公开(公告)号：US20020195343A1

公开(公告)日：2002-12-26

申请号：US10057354

申请日：2002-01-24

Applicant: Coventor, Inc.

Inventor： Sebastian Bohm ,  John Gilbert

IPC: G01N027/26 ,  G01N027/447

CPC classification number: B01L3/502715 ,  B01D57/02 ,  B01J19/0093 ,  B01J2219/00274 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00905 ,  B01J2219/00912 ,  B01L3/0244 ,  B01L3/502761 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0439 ,  G01N27/44743 ,  G01N27/44782 ,  G01N27/44791 ,  G01N2035/1037

Abstract: A fluid interface port in a separation device for separating a sample into different components is provided. The separation device includes an array of separation channels and the fluid interface port comprises an opening formed in the side wall of a separation channel sized and dimensioned to form a virtual wall when the separation channel is filled with a separation medium. The fluid interface port is utilized to introduce a liquid sample into the separation medium. The fluid interface ports formed in the array of separation channels are organized into one or more sample injectors. A cathode reservoir is multiplexed with one or more separation channels. To complete an electrical path, an anode reservoir which is common to some or all separation channels is also provided.

Abstract translation: 提供了用于将样品分离成不同部件的分离装置中的流体接口端口。 分离装置包括分离通道的阵列，并且流体接口端口包括形成在分离通道的侧壁中的开口，其尺寸和尺寸被设计成当分离通道填充有分离介质时形成虚拟壁。 液体接口用于将液体样品引入分离介质。 形成在分离通道阵列中的流体接口端口被组织成一个或多个样品注射器。 阴极储存器与一个或多个分离通道多路复用。 为了完成电路径，还提供了一些或所有分离通道共用的阳极储存器。

公开(公告)号：US20020197733A1

公开(公告)日：2002-12-26

申请号：US10027516

申请日：2001-12-21

Applicant: Coventor, Inc.

Inventor： Sebastian Bohm ,  John Gilbert

IPC: G01N021/05

CPC classification number: G01N27/44782 ,  B01D57/02 ,  B01J2219/00274 ,  B01L3/0244 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0439 ,  C12Q1/00 ,  G01N27/447 ,  G01N27/44743 ,  G01N27/44791 ,  G01N2035/1037 ,  Y10T436/2575

Abstract: A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first liquid. The fluid interface port is utilized to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the microchannel.

Abstract translation: 提供微流体系统中的流体接口端口和形成流体接口端口的方法。 流体接口端口包括形成在微通道的侧壁中的开口，其尺寸和尺寸被设计成当微通道充满第一液体时形成虚拟壁。 流体接口端口用于用第一液体填充微通道，以将第二液体引入第一液体并从微通道喷射流体。

公开(公告)号：US20030015425A1

公开(公告)日：2003-01-23

申请号：US10027484

申请日：2001-12-21

Applicant: Coventor Inc.

Inventor： Sebastian Bohm ,  John Gilbert

IPC: G01N027/26 ,  G01N027/447

CPC classification number: B01L3/0268 ,  B01D57/02 ,  B01J19/0093 ,  B01J2219/00274 ,  B01L3/0244 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0439 ,  C12Q1/00 ,  G01N27/447 ,  G01N27/44743 ,  G01N27/44782 ,  G01N27/44791 ,  G01N2035/1037 ,  Y10T436/2575

Abstract: A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first liquid. The fluid interface port is utilized to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the microchannel.

公开(公告)号：US20030172975A1

公开(公告)日：2003-09-18

申请号：US10179537

申请日：2002-06-24

Applicant: Coventor, Inc.

Inventor： John Richard Gilbert ,  Bernard Bunner ,  Sebastian Bohm ,  Manish Deshpande

IPC: F17D001/00

CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K99/0005 ,  F16K99/0007 ,  F16K99/0009 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K2099/0069 ,  F16K2099/0071 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/008 ,  F16K2099/0084 ,  G05D7/0694 ,  Y10T29/49412 ,  Y10T137/87314

Abstract: A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valve element. The valve chamber is configured to contain a volume of fluid, and the inlet port and the outlet port are in fluid communication with the valve chamber to provide a liquid flow path through the chamber. The actuator assembly comprises a cantilever beam for moving the valve element between an open position and a closed position, an actuator, such as a piezoelectric element, for moving the cantilever beam, and a latch, such as a permanent magnet, for securing the cantilever beam in the closed position. A flow regulation system comprises a plurality of fluid channels of varied flow conductance and a plurality of latching microregulators for selectively blocking or allowing flow through each of the fluid channels.

Abstract translation: 用于调节微量级液体流动的闭锁微调节器包括具有入口端口和出口端口的基板，限定用于打开和关闭入口端口的阀室的阀元件以及用于致动阀元件的致动器组件。 阀室被构造成容纳一定体积的流体，并且入口端口和出口端口与阀室流体连通以提供通过该腔室的液体流动路径。 致动器组件包括用于在打开位置和关闭位置之间移动阀元件的悬臂梁，用于移动悬臂梁的致动器（例如压电元件）以及用于固定悬臂的闩锁（例如永磁体） 梁处于关闭位置。 流量调节系统包括多个不同流量的流体通道和多个用于选择性地阻塞或允许流过每个流体通道的闭锁微调节器。

公开(公告)号：US20030007898A1

公开(公告)日：2003-01-09

申请号：US10028852

申请日：2001-12-21

Applicant: Coventor, Inc.

Inventor： Sebastian Bohm ,  John Gilbert

IPC: C12M001/34 ,  G01N033/543 ,  B01L003/02 ,  G01N001/10

CPC classification number: B01F13/0059 ,  B01D57/02 ,  B01J19/0093 ,  B01J2219/00371 ,  B01J2219/00378 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00837 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01L3/0244 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/502792 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0439 ,  C12Q1/00 ,  G01N27/447 ,  G01N27/44743 ,  G01N27/44782 ,  G01N27/44791 ,  G01N2035/1037 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/2575

Abstract: A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first liquid. The fluid interface port is utilized to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the microchannel.

公开(公告)号：US20030198523A1

公开(公告)日：2003-10-23

申请号：US10179488

申请日：2002-06-24

Applicant: Coventor, Inc.

Inventor： Sebastian Bohm ,  John R. Gilbert ,  Manish Deshpande

IPC: B65G051/00

CPC classification number: B03B5/00 ,  B01L3/5027 ,  B07C5/34 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0028 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N15/14 ,  G01N2015/149 ,  Y10S209/906 ,  Y10S209/932

Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

公开(公告)号：US20030196714A1

公开(公告)日：2003-10-23

申请号：US10179586

申请日：2002-06-24

Applicant: Coventor, Inc.

Inventor： John Richard Gilbert ,  Sebastian Bohm ,  Manish Deshpande

IPC: F15C001/04

CPC classification number: B01L3/502738 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/06 ,  B01L2400/0688 ,  B01L2400/082 ,  B07C5/34 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0019 ,  F16K99/0034 ,  F16K99/0036 ,  F16K99/004 ,  F16K99/0046 ,  F16K99/0048 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N2015/149 ,  Y10T29/49405 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T137/0497 ,  Y10T137/2076 ,  Y10T137/2082 ,  Y10T137/2191 ,  Y10T137/2196 ,  Y10T137/2202 ,  Y10T137/2207 ,  Y10T137/2213 ,  Y10T137/2224 ,  Y10T436/143333 ,  Y10T436/25375

Abstract: A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.

Abstract translation: 微流体系统包括用于调节通过微通道的流体流动的气泡阀。 气泡阀包括与微通道内部接合的流体弯液面和用于将膜偏转到微通道内部以调节流体流动的致动器。 当在膜上产生足够的压力时，致动器在微通道中的液体中产生气泡。