公开(公告)号：US07744613B2

公开(公告)日：2010-06-29

申请号：US10734547

申请日：2003-12-12

申请人： Richard C. Ewers ,  Vahid Saadat ,  Kenneth J. Michlitsch ,  Chris A. Rothe ,  Rodney A. Brenneman ,  Cang C. Lam ,  Eugene G. Chen

发明人： Richard C. Ewers ,  Vahid Saadat ,  Kenneth J. Michlitsch ,  Chris A. Rothe ,  Rodney A. Brenneman ,  Cang C. Lam ,  Eugene G. Chen

IPC分类号： A61B17/08 ,  A61B17/04

CPC分类号： A61B1/0055 ,  A61B1/00135 ,  A61B1/018 ,  A61B1/2736 ,  A61B1/31 ,  A61B17/00234 ,  A61B17/0218 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B17/062 ,  A61B17/0625 ,  A61B17/0644 ,  A61B17/29 ,  A61B17/295 ,  A61B17/3421 ,  A61B17/3468 ,  A61B17/3478 ,  A61B2017/00269 ,  A61B2017/003 ,  A61B2017/00353 ,  A61B2017/00827 ,  A61B2017/0404 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0443 ,  A61B2017/0451 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0461 ,  A61B2017/0462 ,  A61B2017/0464 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/061 ,  A61B2017/06176 ,  A61B2017/0649 ,  A61B2017/2905 ,  A61B2017/2927 ,  A61B2017/2943 ,  A61B2017/3445 ,  A61B2017/3488 ,  A61B2090/3614 ,  A61F5/0086

摘要： Apparatus and methods are provided for forming a gastrointestinal tissue fold by engaging tissue at a first tissue contact point and moving the first tissue contact point from a position initially distal to, or in line with, a second tissue contact point to a position proximal of the second contact point, thereby forming the tissue fold, and extending an anchor assembly through the tissue fold from a vicinity of the second tissue contact point. Adjustable anchor assemblies; as well as anchor delivery systems, shape-lockable guides and methods for endoluminally performing medical procedures, such as gastric reduction, treatment of gastroesophageal reflux disease, resection of lesions, and treatment of bleeding sites; are also provided.

公开(公告)号：US08926634B2

公开(公告)日：2015-01-06

申请号：US11951188

申请日：2007-12-05

申请人： Chris A. Rothe ,  Richard C. Ewers ,  Cang C. Lam ,  Vahid Saadat ,  Kenneth J. Michlitsch

发明人： Chris A. Rothe ,  Richard C. Ewers ,  Cang C. Lam ,  Vahid Saadat ,  Kenneth J. Michlitsch

IPC分类号： A61B17/00 ,  A61B17/10 ,  A61B17/08 ,  A61B1/00 ,  A61B17/06 ,  A61B17/295 ,  A61B19/00 ,  A61B17/04 ,  A61B17/34 ,  A61B17/29

CPC分类号： A61B1/0014 ,  A61B17/0401 ,  A61B17/06066 ,  A61B17/29 ,  A61B17/295 ,  A61B2017/00867 ,  A61B2017/00876 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/06076 ,  A61B2017/3488 ,  A61B2090/037

摘要： Apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.

摘要翻译： 本文描述了用于操纵和固定组织的装置和方法。 在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于 所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。 稳定构件可以适于相对于细长管状构件的纵向轴线成角度。 此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

公开(公告)号：US08343175B2

公开(公告)日：2013-01-01

申请号：US12767731

申请日：2010-04-26

申请人： Richard C. Ewers ,  Vahid Saadat ,  Kenneth J. Michlitsch ,  Chris A. Rothe ,  Rodney C. Brenneman ,  Cang C. Lam ,  Eugene G. Chen

发明人： Richard C. Ewers ,  Vahid Saadat ,  Kenneth J. Michlitsch ,  Chris A. Rothe ,  Rodney C. Brenneman ,  Cang C. Lam ,  Eugene G. Chen

IPC分类号： A61B17/08

CPC分类号： A61B1/0055 ,  A61B1/00135 ,  A61B1/018 ,  A61B1/2736 ,  A61B1/31 ,  A61B17/00234 ,  A61B17/0218 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B17/062 ,  A61B17/0625 ,  A61B17/0644 ,  A61B17/29 ,  A61B17/295 ,  A61B17/3421 ,  A61B17/3468 ,  A61B17/3478 ,  A61B2017/00269 ,  A61B2017/003 ,  A61B2017/00353 ,  A61B2017/00827 ,  A61B2017/0404 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0443 ,  A61B2017/0451 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0461 ,  A61B2017/0462 ,  A61B2017/0464 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/061 ,  A61B2017/06176 ,  A61B2017/0649 ,  A61B2017/2905 ,  A61B2017/2927 ,  A61B2017/2943 ,  A61B2017/3445 ,  A61B2017/3488 ,  A61B2090/3614 ,  A61F5/0086

摘要： Apparatus and methods are provided for forming a gastrointestinal tissue fold by engaging tissue at a first tissue contact point and moving the first tissue contact point from a position initially distal to, or in line with, a second tissue contact point to a position proximal of the second contact point, thereby forming the tissue fold, and extending an anchor assembly through the tissue fold from a vicinity of the second tissue contact point. Adjustable anchor assemblies; as well as anchor delivery systems, shape-lockable guides and methods for endoluminally performing medical procedures, such as gastric reduction, treatment of gastroesophageal reflux disease, resection of lesions, and treatment of bleeding sites; are also provided.

公开(公告)号：US20090082623A1

公开(公告)日：2009-03-26

申请号：US11810850

申请日：2007-06-07

申请人： Chris A. Rothe ,  Vahid Saadat ,  Kevin H. Van Bladel

发明人： Chris A. Rothe ,  Vahid Saadat ,  Kevin H. Van Bladel

IPC分类号： A61B1/04

CPC分类号： A61B1/3137 ,  A61B1/00082 ,  A61B1/00089 ,  A61B1/00147 ,  A61B17/0057 ,  A61B17/064 ,  A61B2017/00243 ,  A61B2017/00579 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/0061 ,  A61B2017/00615 ,  A61B2017/00623 ,  A61B2017/0641

摘要： Visualization and treatment of tissue regions via percutaneous access methods and devices are described herein. The system may include a deployment catheter and an expandable imaging hood. In use, the hood may be introduced from outside the patient body through a percutaneous incision and advanced through a subxiphoid pathway, for example, to the heart where entry may be accomplished via an incision through the left atrial appendage. Once within the heart, the hood can be advanced to any chamber to visualize and/or treat tissue by placing the hood against the tissue to be imaged and pumping translucent fluids into the hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Additionally, any number of therapeutic tools can also be passed through the deployment catheter and into the imaging hood for treating the tissue of interest.

摘要翻译： 本文描述了通过经皮访问方法和装置对组织区域的可视化和治疗。 该系统可以包括展开导管和可扩展成像罩。 在使用中，引擎盖可以通过经皮切口从患者身体的外部引入，并穿过亚剑突途径，例如穿过左心耳通过切口进入心脏。 一旦在心脏内，通过将罩放置在待成像的组织上并将半透明流体泵入罩中直到流体移动任何血液，从而留下清晰的区域 要通过部署导管中的成像元件成像的组织。 此外，任何数量的治疗工具也可以通过展开导管并进入成像罩以用于感兴趣的组织。

公开(公告)号：US10335131B2

公开(公告)日：2019-07-02

申请号：US11877386

申请日：2007-10-23

申请人： Vahid Saadat ,  Ruey-Feng Peh ,  Edmund A. Tam ,  Chris A. Rothe

发明人： Vahid Saadat ,  Ruey-Feng Peh ,  Edmund A. Tam ,  Chris A. Rothe

IPC分类号： A61B1/00 ,  A61B17/02 ,  A61B1/313 ,  A61B17/34 ,  A61B1/005 ,  A61B6/00 ,  A61B8/08

摘要： A method of inhibiting tissue migration comprises positioning an open area of a hood against or adjacent to a tissue region. The method also comprises displacing an opaque fluid with a transparent fluid from the open area. The method includes engaging a portion of the tissue region within the open area via an end effector advanced through the open area and which grasps onto the portion. The end effector includes a tapered section, tapered along its entire length, through which a lumen extends. The tapered section includes threads extending from a surface of the tapered section in a direction orthogonal to the longitudinal axis. The tissue region is pierced while displacing the opaque fluid with the transparent fluid through the distal opening of the hood and while maintaining engagement of the portion of the tissue region such that distal movement of the tissue is inhibited.

公开(公告)号：US09192287B2

公开(公告)日：2015-11-24

申请号：US13526254

申请日：2012-06-18

申请人： Vahid Saadat ,  Chris A. Rothe ,  Edmund Tam ,  Ruey-Feng Peh

发明人： Vahid Saadat ,  Chris A. Rothe ,  Edmund Tam ,  Ruey-Feng Peh

IPC分类号： A61B1/00 ,  A61B1/005 ,  A61B1/015 ,  A61B1/018 ,  A61B1/04 ,  A61B5/02 ,  A61B5/00 ,  A61B17/00 ,  A61B17/04 ,  A61B8/12 ,  A61B17/22 ,  A61B18/24

CPC分类号： A61B1/00085 ,  A61B1/0008 ,  A61B1/00082 ,  A61B1/00089 ,  A61B1/00091 ,  A61B1/00177 ,  A61B1/005 ,  A61B1/012 ,  A61B1/015 ,  A61B1/018 ,  A61B1/04 ,  A61B5/02007 ,  A61B5/6882 ,  A61B8/12 ,  A61B17/00234 ,  A61B17/0057 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0487 ,  A61B17/22012 ,  A61B18/24 ,  A61B2017/048 ,  A61B2017/0496

摘要： Tissue visualization devices and variations thereof are described herein where such devices may utilize a variety of methods for facilitating clearing of the device of opaque bodily fluids and sealing between the device and the underlying tissue surface. Additionally, methods and devices for enhancing navigation of the device through a patient body are also described.

摘要翻译： 本文描述了组织可视化装置及其变型，其中这样的装置可以利用各种方法来促进不透明体液的装置的清除和装置与下面的组织表面之间的密封。 此外，还描述了用于增强穿过患者身体的装置导航的方法和装置。

公开(公告)号：US09055906B2

公开(公告)日：2015-06-16

申请号：US12778878

申请日：2010-05-12

申请人： Vahid Saadat ,  Zachary J. Malchano ,  Jason P. Watson ,  Antony J. Fields ,  Chris A. Rothe ,  Bryan Wylie ,  Veerappan Swaminathan

发明人： Vahid Saadat ,  Zachary J. Malchano ,  Jason P. Watson ,  Antony J. Fields ,  Chris A. Rothe ,  Bryan Wylie ,  Veerappan Swaminathan

IPC分类号： A61B5/05 ,  A61B1/313 ,  A61B1/00 ,  A61B1/005 ,  A61B1/05 ,  A61B1/12 ,  A61B18/14 ,  A61B17/00 ,  A61B19/00

CPC分类号： A61B1/00085 ,  A61B1/00089 ,  A61B1/0052 ,  A61B1/0055 ,  A61B1/015 ,  A61B1/05 ,  A61B1/12 ,  A61B1/3137 ,  A61B18/1492 ,  A61B2017/00314 ,  A61B2034/306 ,  A61B2218/002

摘要： In vivo visualization systems are described which facilitate tissue treatment by a user in utilizing real time visualized tissue images with generated three-dimensional models of the tissue region of interest, such as the left atrial chamber of a subject's heart. Directional indicators on the visualized tissue as well as the imaging systems may be utilized while other variations may utilize image rotation or manipulation of visualized tissue regions to facilitate catheter control. Moreover, visualized tissue regions may be combined with imaged tissue regions as well as navigational information to further facilitate tissue treatments.

摘要翻译： 描述了体内可视化系统，其促进使用者利用实际的可视化组织图像进行组织处理，所述实时可视化组织图像与所关心的组织区域（例如受试者心脏的左心房）的生成的三维模型相关。 可以使用可视化组织以及成像系统上的定向指示器，而其他变化可以利用图像旋转或操纵可视化组织区域以促进导管控制。 此外，可视化组织区域可以与成像的组织区域以及导航信息组合以进一步促进组织治疗。

公开(公告)号：US08235985B2

公开(公告)日：2012-08-07

申请号：US12209057

申请日：2008-09-11

申请人： Vahid Saadat ,  Ruey-Feng Peh ,  Zachary J. Malchano ,  Chris A. Rothe

发明人： Vahid Saadat ,  Ruey-Feng Peh ,  Zachary J. Malchano ,  Chris A. Rothe

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B1/00165 ,  A61B18/1477 ,  A61B90/37 ,  A61B2018/00214 ,  A61B2018/00285 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00898 ,  A61B2018/1425 ,  A61B2218/002

摘要： Visualization and ablation system variations are described which utilize various tissue ablation arrangements. Such assemblies are configured to facilitate the application of bipolar energy delivery, such as RF ablation, to an underlying target tissue for treatment in a controlled manner while directly visualizing the tissue during the bipolar ablation process.

摘要翻译： 描述了利用各种组织消融装置的可视化和消融系统变化。 这种组件被配置为便于将双极能量输送（例如RF消融）应用于潜在的靶组织，以受控的方式进行治疗，同时在双极烧蚀过程期间直接使组织可视化。

公开(公告)号：US20080183036A1

公开(公告)日：2008-07-31

申请号：US11959158

申请日：2007-12-18

申请人： Vahid Saadat ,  Chris A. Rothe ,  Ruey-Feng Peh ,  Edmund Tam

发明人： Vahid Saadat ,  Chris A. Rothe ,  Ruey-Feng Peh ,  Edmund Tam

IPC分类号： A61B1/005 ,  A61B18/14

CPC分类号： A61B1/00089 ,  A61B1/00085 ,  A61B1/005 ,  A61B1/018 ,  A61B1/3137 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/1204 ,  A61B17/12136 ,  A61B17/12172 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00982

摘要： Systems and methods for unobstructed, visualization and ablation, particularly of the pulmonary veins, are described herein. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration as well as one or more expandable anchors which are temporarily securable within a respective pulmonary vein while allowing blood flow to pass through the anchor unimpeded. With the one or more non-impeding anchors secured within a respective pulmonary vein, ablation of the tissue surrounding the ostium or several ostia may be effected with the catheter while the tissue is under direct visualization.

摘要翻译： 本文描述了用于无障碍，可视化和消融，特别是肺静脉的系统和方法。 这样的系统可以包括部署导管和可展开到扩展构型中的附接成像罩，以及一个或多个可扩展锚固件，其可临时固定在相应的肺静脉内，同时允许血液流动通过锚固体而不受阻碍。 利用固定在相应的肺静脉内的一个或多个无阻塞的锚固件，可以在组织处于直接可视化的状态下用导管实现围绕口或组织的几个口的组织的消融。

公开(公告)号：US10064540B2

公开(公告)日：2018-09-04

申请号：US11763399

申请日：2007-06-14

申请人： Vahid Saadat ,  Amir Abolfathi ,  Chris A. Rothe ,  Kevin H. Van Bladel

发明人： Vahid Saadat ,  Amir Abolfathi ,  Chris A. Rothe ,  Kevin H. Van Bladel

IPC分类号： A61B1/00 ,  A61B1/005 ,  A61B1/313 ,  A61B8/12 ,  A61B1/015 ,  A61B1/018 ,  A61B1/04 ,  A61B5/02 ,  A61B8/00

CPC分类号： A61B1/00089 ,  A61B1/0008 ,  A61B1/00082 ,  A61B1/00085 ,  A61B1/005 ,  A61B1/015 ,  A61B1/018 ,  A61B1/04 ,  A61B1/3137 ,  A61B5/02007 ,  A61B8/12 ,  A61B8/4472

摘要： Visualization apparatus and methods for transseptal access are described herein where intravascular access across a septal wall is facilitated via devices which provide for direct visual viewing of tissue area. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to the tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid can be pumped into the imaging hood until the fluid displaces any blood leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Any number of therapeutic tools or a guidewire can be passed through the catheter and into the imaging hood for crossing the septal wall and passing the guidewire or instruments therethrough.