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公开(公告)号：US09815038B2
公开(公告)日：2017-11-14
申请号：US14081121
申请日：2013-11-15
发明人： Michael D. Leach , Jennifer E. Woodell-May , Hillary Overholser , Joel C. Higgins , Jason Chavarria , Ned M. Hamman
CPC分类号： B01F15/026 , A61K35/16 , B01F1/0027 , B01F3/04446 , B01F13/0023 , B01F13/0052 , B01F15/00512 , B01F15/0227 , B01F15/0237 , B01F15/0266
摘要： A clotting serum production device including a main chamber, an inlet housing, and an outlet port. The main chamber is defined by a first end wall, a second end wall opposite to the first end wall, and a side wall extending between the first end wall and the second end wall. The inlet housing extends from the first end wall. The inlet housing includes a first inlet port, a second inlet port, and a first conduit extending between the first inlet port and a second conduit. The second conduit extends between the second inlet port and the main chamber. The inlet housing is configured to provide one-way fluid flow from the first inlet port to the second inlet port and to provide one-way fluid flow from the second inlet port to the main chamber. An outlet port is in fluid communication with the main chamber and provides fluid communication with an exterior of the clotting serum production device.
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公开(公告)号：US09855382B2
公开(公告)日：2018-01-02
申请号：US14674089
申请日：2015-03-31
发明人： Michael D. Leach , Ned M. Hamman , David Abeskaron , Grant D. Cunningham , Randel Dorian , Richard W. Storrs , Scott R. King
IPC分类号： A61M1/36 , A61K35/18 , C12N5/078 , C12N13/00 , A61M1/02 , B01D43/00 , B01D21/28 , B01L3/00 , B01L9/00
CPC分类号： A61M1/3692 , A61K35/18 , A61M1/0281 , A61M1/3678 , A61M2202/0429 , A61M2205/3375 , B01D21/283 , B01D43/00 , B01L3/502761 , B01L9/527 , B01L2200/025 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2300/089 , B01L2400/0436 , C12N5/0641 , C12N13/00
摘要： Devices for washing a composition including cells are provided. The devices include a separation channel, a first wave component and a second wave component. The separation channel is positioned between the first and second wave components. Collectively, the wave components generate a standing bulk acoustic wave that isolates cells from the composition.
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公开(公告)号：US20150111195A1
公开(公告)日：2015-04-23
申请号：US14519302
申请日：2014-10-21
CPC分类号： C12N13/00 , A61K35/18 , A61K2035/124 , A61L33/0094 , A61M1/0209 , A61M1/0281 , A61M1/3678 , A61M1/3692 , A61M1/3693 , B01D21/28 , B01D21/283 , B01L3/502761 , B01L2200/0652 , B01L2400/0433 , F04C2/00 , G01N15/1459 , G01N33/4915 , G01N2015/0288 , G01N2015/1006 , G01N2015/149
摘要： A system is disclosed for washing a selected component and removing the selected component from a wash material. The selected component may include red blood cells that are washed to remove a rejuvenating solution. The red blood cells may then be removed with various systems, such as a standing acoustic wave system from the wash solution. Pumps and flow restrictors that provide steady flow from pumps that generate pulsed flow are also disclosed.
摘要翻译： 公开了一种用于洗涤所选择的部件并从洗涤材料中去除所选择的部件的系统。 所选择的组分可以包括被洗涤以除去恢复活力的溶液的红细胞。 然后可以用各种系统（例如来自洗涤溶液的立体声波系统）去除红细胞。 还公开了从产生脉冲流的泵提供稳定流量的泵和流量限制器。
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公开(公告)号：US10737012B2
公开(公告)日：2020-08-11
申请号：US15217635
申请日：2016-07-22
发明人： Michael D. Leach , Ned M. Hamman , David Abeskaron , Grant Cunningham , Randel Dorian , Richard Wood Storrs , Scott R. King
摘要： Disclosed is a device for separating a cellular component from a multicomponent fluid. The device can include a body, a first acoustic wave generator, and a second acoustic wave propagating component. The body can define a channel having a first surface, an opposing second surface, a first side, and an opposing second side. The channel can extend along a longitudinal axis from a first end to an opposing second end. The first acoustic wave generator can be coupled to the first surface. The second acoustic wave propagating component can be coupled to the second surface. The first acoustic wave generator and second acoustic wave propagating component can be configured to generate a bulk standing acoustic wave in the channel.
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公开(公告)号：US20150290369A1
公开(公告)日：2015-10-15
申请号：US14249763
申请日：2014-04-10
发明人： Ned M. Hamman
IPC分类号： A61M1/02
CPC分类号： A61M1/0281 , A61M2206/16 , B01D21/265
摘要： A device for separating a component out of a multicomponent mixture. The device has a housing that extends along a central longitudinal axis. The housing has a top end and a bottom end, and defines a channel that extends from the top end of the housing around the central axis to the bottom end of the housing to define a helical flow path. The device also includes an inlet port at the top end of the housing that communicates with the channel, and a first outlet port.
摘要翻译： 用于从多组分混合物中分离组分的装置。 该装置具有沿着中心纵向轴线延伸的壳体。 壳体具有顶端和底端，并且限定了从壳体的顶端围绕中心轴线延伸到壳体的底端的通道，以限定螺旋形流动路径。 该装置还包括位于壳体顶端的与通道连通的入口端口和第一出口端口。
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公开(公告)号：US10821218B2
公开(公告)日：2020-11-03
申请号：US15745157
申请日：2016-07-22
摘要： Disclosed is a device for separating a cellular component from a multicomponent fluid. The device can comprise a body, a first acoustic wave generator, and a second acoustic wave propagating component. The body can define a channel having a first surface and a second surface opposite the first surface. The channel can extend along a longitudinal axis from a first end to a second end. The first acoustic wave generator can be coupled to the first surface. The first acoustic wave generator can be configured to generate an acoustic wave having a wavelength. The second acoustic wave propagating component can be coupled to the second surface. The second surface can be spaced an integer fractional multiple of the wavelength from the first surface and each integer factional multiple equals a number of pressure nodes within the channel.
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公开(公告)号：US20180207349A1
公开(公告)日：2018-07-26
申请号：US15745157
申请日：2016-07-22
CPC分类号： A61M1/3678 , A61M1/0281 , A61M1/3692 , A61M2202/0429 , B01L3/502715 , B01L3/502761 , B01L2200/025 , B01L2300/0874 , B01L2300/0887 , B01L2400/0436
摘要： Disclosed is a device for separating a cellular component from a multicomponent fluid. The device can comprise a body, a first acoustic wave generator, and a second acoustic wave propagating component. The body can define a channel having a first surface and a second surface opposite the first surface. The channel can extend along a longitudinal axis from a first end to a second end. The first acoustic wave generator can be coupled to the first surface. The first acoustic wave generator can be configured to generate an acoustic wave having a wavelength. The second acoustic wave propagating component can be coupled to the second surface. The second surface can be spaced an integer fractional multiple of the wavelength from the first surface and each integer factional multiple equals a number of pressure nodes within the channel.
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公开(公告)号：US09963693B2
公开(公告)日：2018-05-08
申请号：US14519302
申请日：2014-10-21
IPC分类号： B01D21/28 , C12N13/00 , A61K35/18 , A61L33/00 , F04C2/00 , A61M1/02 , B01L3/00 , G01N15/14 , A61M1/36 , A61K35/12 , G01N33/49 , G01N15/10 , G01N15/02
CPC分类号： C12N13/00 , A61K35/18 , A61K2035/124 , A61L33/0094 , A61M1/0209 , A61M1/0281 , A61M1/3678 , A61M1/3692 , A61M1/3693 , B01D21/28 , B01D21/283 , B01L3/502761 , B01L2200/0652 , B01L2400/0433 , F04C2/00 , G01N15/1459 , G01N33/4915 , G01N2015/0288 , G01N2015/1006 , G01N2015/149
摘要： A system is disclosed for washing a selected component and removing the selected component from a wash material. The selected component may include red blood cells that are washed to remove a rejuvenating solution. The red blood cells may then be removed with various systems, such as a standing acoustic wave system from the wash solution. Pumps and flow restrictors that provide steady flow from pumps that generate pulsed flow are also disclosed.
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公开(公告)号：US09920313B2
公开(公告)日：2018-03-20
申请号：US14519317
申请日：2014-10-21
发明人： Ned M. Hamman , Michael D. Leach , David Abeskaron
IPC分类号： C12N13/00 , A61K35/18 , A61L33/00 , B01D21/28 , F04C2/00 , A61M1/02 , B01L3/00 , G01N15/14 , A61M1/36 , A61K35/12 , G01N33/49 , G01N15/10 , G01N15/02
CPC分类号： C12N13/00 , A61K35/18 , A61K2035/124 , A61L33/0094 , A61M1/0209 , A61M1/0281 , A61M1/3678 , A61M1/3692 , A61M1/3693 , B01D21/28 , B01D21/283 , B01L3/502761 , B01L2200/0652 , B01L2400/0433 , F04C2/00 , G01N15/1459 , G01N33/4915 , G01N2015/0288 , G01N2015/1006 , G01N2015/149
摘要： A system is disclosed for washing a selected component and removing the selected component from a wash material. The selected component may include red blood cells that are washed to remove a rejuvenating solution. The red blood cells may then be removed with various systems, such as a standing acoustic wave system from the wash solution. Pumps and flow restrictors that provide steady flow from pumps that generate pulsed flow are also disclosed.
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