公开(公告)号：US08221395B2

公开(公告)日：2012-07-17

申请号：US11927174

申请日：2007-10-29

申请人： Brian M. Shelton ,  Ronald J. Lebel ,  Danial H. Villegas

发明人： Brian M. Shelton ,  Ronald J. Lebel ,  Danial H. Villegas

IPC分类号： A61K9/22

CPC分类号： A61M5/14276 ,  A61M5/16827 ,  A61M5/172 ,  A61M2005/14208 ,  A61M2205/52 ,  G06F19/00 ,  G06F19/3468

摘要： The present invention relates to an implantable drug delivery device which includes a fluid drug reservoir, a catheter, a controllable fluid transfer device, e.g., a pump or valve, and a drug delivery control means. The control means in accordance with the invention is configured to initially clear a first, or old, drug from the device based on the content of the Current Profile data containing a first, or old, delivery profile. After the old drug is cleared, then the control means automatically modifies the Current Profile data to match a second, or new, delivery profile for controlling delivery of a second, or new, drug.

摘要翻译： 本发明涉及一种可植入药物递送装置，其包括流体药物储存器，导管，可控流体输送装置，例如泵或阀，以及药物输送控制装置。 根据本发明的控制装置被配置为基于包含第一或更旧的传送简档的当前简档数据的内容来初始地从设备清除第一或旧的药物。 在旧药物被清除之后，控制装置自动修改当前配置文件数据以匹配用于控制第二种或新型药物递送的第二种或新型递送配置文件。

公开(公告)号：US07347854B2

公开(公告)日：2008-03-25

申请号：US11069573

申请日：2005-02-28

申请人： Brian M. Shelton ,  Ronald J. Lebel ,  Danial H. Villegas

发明人： Brian M. Shelton ,  Ronald J. Lebel ,  Danial H. Villegas

IPC分类号： A61K9/22

CPC分类号： A61M5/14276 ,  A61M5/16827 ,  A61M5/172 ,  A61M2005/14208 ,  A61M2205/52 ,  G06F19/00 ,  G06F19/3468

摘要： The present invention relates to an implantable drug delivery device which includes a fluid drug reservoir, a catheter, a controllable fluid transfer device, e.g., a pump or valve, and a drug delivery control means. The control means in accordance with the invention is configured to initially clear a first, or old, drug from the device based on the content of the Current Profile data containing a first, or old, delivery profile. After the old drug is cleared, then the control means automatically modifies the Current Profile data to match a second, or new, delivery profile for controlling delivery of a second, or new, drug.

摘要翻译： 本发明涉及一种可植入药物递送装置，其包括流体药物储存器，导管，可控流体输送装置，例如泵或阀，以及药物输送控制装置。 根据本发明的控制装置被配置为基于包含第一或更旧的传送简档的当前简档数据的内容来初始地从设备清除第一或旧的药物。 在旧药物被清除之后，控制装置自动修改当前配置文件数据以匹配用于控制第二种或新型药物递送的第二种或新型递送配置文件。

公开(公告)号：US20080177254A1

公开(公告)日：2008-07-24

申请号：US11927174

申请日：2007-10-29

申请人： Brian M. Shelton ,  Ronald J. Lebel ,  Daniel H. Villegas

发明人： Brian M. Shelton ,  Ronald J. Lebel ,  Daniel H. Villegas

IPC分类号： A61M5/142

CPC分类号： A61M5/14276 ,  A61M5/16827 ,  A61M5/172 ,  A61M2005/14208 ,  A61M2205/52 ,  G06F19/00 ,  G06F19/3468

摘要： The present invention relates to an implantable drug delivery device which includes a fluid drug reservoir, a catheter, a controllable fluid transfer device, e.g., a pump or valve, and a drug delivery control means. The control means in accordance with the invention is configured to initially clear a first, or old, drug from the device based on the content of the Current Profile data containing a first, or old, delivery profile. After the old drug is cleared, then the control means automatically modifies the Current Profile data to match a second, or new, delivery profile for controlling delivery of a second, or new, drug.

摘要翻译： 本发明涉及一种可植入药物递送装置，其包括流体药物储存器，导管，可控流体输送装置，例如泵或阀，以及药物输送控制装置。 根据本发明的控制装置被配置为基于包含第一或更旧的传送简档的当前简档数据的内容来初始地从设备清除第一或旧的药物。 在旧药物被清除之后，控制装置自动修改当前配置文件数据以匹配用于控制第二种或新型药物递送的第二种或新型递送配置文件。

公开(公告)号：US08105268B2

公开(公告)日：2012-01-31

申请号：US12907454

申请日：2010-10-19

申请人： Ronald J. Lebel ,  Timothy Starkweather

发明人： Ronald J. Lebel ,  Timothy Starkweather

IPC分类号： A61M31/00

CPC分类号： A61M5/1723 ,  A61M5/14276 ,  A61M5/172 ,  A61M2005/14208 ,  A61M2205/52 ,  A61M2207/00 ,  A61M2230/005 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  Y10T29/49826

摘要： A system and process for providing safety limits on the delivery of an infusion formulation by an infusion pump system in response to a sensed biological state. The safety limits may comprise user-initiated event signals corresponding to events that may significantly affect the biological state. The safety limits may further comprise user-initiated event ranking signals for respective events which specify a degree, quantity, or measure for the respective event. The user-initiated event and event ranking signals may be communicated to a computing element associated with the infusion pump by an associated communication device having a user interface which comprises a plurality of user-selectable operators for entering information about the events and event rankings.

摘要翻译： 一种系统和方法，用于响应感测的生物学状态，通过输注泵系统提供输注制剂的安全限制。 安全限制可以包括对应于可能显着影响生物状态的事件的用户发起的事件信号。 安全限制可以进一步包括用于指定相应事件的度数，数量或度量的各个事件的用户发起的事件排序信号。 用户发起的事件和事件排序信号可以通过具有用户界面的相关联的通信设备传送到与输注泵相关联的计算元件，该用户界面包括用于输入关于事件和事件排名的信息的多个用户可选操作符。

公开(公告)号：US20110270045A1

公开(公告)日：2011-11-03

申请号：US12902038

申请日：2010-10-11

申请人： Ronald J. Lebel ,  Timothy J. Starkweather ,  Philip T. Weiss

发明人： Ronald J. Lebel ,  Timothy J. Starkweather ,  Philip T. Weiss

IPC分类号： A61M5/172 ,  A61M5/142 ,  B23P11/00 ,  A61B5/00

CPC分类号： A61M5/172 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/6847 ,  A61B2560/0209 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/168 ,  A61M5/16831 ,  A61M2005/14208 ,  A61M2205/18 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/6018 ,  A61M2205/8206 ,  A61M2207/00 ,  A61N1/37211 ,  A61N1/37247 ,  A61N1/37252 ,  A61N1/37258 ,  A61N1/37264 ,  A61N1/3727 ,  A61N1/37276 ,  A61N1/375 ,  G06F3/0619 ,  G06F3/065 ,  G06F3/0673 ,  G06F8/60 ,  G06F8/65 ,  G06F19/3468 ,  G06Q50/22 ,  G16H40/40 ,  Y02D10/42 ,  Y10S128/13 ,  Y10S128/903 ,  Y10T29/49117 ,  Y10T29/49826

摘要： An implantable infusion pump possesses operational functionality that is, at least in part, controlled by software operating in two processor ICs which are configured to perform some different and some duplicate functions. The pump exchanges messages with an external device via telemetry. Each processor controls a different part of the drug infusion mechanism such that both processors must agree on the appropriateness of drug delivery for infusion to occur. Delivery accumulators are incremented and decremented with delivery requests and with deliveries made. When accumulated amounts reach or exceed, quantized deliverable amounts, infusion is made to occur. The accumulators are capable of being incremented by two or more independent types of delivery requests. Operational modes of the infusion device are changed automatically in view of various system errors that are trapped, various system alarm conditions that are detected, and when excess periods of time lapse between pump and external device interactions.

摘要翻译： 可植入输注泵具有至少部分地由两个处理器IC中的软件操作控制的操作功能，这两个处理器IC被配置为执行一些不同的和一些重复的功能。 泵通过遥测与外部设备交换信息。 每个处理器控制药物输注机制的不同部分，使得两个处理器必须就药物输送的合适性达成一致以进行输注。 交货累加器随着交货请求和交货而递增递减。 当累积量达到或超过量化的可交付量时，进行输液。 累加器能够通过两种或多种独立类型的递送请求递增。 考虑到被捕获的各种系统错误，检测到的各种系统报警条件以及泵和外部设备相互作用之间的超时间时间，输液装置的操作模式自动改变。

公开(公告)号：US20110203923A1

公开(公告)日：2011-08-25

申请号：US12862690

申请日：2010-08-24

申请人： Ronald J. Lebel ,  Rajiv Shah ,  Yanan Zhang ,  Edward Chernoff ,  Rudolph A. Montalvo

发明人： Ronald J. Lebel ,  Rajiv Shah ,  Yanan Zhang ,  Edward Chernoff ,  Rudolph A. Montalvo

IPC分类号： G01N27/30 ,  H01R43/16

CPC分类号： A61N1/05 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/14865 ,  Y10T29/49204

摘要： A sensing apparatus with a connector, a sensor lead and a sensor module with a spacer placed over electrodes that have been deposited on a substrate. The spacer may have a space for receiving an enzyme. End portions of the sensor module may be encapsulated, such as with molded beads. A sensor lead may attach to the sensor module and may have an outer tubing that passes over the module and attaches to the beads at the end of the sensor module. The sensor lead may also attach to the connector such that the sensing apparatus may be electrically coupled to a pump, electronics or other devices. The sensing apparatus may be implanted into a vein or artery.

摘要翻译： 具有连接器，传感器引线和传感器模块的感测装置，其具有放置在已经沉积在基板上的电极上的隔离物。 间隔物可以具有用于接受酶的空间。 传感器模块的端部可以被封装，例如用模制的珠子。 传感器引线可以附接到传感器模块，并且可以具有穿过模块并且附接到传感器模块的端部处的珠的外管。 传感器引线还可以附接到连接器，使得感测装置可以电耦合到泵，电子设备或其他装置。 感测装置可以植入静脉或动脉。

公开(公告)号：US07127078B2

公开(公告)日：2006-10-24

申请号：US10702565

申请日：2003-11-05

申请人： Alfred E. Mann ,  Albert S. Maltan ,  Yitzhak Zilberman ,  Byron L. Moran ,  Ronald J. Lebel

发明人： Alfred E. Mann ,  Albert S. Maltan ,  Yitzhak Zilberman ,  Byron L. Moran ,  Ronald J. Lebel

IPC分类号： H04R25/00

CPC分类号： H04R25/558 ,  H04R25/554 ,  H04R2225/31 ,  H04R2225/67

摘要： A hearing aid system including an implant (60) configured for insertion into a recess (40) formed under the skin of the retro-auricular space (50), which implant does not occlude the ear canal (30). The implant includes electronic circuitry (72), a transducer (65, e.g., speaker), antenna (64), and power source (66). The hearing aid also includes an external module (70), which module includes a microphone (163), electronics (172), antenna (164), and power source (166). A telemetry link (76) between the external module antenna and the implant antenna allows transmissions between the microphone module and the implant.

摘要翻译： 一种助听器系统，包括构造成用于插入形成在后耳孔空间（50）的皮肤下方的凹部（40）中的植入物（60），该植入物不会封闭耳道（30）。 植入物包括电子电路（72），换能器（65，例如扬声器），天线（64）和电源（66）。 助听器还包括外部模块（70），该模块包括麦克风（163），电子设备（172），天线（164）和电源（166）。 外部模块天线和植入物天线之间的遥测链路（76）允许麦克风模块和植入物之间的传输。

公开(公告)号：US06585644B2

公开(公告)日：2003-07-01

申请号：US09768203

申请日：2001-01-22

申请人： Ronald J. Lebel ,  Varaz Shahmirian ,  Timothy J. Starkweather ,  Philip T. Weiss ,  Daniel H. Villegas ,  Robert C. Dennard ,  John T. Armstrong ,  John D. Richert

发明人： Ronald J. Lebel ,  Varaz Shahmirian ,  Timothy J. Starkweather ,  Philip T. Weiss ,  Daniel H. Villegas ,  Robert C. Dennard ,  John T. Armstrong ,  John D. Richert

IPC分类号： A61B500

CPC分类号： A61M5/172 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/6847 ,  A61B2560/0209 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/168 ,  A61M5/16831 ,  A61M2005/14208 ,  A61M2205/18 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/6018 ,  A61M2205/8206 ,  A61M2207/00 ,  A61N1/37211 ,  A61N1/37247 ,  A61N1/37252 ,  A61N1/37258 ,  A61N1/37264 ,  A61N1/3727 ,  A61N1/37276 ,  A61N1/375 ,  G06F3/0619 ,  G06F3/065 ,  G06F3/0673 ,  G06F8/60 ,  G06F8/65 ,  G06F19/00 ,  G06F19/3468 ,  G06Q50/22 ,  G16H40/40 ,  Y02D10/42 ,  Y10S128/13 ,  Y10S128/903 ,  Y10T29/49117 ,  Y10T29/49826

摘要： An implanted medical device (e.g. infusion pump) and an external device communicate with one another via telemetry messages that are receivable only during windows or listening periods. Each listening period is open for a prescribed period of time and is spaced from successive listening periods by an interval. The prescribed period of time is typically kept small to minimize power consumption. To increase likelihood of successful communication, the window may be forced to an open state, by use of an attention signal, in anticipation of an incoming message. To further minimize power consumption, it is desirable to minimize use of extended attention signals, which is accomplished by the transmitter maintaining an estimate of listening period start times and attempting to send messages only during listening periods. In the communication device, the estimate is updated as a result of information obtained with the reception of each message from the medical device.

摘要翻译： 植入式医疗装置（例如输液泵）和外部装置通过仅在窗口或收听期间可接收的遥测信息相互通信。 每个聆听期间开放一段规定的时间段，并且与连续的收听周期间隔一段间隔。 规定的时间段通常保持较小以最小化功耗。 为了增加成功通信的可能性，可以通过使用注意信号将窗口强制为打开状态，以预期传入的消息。 为了进一步最小化功率消耗，期望最小化延长的注意信号的使用，其由发射机维持听觉周期开始时间的估计并且仅在听音周期期间尝试发送消息来实现。 在通信装置中，作为来自医疗装置的每个消息的接收获得的信息的结果，更新估计。

公开(公告)号：US06562001B2

公开(公告)日：2003-05-13

申请号：US09768044

申请日：2001-01-22

申请人： Ronald J. Lebel ,  Varaz Shahmirian ,  Timothy J. Starkweather ,  Daniel H. Villegas ,  Philip T. Weiss

发明人： Ronald J. Lebel ,  Varaz Shahmirian ,  Timothy J. Starkweather ,  Daniel H. Villegas ,  Philip T. Weiss

IPC分类号： A61M3100

CPC分类号： A61M5/172 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/6847 ,  A61B2560/0209 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/168 ,  A61M5/16831 ,  A61M2005/14208 ,  A61M2205/18 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/6018 ,  A61M2205/8206 ,  A61M2207/00 ,  A61N1/37211 ,  A61N1/37247 ,  A61N1/37252 ,  A61N1/37258 ,  A61N1/37264 ,  A61N1/3727 ,  A61N1/37276 ,  A61N1/375 ,  G06F3/0619 ,  G06F3/065 ,  G06F3/0673 ,  G06F8/60 ,  G06F8/65 ,  G06F19/00 ,  G06F19/3468 ,  G06Q50/22 ,  G16H40/40 ,  Y02D10/42 ,  Y10S128/13 ,  Y10S128/903 ,  Y10T29/49117 ,  Y10T29/49826

摘要： An implantable infusion pump possesses operational functionality that is, at least in part, controlled by software operating in two processor ICs which are configured to perform some different and some duplicate functions. The pump exchanges messages with an external device via telemetry. Each processor controls a different part of the drug infusion mechanism such that both processors must agree on the appropriateness of drug delivery for infusion to occur. Delivery accumulators are incremented and decremented with delivery requests and with deliveries made. When accumulated amounts reach or exceed, quantized deliverable amounts, infusion is made to occur. The accumulators are capable of being incremented by two or more independent types of delivery requests. Operational modes of the infusion device are changed automatically in view of various system errors that are trapped, various system alarm conditions that are detected, and when excess periods of time lapse between pump and external device interactions.

公开(公告)号：US06427088B1

公开(公告)日：2002-07-30

申请号：US09768206

申请日：2001-01-22

申请人： Sam W. Bowman, IV ,  Ronald J. Lebel ,  Daniel H. Villegas ,  John C. Gord

发明人： Sam W. Bowman, IV ,  Ronald J. Lebel ,  Daniel H. Villegas ,  John C. Gord

IPC分类号： A61N100

CPC分类号： A61M5/172 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/6847 ,  A61B2560/0209 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/168 ,  A61M5/16831 ,  A61M2005/14208 ,  A61M2205/18 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/6018 ,  A61M2205/8206 ,  A61M2207/00 ,  A61N1/37211 ,  A61N1/37247 ,  A61N1/37252 ,  A61N1/37258 ,  A61N1/37264 ,  A61N1/3727 ,  A61N1/37276 ,  A61N1/375 ,  G06F3/0619 ,  G06F3/065 ,  G06F3/0673 ,  G06F8/60 ,  G06F8/65 ,  G06F19/00 ,  G06F19/3468 ,  G06Q50/22 ,  G16H40/40 ,  Y02D10/42 ,  Y10S128/13 ,  Y10S128/903 ,  Y10T29/49117 ,  Y10T29/49826

摘要： An implanted medical device (e.g. infusion pump) and an external device communicate with one another via telemetry messages that are receivable only during windows or listening periods. Each listening period is open for a prescribed period of time and is spaced from successive listening periods by an interval. The prescribed period of time is typically kept small to minimize power consumption. To increase likelihood of successful communication, the window may be forced to an open state, by use of an attention signal, in anticipation of an incoming message. To further minimize power consumption, it is desirable to minimize use of extended attention signals, which is accomplished by the transmitter maintaining an estimate of listening period start times and attempting to send messages only during listening periods. In the communication device, the estimate is updated as a result of information obtained with the reception of each message from the medical device.

摘要翻译： 植入式医疗装置（例如输液泵）和外部装置通过仅在窗口或收听期间可接收的遥测信息相互通信。 每个聆听期间开放一段规定的时间段，并且与连续的收听周期间隔一段间隔。 规定的时间段通常保持较小以最小化功耗。 为了增加成功通信的可能性，可以通过使用注意信号将窗口强制为打开状态，以预期传入的消息。 为了进一步最小化功率消耗，期望最小化延长的关注信号的使用，其由发射机维持听觉周期开始时间的估计并且仅在收听期间尝试发送消息来实现。 在通信装置中，作为来自医疗装置的每个消息的接收获得的信息的结果，更新估计。