Method for Applying a Coating to a Substrate, Coating, and Use of Particles
    3.
    发明申请
    Method for Applying a Coating to a Substrate, Coating, and Use of Particles 审中-公开
    将涂层施加到基材,涂覆和使用颗粒的方法

    公开(公告)号:US20140170410A1

    公开(公告)日:2014-06-19

    申请号:US14234811

    申请日:2012-07-25

    IPC分类号: C23C16/513

    摘要: The present invention relates to a method for applying a coating to a substrate using cold plasma, wherein particles provided with a polymer coating are fed into a cold plasma at less than 3,000 K and the particles activated by this are deposited on a substrate. The present invention furthermore relates to a substrate coating which can be obtained by the methods according to the invention. The present invention furthermore relates to the use of platelet-shaped particles with a polymer coating with an average thickness of less than 2 μm in the coating of a substrate using a cold plasma.

    摘要翻译: 本发明涉及一种使用冷等离子体将涂层施加到基板上的方法,其中提供有聚合物涂层的颗粒在低于3,000K的条件下进料到冷等离子体中,并且由此激活的颗粒沉积在基材上。 本发明还涉及可以通过根据本发明的方法获得的基底涂层。 本发明还涉及在使用冷等离子体的基板的涂层中使用具有平均厚度小于2μm的聚合物涂层的片状颗粒。

    Compositions and methods for mediating RNAi in vivo
    10.
    发明授权
    Compositions and methods for mediating RNAi in vivo 有权
    用于在体内介导RNAi的组合物和方法

    公开(公告)号:US08148344B2

    公开(公告)日:2012-04-03

    申请号:US12412206

    申请日:2009-03-26

    CPC分类号: A61K47/69 A61K47/554

    摘要: This invention relates to new formulated lipid particles (FLiPs) comprising at least one of a single or double stranded oligonucleotide, where the oligonucleotide has been conjugated to a lipophile and at least one of an emulsion or liposome to which the conjugated oligonucleotide has been aggregated, admixed or associated. These particles have surprisingly been shown to effectively deliver oligonucleotides to heart, lung and muscle where they effect gene silencing.

    摘要翻译: 本发明涉及包含单链或双链寡核苷酸中的至少一种的新配制的脂质颗粒(FLiP),其中所述寡核苷酸已经与亲脂体共轭,并且已经聚合了缀合的寡核苷酸的乳剂或脂质体中的至少一种, 混合或相关。 这些颗粒令人惊讶地被证明可以有效地将寡核苷酸递送到心脏,肺和肌肉,在那里它们影响基因沉默。