公开(公告)号：US20030059949A1

公开(公告)日：2003-03-27

申请号：US10029108

申请日：2001-12-21

Applicant: Coventor, Inc.

Inventor： John Gilbert

IPC: G01N001/10 ,  B01L003/02

CPC classification number: C12Q1/00 ,  B01L3/0244 ,  B01L3/0248 ,  B01L3/0268 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2400/0439 ,  G01N27/447 ,  G01N2035/1037 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: A droplet dispensing system for forming and dispensing droplets of a liquid sample is provided. The droplet dispensing system is fabricated on the tip of a dispensing pin. The tip of the dispensing pin includes a droplet ejection nozzle, a filling channel, a chamber and an actuator for ejecting droplets on demand. The system further includes a holder for mounting the dispensing pin. The holder also contains a control circuit for activating the actuator.

Abstract translation: 提供了用于形成和分配液体样品的液滴的液滴分配系统。 液滴分配系统制造在分配销的尖端上。 分配销的末端包括液滴喷射嘴，填充通道，腔室和用于根据需要喷射液滴的致动器。 该系统还包括用于安装分配销的保持器。 支架还包含用于启动致动器的控制电路。

公开(公告)号：US20020197733A1

公开(公告)日：2002-12-26

申请号：US10027516

申请日：2001-12-21

Applicant: Coventor, Inc.

Inventor： Sebastian Bohm ,  John Gilbert

IPC: G01N021/05

CPC classification number: G01N27/44782 ,  B01D57/02 ,  B01J2219/00274 ,  B01L3/0244 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0439 ,  C12Q1/00 ,  G01N27/447 ,  G01N27/44743 ,  G01N27/44791 ,  G01N2035/1037 ,  Y10T436/2575

Abstract: A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first liquid. The fluid interface port is utilized to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the microchannel.

Abstract translation: 提供微流体系统中的流体接口端口和形成流体接口端口的方法。 流体接口端口包括形成在微通道的侧壁中的开口，其尺寸和尺寸被设计成当微通道充满第一液体时形成虚拟壁。 流体接口端口用于用第一液体填充微通道，以将第二液体引入第一液体并从微通道喷射流体。

公开(公告)号：US20020195343A1

公开(公告)日：2002-12-26

申请号：US10057354

申请日：2002-01-24

Applicant: Coventor, Inc.

Inventor： Sebastian Bohm ,  John Gilbert

IPC: G01N027/26 ,  G01N027/447

CPC classification number: B01L3/502715 ,  B01D57/02 ,  B01J19/0093 ,  B01J2219/00274 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00905 ,  B01J2219/00912 ,  B01L3/0244 ,  B01L3/502761 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0439 ,  G01N27/44743 ,  G01N27/44782 ,  G01N27/44791 ,  G01N2035/1037

Abstract: A fluid interface port in a separation device for separating a sample into different components is provided. The separation device includes an array of separation channels and the fluid interface port comprises an opening formed in the side wall of a separation channel sized and dimensioned to form a virtual wall when the separation channel is filled with a separation medium. The fluid interface port is utilized to introduce a liquid sample into the separation medium. The fluid interface ports formed in the array of separation channels are organized into one or more sample injectors. A cathode reservoir is multiplexed with one or more separation channels. To complete an electrical path, an anode reservoir which is common to some or all separation channels is also provided.

Abstract translation: 提供了用于将样品分离成不同部件的分离装置中的流体接口端口。 分离装置包括分离通道的阵列，并且流体接口端口包括形成在分离通道的侧壁中的开口，其尺寸和尺寸被设计成当分离通道填充有分离介质时形成虚拟壁。 液体接口用于将液体样品引入分离介质。 形成在分离通道阵列中的流体接口端口被组织成一个或多个样品注射器。 阴极储存器与一个或多个分离通道多路复用。 为了完成电路径，还提供了一些或所有分离通道共用的阳极储存器。

公开(公告)号：US20030007898A1

公开(公告)日：2003-01-09

申请号：US10028852

申请日：2001-12-21

Applicant: Coventor, Inc.

Inventor： Sebastian Bohm ,  John Gilbert

IPC: C12M001/34 ,  G01N033/543 ,  B01L003/02 ,  G01N001/10

CPC classification number: B01F13/0059 ,  B01D57/02 ,  B01J19/0093 ,  B01J2219/00371 ,  B01J2219/00378 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00837 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01L3/0244 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/502792 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0439 ,  C12Q1/00 ,  G01N27/447 ,  G01N27/44743 ,  G01N27/44782 ,  G01N27/44791 ,  G01N2035/1037 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/2575

Abstract: A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first liquid. The fluid interface port is utilized to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the microchannel.

公开(公告)号：US20030210607A1

公开(公告)日：2003-11-13

申请号：US10183726

申请日：2002-06-25

Applicant: Coventor, Inc.

Inventor： John Gilbert ,  Manish Deshpande

IPC: B01F005/00

CPC classification number: B01F3/088 ,  B01F13/0059 ,  B01F15/00019 ,  B01F15/00064 ,  B01F2003/0896 ,  B01L3/502738 ,  B01L2200/148 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0655 ,  B01L2400/082 ,  Y10T137/2499 ,  Y10T137/7736 ,  Y10T137/87676 ,  Y10T137/87684 ,  Y10T436/10 ,  Y10T436/25625

Abstract: An on-chip chemical compound dilution system for providing dilution of a chemical compound in a microfluidic application includes at least one sample well for providing a selected chemical compound to be diluted, a dilution well for providing a diluent for diluting the chemical compound, a network of channels for carrying the chemical compound and diluent, a first syringe pump for effecting dilution, a second syringe pump, a detector and a plurality of valves for selectively controlling the flow of liquid through the channels. The dilution system may be a multiple-stage dilution system for precisely mixing a plurality of chemical compounds in a diluent. The dilution system allows for accurate calibration to compensate for variations due to manufacturing, thereby providing precise dilution ratios. The dilution system further enables flushing to allow re-use of the system with another chemical compound.

Abstract translation: 用于在微流体应用中提供化学化合物稀释的片上化学稀释系统包括至少一个用于提供所要稀释的化学化合物的样品孔，用于提供用于稀释化合物的稀释剂的稀释液，网络 用于运送化合物和稀释剂的通道，用于稀释的第一注射泵，第二注射器泵，检测器和用于选择性地控制通过通道的液体流动的多个阀。 稀释系统可以是用于在稀释剂中精确混合多种化合物的多级稀释系统。 稀释系统允许精确的校准来补偿由于制造造成的变化，从而提供精确的稀释比。 稀释系统还可以冲洗以允许再次使用另一种化合物的系统。

公开(公告)号：US20030059345A1

公开(公告)日：2003-03-27

申请号：US10027171

申请日：2001-12-21

Applicant: Coventor, Inc.

Inventor： John Gilbert ,  John Harley

IPC: G01N001/10 ,  H01L021/00 ,  G01N035/10

CPC classification number: B01L3/0244 ,  B01L3/0248 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2400/0439 ,  G01N2035/1037 ,  Y10T436/119163 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: A two-pin liquid sample dispensing system is provided. The two-pin dispensing system comprises a pair of separately movable pins for holding a droplet of liquid therebetween. Each pin includes a tip spaced predetermined distance from the other pin to define a sample acquisition region. The pins acquire and hold a droplet of the liquid sample in the sample acquisition region formed in the space between the tips and apply the droplet to a selected sample handing system. The distance between the tips is variable to accommodate different liquid samples having varying physical properties and to vary the volume of the acquired droplet.

Abstract translation: 提供了两针液体样品分配系统。 双针分配系统包括一对可独立移动的销，用于在其间保持液滴。 每个引脚包括与另一个引脚间隔预定距离的尖端以限定采样区域。 这些销钉在液体样品的液滴中形成在尖端之间的空间中形成的样品采集区域，并将液滴施加到选定的样品处理系统上。 尖端之间的距离是可变的以适应具有不同物理性质的不同液体样品并改变所获取的液滴的体积。

公开(公告)号：US20030015425A1

公开(公告)日：2003-01-23

申请号：US10027484

申请日：2001-12-21

Applicant: Coventor Inc.

Inventor： Sebastian Bohm ,  John Gilbert

IPC: G01N027/26 ,  G01N027/447

CPC classification number: B01L3/0268 ,  B01D57/02 ,  B01J19/0093 ,  B01J2219/00274 ,  B01L3/0244 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0439 ,  C12Q1/00 ,  G01N27/447 ,  G01N27/44743 ,  G01N27/44782 ,  G01N27/44791 ,  G01N2035/1037 ,  Y10T436/2575

Abstract: A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first liquid. The fluid interface port is utilized to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the microchannel.