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公开(公告)号：US20060004317A1
公开(公告)日：2006-01-05
申请号：US10881497
申请日：2004-06-30
申请人： Christophe Mauge , Thomas DiMauro , Mohamed Attawia , Hassan Serhan , Jeffrey Sutton , Timothy Beardsley , Alan Dextradeur
发明人： Christophe Mauge , Thomas DiMauro , Mohamed Attawia , Hassan Serhan , Jeffrey Sutton , Timothy Beardsley , Alan Dextradeur
IPC分类号： A61M5/00
CPC分类号： A61M27/006 , A61M25/0045 , A61M2025/0056 , A61N5/0601 , A61N5/062 , A61N2005/0651 , A61N2005/0659 , A61N2005/0661
摘要： A hydrocephalus shunt has photocatalytic capabilities. The shunt is used to treat hydrocephalus by inserting into a human cranium a hydrocephalus shunt having a component having a surface. Thereafter, a reactive oxygen species is produced on the component surface. The component may be a catheter. The shunt may also include a light source.
摘要翻译： 脑积水分流具有光催化能力。 分流器用于通过将具有具有表面的部件的脑积水分流器插入人类颅骨来治疗脑积水。 此后，在组件表面上产生活性氧。 该组件可以是导管。 分流器还可以包括光源。
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公开(公告)号：US20100268151A1
公开(公告)日：2010-10-21
申请号：US12727794
申请日：2010-03-19
申请人： Christoph Mauge , Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Jeffrey Sutton , Timothy Beardsley , Alan Dextradeur , Robert Kraus
发明人： Christoph Mauge , Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Jeffrey Sutton , Timothy Beardsley , Alan Dextradeur , Robert Kraus
IPC分类号： A61N5/06
CPC分类号： A61M27/006 , A61M25/0045 , A61M2025/0056 , A61N5/0601 , A61N5/062 , A61N2005/0651 , A61N2005/0659 , A61N2005/0661
摘要： An intracranial implant emitting light having a wavelength between blue and yellow light
摘要翻译： 发射具有蓝色和黄色光之间的波长的光的颅内植入物
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公开(公告)号：US20050175658A1
公开(公告)日：2005-08-11
申请号：US10774105
申请日：2004-02-06
申请人： Thomas DiMauro , Jeffrey Sutton , Mohamed Attawia , Hassan Serhan , John Malone , Tim Beardsley
发明人： Thomas DiMauro , Jeffrey Sutton , Mohamed Attawia , Hassan Serhan , John Malone , Tim Beardsley
IPC分类号： A61B17/86 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/34 , A61F2/36 , A61F2/38 , A61F2/44 , A61L27/06 , A61L27/42 , A61L27/56 , A61L31/02 , A61L31/12 , A61L31/14 , A61M5/158 , A61N1/30 , B01J35/00
CPC分类号： A61F2/30767 , A61B17/866 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/38 , A61F2/4455 , A61F2002/30663 , A61F2002/30668 , A61F2002/30929 , A61F2002/30981 , A61F2002/3611 , A61F2002/3625 , A61F2002/443 , A61F2250/0001 , A61F2310/00023 , A61F2310/00604 , A61F2310/0061 , A61F2310/00616 , A61L27/06 , A61L27/427 , A61L27/56 , A61L31/022 , A61L31/124 , A61L31/146 , A61M5/158 , A61N5/0601 , A61N5/0624 , A61N2005/0651 , A61N2005/0661 , B01J35/004
摘要： An implant comprises a photocatalytic layer on at least one surface. In some embodiments, the photocatalytic layer is a semiconductor oxide that is doped. According to some embodiments, the implant comprises a wave guide. According to some embodiments the implant comprises a light port. According to some embodiments, the implant comprises a reflective material on a surface of the waveguide. According to some embodiments the implant comprises a composite material comprising a first material that has a transmissivity when exposed to a predetermined wavelength of light and a second material that has photocatalytic activity when exposed to the predetermined wavelength of light. According to some embodiments the implant comprises a light source adapted to irradiate the photocatalytic surface.
摘要翻译： 植入物包括在至少一个表面上的光催化层。 在一些实施方案中，光催化层是掺杂的半导体氧化物。 根据一些实施例，植入物包括波导。 根据一些实施例，植入物包括光端口。 根据一些实施例，植入物在波导的表面上包括反射材料。 根据一些实施例，植入物包括复合材料，其包括当暴露于预定波长的光时具有透射率的第一材料和当暴露于预定波长的光时具有光催化活性的第二材料。 根据一些实施方案，植入物包括适于照射光催化表面的光源。
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4.发明申请TRANSDISCAL ADMINISTRATION OF SPECIFIC INHIBITORS OF PRO-INFLAMMATORY CYTOKINES 有权炎性细胞因子特异性抑制剂的透析管理公开(公告)号：US20070237777A1
公开(公告)日：2007-10-11
申请号：US10456948
申请日：2003-06-06
申请人： Thomas DiMauro , Hassan Serhan , Mohamed Attawia
发明人： Thomas DiMauro , Hassan Serhan , Mohamed Attawia
IPC分类号： A61K39/395 , A61K48/00 , A61K38/18
CPC分类号： A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要： The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译： 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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公开(公告)号：US20060019889A1
公开(公告)日：2006-01-26
申请号：US11018438
申请日：2004-12-21
申请人： Thomas DiMauro , Mohamed Attawia , Hassan Serhan
发明人： Thomas DiMauro , Mohamed Attawia , Hassan Serhan
IPC分类号： A61K38/17
CPC分类号： A61L27/54 , A61K38/1841 , A61K38/2066 , A61K38/2264 , A61K38/39 , A61K38/57 , A61L2300/252 , A61L2430/38 , A61K2300/00
摘要： Administering an effective amount of adiponectin into an osteolytic region.
摘要翻译： 将有效量的脂联素施用于溶骨性区域。
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6.发明申请Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints 有权将高特异性细胞因子抑制剂的跨荚膜施用于矫形关节公开(公告)号：US20050025765A1
公开(公告)日：2005-02-03
申请号：US10630227
申请日：2003-07-30
申请人： Thomas DiMauro , Mohamed Attawia , Hassan Serhan , Martin Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura Brown , Jeff Geesin , Pamela Plouhar , Catherine Smith , John Siekierka
发明人： Thomas DiMauro , Mohamed Attawia , Hassan Serhan , Martin Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura Brown , Jeff Geesin , Pamela Plouhar , Catherine Smith , John Siekierka
IPC分类号： A61K31/198 , A61K31/436 , A61K38/18 , A61K38/30 , A61P19/02 , A61K39/395 , A61K38/17
CPC分类号： A61K38/30 , A61K31/198 , A61K31/436 , A61K38/1816 , A61K2039/505
摘要： The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
摘要翻译： 本发明涉及向患病关节中透射施用高特异性拮抗剂，所述高特异性拮抗剂选自：i）促炎白细胞介素的抑制剂; ii）TNF-α合成抑制剂; iii）膜结合TNF-α的抑制剂; iv）TNF-α的天然受体的抑制剂; v）NO合酶抑制剂，vi）PLA2酶抑制剂; vii）抗增殖剂; viii）抗氧化剂; ix）选自EPO模拟肽，EPO模拟物，IGF-I，IGF-II和胱天蛋白酶抑制剂的细胞凋亡抑制剂，和x）MMP的抑制剂; 和xi）p38激酶的抑制剂。
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公开(公告)号：US20050038001A1
公开(公告)日：2005-02-17
申请号：US10640412
申请日：2003-08-13
申请人： Mohamed Attawia , Thomas DiMauro , Hassan Serhan , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura Brown , Jeff Geesin , Pamela Plouhar , Catherine Smith , John Siekierka
发明人： Mohamed Attawia , Thomas DiMauro , Hassan Serhan , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura Brown , Jeff Geesin , Pamela Plouhar , Catherine Smith , John Siekierka
IPC分类号： A61K31/65
CPC分类号： A61K31/65 , A61K38/20 , A61K45/06 , A61K2300/00
摘要： The present invention relates to injecting a cycline compound into a diseased intervertebral disc.
摘要翻译： 本发明涉及将环状化合物注射到患病的椎间盘中。
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公开(公告)号：US20100317948A1
公开(公告)日：2010-12-16
申请号：US12817585
申请日：2010-06-17
申请人： Thomas M. DiMauro , Jeffrey K. Sutton , Mohamed Attawia , Hassan Serhan , John Daniel Malone , Timothy Beardsley
发明人： Thomas M. DiMauro , Jeffrey K. Sutton , Mohamed Attawia , Hassan Serhan , John Daniel Malone , Timothy Beardsley
IPC分类号： A61B5/1459
CPC分类号： A61L31/146 , A61B17/866 , A61F2/30767 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/38 , A61F2/4455 , A61F2002/30663 , A61F2002/30929 , A61F2002/30981 , A61F2002/3611 , A61F2002/3625 , A61F2002/443 , A61F2310/00023 , A61F2310/00604 , A61F2310/0061 , A61F2310/00616 , A61L27/06 , A61L27/427 , A61L27/56 , A61L31/022 , A61L31/124 , A61M5/158 , A61N5/0601 , A61N5/0624 , A61N2005/0651 , A61N2005/0661 , B01J35/004
摘要： An implant comprises a photocatalytic layer on at least one surface and is adapted to act as a sensor. In some embodiments, the photocatalytic layer is a semiconductor oxide that is doped. According to some embodiments, the implant comprises a wave guide. According to some embodiments the implant comprises a light port. According to some embodiments, the implant comprises a reflective material on a surface of the waveguide. According to some embodiments the implant comprises a composite material comprising a first material that has a transmissivity when exposed to a predetermined wavelength of light and a second material that has photocatalytic activity when exposed to the predetermined wavelength of light. According to some embodiments the implant comprises a light source adapted to irradiate the photocatalytic surface.
摘要翻译： 植入物包括在至少一个表面上的光催化层，并且适于作为传感器。 在一些实施方案中，光催化层是掺杂的半导体氧化物。 根据一些实施例，植入物包括波导。 根据一些实施例，植入物包括光端口。 根据一些实施例，植入物在波导的表面上包括反射材料。 根据一些实施例，植入物包括复合材料，其包括当暴露于预定波长的光时具有透射率的第一材料和当暴露于预定波长的光时具有光催化活性的第二材料。 根据一些实施例，植入物包括适于照射光催化表面的光源。
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公开(公告)号：US20070269413A1
公开(公告)日：2007-11-22
申请号：US11881925
申请日：2007-07-30
CPC分类号： A61K38/1841 , A61K35/28 , A61K38/57 , A61K2300/00
摘要： The present invention relates to injecting a high affinity antagonist of MMPs into a diseased intervertebral disc.
摘要翻译： 本发明涉及将MMP的高亲和力拮抗剂注射到患病的椎间盘中。
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10.发明申请公开(公告)号：US20050112091A1
公开(公告)日：2005-05-26
申请号：US10723250
申请日：2003-11-26
申请人： Thomas DiMauro , Mohamed Attawia , Hassan Serhan , Melissa Grace , Michael Slivka , Thomas Ferro , Vivek Shenoy , Alonzo Cook , Scott Bruder
发明人： Thomas DiMauro , Mohamed Attawia , Hassan Serhan , Melissa Grace , Michael Slivka , Thomas Ferro , Vivek Shenoy , Alonzo Cook , Scott Bruder
IPC分类号： A61B17/34 , A61F2/28 , A61F2/30 , A61K38/19 , A61K38/20 , A61K39/395 , A61K45/06 , A61K31/56
CPC分类号： A61K33/42 , A61B17/3472 , A61F2002/2817 , A61F2002/30677 , A61K9/0004 , A61K31/565 , A61K31/566 , A61K38/1825 , A61K38/1875 , A61K38/39 , A61K39/395 , A61K45/06 , A61M5/14276 , A61M2005/14513 , A61K2300/00
摘要： This invention relates to local administration of a bone-forming agent and at least one anti-resorptive agent to treat osteoporosis and related disorders.
摘要翻译： 本发明涉及局部施用骨形成剂和至少一种抗再吸收剂来治疗骨质疏松症和相关疾病。
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