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    Porous spherical glass filtrating beads and method for the manufacturing thereof
    1.
    发明授权
    Porous spherical glass filtrating beads and method for the manufacturing thereof 失效
    多孔球形玻璃过滤珠及其制造方法

    公开(公告)号：US4713338A

    公开(公告)日：1987-12-15

    申请号：US893922

    申请日：1986-08-06

    申请人： Carlos J. R. Gonzalez Oliver ,  Olivier De Pous ,  Michel Schneider

    发明人： Carlos J. R. Gonzalez Oliver ,  Olivier De Pous ,  Michel Schneider

    IPC分类号： B01J20/281 ,  B01D39/06 ,  B01J20/06 ,  B01J20/10 ,  B01J20/28 ,  B01J20/283 ,  C03B8/02 ,  C03B19/10 ,  C03B19/12 ,  G01N30/88 ,  C12N11/14 ,  C03C11/00

    CPC分类号： G01N30/482 ,  B01J20/06 ,  B01J2220/54 ,  Y10S435/814 ,  Y10S435/815

    摘要： Porous glass beads for filtation applications having a homogeneous metaloxane structure and comprising oxides of Si, Zr and optionally Ti and Al. A preferred method for making these beads comprises the steps of (a) providing a mother solution of Si and Zr alkoxides in a water soluble solvent, for instance a lower aliphatic alcohol, (b) providing a liquid dispersant phase in which solution (a) is dispersible and stirring this liquid phase sufficiently to cause (a) to be formed into droplets of substantially uniform size when added to (b), (c) adding (a) to (b) at a rate sufficient to provide said droplets and effecting the hydrolysis of the alkoxides contained therein with consecutive gelation of said droplets into corresponding hardened beads of condensed mixed Si and Zr hydroxides, and (d) separating said beads from the liquid phase and drying to achieve the desired porous mixed oxide structure for the beads.

    摘要翻译： 用于过滤应用的多孔玻璃珠具有均匀的金属氧化物结构并且包含Si，Zr和任选的Ti和Al的氧化物。 制备这些珠粒的优选方法包括以下步骤：（a）在水溶性溶剂例如低级脂族醇中提供Si和Zr醇盐的母溶液，（b）提供液体分散相，其中溶液（a） 是可分散的并且充分搅拌该液相以使（a）在加入到（b）中时形成基本上均匀大小的液滴，（c）以足以提供所述液滴的速度加入（a）至（b） 其中所含的醇盐的水解使所述液滴连续凝胶化成冷凝的混合Si和Zr氢氧化物的相应的硬化珠粒，和（d）将所述珠粒与液相分离并干燥以达到所需的多孔混合氧化物结构。

    Quantification analysis of immobilized contrast agent in medical imaging applications
    2.
    发明授权
    Quantification analysis of immobilized contrast agent in medical imaging applications 有权
    医学成像应用中固定化造影剂的定量分析

    公开(公告)号：US09072492B2

    公开(公告)日：2015-07-07

    申请号：US12811089

    申请日：2008-12-23

    申请人： Marcel Arditi ,  Tristan Messager ,  Michel Schneider ,  Peter Frinking

    发明人： Marcel Arditi ,  Tristan Messager ,  Michel Schneider ,  Peter Frinking

    IPC分类号： A61B8/14 ,  A61B8/08 ,  G06F19/12

    CPC分类号： A61B8/481 ,  A61B8/14 ,  A61B8/5223 ,  G06F19/12

    摘要： An embodiment analyzes a body part of a patient, which patient is perfused with a contrast agent that is capable of circulating within the patient and of being substantially immobilized on a biological target. An embodiment of a corresponding system provides an echo signal that is indicative of a response over time to an interrogation signal of the body part, fits the echo signal with a time model function that models an evolution over time of the contrast agent in the body part, the time model function including a combination of a circulation function that models the circulation of the contrast agent and a decay function that models a decay of the echo signal from the immobilized contrast agent, and estimates at least one kinetics indicator of the contrast agent from the time model function.

    摘要翻译： 一个实施方案分析患者的身体部分，该患者被灌注了能够在患者体内循环并且基本上固定在生物靶上的造影剂。 对应系统的一个实施例提供一个回波信号，其指示随着时间的推移对身体部位的询问信号的响应，将回波信号与时间模型函数拟合，该时间模型函数对身体部位中造影剂的时间演化进行建模 时间模型功能包括对造影剂的循环进行建模的循环功能和对来自固定的造影剂的回波信号的衰减进行建模的衰减函数的组合，并估计造影剂的至少一个动力学指标 时间模型功能。

    Liposomal assembly for therapeutic and/or diagnostic use
    4.
    发明授权
    Liposomal assembly for therapeutic and/or diagnostic use 有权
    用于治疗和/或诊断用途的脂质体组装

    公开(公告)号：US07749485B2

    公开(公告)日：2010-07-06

    申请号：US11596447

    申请日：2005-05-31

    申请人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    发明人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    IPC分类号： A61K51/00 ,  A61M36/14 ,  B32B5/16 ,  B01F3/00

    CPC分类号： A61K9/1075 ,  A61K9/1271 ,  A61K48/0091 ,  A61K49/1812 ,  C12N15/88 ,  Y10S977/907 ,  Y10T428/2982

    摘要： Composition for diagnostic or therapeutic use which comprises an assembly comprising an active agent. The assembly comprises a liposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a substantially electrostatic interaction, When an active compound is incorporated into the micelles, a substantial amount of said active compound can be linked to a singe liposome. Furthermore, the presence of the outer micellar layer allows to increase the residence time of said liposome in the blood stream.

    摘要翻译： 用于诊断或治疗用途的组合物，其包含包含活性剂的组合物。 组合物包含脂质体和与其相关联的多个胶束组分，所述胶束组分通过基本上静电的相互作用与所述脂质体的外壳的外表面结合。当将活性化合物并入胶束中时，大量的所述 活性化合物可以连接到单个脂质体。 此外，外胶束层的存在允许增加所述脂质体在血流中的停留时间。

    Gas- Filled Microvesicles Composition for Contrast Imaging
    5.
    发明申请
    Gas- Filled Microvesicles Composition for Contrast Imaging 有权
    气体填充的微泡组合物用于对比成像

    公开(公告)号：US20080008657A1

    公开(公告)日：2008-01-10

    申请号：US11660188

    申请日：2005-08-17

    申请人： Philippe Bussat ,  Peter Frinking ,  Christian Guillot ,  Michel Schneider

    发明人： Philippe Bussat ,  Peter Frinking ,  Christian Guillot ,  Michel Schneider

    IPC分类号： A61K49/22

    CPC分类号： A61K49/223

    摘要： The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles, which preferably have respective different mean sizes. In particular, said preparations preferably have respective Dv values differing from each other by at least 0.5 μm, more preferably at least 1.0 μm. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher. According to a preferred embodiment, at least 95% of the total volume of gas contained in said microvesicles, calculated on the population of microvesicles up to a diameter of 10 μm, is contained in microvesicles having a diameter of 8 micron or less. The composition of the invention can be effectively employed at rather different ultrasound transmission frequencies differing by about 8 MHz.

    摘要翻译： 本发明涉及一种新的组合物，其包括用于对比成像的气体填充微泡，其特别适合于向至少两个具有不同频率的选定超声波提供有效的回波响应。 所述组合物优选包含至少两种气体填充微泡的不同制剂，其优选具有不同的平均尺寸。 特别地，所述制剂优选具有彼此不同的至少0.5μm，更优选至少1.0μm的相应的D V值。 或者，所述组合物具有显示Bowley偏度值为0.16或更高的体积大小分布。 根据一个优选实施方案，所述微泡中包含的气体的总体积的至少95％是以直径为10微米的微泡总数计算的，包含在直径为8微米或更小的微泡中。 本发明的组合物可以以不同于约8MHz的相当不同的超声波传播频率有效地使用。

    Gas-filled microvesicle assembly for contrast imaging
    6.
    发明申请
    Gas-filled microvesicle assembly for contrast imaging 有权
    气体填充微泡组件，用于对比成像

    公开(公告)号：US20070071685A1

    公开(公告)日：2007-03-29

    申请号：US10584327

    申请日：2004-12-21

    申请人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

    发明人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

    IPC分类号： A61K49/22

    CPC分类号： A61K47/6925 ,  A61K41/0028 ,  A61K49/225

    摘要： Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.

    摘要翻译： 组件包括充气微泡和结构实体，其能够通过静电相互作用与所述微囊体（微泡相关组分-MAC）的外表面缔合，从而改变其物理化学性质。 所述MAC可以任选地包含靶向配体，生物活性剂，诊断剂或其任何组合。 本发明的组件可以由气体填充的微泡或微球和直径小于100μm的MAC，特别是胶束形成，并且用作诊断和/或治疗活性制剂中的活性成分，特别是用于增强 在超声对比成像领域的成像，包括靶向超声成像，超声介导的药物递送和其他成像技术如分子共振成像（MRI）或核成像。

    Delivery of biologically active substance to target sites in the body of patients
    10.
    发明授权
    Delivery of biologically active substance to target sites in the body of patients 有权
    将生物活性物质交付给患者体内的靶点

    公开(公告)号：US06258378B1

    公开(公告)日：2001-07-10

    申请号：US09243787

    申请日：1999-02-03

    申请人： Michel Schneider ,  Feng Yan ,  Agnés Hiver

    发明人： Michel Schneider ,  Feng Yan ,  Agnés Hiver

    IPC分类号： A61K9127

    CPC分类号： A61K9/127 ,  A61K9/0009 ,  A61K41/0028 ,  Y10S424/812 ,  Y10S436/829

    摘要： The invention concerns a method for administering bioactive substances to patients at selected sites in the body and remotely promoting delivery of said media to selected organs or tissues in the body. The method comprises providing an administrable formulation comprising, dispersed in an aqueous carrier liquid, liposomes filled with bioactive substances and gas-filled microspheres, injecting said formulation into the circulation of a patient so that it is directed to a site of interest, and applying ultrasound pulses to said site so as to make the gas-filled microbodies explode and the gas confined therein to expand in the carrier liquid, the energy of expansion of said confined gas causing the liposome vesicles to open and release the trapped substances at said site. Also disclosed are formulations for delivery of biologically active substances to selected target sites in the organism, the formulations comprising an aqueous suspension of gas-filled microvesicles and liposomes filled with active susbstances such as drugs or diagnostic agents. The formulations are available in a kit form in which the kit comprises sterile precursor components.

    摘要翻译： 本发明涉及一种用于向身体中选定部位的患者施用生物活性物质的方法，并远程促进将所述培养基递送至身体中选定的器官或组织。 该方法包括提供可施用的制剂，其包含在水性载体液体中分散有填充有生物活性物质和充气微球的脂质体，将所述制剂注射到患者的循环中，使其被引导到感兴趣的部位，并施加超声波 脉冲到所述位置，以使气体充填的微体体积膨胀，并且其中限制的气体在载体液体中膨胀，所述密闭气体的膨胀能使脂质体囊泡打开并释放所述位点处的被捕获的物质。 还公开了用于将生物活性物质递送到生物体中的选定靶位点的制剂，该制剂包含充满气体的微泡的水性悬浮液和填充有活性物质如药物或诊断剂的脂质体。 制剂可以试剂盒形式获得，其中试剂盒包含无菌前体组分。