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    OPTICAL DETECTOR FOR A PARTICLE SORTING SYSTEM
    1.
    发明申请
    OPTICAL DETECTOR FOR A PARTICLE SORTING SYSTEM 审中-公开

    公开(公告)号：US20200240897A1

    公开(公告)日：2020-07-30

    申请号：US16721431

    申请日：2019-12-19

    申请人： CYTONOME/ST, LLC

    发明人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    IPC分类号： G01N15/14 ,  G01N21/64

    摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

    MULTILAYER HYDRODYNAMIC SHEATH FLOW STRUCTURE
    2.
    发明申请
    MULTILAYER HYDRODYNAMIC SHEATH FLOW STRUCTURE 审中-公开

    公开(公告)号：US20200122937A1

    公开(公告)日：2020-04-23

    申请号：US16719537

    申请日：2019-12-18

    申请人： CYTONOME/ST, LLC

    发明人： John R. Gilbert ,  Manish Deshpande ,  Bernard Bunner

    IPC分类号： B65G51/08 ,  B01F13/00 ,  G01N15/14 ,  B01L3/00

    摘要： A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

    Multilayer hydrodynamic sheath flow structure
    3.
    发明授权
    Multilayer hydrodynamic sheath flow structure 有权

    公开(公告)号：US10543992B2

    公开(公告)日：2020-01-28

    申请号：US15797790

    申请日：2017-10-30

    申请人： CYTONOME/ST, LLC

    发明人： John R. Gilbert ,  Manish Deshpande ,  Bernard Bunner

    IPC分类号： B65G51/01 ,  B65G51/08 ,  B01L3/00 ,  G01N15/14 ,  B01F13/00 ,  B65G51/00

    摘要： A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

    Method and apparatus for sorting particles
    6.
    发明授权
    Method and apparatus for sorting particles 有权

    公开(公告)号：US10029263B2

    公开(公告)日：2018-07-24

    申请号：US13849365

    申请日：2013-03-22

    申请人： CYTONOME/ST, LLC

    发明人： Sebastian Böhm ,  John R. Gilbert ,  Manish Deshpande

    IPC分类号： B07C5/34 ,  B03B5/00 ,  F15C5/00 ,  F16K99/00 ,  G01N15/14 ,  B01L3/00

    摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

    OPTICAL DETECTOR FOR A PARTICLE SORTING SYSTEM
    7.
    发明申请
    OPTICAL DETECTOR FOR A PARTICLE SORTING SYSTEM 审中-公开

    公开(公告)号：US20180088022A1

    公开(公告)日：2018-03-29

    申请号：US15669529

    申请日：2017-08-04

    申请人： CYTONOME/ST, LLC

    发明人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    IPC分类号： G01N15/14 ,  G01N15/10

    摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

    Methods for controlling fluid flow in a microfluidic system
    10.
    发明授权
    Methods for controlling fluid flow in a microfluidic system 有权

    公开(公告)号：US11027278B2

    公开(公告)日：2021-06-08

    申请号：US16584315

    申请日：2019-09-26

    申请人： CYTONOME/ST, LLC

    发明人： John R. Gilbert ,  Sebastian Böhm ,  Manish Deshpande

    IPC分类号： B01L3/00 ,  F16K99/00

    摘要： A microfluidic device includes a microchannel having an interior bounded by a side wall, an inlet, a switching region, and a plurality of outlet channels downstream of the switching region. The microchannel is formed in a microfluidic chip substrate and configured to accommodate a flow of liquid through the microchannel. The microfluidic device includes a valve operatively coupled to the switching region comprising a sealed reservoir. A side passage extends between the reservoir and the interior of the microchannel via an aperture in the side wall and is configured to accommodate a volume of liquid between the interior of the microchannel and the reservoir. The microfluidic device includes an actuator integrated into the microfluidic chip and configured to increase an internal pressure of the reservoir and move at least a portion of the volume of the liquid from the side passage into the microchannel to deflect a portion of the liquid flowing through the microchannel.