公开(公告)号：US20070037219A1

公开(公告)日：2007-02-15

申请号：US10553812

申请日：2004-04-14

申请人： Carina Tan ,  Andrew Howard ,  Hideki Sano

发明人： Carina Tan ,  Andrew Howard ,  Hideki Sano

IPC分类号： G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K14/705

CPC分类号： C07K14/70571 ,  C07K14/723 ,  G01N2333/70571

摘要： A rhesus monkey bombesin receptor subtype-3 has been isolated, cloned and sequenced. This receptor is characteristic of the G-protein family of receptors. Isolated rhesus monkey bombesin receptor subtype-3 may be used to screen and identify novel bombesin receptor modulators that may contribute to the regulation of endocrine processes, metabolism, or the cell cycle. Such compounds may be used in the treatment of conditions that result from deregulated expression of bombesin receptor subtype-3.

摘要翻译： 已经分离，克隆和测序了恒河猴铃蟾肽受体亚型3。 该受体是G-蛋白家族受体的特征。 分离的恒河猴铃蟾肽受体亚型-3可用于筛选和鉴定可能有助于调节内分泌过程，代谢或细胞周期的新型bombesin受体调节剂。 这些化合物可用于治疗由bombesin受体亚型-3的失调表达引起的病症。

公开(公告)号：US07208282B2

公开(公告)日：2007-04-24

申请号：US10478534

申请日：2002-05-28

申请人： Carina Tan ,  Hideki Sano

发明人： Carina Tan ,  Hideki Sano

IPC分类号： C07K14/705 ,  C12N15/12 ,  G01N33/566

CPC分类号： C07K14/72 ,  G01N33/74 ,  G01N33/9406

摘要： The present invention identifies the presence of MCH-2R in the dog, ferret and rhesus monkey. MCH-2R is a G-protein coupled receptor that responds to MCH and is distinct from MCH-1R. MCH-2R polypeptide and nucleic acid sequences related to the dog, ferret, and rhesus monkey MCH-2R are described herein along with uses of such polypeptides and nucleic acids.

摘要翻译： 本发明鉴定了狗，白鼬和恒河猴中MCH-2R的存在。 MCH-2R是对MCH反应的G蛋白偶联受体，不同于MCH-1R。 本文中描述了与狗，白鼬和恒河猴MCH-2R相关的MCH-2R多肽和核酸序列以及这些多肽和核酸的用途。

公开(公告)号：US09553299B2

公开(公告)日：2017-01-24

申请号：US14235471

申请日：2011-07-29

申请人： Koji Takahata ,  Hideki Sano

发明人： Koji Takahata ,  Hideki Sano

IPC分类号： H01M4/587 ,  H01M4/04 ,  H01M4/133 ,  H01M4/1393 ,  H01M4/36 ,  H01M10/0525

CPC分类号： H01M4/0404 ,  H01M4/133 ,  H01M4/1393 ,  H01M4/364 ,  H01M4/587 ,  H01M10/0525 ,  Y02E60/122 ,  Y02P70/54 ,  Y02T10/7011

摘要： A negative electrode sheet of a lithium-ion secondary battery has a negative electrode current collector and a negative electrode active material layer on the negative electrode current collector. The negative electrode active material layer contains flake graphite particles and has a first region neighboring the negative electrode current collector and a second region neighboring a surface side that are different in perpendicularity of the graphite particles. The perpendicularity of the graphite particles is defined as (m1/m2), where, when the inclination θn of each of the graphite particles is specified relative to a surface of the negative electrode current collector, m1 is the number of the graphite particles having an inclination θn of 60°≦θn≦90° and m2 is the number of the graphite particles having an inclination θn of 0°≦θn≦30°.

摘要翻译： 锂离子二次电池的负极片在负极集电体上具有负极集电体和负极活性物质层。 负极活性物质层含有片状石墨粒子，具有与负极集电体相邻的第一区域和与石墨粒子的垂直度不同的与表面侧相邻的第二区域。 石墨颗粒的垂直度定义为（m1 / m2），其中当相对于负极集电体的表面规定每个石墨颗粒的倾斜度θn时，m1是具有 倾角θn为60°≤θn≤90°，m2为倾斜度θn为0°≤θn≤30°的石墨颗粒的数量。

公开(公告)号：US09059436B2

公开(公告)日：2015-06-16

申请号：US13881769

申请日：2010-10-27

申请人： Koji Takahata ,  Hideki Sano

发明人： Koji Takahata ,  Hideki Sano

IPC分类号： H01M4/133 ,  H01M4/04 ,  H01M4/13 ,  H01M4/139 ,  H01M4/587 ,  H01M10/052 ,  H01M10/0566 ,  H01M4/02 ,  H01M4/62

CPC分类号： H01M4/04 ,  H01M4/0404 ,  H01M4/13 ,  H01M4/133 ,  H01M4/139 ,  H01M4/587 ,  H01M4/622 ,  H01M10/052 ,  H01M10/0566 ,  H01M2004/027 ,  Y02E60/122 ,  Y02P70/54 ,  Y02T10/7011 ,  Y10T29/49115

摘要： A method for producing a lithium-ion secondary battery comprising positive and negative electrodes and a non-aqueous electrolyte solution is provided. The method comprises (A) with several different negative electrode active materials, determining density Xn (g/cm3) at several different number of taps applied, n, respectively; (B) determining density Y (g/cm3) of a negative electrode active material layer constituted with a mixture comprising each negative electrode active material; (C) based on a regression line, Y=aXn+b, determining the number of taps applied, n′, that gives a≦0.5 and a determination coefficient R2≧0.99; (D) based on a plot of Y=aXn′+b, determining a passing range of Xn′ where negative electrode active material layer density Y is in a prescribed range; (E) selecting a negative electrode active material having Xn′in the passing range, and fabricating a negative electrode with this material.

摘要翻译： 提供了一种包括正极和负极和非水电解质溶液的锂离子二次电池的制造方法。 该方法包括（A）几种不同的负极活性物质，分别在几个不同的抽头数量n上确定密度Xn（g / cm3）。 （B）确定由包含各负极活性物质的混合物构成的负极活性物质层的密度Y（g / cm 3） （C）基于回归线，Y = aXn + b，确定施加的抽头数，n'，其给出＆nlE; 0.5，确定系数R2≥0.99; （D）基于Y = aXn'+ b的图，确定负极活性物质层密度Y在规定范围内的Xn'的通过范围; （E）选择在通过范围内具有Xn'的负极活性物质，并用该材料制造负极。

公开(公告)号：US20140349189A1

公开(公告)日：2014-11-27

申请号：US14366849

申请日：2011-12-21

申请人： Koji Takahata ,  Hideki Sano

发明人： Koji Takahata ,  Hideki Sano

IPC分类号： H01M10/0583 ,  H01M4/587 ,  H01M10/0525 ,  H01M4/133

CPC分类号： H01M10/0583 ,  B60L11/18 ,  B60L11/1862 ,  B60L11/1879 ,  H01M4/133 ,  H01M4/366 ,  H01M4/587 ,  H01M10/0525 ,  H01M10/0587 ,  H01M2004/027 ,  Y02E60/122 ,  Y02T10/7011 ,  Y02T10/7044 ,  Y02T10/705

摘要： A lithium secondary battery 10 of the present invention is a secondary battery provided with a positive electrode 30 having a positive electrode active material layer 34 on a positive electrode collector 32, and a negative electrode 50 having a negative electrode active material layer 54 on a negative electrode collector 52. The positive electrode active material layer 34 contains a positive electrode active material capable of reversibly storing and releasing lithium ions. The negative electrode active material layer 54 contains a negative electrode active material made up of lamellar graphite that is bent so as to have an average number of bends f per particle of 0

摘要翻译： 本发明的锂二次电池10是具有在正极集电体32上具有正极活性物质层34的正极30的二次电池，负极50具有负极活性物质层54的负极 正极活性物质层34含有可逆地储存和释放锂离子的正极活性物质。 负极活性物质层54含有由层状石墨构成的负极活性物质，该负极活性物质被弯曲成具有每个颗粒的平均弯曲数f为0

公开(公告)号：US07696339B2

公开(公告)日：2010-04-13

申请号：US12215324

申请日：2008-06-26

申请人： Hideki Sano ,  Hisashi Iwaasa ,  Satoshi Mashiko

发明人： Hideki Sano ,  Hisashi Iwaasa ,  Satoshi Mashiko

IPC分类号： C07H21/04 ,  C07K14/435

CPC分类号： C07K14/705 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2333/726

摘要： There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for functional analysis of the GPR103 genes and proteins and for the compound evaluation. The nucleic acids or proteins having the sequences listed as SEQ ID NOS: 1 to 4 provide non-human primate or rat GPR103 genes and proteins and information based on the genes and proteins. The genes and proteins can be used for evaluation of compounds. The nucleic acids or proteins having the sequence listed as SEQ ID NO: 5 or 6 provide a GPR103 ligand.

摘要翻译： 提供了非人灵长类动物和大鼠GPR103基因和蛋白质，以及使用基因或蛋白质的化合物评估方法。 还提供了非常有用的新配体，用于GPR103基因和蛋白质的功能分析以及化合物评估。 具有SEQ ID NO：1至4列出的序列的核酸或蛋白质提供非人灵长类动物或大鼠GPR103基因和基于基因和蛋白质的蛋白质和信息。 基因和蛋白质可用于评价化合物。 具有SEQ ID NO：5或6所列序列的核酸或蛋白质提供GPR103配体。

公开(公告)号：US20090311595A1

公开(公告)日：2009-12-17

申请号：US12376248

申请日：2007-08-09

申请人： Katsuhiko Mori ,  Fumiharu Sakashita ,  Hideki Sano

发明人： Katsuhiko Mori ,  Fumiharu Sakashita ,  Hideki Sano

IPC分类号： H01M2/08

CPC分类号： H01M2/0275 ,  B32B15/015 ,  H01M2/0272 ,  H01M2/0287

摘要： An Fe—Ni diffusion layer (3) is formed on the surface of a steel plate (2) containing Fe in an amount of 98 percent by weight or more, and the Fe/Ni ratio is adjusted within the range of 0.1 to 2.5. The steel plate (2) is shaped into a battery case (1) having a predetermined shape with predetermined dimensions such that the Fe—Ni diffusion layer (3) serves as the inner surface of the battery case (1). When a battery is produced using the battery case (1), corrosion due to over-discharge is suppressed even when the amount of Ni used is small. Therefore, the produced battery is excellent in leakage resistance.

摘要翻译： 在含有98重量％以上的Fe的钢板（2）的表面上形成Fe-Ni扩散层（3），将Fe / Ni比调节在0.1〜2.5的范围内。 钢板（2）成形为具有预定尺寸的预定尺寸的电池壳体（1），使得Fe-Ni扩散层（3）用作电池壳体（1）的内表面。 当使用电池壳体（1）制造电池时，即使当使用的Ni量小时，也会抑制由于过度放电引起的腐蚀。 因此，所生产的电池具有优异的耐漏电性。

公开(公告)号：US20090176243A1

公开(公告)日：2009-07-09

申请号：US12215324

申请日：2008-06-26

申请人： Hideki Sano ,  Hisashi Iwaasa ,  Satoshi Mashiko

发明人： Hideki Sano ,  Hisashi Iwaasa ,  Satoshi Mashiko

IPC分类号： G01N33/53 ,  C12Q1/02 ,  C12N15/11

CPC分类号： C07K14/705 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2333/726

摘要： There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for functional analysis of the GPR103 genes and proteins and for the compound evaluation. The nucleic acids or proteins having the sequences listed as SEQ ID NOS: 1 to 4 provide non-human primate or rat GPR103 genes and proteins and information based on the genes and proteins. The genes and proteins can be used for evaluation of compounds. The nucleic acids or proteins having the sequence listed as SEQ ID NO: 5 or 6 provide a GPR103 ligand.

摘要翻译： 提供了非人灵长类动物和大鼠GPR103基因和蛋白质，以及使用基因或蛋白质的化合物评估方法。 还提供了非常有用的新配体，用于GPR103基因和蛋白质的功能分析以及化合物评估。 具有SEQ ID NO：1至4列出的序列的核酸或蛋白质提供非人灵长类动物或大鼠GPR103基因和基于基因和蛋白质的蛋白质和信息。 基因和蛋白质可用于评价化合物。 具有SEQ ID NO：5或6所列序列的核酸或蛋白质提供GPR103配体。

公开(公告)号：US07186681B2

公开(公告)日：2007-03-06

申请号：US09805449

申请日：2001-03-13

申请人： Fu-Tong Liu ,  Hideki Sano ,  Daniel K. Hsu

发明人： Fu-Tong Liu ,  Hideki Sano ,  Daniel K. Hsu

IPC分类号： A01N37/18 ,  A61K38/00 ,  A61K39/395

CPC分类号： G01N33/5094 ,  A61K38/1709 ,  A61K45/06 ,  A61K2039/505 ,  A61L26/0028 ,  A61L26/0066 ,  A61L27/22 ,  A61L27/227 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/802 ,  C07K16/18 ,  G01N33/5047

摘要： The present invention relates to methods of modulating cell migration, particularly, monocyte, neutrophil or macrophage migration, using galectin-3, galectin-3 binding polypeptide, or galectin-3 receptor binding polypeptide. Specifically provided are methods for increasing cell migration to sites of inflammation, infection or a tumor. Also provided are methods for identifying agents that modulate galectin-3 mediated migration, compositions containing galectin-3 or a functional subsequence thereof, and microfabricated devices that deliver galectin-3 or functional galectin-3 subsequences.

摘要翻译： 本发明涉及使用半乳凝素-3，半乳凝素-3结合多肽或半乳凝素-3受体结合多肽调节细胞迁移，特别是单核细胞，中性粒细胞或巨噬细胞迁移的方法。 具体提供的是用于增加细胞迁移到炎症，感染或肿瘤部位的方法。 还提供了用于鉴定调节半乳凝素-3介导的迁移的试剂的方法，含有半乳凝素-3或其功能性亚序列的组合物，以及递送半乳凝素-3或功能性半乳凝素-3子序列的微制剂。

公开(公告)号：US06280219B1

公开(公告)日：2001-08-28

申请号：US09753479

申请日：2001-01-03

申请人： Hideki Sano ,  Kiyokazu Ikeya

发明人： Hideki Sano ,  Kiyokazu Ikeya

IPC分类号： H01R1122

CPC分类号： H01R13/193 ,  H01R12/89 ,  H01R2201/20

摘要： A socket (10) having a base (12), an adapter (24) which has a mounting seat for a semiconductor device (100) and which is installed on the base, and a plurality of contact members (14) which are caused to engage respective terminals of the semiconductor device that has been placed on the mounting seat of the adapter. Each contact member (14) has a pair of arms (90, 130, 144) provided by the bifurcation of one end, with the other end being fixed to the base. Each contact member is caused to nip a respective terminal (102) of the semiconductor device arranged on the mounting seat at the tip portion of the pair of arms and has butting surfaces (92, 131, 148) that determine the minimum spacing distance of the tip portions of the arms on the opposing sides of each pair of arms. Contact members (14) are connected to socket terminals (21) via a connector including an expansion board (20), conductive wires (150, 160), flexible printed substrate (170), sockets (190, 200, 214) and lead guides (222, 224) in several embodiments.

摘要翻译： 一种具有基座（12）的插座（10），具有用于半导体器件（100）的安装座并安装在基座上的适配器（24）和多个接触构件（14） 接合已经放置在适配器的安装座上的半导体器件的各个端子。 每个接触构件（14）具有由一端的分叉提供的一对臂（90,130,144），另一端固定在基座上。 导致每个接触构件夹在布置在安装座上的在一对臂的尖端部分处的半导体器件的相应端子（102），并且具有确定最小间隔距离的对接表面（92,131,148） 在每对臂的相对侧上的臂的尖端部分。 接触构件（14）经由包括扩展板（20），导线（150,160），柔性印刷基板（170），插座（190,200,214）和导线引导件 （222,224）。