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公开(公告)号:US20170372002A1
公开(公告)日:2017-12-28
申请号:US15631832
申请日:2017-06-23
发明人: Yang Yang , Sophie Paquerault , Bradley Scott Denney , Lance Charlton , Jeanette Paek , Attaullah Seikh , Vyshnnavi Parthasarathy , Ken Pearson , Hung Huang , Tejinder Uppal
CPC分类号: G16B25/00 , B01L3/5027 , B01L2300/02 , B01L2300/023 , B01L2300/0654 , B01L2300/0829 , B01L2300/18 , C12Q1/68 , C12Q1/6851 , G01N25/04 , G01N25/4846 , G01N35/00029 , G01N35/00871 , G01N2035/00148 , G01N2035/00366 , G01N2035/00881 , G01N2035/0091 , G16B25/20 , G16B45/00 , G16B50/00 , C12Q2527/107 , C12Q2537/165
摘要: The present invention relates to methods for the analysis of nucleic acids present in biological samples, and more specifically to normalize a high resolution melt curve to assist in the identification of one or more properties of the nucleic acids. The present invention provides methods and systems that incorporate a background identification algorithm according to invention principles using raw melt curve data to identify reactions that are unrelated actual DNA melt reactions. Furthermore, a web-based application for analyzing experimental data is provided. The raw experimental data obtained from a variety of instruments is processed and analyzed on a server and presented to a user through a user interface (UI).
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公开(公告)号:US11232851B2
公开(公告)日:2022-01-25
申请号:US15631832
申请日:2017-06-23
发明人: Yang Yang , Sophie Paquerault , Bradley Scott Denney , Lance Charlton , Jeanette Paek , Attaullah Seikh , Vyshnnavi Parthasarathy , Ken Pearson , Hung Huang , Tejinder Uppal
IPC分类号: G16B25/00 , G01N25/04 , C12Q1/68 , G01N35/00 , G16B45/00 , G16B50/00 , G01N25/48 , G16B25/20 , G16B5/30 , B01L3/00 , C12Q1/6851
摘要: The present invention relates to methods for the analysis of nucleic acids present in biological samples, and more specifically to normalize a high resolution melt curve to assist in the identification of one or more properties of the nucleic acids. The present invention provides methods and systems that incorporate a background identification algorithm according to invention principles using raw melt curve data to identify reactions that are unrelated actual DNA melt reactions. Furthermore, a web-based application for analyzing experimental data is provided. The raw experimental data obtained from a variety of instruments is processed and analyzed on a server and presented to a user through a user interface (UI).
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公开(公告)号:US20180011969A1
公开(公告)日:2018-01-11
申请号:US15631794
申请日:2017-06-23
发明人: Yang Yang , Bradley Scott Denney , Attaullah Seikh
CPC分类号: G16B40/00 , C12Q1/6844 , G01N21/6428 , G01N25/04 , G01N2021/6439 , G06F17/18 , G16B20/20 , G16B40/30 , C12Q2527/107 , C12Q2531/113 , C12Q2537/165 , C12Q2561/113 , C12Q2563/107
摘要: The present invention relates to methods and systems for the analysis of nucleic acids present in biological samples, and more specifically, relates to clustering melt curves derived from high resolution thermal melt analysis performed on a sample of nucleic acids, the resulting clusters being usable, in one embodiment, for analyzing the sequences of nucleic acids and to classify their genotypes that are useful for determining the identity of the genotype of a nucleic acid that is present in a biological sample.
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公开(公告)号:US11056214B2
公开(公告)日:2021-07-06
申请号:US15631794
申请日:2017-06-23
发明人: Yang Yang , Bradley Scott Denney , Attaullah Seikh
摘要: The present invention relates to methods and systems for the analysis of nucleic acids present in biological samples, and more specifically, relates to clustering melt curves derived from high resolution thermal melt analysis performed on a sample of nucleic acids, the resulting clusters being usable, in one embodiment, for analyzing the sequences of nucleic acids and to classify their genotypes that are useful for determining the identity of the genotype of a nucleic acid that is present in a biological sample.
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