工以产生固体或半固体材料颗粒和载体材料的混合物，固体或半固体材料颗粒与载体材料的颗粒，部分或完全涂覆有固体的载体材料或 半固体材料颗粒或其混合物。