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    In vitro gastrointestinal model system and uses thereof
    1.
    发明申请
    In vitro gastrointestinal model system and uses thereof 审中-公开
    体外胃肠道模型系统及其用途

    公开(公告)号：US20050186633A9

    公开(公告)日：2005-08-25

    申请号：US10436976

    申请日：2003-05-14

    申请人： Christophe Lacroix ,  Gwenaelle LeBlay ,  Cecile Cinquin ,  Ismail Fliss

    发明人： Christophe Lacroix ,  Gwenaelle LeBlay ,  Cecile Cinquin ,  Ismail Fliss

    IPC分类号： C12N11/10 ,  G01N33/50 ,  G01N33/53

    CPC分类号： G01N33/5082 ,  C12N11/10

    摘要： A system utilizing cell immobilization in anaerobic continuous-flow cultures for modelling the gastrointestinal system is described. Microbial cells derived from flora, e.g. in fresh faecal samples, are used as the source of inocula for immobilisation in a mixed gel of gellan and xanthan. The beads produced are then introduced in a single or multi-stage chemostat fed with a nutrient media, and the composition and metabolic activities of the flora are monitored over time in reactors operated with conditions simulating the characteristics of different segments of the gastrointestinal tract. The conditions of this intestinal fermentation model are more akin to that for the gastrointestinal system, in which cells are naturally in the immobilized state, entrapped in fibrous particles or forming biofilms on the intestine epithelium. A use of such a system for studying various aspects of the gastrointestinal tract is also described.

    摘要翻译： 描述了利用细菌固定在厌氧连续流动培养物中用于建模胃肠系统的系统。 来自植物区系的微生物细胞，例如。 在新鲜的粪便样品中，用作在凝胶和黄原胶的混合凝胶中固定的接种物的来源。 然后将所产生的小珠引入供给营养培养基的单级或多级恒化器中，随着时间的推移，在用模拟胃肠道不同部分特征的条件下操作的反应器中监测组合物和代谢活性。 这种肠发酵模型的条件更类似于胃肠系统，其中细胞天然处于固定状态，被包裹在纤维颗粒中或在肠上皮上形成生物膜。 还描述了用于研究胃肠道的各个方面的这种系统的使用。

    Mixtures based on thermoplastic elastomers
    5.
    发明授权
    Mixtures based on thermoplastic elastomers 有权
    基于热塑性弹性体的混合物

    公开(公告)号：US07718740B2

    公开(公告)日：2010-05-18

    申请号：US11911219

    申请日：2006-04-12

    申请人： Frederic Malet ,  Thibaut Montanari ,  Christophe Lacroix

    发明人： Frederic Malet ,  Thibaut Montanari ,  Christophe Lacroix

    IPC分类号： C08L77/00

    CPC分类号： C08L77/12 ,  C08L77/00 ,  C08L77/02 ,  C08L77/06 ,  C08L2666/20

    摘要： The invention relates to a mixture comprising by weight, to give a total of 100%, 99-10% a polyamide block and polyether block copolymer (A) predominately consisting of lauryl lactam radicals, 1-99% at least on type of polymer (B) selected from polyamides other than polyamide 12, copolyamides which do not consist of the lauryl lactam radicals and the polyamide block and polyether block copolymers whose polyamide blocks do not predominantly consist of the lauryl lactam radicals. The articles, for example, films, foils, strings and tubes made from the inventive mixture are also disclosed.

    摘要翻译： 本发明涉及一种包含重量比的混合物，以总共100％，99-10％为主要由月桂基内酰胺基团组成的聚酰胺嵌段和聚醚嵌段共聚物（A），1-99％的至少一种类型的聚合物 B）选自聚酰胺12以外的聚酰胺，不由月桂基内酰胺基团组成的共聚酰胺和聚酰胺嵌段和聚醚嵌段共聚物，其聚酰胺嵌段不主要由月桂基内酰胺基团组成。 还公开了由本发明混合物制成的制品，例如薄膜，箔，线和管。

    Thermoplastic polyester compositions having improved impact properties
    6.
    发明授权
    Thermoplastic polyester compositions having improved impact properties 失效
    热塑性聚酯组合物具有改进的冲击性能

    公开(公告)号：US07119152B1

    公开(公告)日：2006-10-10

    申请号：US09718427

    申请日：2000-11-24

    申请人： Christophe Lacroix ,  Alain Bouilloux

    发明人： Christophe Lacroix ,  Alain Bouilloux

    IPC分类号： C08L65/00

    CPC分类号： C08L67/02 ,  Y10S525/902 ,  C08L2666/02

    摘要： The present invention relates to thermoplastic polyesters, which comprise, by weight: (i) a thermoplastic polyester; (ii) an impact modifier comprising: (a) a core-shell copolymer (A); (b) an ethylene copolymer (B) chosen from ethylene-unsaturated carboxylic acid anhydride copolymers (B1), ethylene-unsaturated epoxide copolymers (B2) and blends thereof; (iii) the (B)/(A) ratio being between 40/60 and 10/90 for proportions of impact modifier between 18 and 40% in 82 to 60% of polyester, respectively; (iv) the (B)/(A) ratio being between 40/60 and 25/75 for proportions of impact modifier between 2 and 18% in 98 to 82% of polyester, respectively. It is particularly useful for PET and PBT.

    摘要翻译： 本发明涉及热塑性聚酯，其包含：（i）热塑性聚酯; （ii）抗冲改性剂，其包含：（a）核 - 壳共聚物（A）; （b）选自乙烯 - 不饱和羧酸酐共聚物（B1），乙烯 - 不饱和环氧化物共聚物（B2）及其共混物的乙烯共聚物（B） （iii）分别在82至60％的聚酯中，抗冲改性剂的比例为18至40％时，（B）/（A）的比率为40/60至10/90; （iv）分别在98至82％的聚酯中，抗冲改性剂的比例为2至18％时，（B）/（A）比为40/60至25/75。 它对PET和PBT特别有用。

    Lantibiotic from Streptococcus mutans and uses thereof
    7.
    发明授权
    Lantibiotic from Streptococcus mutans and uses thereof 失效
    来自变形链球菌的Lantibiotic及其用途

    公开(公告)号：US06218362B1

    公开(公告)日：2001-04-17

    申请号：US08924952

    申请日：1997-09-08

    申请人： Marc Lavoie ,  Marilaine Mota-Meira ,  Christophe Lacroix ,  Gisèle LaPointe

    发明人： Marc Lavoie ,  Marilaine Mota-Meira ,  Christophe Lacroix ,  Gisèle LaPointe

    IPC分类号： A61K3800

    CPC分类号： C07K14/315 ,  A61K38/00

    摘要： Mutacin are bactericidal substances of proteinaceous natures produced by Streptococcus mutans. Lantibiotics are antibacterial substances containing posttranslationnally modified amino acids such as lanthionine. The present invention teaches a simple method of purifying mutacin B-Ny266 from Streptococcus mutans strain Ny266 to homogeneity. The present invention further teaches the primary amino acid sequence of mutacin B-Ny266 as well as its proposed modified structure. Further, the present invention teaches compositions comprising mutacin B-Ny266 as well as methods for the treatment and/or prophylaxy of bacterial infections comprising an administration of a suitable dose of composition comprising mutacin B-Ny266.

    摘要翻译： 变态链霉菌是由变形链球菌产生的蛋白质性质的杀菌物质。 拉链抗生素是含有经过翻译后修饰的氨基酸如羊毛硫蛋白的抗菌物质。 本发明教导了将Mutacin B-Ny266从变异链球菌菌株Ny266纯化为均质的简单方法。 本发明进一步教导了Mutacin B-Ny266的初级氨基酸序列以及其提出的修饰结构。 此外，本发明教导了包含mutacin B-Ny266的组合物以及用于治疗和/或预防细菌感染的方法，包括给予包含Mutacin B-Ny266的合适剂量的组合物。

    Structure comprising a fluoropolymer layer and a piperazine-based tie resin
    8.
    发明授权
    Structure comprising a fluoropolymer layer and a piperazine-based tie resin 失效
    包含含氟聚合物层和哌嗪类粘结树脂的结构

    公开(公告)号：US06962754B2

    公开(公告)日：2005-11-08

    申请号：US10174507

    申请日：2002-06-19

    申请人： Philippe Bussi ,  Christophe Lacroix ,  David Silagy

    发明人： Philippe Bussi ,  Christophe Lacroix ,  David Silagy

    IPC分类号： B32B27/30 ,  B32B7/10 ,  B32B27/08 ,  B32B27/34 ,  C09J7/02 ,  C09J177/02 ,  C09J177/04 ,  C09J177/06

    CPC分类号： B32B27/08 ,  B32B7/10 ,  B32B27/18 ,  B32B27/20 ,  B32B27/304 ,  Y10T156/10 ,  Y10T428/31504 ,  Y10T428/31725 ,  Y10T428/31743 ,  Y10T428/3175

    摘要： A structure made of a fluoropolymer layer and directly attached to one of its sides a tie layer based on a polyamide which results from the condensation of at least one diacid and at least one diamine of the following formula (1): in which R1 represents H or -Z1-NH2 and Z1 represents an alkyl, a cycloalkyl or an aryl having up to 15 carbon atoms and R2 represents H or -Z2-NH2 and Z2 represents an alkyl, a cycloalkyl or an aryl having up to 15 carbon atoms, it being possible for R1 and R2 to be identical or different. The tie resin may also be a copolymer having polyamide blocks and polyether blocks, the polyamide blocks resulting from condensation of at least one diacid and at least one diamine of formula (1). The invention also relates to a structure comprising a fluoropolymer layer, the tie layer and a substrate layer, respectively, as well as to a structure comprising a tie layer, respectively. This structure may be placed between two substrate layers and may be in the form of a sheet, film, profile or tube. It is particularly useful in the form of a tube for transporting gasoline between the tank and the injection device in motor-vehicle engines.

    摘要翻译： 由含氟聚合物层制成的结构，其直接连接到其一侧，基于由至少一种二酸和至少一种下式（1）的二胺缩合而得到的聚酰胺：其中R 1表示H或-Z 1 -NH 2，Z 1表示烷基，环烷基或具有至多15个碳原子的芳基，R 2表示H 或-Z 2 -NH 2，Z 2代表具有至多15个碳原子的烷基，环烷基或芳基，R 1和R 2可以是 相同或不同。 粘结树脂还可以是具有聚酰胺嵌段和聚醚嵌段的共聚物，由至少一种二酸和至少一种式（1）的二胺的缩合产生的聚酰胺嵌段。 本发明还涉及分别包括含氟聚合物层，连接层和基底层的结构，以及分别包括粘结层的结构。 该结构可以放置在两个基底层之间，并且可以是片，膜，轮廓或管的形式。 在汽车发动机中的罐和注射装置之间输送汽油的管子的形式特别有用。

    Polyamide/polyurethane multilayer structures for decorated articles
    10.
    发明申请
    Polyamide/polyurethane multilayer structures for decorated articles 有权
    用于装饰物品的聚酰胺/聚氨酯多层结构

    公开(公告)号：US20050084685A1

    公开(公告)日：2005-04-21

    申请号：US10967587

    申请日：2004-10-18

    申请人： Christophe Lacroix ,  Thibaut Montanari

    发明人： Christophe Lacroix ,  Thibaut Montanari

    IPC分类号： A63C5/00 ,  A63C5/12 ,  B29C41/22 ,  B32B27/08 ,  B32B27/34 ,  B32B27/40 ,  B44C1/10 ,  B44C1/17 ,  B32B31/00

    CPC分类号： B32B27/08 ,  A43B1/0027 ,  A63C5/003 ,  A63C5/12 ,  B32B27/18 ,  B32B27/34 ,  B32B27/40 ,  B32B2307/412 ,  B32B2437/02 ,  B44C1/105 ,  B44C1/1716 ,  Y10T428/31551 ,  Y10T428/31562 ,  Y10T428/31725 ,  Y10T428/31739

    摘要： The present invention relates to a multilayer structure comprising a transparent polyamide-based layer and a layer based on a thermoplastic polyurethane (TPU). The invention also relates to a decorated article consisting of an object to which the above structure has been bonded, the polyamide layer being on the outside. According to another embodiment, the polyamide/TPU structures may be bonded to a polyurethane foam or to a polyurethane resin. It is also possible to overmould the polyurethane foam or the polyurethane resin to the polyamide/TPU structure placed in a mould, the polyamide layer being adjacent to the mould wall. The structure obtained is useful, for example for making skis or sports shoes. The invention also relates to these structures. Advantageously, the polyamide layer is semicrystalline. Advantageously, the TPU layer is transparent. Each of the layers may be formed from several layers.

    摘要翻译： 本发明涉及包含透明聚酰胺基层和基于热塑性聚氨酯（TPU）的层的多层结构。 本发明还涉及一种由上述结构粘合的物体组成的装饰物品，聚酰胺层位于外侧。 根据另一个实施方案，聚酰胺/ TPU结构可以结合到聚氨酯泡沫或聚氨酯树脂上。 也可以将聚氨酯泡沫或聚氨酯树脂过模制到放置在模具中的聚酰胺/ TPU结构，聚酰胺层与模具壁相邻。 获得的结构是有用的，例如用于制造滑雪板或运动鞋。 本发明还涉及这些结构。 有利地，聚酰胺层是半结晶的。 有利地，TPU层是透明的。 每个层可以由几层形成。