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    Medical implants and methods of making medical implants
    1.
    发明授权
    Medical implants and methods of making medical implants 有权
    医疗植入物和制造医疗植入物的方法

    公开(公告)号：US08834913B2

    公开(公告)日：2014-09-16

    申请号：US12648106

    申请日：2009-12-28

    申请人： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

    发明人： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

    IPC分类号： A61F2/00 ,  A61K31/727

    CPC分类号： A61L31/10 ,  A61K31/727 ,  A61L31/16 ,  A61L2300/42 ,  A61L2400/18

    摘要： A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

    摘要翻译： 一种具有氧化表面的基底和与氧化表面共价结合的硅烷衍生物涂层的医用植入装置。 生物活性剂与硅烷衍生物涂层共价键合。 一种可植入支架装置，其包括具有氧化表面的支架芯，其具有与其共价键合的硅烷衍生物层。 包含聚乙二醇（PEG）的间隔层与硅烷衍生物层共价键合，蛋白质与PEG共价键合。 一种制造医疗植入装置的方法，包括提供具有表面的基底，氧化表面并与衍生的硅烷反应以形成共价键合到该表面的硅烷涂层。 然后将生物活性剂共价键合到硅烷涂层。 在特定情况下，生物吸收性聚合物和/或药剂的附加涂层沉积在生物活性剂上。

    Methods for producing films using supercritical fluid
    3.
    发明授权
    Methods for producing films using supercritical fluid 有权
    使用超临界流体生产膜的方法

    公开(公告)号：US06749902B2

    公开(公告)日：2004-06-15

    申请号：US10157591

    申请日：2002-05-28

    申请人： Clement R. Yonker ,  John L. Fulton

    发明人： Clement R. Yonker ,  John L. Fulton

    IPC分类号： B05D104

    CPC分类号： B05D1/025 ,  B05D5/083

    摘要： A method for forming a continuous film on a substrate surface that involves depositing particles onto a substrate surface and contacting the particle-deposited substrate surface with a supercritical fluid under conditions sufficient for forming a continuous film from the deposited particles. The particles may have a mean particle size of less 1 micron. The method may be performed by providing a pressure vessel that can contain a compressible fluid. A particle-deposited substrate is provided in the pressure vessel and the compressible fluid is maintained at a supercritical or sub-critical state sufficient for forming a film from the deposited particles. The Tg of particles may be reduced by subjecting the particles to the methods detailed in the present disclosure.

    摘要翻译： 一种用于在基板表面上形成连续膜的方法，其包括在足以从沉积颗粒形成连续膜的条件下将颗粒沉积到基板表面上并使颗粒沉积的基板表面与超临界流体接触。 颗粒可以具有小于1微米的平均粒度。 该方法可以通过提供可容纳可压缩流体的压力容器来进行。 在压力容器中提供颗粒沉积的基底，并且可压缩流体保持在足以从沉积的颗粒形成膜的超临界或亚临界状态。 颗粒的Tg可以通过使颗粒经受本公开中详述的方法来降低。

    Method of filtering a target compound from a first solvent that is above its critical density
    4.
    发明授权
    Method of filtering a target compound from a first solvent that is above its critical density 失效
    从高于其临界密度的第一溶剂过滤目标化合物的方法

    公开(公告)号：US06264726B1

    公开(公告)日：2001-07-24

    申请号：US09410165

    申请日：1999-09-30

    申请人： Max R. Phelps ,  Clement R. Yonker ,  John L. Fulton ,  Lawrence E. Bowman

    发明人： Max R. Phelps ,  Clement R. Yonker ,  John L. Fulton ,  Lawrence E. Bowman

    IPC分类号： B01D5322

    CPC分类号： B01D61/145

    摘要： The present invention is a method of separating a first compound having a macromolecular structure from a mixture. The first solvent is a fluid that is a gas at standard temperature and pressure and is at a density greater than a critical density of the fluid. A macromolecular structure containing a first compound is dissolved therein as a mixture. The mixture is contacted onto a selective barrier and the first solvent passed through the selective barrier thereby retaining the first compound, followed by recovering the first compound. By using a fluid that is a gas at standard temperature and pressure at a density greater than its critical density, separation without depressurization is fast and efficient.

    摘要翻译： 本发明是从混合物中分离具有大分子结构的第一化合物的方法。 第一溶剂是在标准温度和压力下为气体的流体，其密度大于流体的临界密度。 含有第一化合物的大分子结构作为混合溶解在其中。 将混合物接触到选择性屏障上，并且第一溶剂通过选择性屏障从而保留第一化合物，然后回收第一化合物。 通过在标准温度和压力下以大于其临界密度的密度使用作为气体的流体，没有减压的分离是快速和有效的。

    Medical Implants and Methods of Making Medical Implants
    6.
    发明申请
    Medical Implants and Methods of Making Medical Implants 有权
    医疗植入物和医疗植入物的方法

    公开(公告)号：US20110159069A1

    公开(公告)日：2011-06-30

    申请号：US12648106

    申请日：2009-12-28

    申请人： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

    发明人： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

    IPC分类号： A61F2/02 ,  A61K31/727 ,  A61K38/16 ,  A61F11/00 ,  A61P43/00

    CPC分类号： A61L31/10 ,  A61K31/727 ,  A61L31/16 ,  A61L2300/42 ,  A61L2400/18

    摘要： A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

    摘要翻译： 一种具有氧化表面的基底和与氧化表面共价结合的硅烷衍生物涂层的医用植入装置。 生物活性剂与硅烷衍生物涂层共价键合。 一种可植入支架装置，其包括具有氧化表面的支架芯，其具有与其共价键合的硅烷衍生物层。 包含聚乙二醇（PEG）的间隔层与硅烷衍生物层共价键合，蛋白质与PEG共价键合。 一种制造医疗植入装置的方法，包括提供具有表面的基底，氧化表面并与衍生的硅烷反应以形成共价键合到该表面的硅烷涂层。 然后将生物活性剂共价键合到硅烷涂层。 在特定情况下，生物吸收性聚合物和/或药剂的附加涂层沉积在生物活性剂上。

    Capture and release of acid-gasses with acid-gas binding organic compounds
    10.
    发明授权
    Capture and release of acid-gasses with acid-gas binding organic compounds 有权
    用酸性气体结合有机化合物捕获和释放酸气

    公开(公告)号：US08980210B2

    公开(公告)日：2015-03-17

    申请号：US12427851

    申请日：2009-04-22

    申请人： David J. Heldebrant ,  Clement R. Yonker ,  Phillip K. Koech

    发明人： David J. Heldebrant ,  Clement R. Yonker ,  Phillip K. Koech

    IPC分类号： C01B17/16 ,  B01D47/00 ,  B01D53/14 ,  B01D53/40

    CPC分类号： B01D53/1493 ,  B01D53/1425 ,  B01D53/1456 ,  B01D53/40 ,  B01D2257/302 ,  B01D2257/304 ,  B01D2257/308 ,  B01D2257/404 ,  B01D2257/504

    摘要： A system and method for acid-gas capture wherein organic acid-gas capture materials form hetero-atom analogs of alkyl-carbonate when contacted with an acid gas. These organic-acid gas capture materials include combinations of a weak acid and a base, or zwitterionic liquids. This invention allows for reversible acid-gas binding to these organic binding materials thus allowing for the capture and release of one or more acid gases. These acid-gas binding organic compounds can be regenerated to release the captured acid gasses and enable these organic acid-gas binding materials to be reused. This enables transport of the liquid capture compounds and the release of the acid gases from the organic liquid with significant energy savings compared to current aqueous systems.

    摘要翻译： 一种用于酸气捕获的系统和方法，其中当与酸性气体接触时，有机酸 - 气体捕获材料形成碳酸烷基酯的杂原子类似物。 这些有机酸气体捕获材料包括弱酸和碱或两性离子液体的组合。 本发明允许可逆的酸气与这些有机结合材料结合，从而允许捕获和释放一种或多种酸性气体。 这些酸 - 气结合有机化合物可以被再生以释放所捕获的酸性气体，并使这些有机酸 - 气体结合材料能够被再利用。 这使得液体捕获化合物的运输和从有机液体释放酸性气体与现有的水系统相比显着节能。