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公开(公告)号：US20080312726A1
公开(公告)日：2008-12-18
申请号：US11794016
申请日：2005-12-22
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/05 , A61N1/37205 , A61N1/3756
摘要： Implantable hermetically sealed structures and methods for making the same are provided. Also provided are devices, systems and kits including the hermetically sealed structures, as well as methods of using such devices and systems.
摘要翻译： 提供了可植入密封结构及其制造方法。 还提供了包括密封结构的装置，系统和试剂盒以及使用这种装置和系统的方法。
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公开(公告)号：US20080255647A1
公开(公告)日：2008-10-16
申请号：US11793904
申请日：2005-12-22
申请人： Marc Jensen , Benedict J. Costello , Todd Thompson , Mark Zdeblick , Jeremy Frank , Dino Lei , Olivier Colliou , George M. Savage
发明人： Marc Jensen , Benedict J. Costello , Todd Thompson , Mark Zdeblick , Jeremy Frank , Dino Lei , Olivier Colliou , George M. Savage
IPC分类号： A61N1/05
摘要： Implantable addressable segmented electrode devices, as well as methods for making and using the same, are provided. The subject devices include segmented electrode structures made up of an integrated circuit electrically coupled to two or more electrodes, where each electrode can be individually activated. Also provided are implantable devices and systems, as well as kits containing such devices and systems or components thereof, which include the segmented electrode structures.
摘要翻译： 提供了可植入可寻址的分段电极装置，以及制造和使用它们的方法。 主题装置包括由电耦合到两个或更多个电极的集成电路构成的分段电极结构，其中每个电极可以被单独激活。 还提供了可植入装置和系统，以及包含这种装置和系统或其组件的试剂盒，其包括分段的电极结构。
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3.发明申请公开(公告)号：US20100131023A1
公开(公告)日：2010-05-27
申请号：US12305894
申请日：2007-06-21
申请人： Benedict James Costello , Marc Jensen , Mark Zdeblick , Jeremy Frank , Vladimer Gelfandbein , Lawrence Arne
发明人： Benedict James Costello , Marc Jensen , Mark Zdeblick , Jeremy Frank , Vladimer Gelfandbein , Lawrence Arne
CPC分类号： C23C14/0641 , C04B35/56 , C04B35/5611 , C04B35/5626 , C04B35/58 , C04B38/0022 , C04B2111/00793 , C04B2111/0081 , C04B2111/00836 , C04B2111/00844 , C23C14/0635 , C23C14/0664 , C23C14/325 , H01J37/32055
摘要： Implantable medical devices that include cathodic arc produced structures are provided. Cathodic arc produced structures of the invention may be thick, stress-free metallic structures that have configurations heretofore not available in implantable medical devices. In yet other embodiments, the structures may be crenulated or porous layers. Also provided are methods of producing implantable medical devices as well as systems for practicing the subject methods.
摘要翻译： 提供了包括阴极电弧产生结构的植入式医疗设备。 本发明的阴极电弧产生的结构可以是厚的，无应力的金属结构，其具有以前在植入式医疗装置中不可用的构造。 在其他实施例中，结构可以是经过弯曲的或多孔的层。 还提供了生产可植入医疗装置的方法以及用于实施本发明方法的系统。
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公开(公告)号：US08858432B2
公开(公告)日：2014-10-14
申请号：US12524837
申请日：2008-02-01
申请人： Timothy Robertson , George Savage , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Jeremy Frank , Hooman Hafezi , Tariq Haniff , David O'Reilly
发明人： Timothy Robertson , George Savage , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Jeremy Frank , Hooman Hafezi , Tariq Haniff , David O'Reilly
IPC分类号： A61B1/00 , H04B5/00 , H01M6/00 , H01Q1/27 , A61B5/07 , A61B5/00 , A61J3/00 , H01Q1/00 , A61B5/0205
CPC分类号： A61B5/073 , A61B5/0028 , A61B5/0031 , A61B5/0073 , A61B5/0205 , A61B5/14507 , A61B5/6846 , A61B5/6861 , A61B5/6873 , A61B2560/0214 , A61J3/007 , G01N27/3277 , H01M6/005 , H01Q1/273 , H04B5/0068 , Y10S128/903
摘要： Ingestible event marker systems that include an ingestible event marker (i.e., an IEM) and a personal signal receiver are provided. Embodiments of the IEM include an identifier, which may or may not be present in a physiologically acceptable carrier. The identifier is characterized by being activated upon contact with a target internal physiological site of a body, such as digestive tract internal target site. The personal signal receiver is configured to be associated with a physiological location, e.g., inside of or on the body, and to receive a signal the IEM. During use, the IEM broadcasts a signal which is received by the personal signal receiver.
摘要翻译： 提供了包含可摄入事件标记（即IEM）和个人信号接收器的可摄入事件标记系统。 IEM的实施方案包括标识符，其可以或可以不存在于生理上可接受的载体中。 标识符的特征在于与身体的目标内部生理部位（例如消化道内部靶位点）接触时被激活。 个人信号接收器被配置为与身体内部或身体上的生理位置相关联并且接收IEM的信号。 在使用期间，IEM广播由个人信号接收机接收的信号。
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公开(公告)号：US20100185055A1
公开(公告)日：2010-07-22
申请号：US12524837
申请日：2008-02-01
申请人： Timothy Robertson , George Savage , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Jeremy Frank , Hooman Hafezi , Tariq Haniff , David O'Reilly
发明人： Timothy Robertson , George Savage , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Jeremy Frank , Hooman Hafezi , Tariq Haniff , David O'Reilly
IPC分类号： A61B1/00
CPC分类号： A61B5/073 , A61B5/0028 , A61B5/0031 , A61B5/0073 , A61B5/0205 , A61B5/14507 , A61B5/6846 , A61B5/6861 , A61B5/6873 , A61B2560/0214 , A61J3/007 , G01N27/3277 , H01M6/005 , H01Q1/273 , H04B5/0068 , Y10S128/903
摘要： Ingestible event marker systems that include an ingestible event marker (i.e., an IEM) and a personal signal receiver are provided. Embodiments of the IEM include an identifier, which may or may not be present in a physiologically acceptable carrier. The identifier is characterized by being activated upon contact with a target internal physiological site of a body, such as digestive tract internal target site. The personal signal receiver is configured to be associated with a physiological location, e.g., inside of or on the body, and to receive a signal the IEM. During use, the IEM broadcasts a signal which is received by the personal signal receiver.
摘要翻译： 提供了包含可摄入事件标记（即IEM）和个人信号接收器的可摄入事件标记系统。 IEM的实施方案包括标识符，其可以或可以不存在于生理上可接受的载体中。 标识符的特征在于与身体的目标内部生理部位（例如消化道内部靶位点）接触时被激活。 个人信号接收器被配置为与身体内部或身体上的生理位置相关联并且接收IEM的信号。 在使用期间，IEM广播由个人信号接收机接收的信号。
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公开(公告)号：US20130018434A1
公开(公告)日：2013-01-17
申请号：US13619055
申请日：2012-09-14
申请人： Mark J. Zdeblick , Benedict James Costello , Jeremy Frank , Marc Jensen , Todd Thompson , Mohammed Z. Islam
发明人： Mark J. Zdeblick , Benedict James Costello , Jeremy Frank , Marc Jensen , Todd Thompson , Mohammed Z. Islam
CPC分类号： A61N1/05 , H01L21/561 , H01L23/3107 , H01L24/63 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01024 , H01L2924/01033 , H01L2924/01044 , H01L2924/01045 , H01L2924/01047 , H01L2924/01049 , H01L2924/01074 , H01L2924/01076 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/10253 , H01L2924/12042 , H01L2924/14 , H01L2924/1461 , H01L2924/15787 , Y10T29/49117 , H01L2924/00
摘要： An implantable integrated circuit structure comprising a conformal thin-film sealing layer for hermetically sealing circuitry layers is provided. Also disclosed are electrode structures, leads that include the same, implantable pulse generators that include the leads, as well as systems and kits having components thereof, other implantable devices utilizing the structures, and methods of making and using the subject structures.
摘要翻译： 提供了一种包括用于密封电路层的保形薄膜密封层的可植入集成电路结构。 还公开了电极结构，包括相同的引线，包括引线的可植入脉冲发生器，以及具有其部件的系统和套件，利用该结构的其它可植入装置，以及制造和使用受试结构的方法。
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公开(公告)号：US08195308B2
公开(公告)日：2012-06-05
申请号：US11794016
申请日：2005-12-22
申请人： Jeremy Frank , Vladimier Gelfandbein , Marc Jensen , Mark J. Zdeblick , Benedict James Costello
发明人： Jeremy Frank , Vladimier Gelfandbein , Marc Jensen , Mark J. Zdeblick , Benedict James Costello
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/05 , A61N1/37205 , A61N1/3756
摘要： Implantable hermetically sealed structures and methods for making the same. Devices, systems and kits including the hermetically sealed structures, as well as methods of using such devices and systems are included.
摘要翻译： 可植入的密封结构及其制造方法。 还包括包括密封结构在内的装置，系统和试剂盒以及使用这些装置和系统的方法。
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公开(公告)号：US20100016928A1
公开(公告)日：2010-01-21
申请号：US12296654
申请日：2007-04-12
申请人： Mark J. Zdeblick , Benedict Costello , Jeremy Frank , Marc Jensen , Todd Thompson , Mohammed Z. Islam
发明人： Mark J. Zdeblick , Benedict Costello , Jeremy Frank , Marc Jensen , Todd Thompson , Mohammed Z. Islam
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , H01L21/561 , H01L23/3107 , H01L24/63 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01024 , H01L2924/01033 , H01L2924/01044 , H01L2924/01045 , H01L2924/01047 , H01L2924/01049 , H01L2924/01074 , H01L2924/01076 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/10253 , H01L2924/12042 , H01L2924/14 , H01L2924/1461 , H01L2924/15787 , Y10T29/49117 , H01L2924/00
摘要： An implantable integrated circuit structure comprising a conformal thin-film sealing layer for hermetically sealing circuitry layers is provided. Also disclosed are electrode structures, leads that include the same, implantable pulse generators that include the leads, as well as systems and kits having components thereof, other implantable devices utilizing the structures, and methods of making and using the subject structures.
摘要翻译： 提供了一种包括用于密封电路层的保形薄膜密封层的可植入集成电路结构。 还公开了电极结构，包括相同的引线，包括引线的可植入脉冲发生器，以及具有其部件的系统和套件，利用该结构的其它可植入装置，以及制造和使用受试结构的方法。
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公开(公告)号：US08121687B2
公开(公告)日：2012-02-21
申请号：US11718201
申请日：2005-10-31
申请人： Marc Jensen , Todd Thompson , Olivier Colliou , George M. Savage , Mark J. Zdeblick , Jeremy Frank , Lawrence W. Arne , Robert White
发明人： Marc Jensen , Todd Thompson , Olivier Colliou , George M. Savage , Mark J. Zdeblick , Jeremy Frank , Lawrence W. Arne , Robert White
IPC分类号： A61N1/18
CPC分类号： A61N1/056 , A61B5/1107 , A61B5/6851 , A61B5/6857 , A61B5/6858 , A61B5/686 , A61B2562/0266 , A61N1/08 , A61N1/3627
摘要： Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译： 提供了用于评估心脏组织位置例如心脏壁的运动的方法。 在本方法中，采用从与感兴趣的组织位置稳定相关联的应变仪获得的信号的定时来评估心脏组织位置的运动。 还提供了用于实践主题方法的系统，装置和相关组合物。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。
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公开(公告)号：US20080255629A1
公开(公告)日：2008-10-16
申请号：US11718201
申请日：2005-10-31
申请人： Marc Jenson , Todd Thompson , Olivier Colliou , George M. Savage , Mark J. Zdeblick , Jeremy Frank , Lawrence W. Arne , Robert White
发明人： Marc Jenson , Todd Thompson , Olivier Colliou , George M. Savage , Mark J. Zdeblick , Jeremy Frank , Lawrence W. Arne , Robert White
CPC分类号： A61N1/056 , A61B5/1107 , A61B5/6851 , A61B5/6857 , A61B5/6858 , A61B5/686 , A61B2562/0266 , A61N1/08 , A61N1/3627
摘要： Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译： 提供了用于评估心脏组织位置例如心脏壁的运动的方法。 在本方法中，采用从与感兴趣的组织位置稳定相关联的应变仪获得的信号的定时来评估心脏组织位置的运动。 还提供了用于实践主题方法的系统，装置和相关组合物。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。
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