公开(公告)号：US20100131023A1

公开(公告)日：2010-05-27

申请号：US12305894

申请日：2007-06-21

申请人： Benedict James Costello ,  Marc Jensen ,  Mark Zdeblick ,  Jeremy Frank ,  Vladimer Gelfandbein ,  Lawrence Arne

发明人： Benedict James Costello ,  Marc Jensen ,  Mark Zdeblick ,  Jeremy Frank ,  Vladimer Gelfandbein ,  Lawrence Arne

IPC分类号： A61N1/05 ,  C23C14/34

CPC分类号： C23C14/0641 ,  C04B35/56 ,  C04B35/5611 ,  C04B35/5626 ,  C04B35/58 ,  C04B38/0022 ,  C04B2111/00793 ,  C04B2111/0081 ,  C04B2111/00836 ,  C04B2111/00844 ,  C23C14/0635 ,  C23C14/0664 ,  C23C14/325 ,  H01J37/32055

摘要： Implantable medical devices that include cathodic arc produced structures are provided. Cathodic arc produced structures of the invention may be thick, stress-free metallic structures that have configurations heretofore not available in implantable medical devices. In yet other embodiments, the structures may be crenulated or porous layers. Also provided are methods of producing implantable medical devices as well as systems for practicing the subject methods.

摘要翻译： 提供了包括阴极电弧产生结构的植入式医疗设备。 本发明的阴极电弧产生的结构可以是厚的，无应力的金属结构，其具有以前在植入式医疗装置中不可用的构造。 在其他实施例中，结构可以是经过弯曲的或多孔的层。 还提供了生产可植入医疗装置的方法以及用于实施本发明方法的系统。

公开(公告)号：US20130018434A1

公开(公告)日：2013-01-17

申请号：US13619055

申请日：2012-09-14

申请人： Mark J. Zdeblick ,  Benedict James Costello ,  Jeremy Frank ,  Marc Jensen ,  Todd Thompson ,  Mohammed Z. Islam

发明人： Mark J. Zdeblick ,  Benedict James Costello ,  Jeremy Frank ,  Marc Jensen ,  Todd Thompson ,  Mohammed Z. Islam

IPC分类号： A61N1/375 ,  H01R43/00

CPC分类号： A61N1/05 ,  H01L21/561 ,  H01L23/3107 ,  H01L24/63 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01024 ,  H01L2924/01033 ,  H01L2924/01044 ,  H01L2924/01045 ,  H01L2924/01047 ,  H01L2924/01049 ,  H01L2924/01074 ,  H01L2924/01076 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/10253 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/15787 ,  Y10T29/49117 ,  H01L2924/00

摘要： An implantable integrated circuit structure comprising a conformal thin-film sealing layer for hermetically sealing circuitry layers is provided. Also disclosed are electrode structures, leads that include the same, implantable pulse generators that include the leads, as well as systems and kits having components thereof, other implantable devices utilizing the structures, and methods of making and using the subject structures.

摘要翻译： 提供了一种包括用于密封电路层的保形薄膜密封层的可植入集成电路结构。 还公开了电极结构，包括相同的引线，包括引线的可植入脉冲发生器，以及具有其部件的系统和套件，利用该结构的其它可植入装置，以及制造和使用受试结构的方法。

公开(公告)号：US08195308B2

公开(公告)日：2012-06-05

申请号：US11794016

申请日：2005-12-22

申请人： Jeremy Frank ,  Vladimier Gelfandbein ,  Marc Jensen ,  Mark J. Zdeblick ,  Benedict James Costello

发明人： Jeremy Frank ,  Vladimier Gelfandbein ,  Marc Jensen ,  Mark J. Zdeblick ,  Benedict James Costello

IPC分类号： A61N1/05

CPC分类号： A61N1/375 ,  A61N1/05 ,  A61N1/37205 ,  A61N1/3756

摘要： Implantable hermetically sealed structures and methods for making the same. Devices, systems and kits including the hermetically sealed structures, as well as methods of using such devices and systems are included.

摘要翻译： 可植入的密封结构及其制造方法。 还包括包括密封结构在内的装置，系统和试剂盒以及使用这些装置和系统的方法。

公开(公告)号：US09883819B2

公开(公告)日：2018-02-06

申请号：US13141048

申请日：2010-01-06

申请人： Marc Jensen ,  Robert Leichner ,  Patrick Beaulieu ,  Kit Yee Au-Yeung ,  Lawrence Arne ,  Mark Zdeblick ,  Andrew Thompson ,  George Savage ,  Timothy Robertson ,  Yashar Behzadi

发明人： Marc Jensen ,  Robert Leichner ,  Patrick Beaulieu ,  Kit Yee Au-Yeung ,  Lawrence Arne ,  Mark Zdeblick ,  Andrew Thompson ,  George Savage ,  Timothy Robertson ,  Yashar Behzadi

IPC分类号： A61B5/07 ,  A61B5/00 ,  G06F19/00 ,  H04B13/00 ,  A61B5/021 ,  A61B5/024 ,  A61B5/11

CPC分类号： A61B5/073 ,  A61B5/0002 ,  A61B5/021 ,  A61B5/024 ,  A61B5/1112 ,  A61B5/486 ,  A61B5/6833 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3481 ,  G16H10/60 ,  G16H20/00 ,  G16H20/10 ,  H04B13/005

摘要： Methods, devices and systems for acquiring information useful to support a patient in implementing and adhering to a medically prescribed therapy plan are provided. The therapy may incorporate biofeedback methods and/or personalized therapy aspects. A method includes steps of receiving, by a receiving device, biometric information associated with an ingestible event marker; analyzing, by a computing device having a microprocessor configured to perform a biometric information analysis, the biometric information; and determining a therapeutic recommendation at least partly on the basis of the analysis and/or integrating biofeedback techniques into patient therapy or activity. A system includes a biometric information module to receive biometric information associated with an ingestible event marker; an analysis module to analyze the biometric information; and a determination module to optionally determine and communicate a therapeutic recommendation at least partly on the basis of the analysis.

公开(公告)号：US20110270052A1

公开(公告)日：2011-11-03

申请号：US13141048

申请日：2010-01-06

申请人： Marc Jensen ,  Robert Leichner ,  Patrick Beaulieu ,  Kit Yee Au-Yeung ,  Lawrence Arne ,  Mark Zdeblick ,  Andrew Thompson ,  George Savage ,  Timothy Robertson ,  Yashar Behzadi

发明人： Marc Jensen ,  Robert Leichner ,  Patrick Beaulieu ,  Kit Yee Au-Yeung ,  Lawrence Arne ,  Mark Zdeblick ,  Andrew Thompson ,  George Savage ,  Timothy Robertson ,  Yashar Behzadi

IPC分类号： A61B5/07

CPC分类号： A61B5/073 ,  A61B5/0002 ,  A61B5/021 ,  A61B5/024 ,  A61B5/1112 ,  A61B5/486 ,  A61B5/6833 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3481 ,  G16H10/60 ,  G16H20/00 ,  G16H20/10 ,  H04B13/005

摘要： Methods, devices and systems for acquiring information useful to support a patient in implementing and adhering to a medically prescribed therapy plan are provided. The therapy may incorporate biofeedback methods and/or personalized therapy aspects. A method includes steps of receiving, by a receiving device, biometric information associated with an ingestible event marker; analyzing, by a computing device having a microprocessor configured to perform a biometric information analysis, the biometric information; and determining a therapeutic recommendation at least partly on the basis of the analysis and/or integrating biofeedback techniques into patient therapy or activity. A system includes a biometric information module to receive biometric information associated with an ingestible event marker; an analysis module to analyze the biometric information; and a determination module to optionally determine and communicate a therapeutic recommendation at least partly on the basis of the analysis.

摘要翻译： 提供了用于获取有助于支持患者实施和遵守医学上规定的治疗方案的信息的方法，装置和系统。 该疗法可以包括生物反馈方法和/或个性化治疗方面。 一种方法包括以下步骤：由接收装置接收与可摄取事件标记相关联的生物特征信息; 通过具有微处理器的计算设备分析生物特征信息; 以及至少部分地基于分析和/或将生物反馈技术集成到患者治疗或活动中来确定治疗推荐。 一种系统包括用于接收与可摄取事件标记相关联的生物特征信息的生物特征信息模块; 分析生物特征信息的分析模块; 以及确定模块，用于至少部分地基于分析来可选地确定和传达治疗推荐。

公开(公告)号：US20080312726A1

公开(公告)日：2008-12-18

申请号：US11794016

申请日：2005-12-22

申请人： Jeremy Frank ,  Vladimir Gelfandbein ,  Marc Jensen ,  Mark Zdeblick ,  Benedict J. Costello

发明人： Jeremy Frank ,  Vladimir Gelfandbein ,  Marc Jensen ,  Mark Zdeblick ,  Benedict J. Costello

IPC分类号： A61N1/05

CPC分类号： A61N1/375 ,  A61N1/05 ,  A61N1/37205 ,  A61N1/3756

摘要： Implantable hermetically sealed structures and methods for making the same are provided. Also provided are devices, systems and kits including the hermetically sealed structures, as well as methods of using such devices and systems.

摘要翻译： 提供了可植入密封结构及其制造方法。 还提供了包括密封结构的装置，系统和试剂盒以及使用这种装置和系统的方法。

公开(公告)号：US20080255647A1

公开(公告)日：2008-10-16

申请号：US11793904

申请日：2005-12-22

申请人： Marc Jensen ,  Benedict J. Costello ,  Todd Thompson ,  Mark Zdeblick ,  Jeremy Frank ,  Dino Lei ,  Olivier Colliou ,  George M. Savage

发明人： Marc Jensen ,  Benedict J. Costello ,  Todd Thompson ,  Mark Zdeblick ,  Jeremy Frank ,  Dino Lei ,  Olivier Colliou ,  George M. Savage

IPC分类号： A61N1/05

CPC分类号： A61N1/05 ,  A61N1/375

摘要： Implantable addressable segmented electrode devices, as well as methods for making and using the same, are provided. The subject devices include segmented electrode structures made up of an integrated circuit electrically coupled to two or more electrodes, where each electrode can be individually activated. Also provided are implantable devices and systems, as well as kits containing such devices and systems or components thereof, which include the segmented electrode structures.

摘要翻译： 提供了可植入可寻址的分段电极装置，以及制造和使用它们的方法。 主题装置包括由电耦合到两个或更多个电极的集成电路构成的分段电极结构，其中每个电极可以被单独激活。 还提供了可植入装置和系统，以及包含这种装置和系统或其组件的试剂盒，其包括分段的电极结构。

公开(公告)号：US08419638B2

公开(公告)日：2013-04-16

申请号：US12273503

申请日：2008-11-18

申请人： Lawrence W. Arne ,  Olivier Colliou ,  Marc Jensen ,  Mark Zdeblick

发明人： Lawrence W. Arne ,  Olivier Colliou ,  Marc Jensen ,  Mark Zdeblick

IPC分类号： A61B5/00

CPC分类号： A61B5/6876 ,  A61B5/04005 ,  A61B5/053 ,  A61B5/1459 ,  A61B5/6862 ,  A61F2250/0002 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3661 ,  A61M1/3663 ,  A61M2025/0031 ,  A61M2025/0037

摘要： Implantable devices for evaluating body-associated fluid transport structures and methods for using the same are provided. In some instances, the implantable devices include an elongated structure with at least one hermetically sealed integrated circuit sensor stably associated therewith and a transmitter. The devices find use in a variety of different applications, including monitoring the function of various types of body-associated fluid transport structures, such as arteriovenous fistulae, vascular grafts, catheters, cerebrospinal fluid shunts, and implantable central venous access devices.

公开(公告)号：US08036748B2

公开(公告)日：2011-10-11

申请号：US12665111

申请日：2009-11-13

申请人： Mark Zdeblick ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

发明人： Mark Zdeblick ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

IPC分类号： A61N1/00 ,  A61K9/22

CPC分类号： A61N1/37217 ,  A61B5/073 ,  A61J3/06 ,  A61J3/07 ,  A61M5/1723 ,  A61M31/002 ,  G06F19/00

摘要： An ingestible therapy activator system and method are provided. In one aspect, the ingestible therapy activator includes an ingestible device having an effector module to send an effector instruction and a responder module associated with a therapeutic device. The responder module may receive and process the effector instruction, resulting in a response by the therapeutic device. Examples of responses by therapeutic device include activating a therapy, deactivating a therapy, modulating a therapy, and discontinuing a therapy.

摘要翻译： 提供了一种可摄取的治疗激活剂系统和方法。 在一个方面，可摄入治疗激活剂包括具有效应器模块的可摄取装置，以发送效应器指令和与治疗装置相关联的应答模块。 应答器模块可以接收并处理效应器指令，导致治疗装置的响应。 治疗装置的反应的实例包括激活治疗，停用治疗，调节治疗和停止治疗。

公开(公告)号：US20080077186A1

公开(公告)日：2008-03-27

申请号：US11734617

申请日：2007-04-12

申请人： Todd Thompson ,  Mark Zdeblick ,  Olivier Colliou ,  Benedict Costello ,  Marc Jensen ,  George Savage

发明人： Todd Thompson ,  Mark Zdeblick ,  Olivier Colliou ,  Benedict Costello ,  Marc Jensen ,  George Savage

IPC分类号： A61N1/00

CPC分类号： A61N1/3627

摘要： Methods of highly selective cardiac tissue stimulation and devices for practicing the same, e.g., implantable segmented electrode devices, are provided. The methods and devices provide a previously unavailable high phrenic nerve capture voltage paired with a low pacing capture voltage threshold. The subject methods and devices provide a number of benefits. For example, patients who previously would have been required to have their resynchronization device turned off due to phrenic nerve capture will now be able to reap the benefits of resynchronization therapy.

摘要翻译： 提供了高选择性心脏组织刺激的方法和用于实施该方法的装置，例如可植入分段的电极装置。 这些方法和装置提供了与低起搏捕获电压阈值配对的先前不可用的高膈神经捕获电压。 主题方法和设备提供了许多好处。 例如，以前由于膈神经捕获而被关闭的再同步装置的患者现在将能够获得再同步治疗的好处。