公开(公告)号：US20080311589A1

公开(公告)日：2008-12-18

申请号：US12107042

申请日：2008-04-21

申请人： Brent R. Stockwell ,  Stuart L. Schreiber ,  Timothy J. Mitchison ,  Tarun M. Kapoor ,  Thomas Mayer ,  Stephen J. Haggarty

发明人： Brent R. Stockwell ,  Stuart L. Schreiber ,  Timothy J. Mitchison ,  Tarun M. Kapoor ,  Thomas Mayer ,  Stephen J. Haggarty

IPC分类号： G01N33/53

CPC分类号： G01N33/6803

摘要： The present invention provides a system for high-throughput analysis of chemical compounds. Assays are performed in a high density platform, and compounds having pre-determined desirable effects are identified. Preferably, the compounds have biological effects, more preferably, the assays and detection are performed on whole cells.

摘要翻译： 本发明提供了化合物的高通量分析系统。 测定在高密度平台中进行，并且鉴定了具有预定的期望效果的化合物。 优选地，化合物具有生物学效应，更优选地，测定和检测在全细胞上进行。

公开(公告)号：US06890933B1

公开(公告)日：2005-05-10

申请号：US09791339

申请日：2001-02-23

申请人： Yan Feng ,  Tarun M. Kapoor ,  Thomas Mayer ,  Zoltan Maliga ,  Timothy J. Mitchison ,  Justin Yarrow

发明人： Yan Feng ,  Tarun M. Kapoor ,  Thomas Mayer ,  Zoltan Maliga ,  Timothy J. Mitchison ,  Justin Yarrow

IPC分类号： C07D471/14 ,  A61K31/437 ,  C02D471/04

CPC分类号： C07D471/14

摘要： The present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions which are capable of inhibiting mitosis in metabolically active cells. Compounds, compositions and methods of the present invention inhibit the activity of a protein involved in the assembly and maintenance of the mitotic spindle. One class of proteins which acts on the mitotic spindle is the family of mitotic kinesins, a subset of the kinesin superfamily.

公开(公告)号：US20150381214A1

公开(公告)日：2015-12-31

申请号：US14318829

申请日：2014-06-30

申请人： Stefan Tertinek ,  Peter Preyler ,  Thomas Mayer

发明人： Stefan Tertinek ,  Peter Preyler ,  Thomas Mayer

IPC分类号： H04B1/00 ,  H04L27/14 ,  H04L27/227 ,  G04F10/00

CPC分类号： H04B1/0082 ,  G04F10/005

摘要： This application discusses, among other things, apparatus and methods for improving spurious frequency performance of digital-to-time converters (DTCs). In an example, a method can include receiving a code at selection logic of a digital-to-time converter at a first instant, selecting a first delay path of the DTC to provide a delay associated with the code, associating a second delay path with the code, receiving the code at the selection logic at a second instant, and selecting the second delay path of the DTC to provide the delay associated with the code.

摘要翻译： 该应用尤其讨论了用于改善数字 - 时间转换器（DTC）的杂散频率性能的装置和方法。 在一个示例中，方法可以包括在第一时刻接收数字到时间转换器的选择逻辑的代码，选择DTC的第一延迟路径以提供与代码相关联的延迟，将第二延迟路径与 代码，在第二时刻在选择逻辑处接收代码，并且选择DTC的第二延迟路径以提供与代码相关联的延迟。

公开(公告)号：US09123716B2

公开(公告)日：2015-09-01

申请号：US13719799

申请日：2012-12-19

申请人： Julian Gonska ,  Heribert Weber ,  Jens Frey ,  Timo Schary ,  Thomas Mayer

发明人： Julian Gonska ,  Heribert Weber ,  Jens Frey ,  Timo Schary ,  Thomas Mayer

IPC分类号： H01L21/00 ,  H01L23/48 ,  H01L21/50 ,  H01L23/488 ,  H01L21/18 ,  B81C1/00 ,  H01L23/00

CPC分类号： H01L21/50 ,  B81B2201/0235 ,  B81B2201/0264 ,  B81C1/00269 ,  B81C2203/0118 ,  B81C2203/035 ,  H01L21/185 ,  H01L21/187 ,  H01L23/488 ,  H01L24/94 ,  H01L2224/83805 ,  H01L2924/0132 ,  H01L2924/01322 ,  H01L2924/10253 ,  H01L2924/16251 ,  H01L2924/01013 ,  H01L2924/01032 ,  H01L2924/00

摘要： A method for bonding two silicon substrates and a corresponding system of two silicon substrates. The method includes: providing first and second silicon substrates; depositing a first bonding layer of pure aluminum or of aluminum-copper having a copper component between 0.1 and 5% on a first bonding surface of the first silicon substrate; depositing a second bonding layer of germanium above the first bonding surface or above a second bonding surface of the second silicon substrate; subsequently joining the first and second silicon substrates, so that the first and the second bonding surfaces lie opposite each other; and implementing a thermal treatment step to form an eutectic bonding layer of aluminum-germanium or containing aluminum-germanium as the main component, between the first silicon substrate and the second silicon substrate, spikes which contain aluminum as a minimum and extend into the first silicon substrate, forming at least on the first bonding surface.

摘要翻译： 一种用于接合两个硅衬底和两个硅衬底的对应系统的方法。 该方法包括：提供第一和第二硅衬底; 在第一硅衬底的第一接合表面上沉积具有0.1至5％铜含量的纯铝或铝 - 铜的第一接合层; 在所述第一接合表面上方或第二硅衬底的第二接合表面上方沉积锗的第二接合层; 随后接合第一和第二硅衬底，使得第一和第二接合表面彼此相对; 并且在第一硅衬底和第二硅衬底之间实现热处理步骤以形成铝锗或含有铝 - 锗的共晶结合层作为主要组分，最小含有铝并延伸到第一硅中的尖峰 衬底，至少形成在第一结合表面上。

公开(公告)号：US20140377783A1

公开(公告)日：2014-12-25

申请号：US13883067

申请日：2011-11-04

申请人： Lukas Wick ,  Urs Spitz ,  Christophe Weymuth ,  Günter Schabert ,  Thomas Mayer ,  Alexander Bayer

发明人： Lukas Wick ,  Urs Spitz ,  Christophe Weymuth ,  Günter Schabert ,  Thomas Mayer ,  Alexander Bayer

IPC分类号： G01N33/58 ,  C12Q1/04 ,  C12Q1/34 ,  C12Q1/10 ,  C09B57/00 ,  C12Q1/44

CPC分类号： G01N33/583 ,  C09B57/00 ,  C09B67/0083 ,  C12Q1/04 ,  C12Q1/10 ,  C12Q1/34 ,  C12Q1/44 ,  G01N2333/938

摘要： A novel type of dye systems comprises a selection of 10H-indolo[1,2-a]indole compounds (henceforth abbreviated as IO compounds) and (5H,7H)-indolo[1,2-a]quinoline compounds (henceforth abbreviated as IQ compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the IO/IQ compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth. The response of a precursor to external stimuli can also be used to determine the presence or absence of such stimuli.

摘要翻译： 一种新型染料体系包括10H-吲哚并[1,2-a]吲哚化合物（以下简称为IO化合物）和（5H，7H） - 吲哚并[1,2-a]喹啉化合物（以下简称为 IQ化合物），显示出溶剂化色素效应，并在各种材料如聚丙烯，聚乙烯，油，各种溶剂，乳液中表现出强烈的荧光。 还公开了如何施用IO / IQ化合物的各种方法，特别是如何从前体产生和原位施用，对外部刺激如酶活性，温度等进行响应。 前体对外部刺激的反应也可以用于确定这种刺激的存在或不存在。

公开(公告)号：US08686353B2

公开(公告)日：2014-04-01

申请号：US12863045

申请日：2009-01-16

申请人： Thomas Mayer

发明人： Thomas Mayer

IPC分类号： G01N30/00

CPC分类号： H01J49/0431 ,  G01N30/7233 ,  H01J49/0095

摘要： A mass spectrometer comprised of a mass analyzer, ion source and detector has the capability of analyzing samples in both positive and negative ionization modes. The mass spectrometer used in conjunction with a liquid chromatograph, fluid splitters and a plurality fluid pathways so that a large volume of analysis may be performed quickly and with high precision and accuracy. The apparatus is also capable of analyzing complex mixtures such as coeluting samples.

摘要翻译： 由质量分析仪，离子源和检测器组成的质谱仪具有分析正离子和负离子两种模式的样品的能力。 质谱仪与液相色谱仪，流体分离器和多个流体通道结合使用，使得可以快速且高精度和高精度地进行大量的分析。 该装置还能够分析诸如coeluting样品的复杂混合物。

公开(公告)号：US08670610B2

公开(公告)日：2014-03-11

申请号：US13213339

申请日：2011-08-19

申请人： Matthias Prams ,  Thomas Mayer

发明人： Matthias Prams ,  Thomas Mayer

IPC分类号： G06K9/00

CPC分类号： G01B11/24 ,  G06T7/30 ,  G06T2207/10028 ,  G06T2207/20021

摘要： In a method for the 3D digitalization of an object with variable surface a plurality of camera pictures of partial surfaces of the object (4) are taken and put together for determining the 3D coordinates of the partial surface of the object (4). Camera pictures are taken of partial surfaces of the object (4), which overlap at their edges. For each camera picture the 3D coordinates of the associated partial surface of the object (4) are determined. The 3D coordinates of these partial surfaces of the object (4) are matched and put together by a matching method. Each camera picture is divided into subframes (1.1-1.9, 2.1-2.9, 3.1-3.9) which overlap at their edges and which overlap with the subframes of adjacent camera pictures. To the subframes (1.1-3.9), the associated 3D coordinates from the camera pictures are assigned. The 3D coordinates of the subframes (1.1-3.9) are matched and put together by a matching method. The method can iteratively be carried out several times.

摘要翻译： 在用于具有可变表面的对象的3D数字化的方法中，取对象（4）的部分表面的多个相机图片并放在一起以确定对象（4）的部分表面的3D坐标。 拍摄照片照片是物体（4）的部分表面，它们的边缘重叠。 对于每个相机图像，确定对象（4）的相关联的部分表面的3D坐标。 通过匹配方法将对象（4）的这些部分表面的3D坐标相匹配并放在一起。 每个摄像机图像被分成在它们的边缘重叠并与相邻相机图像的子帧重叠的子帧（1.1-1.9,2.1-2.9,3.1-3.9）。 对于子帧（1.1-3.9），分配来自相机图像的相关3D坐标。 通过匹配方法将子帧（1.1-3.9）的3D坐标进行匹配并放在一起。 该方法可以迭代地进行几次。

公开(公告)号：US08598929B1

公开(公告)日：2013-12-03

申请号：US13664536

申请日：2012-10-31

申请人： Christian Wicpalek ,  Thomas Mayer

发明人： Christian Wicpalek ,  Thomas Mayer

IPC分类号： H03L7/06

CPC分类号： H03L7/1075 ,  H03L7/093 ,  H03L7/095 ,  H03L7/101 ,  H03L7/104

摘要： The disclosed invention relates to a digital phase locked loop having a switchable digital loop filter configured to selectively operate at different levels of resolution. The digital phase locked loop has a phase frequency detector that determines a phase difference between a reference signal and a feedback signal and to convert the phase difference to a digital word. A digital loop filter filters the digital word to generate a control word. A bit shift network modifies the digital word in a manner that switches the resolution of the digital loop filter between two or more distinct resolution states that comprise a bit sequence located at different positions in the digital word. The two or more distinct resolution states allow the digital loop filter to provide a low resolution (high amplitude) for a settling state of operation and a high resolution (low amplitude) for a locked state of operation.

摘要翻译： 所公开的本发明涉及一种具有可切换数字环路滤波器的数字锁相环，其被配置为选择性地以不同的分辨率水平进行操作。 数字锁相环具有相位频率检测器，其确定参考信号和反馈信号之间的相位差，并将相位差转换为数字字。 数字环路滤波器对数字字进行滤波以产生控制字。 位移网络以使数字环路滤波器的分辨率在两个或多个不同分辨率状态之间切换的方式修改数字字，该状态包括位于数字字中的不同位置的位序列。 两个或更多个不同的分辨率状态允许数字环路滤波器为操作的建立状态提供低分辨率（高幅度），并且对于锁定操作状态提供高分辨率（低幅度）。

公开(公告)号：US08330803B2

公开(公告)日：2012-12-11

申请号：US12459640

申请日：2009-07-06

申请人： Alexander Frey ,  Daniel Kreutzer ,  Thomas Mayer ,  Marcus Steinbichler

发明人： Alexander Frey ,  Daniel Kreutzer ,  Thomas Mayer ,  Marcus Steinbichler

IPC分类号： H04N13/02

CPC分类号： G01B11/25 ,  G01B2210/52 ,  G06T7/593 ,  G06T2207/10012

摘要： In a method for 3D digitization of an object (1), a plurality of camera images of the object are recorded and assembled to determine the 3D coordinates of the object. To improve such method, pictures are taken from the object (1), from which 2D feature points (11, 12, 13; 21, 22, 23) of the object (1) are determined. The 3D coordinates of the 2D feature points are determined. The 2D point correspondences (32, 32, 22) between the 2D feature points of a picture and the 2D feature points of another picture are determined. Several of these 2D point correspondences are selected, and an associated 3D transformation is determined. The quality of this 3D transformation is determined with reference to the transformed 3D coordinates of the 2D feature points. Valid 3D feature points are determined therefrom. For assembling the camera images of the object (1), the 3D coordinates of the valid 3D feature points are used.

摘要翻译： 在用于对象（1）的3D数字化的方法中，记录和组合对象的多个相机图像以确定对象的3D坐标。 为了改善这种方法，从物体（1）取出图像，从物体（1）的2D特征点（11,12,13,21,23,23）确定。 确定2D特征点的3D坐标。 确定图像的2D特征点与另一图像的2D特征点之间的2D点对应（32,32,22）。 选择这些2D点对应中的几个，并且确定相关联的3D变换。 参考2D特征点的变换3D坐标来确定该3D变换的质量。 确定有效的3D特征点。 为了组装对象（1）的相机图像，使用有效3D特征点的3D坐标。

公开(公告)号：US20110298063A1

公开(公告)日：2011-12-08

申请号：US13112351

申请日：2011-05-20

申请人： Thomas Mayer

发明人： Thomas Mayer

IPC分类号： H01L21/52 ,  H01L29/84

CPC分类号： B81C1/00269 ,  B81B2201/0235 ,  B81B2201/0242 ,  B81B2201/0264

摘要： A method is described for manufacturing a micromechanical component. The method includes providing a first substrate, forming a first connecting structure on the first substrate, and forming a microstructure on the first substrate after forming the first connecting structure. The microstructure has at least one movable functional element. The method further includes providing a second substrate having a second connecting structure, and joining the first and second substrates by carrying out a bonding process, the first and second connecting structures being joined to form a common connecting structure, and a sealed cavity being formed in the region of the microstructure. The method provides that the first connecting structure takes the form of a buried connecting structure extending up to an upper surface of the first substrate. Also described is a related micromechanical component.

摘要翻译： 描述了用于制造微机械部件的方法。 该方法包括提供第一基板，在第一基板上形成第一连接结构，以及在形成第一连接结构之后在第一基板上形成微结构。 微结构具有至少一个可移动功能元件。 所述方法还包括提供具有第二连接结构的第二基板，并且通过进行接合工艺来接合所述第一和第二基板，所述第一和第二连接结构被连接以形成共同的连接结构，并且形成密封空腔 微结构的区域。 该方法提供了第一连接结构采取延伸到第一基底的上表面的掩埋连接结构的形式。 还描述了相关的微机械部件。