利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

24 条记录 (耗时 0.027 秒)

    CROSSLINKED HUMAN OR ANIMAL TISSUE PRODUCTS AND THEIR METHODS OF MANUFACTURE AND USE
    2.
    发明申请
    CROSSLINKED HUMAN OR ANIMAL TISSUE PRODUCTS AND THEIR METHODS OF MANUFACTURE AND USE 有权

    公开(公告)号：US20130030153A1

    公开(公告)日：2013-01-31

    申请号：US13560696

    申请日：2012-07-27

    申请人： W. Jerry Mezger ,  Keith E. Myers

    发明人： W. Jerry Mezger ,  Keith E. Myers

    IPC分类号： C07K14/78

    CPC分类号： C07K14/78 ,  A61K38/16 ,  A61K38/17 ,  A61K38/39 ,  A61L27/24 ,  A61L27/3687 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/404 ,  A61L2430/34 ,  A61L2430/40

    摘要： Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.

    ANCHORING STRUCTURE WITH CONCAVE LANDING ZONE
    3.
    发明申请
    ANCHORING STRUCTURE WITH CONCAVE LANDING ZONE 有权
    带有土地的锚固结构

    公开(公告)号：US20100100176A1

    公开(公告)日：2010-04-22

    申请号：US12603315

    申请日：2009-10-21

    申请人： David Elizondo ,  Andrzej M. Malewicz ,  Matthew W. Weston ,  Keith E. Myers

    发明人： David Elizondo ,  Andrzej M. Malewicz ,  Matthew W. Weston ,  Keith E. Myers

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2220/0016 ,  A61F2230/00 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2230/0065

    摘要： A method and device for reducing paravalvular leakage upon implantation of a replacement heart valve is provided. The valve assembly includes a tissue or bioprosthetic heart valve attached to an anchoring structure. The anchoring structure includes an inlet rim that is substantially C-shaped in cross section to form a concave landing zone. The anchoring structure self-seats when implanted in the sinus of a patient with the proximal and distal ends of the C-shaped inlet rim pushed against the aorta to effectively prevent paravalvular leakage.

    摘要翻译： 提供了一种用于在置换心脏瓣膜植入时减少瓣膜漏出的方法和装置。 瓣膜组件包括连接到锚固结构的组织或生物假体心脏瓣膜。 锚定结构包括入口边缘，该入口边缘的横截面基本上为C形，以形成凹入的着陆区域。 当植入患者的窦内时，锚定结构自行座位，其中C形入口边缘的近端和远端被推压到主动脉上，以有效地防止瓣膜溢出。

    Method of Cutting Tissue Using a Laser
    6.
    发明申请
    Method of Cutting Tissue Using a Laser 有权
    使用激光切割组织的方法

    公开(公告)号：US20120035720A1

    公开(公告)日：2012-02-09

    申请号：US13279754

    申请日：2011-10-24

    申请人： Douglas S. CALI ,  Keith E. Myers

    发明人： Douglas S. CALI ,  Keith E. Myers

    IPC分类号： A61F2/24

    CPC分类号： B23K26/324 ,  A61F2/2415 ,  A61F2220/0075 ,  B23K26/32 ,  B23K26/40 ,  B23K2103/16 ,  B23K2103/30 ,  B23K2103/38 ,  B23K2103/42 ,  B23K2103/50 ,  Y10T156/1054

    摘要： A prosthetic heart valve assembly comprises a plurality of leaflets configured to replace the function of a native heart valve. Each leaflet comprises laminar pericardium tissue. Each leaflet has a coaptation edge formed by laser cutting. The tissue layers of each leaflet are fused together along an entire length of the coaptation edge, and tissue adjacent each coaptation edge does not have significant thermal energy damage.

    摘要翻译： 假体心脏瓣膜组件包括构造成替代天然心脏瓣膜功能的多个小叶。 每片小叶均包含层状心包组织。 每个小叶具有通过激光切割形成的接合边缘。 每个叶片的组织层沿着接合边缘的整个长度融合在一起，并且每个接合边缘附近的组织不具有显着的热能损伤。

    Method of cutting material for use in implantable medical device
    7.
    再颁专利
    Method of cutting material for use in implantable medical device 有权
    切割用于可植入医疗器械的材料的方法

    公开(公告)号：USRE42818E1

    公开(公告)日：2011-10-11

    申请号：US12765449

    申请日：2010-04-22

    申请人： Douglas S. Cali ,  Keith E. Myers

    发明人： Douglas S. Cali ,  Keith E. Myers

    IPC分类号： B32B37/00

    CPC分类号： B23K26/324 ,  A61F2/2415 ,  A61F2220/0075 ,  B23K26/32 ,  B23K26/40 ,  B23K2103/16 ,  B23K2103/30 ,  B23K2103/38 ,  B23K2103/42 ,  B23K2103/50 ,  Y10T156/1054

    摘要： A method of cutting material for use in an implantable medical device employs a plotted laser cutting system. The laser cutting system is computer controlled and includes a laser combined with a motion system. The laser precisely cuts segments out of source material according to a predetermined pattern as designated by the computer. The segments are used in constructing implantable medical devices. The cutting energy of the laser is selected so that the cut edges of the segments are melted to discourage delamination or fraying, but communication of thermal energy into the segment beyond the edge is minimized to avoid damaging the segment adjacent the edge.

    摘要翻译： 切割用于可植入医疗装置的材料的方法采用绘制的激光切割系统。 激光切割系统由计算机控制，包括与运动系统组合的激光。 激光根据计算机指定的预定图案精确地切割源材料的部分。 这些段用于构建可植入医疗装置。 选择激光器的切割能量，使得片段的切割边缘被熔化以防止分层或磨损，但是将热能传递到超过边缘的片段中被最小化以避免损坏邻近边缘的片段。

    Methods for harvesting adipose tissue containing autologous microvascular endothelial cells
    9.
    发明授权
    Methods for harvesting adipose tissue containing autologous microvascular endothelial cells 失效
    收集含有自体微血管内皮细胞的脂肪组织的方法

    公开(公告)号：US5744360A

    公开(公告)日：1998-04-28

    申请号：US647155

    申请日：1996-05-09

    申请人： Can B. Hu ,  Keith E. Myers ,  Robert C. Peterson

    发明人： Can B. Hu ,  Keith E. Myers ,  Robert C. Peterson

    IPC分类号： A61B10/02 ,  A61F2/06 ,  A61J1/00 ,  A61J1/20 ,  A61M1/00 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32 ,  C12N5/00 ,  A61B17/20 ,  A61N1/30

    CPC分类号： A61J1/2096 ,  A61F2/062 ,  A61M1/008 ,  C12M45/02 ,  C12M45/05 ,  C12M45/09 ,  A61J1/201 ,  A61J1/2086 ,  A61M1/0009 ,  A61M2005/31508 ,  A61M2202/08 ,  A61M2202/097 ,  A61M5/3291

    摘要： Disclosed herein are methods for harvesting adipose tissue so as to preserve an increased population of viable microvascular endothelial cells. Adipose tissue containing microvascular endothelial cells is harvested using a collection apparatus incorporating an elongate cannula having apertures with tissue cutting edges. A sub-ambient pressure is applied to a lumen in the cannula to draw the adipose tissue through the aperture where it is then severed using the cutting edge to disrupt the connective adipose matrix. This harvesting provides a cleaner, more homogeneous sample of adipose tissue, thereby increasing the population of viable microvascular endothelial cells obtained through further processing. Rapid and easy methods for the further homogenization of the harvested adipose tissue are also disclosed.

    摘要翻译： 本文公开了用于收获脂肪组织的方法，以便保持增加的活微血管内皮细胞的数量。 使用收集装置收集含有微血管内皮细胞的脂肪组织，所述收集装置包含具有带有组织切割边缘的孔的细长插管。 将副环境压力施加到套管中的内腔以通过孔将纤维组织穿过，然后使用切割边缘切断脂肪组织以破坏连接性脂肪基质。 这种收获提供了更清洁，更均匀的脂肪组织样品，从而增加了通过进一步加工获得的活微血管内皮细胞的数量。 还公开了用于进一步均化收获的脂肪组织的快速和容易的方法。

    Method of cutting tissue using a laser
    10.
    发明授权
    Method of cutting tissue using a laser 有权
    使用激光切割组织的方法

    公开(公告)号：US08043450B2

    公开(公告)日：2011-10-25

    申请号：US12548536

    申请日：2009-08-27

    申请人： Douglas S. Cali ,  Keith E. Myers

    发明人： Douglas S. Cali ,  Keith E. Myers

    IPC分类号： B32B37/00

    CPC分类号： B23K26/324 ,  A61F2/2415 ,  A61F2220/0075 ,  B23K26/32 ,  B23K26/40 ,  B23K2103/16 ,  B23K2103/30 ,  B23K2103/38 ,  B23K2103/42 ,  B23K2103/50 ,  Y10T156/1054

    摘要： A method of cutting tissue for use as an implantable medical device employs a laser cutting system. The laser cutting system is computer controlled and includes a laser combined with a motion system. The laser precisely cuts segments out of source tissue according to predetermined pattern as designated by the computer. The cutting energy of the laser is selected so that the cut edges of the tissue segments are fused, melted or welded to discourage delamination or fraying, but communication of thermal energy into the segment beyond the edge is minimized to avoid damaging the tissue adjacent the edge.

    摘要翻译： 切割用作可植入医疗装置的组织的方法采用激光切割系统。 激光切割系统由计算机控制，包括与运动系统组合的激光。 激光根据计算机指定的预定图案精确地切割源组织之间的部分。 选择激光的切割能量，使得组织片段的切割边缘熔化，熔化或焊接，以防止分层或磨损，但是将热能传递到超过边缘的片段中被最小化，以避免损伤邻近边缘的组织 。