公开(公告)号：US06852290B2

公开(公告)日：2005-02-08

申请号：US10094253

申请日：2002-03-08

申请人： David C. Hager ,  Jeffrey D. Donaldson ,  Patrick Kearney ,  Douglas O. Keller ,  James W. Leahy ,  Robert D. Mercer ,  Michael Morrissey ,  Troy M. Swartwood

发明人： David C. Hager ,  Jeffrey D. Donaldson ,  Patrick Kearney ,  Douglas O. Keller ,  James W. Leahy ,  Robert D. Mercer ,  Michael Morrissey ,  Troy M. Swartwood

IPC分类号： G01N35/02 ,  B01J19/00 ,  B01L3/00 ,  C40B50/08 ,  C40B60/14 ,  A61B10/00 ,  A61M37/00 ,  B01L3/02 ,  G01N1/18

CPC分类号： B01L3/5635 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00286 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00319 ,  B01J2219/00333 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/563 ,  B01L2200/025 ,  B01L2200/141 ,  B01L2300/0829 ,  C40B50/08 ,  C40B60/14 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A multi-well assembly according to one embodiment comprises a multi-well block and a guide plate. The multi-well block defines a plurality of wells, with each well having a fluid-impermeable bottom surface. The guide plate defines a plurality of fluid passageways corresponding to the wells of the multi-well block. The guide plate is configured such that, whenever the guide plate is registered with the multi-well block, fluid communication is established between each well and an associated fluid passageway.

摘要翻译： 根据一个实施例的多孔组件包括多孔块和引导板。 多孔块限定多个井，每个井具有不透液体的底表面。 引导板限定对应于多井区块的井的多个流体通道。 引导板被构造成使得每当导板与多孔块对准时，在每个井和相关联的流体通道之间建立流体连通。

公开(公告)号：US08440663B2

公开(公告)日：2013-05-14

申请号：US11992224

申请日：2007-01-30

申请人： Grace Mann ,  Naing Aay ,  Arlyn Arcalas ,  S. David Brown ,  Wai Ki Vicky Chan ,  Jeff Chen ,  Hongwang Du ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Adam A. Galan ,  Tai Phat Huynh ,  Mohamed Abdulkader Ibrahim ,  Henry William Beecroft Johnson ,  Brian Kane ,  Patrick Kearney ,  Byung Gyu Kim ,  Elena S. Koltun ,  James W. Leahy ,  Matthew Sangyup Lee ,  Gary L. Lewis ,  Lisa E. Meyr ,  Robin Tammie Noguchi ,  Michael Pack ,  Brian Hugh Ridgway ,  Xian Shi ,  John Woolfrey ,  Peiwen Zhou

发明人： Grace Mann ,  Naing Aay ,  Arlyn Arcalas ,  S. David Brown ,  Wai Ki Vicky Chan ,  Jeff Chen ,  Hongwang Du ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Adam A. Galan ,  Tai Phat Huynh ,  Mohamed Abdulkader Ibrahim ,  Henry William Beecroft Johnson ,  Brian Kane ,  Patrick Kearney ,  Byung Gyu Kim ,  Elena S. Koltun ,  James W. Leahy ,  Matthew Sangyup Lee ,  Gary L. Lewis ,  Lisa E. Meyr ,  Robin Tammie Noguchi ,  Michael Pack ,  Brian Hugh Ridgway ,  Xian Shi ,  John Woolfrey ,  Peiwen Zhou

IPC分类号： A61K31/535 ,  C07D239/24 ,  C07D401/10 ,  C07D413/10

CPC分类号： C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D453/02 ,  C07D487/04

摘要： This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.

摘要翻译： 本发明涉及具有式（I）的JAK-2的某些嘧啶衍生物抑制剂：其中D，E，L，Z，R 1，R 2，R 25和n 1如说明书中所定义，其药学上可接受的盐，药物组合物 及其使用方法。

公开(公告)号：US08791102B2

公开(公告)日：2014-07-29

申请号：US13124604

申请日：2009-10-16

申请人： Mohamed Abdulkader Ibrahim ,  Joon Won Jeong ,  Henry William Beecroft Johnson ,  Patrick Kearney ,  James W. Leahy ,  Gary L. Lewis ,  Robin Tammie Noguchi ,  John M. Nuss

发明人： Mohamed Abdulkader Ibrahim ,  Joon Won Jeong ,  Henry William Beecroft Johnson ,  Patrick Kearney ,  James W. Leahy ,  Gary L. Lewis ,  Robin Tammie Noguchi ,  John M. Nuss

IPC分类号： A61K31/4196 ,  A61K31/417 ,  A61K31/4192 ,  A61K31/167 ,  A61K31/341 ,  A61K31/4015 ,  A61K31/455 ,  A61K31/506 ,  A61K31/541 ,  A61K31/55 ,  A61P35/00 ,  A61P35/02 ,  C07D207/452 ,  C07D213/56 ,  C07D223/04 ,  C07D307/54 ,  C07D403/04 ,  C07D403/06 ,  C07D417/06

CPC分类号： C07D207/06 ,  C07D207/10 ,  C07D207/16 ,  C07D207/277 ,  C07D207/452 ,  C07D209/08 ,  C07D211/14 ,  C07D211/58 ,  C07D213/56 ,  C07D215/06 ,  C07D233/61 ,  C07D233/64 ,  C07D235/14 ,  C07D237/20 ,  C07D239/42 ,  C07D241/12 ,  C07D241/44 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D261/08 ,  C07D263/32 ,  C07D265/30 ,  C07D277/36 ,  C07D279/12 ,  C07D307/14 ,  C07D307/16 ,  C07D307/56 ,  C07D307/85 ,  C07D317/60 ,  C07D333/24 ,  C07D401/06 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D407/06 ,  C07D407/10 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12

摘要： This disclosure relates to sphingosine-1-phosphate (S1P) receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the S1P receptor antagonists. In particular, this disclosure relates to sphingosine-1-phosphate 1 (S1P1) receptor antagonists, compositions comprising the S1P1 receptor antagonist and methods for using the S1P1 receptor antagonist, such as in the treatment of cancer, and processes for making the S1P1 receptor antagonists.

摘要翻译： 本公开涉及鞘氨醇-1-磷酸（S1P）受体拮抗剂，包含S1P受体拮抗剂的组合物，以及用于制备S1P受体拮抗剂的方法和方法。 特别地，本公开内容涉及鞘氨醇-1-磷酸酯1（S1P1）受体拮抗剂，包含S1P1受体拮抗剂的组合物和使用S1P1受体拮抗剂的方法，例如用于治疗癌症，以及制备S1P1受体拮抗剂的方法 。

公开(公告)号：US20110288076A1

公开(公告)日：2011-11-24

申请号：US13124604

申请日：2009-10-16

申请人： Mohamed Abdulkader Ibrahim ,  Joon Won Jeong ,  Henry William Beecroft Johnson ,  Patrick Kearney ,  James W. Leahy ,  Gary L. Lewis ,  Robin Tammie Noguchi ,  John M. Nuss

发明人： Mohamed Abdulkader Ibrahim ,  Joon Won Jeong ,  Henry William Beecroft Johnson ,  Patrick Kearney ,  James W. Leahy ,  Gary L. Lewis ,  Robin Tammie Noguchi ,  John M. Nuss

IPC分类号： A61K31/4196 ,  C07D403/06 ,  C07C237/22 ,  C07D307/54 ,  C07D207/452 ,  C07D213/56 ,  C07D403/04 ,  C07D417/06 ,  C07D223/04 ,  A61K31/417 ,  A61K31/4192 ,  A61K31/167 ,  A61K31/341 ,  A61K31/4015 ,  A61K31/455 ,  A61K31/506 ,  A61K31/541 ,  A61K31/55 ,  A61P35/00 ,  A61P35/02 ,  C07D277/30

CPC分类号： C07D207/06 ,  C07D207/10 ,  C07D207/16 ,  C07D207/277 ,  C07D207/452 ,  C07D209/08 ,  C07D211/14 ,  C07D211/58 ,  C07D213/56 ,  C07D215/06 ,  C07D233/61 ,  C07D233/64 ,  C07D235/14 ,  C07D237/20 ,  C07D239/42 ,  C07D241/12 ,  C07D241/44 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D261/08 ,  C07D263/32 ,  C07D265/30 ,  C07D277/36 ,  C07D279/12 ,  C07D307/14 ,  C07D307/16 ,  C07D307/56 ,  C07D307/85 ,  C07D317/60 ,  C07D333/24 ,  C07D401/06 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D407/06 ,  C07D407/10 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12

摘要： This disclosure relates to sphingosine-1-phosphate (S1P) receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the S1P receptor antagonists. In particularly, this disclosure relates to sphingosine-1-phosphate 1 (S1P1) receptor antagonists, compositions comprising the S1P1 receptor antagonist and methods for using the S1P1 receptor antagonist, such as in the treatment of cancer, and processes for making the S1P1 receptor antagonists.

摘要翻译： 本公开涉及鞘氨醇-1-磷酸（S1P）受体拮抗剂，包含S1P受体拮抗剂的组合物，以及用于制备S1P受体拮抗剂的方法和方法。 特别地，本公开内容涉及鞘氨醇-1-磷酸酯1（S1P1）受体拮抗剂，包含S1P1受体拮抗剂的组合物和用于治疗癌症的S1P1受体拮抗剂的方法，以及制备S1P1受体拮抗剂的方法 。

公开(公告)号：US20100136136A1

公开(公告)日：2010-06-03

申请号：US12443103

申请日：2007-09-28

申请人： Adam Antoni Galan ,  Jeff Chen ,  Hongwang Du ,  Timothy Forsyth ,  Tai Phat Huynh ,  Henry William Beecroft Johnson ,  Patrick Kearney ,  James W. Leahy ,  Matthew Sangyup Lee ,  Grace Mann ,  Brian Hugh Ridgway ,  Craig Stacy Takeuchi ,  Peiwen Zhou

发明人： Adam Antoni Galan ,  Jeff Chen ,  Hongwang Du ,  Timothy Forsyth ,  Tai Phat Huynh ,  Henry William Beecroft Johnson ,  Patrick Kearney ,  James W. Leahy ,  Matthew Sangyup Lee ,  Grace Mann ,  Brian Hugh Ridgway ,  Craig Stacy Takeuchi ,  Peiwen Zhou

IPC分类号： A61K31/4178 ,  C07D403/12 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  C12N5/00 ,  A61P35/00 ,  A61K31/7076 ,  A61K31/437 ,  A61K31/704 ,  A61K33/24

CPC分类号： C07D405/14 ,  C07D233/90 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

摘要： This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.

摘要翻译： 本发明涉及蛋白酪氨酸激酶及其抑制剂的领域。 特别地，本发明涉及JAK-2抑制剂，用于抑制JAK-2的化合物的药物组合物，抑制细胞中JAK-2的方法，包括使需要JAK-2抑制的细胞与化合物 或包含根据本发明的化合物的药物组合物。 还包括治疗涉及JAK-2的疾病或病症的方法，包括向患者施用包含本发明化合物的药物组合物。

公开(公告)号：US08088767B2

公开(公告)日：2012-01-03

申请号：US12443103

申请日：2007-09-28

申请人： Adam Antoni Galan ,  Jeff Chen ,  Hongwang Du ,  Timothy Forsyth ,  Tai Phat Huynh ,  Henry William Beecroft Johnson ,  Patrick Kearney ,  James W. Leahy ,  Matthew Sangyup Lee ,  Grace Mann ,  Brian Hugh Ridgway ,  Craig Stacy Takeuchi ,  Peiwen Zhou

发明人： Adam Antoni Galan ,  Jeff Chen ,  Hongwang Du ,  Timothy Forsyth ,  Tai Phat Huynh ,  Henry William Beecroft Johnson ,  Patrick Kearney ,  James W. Leahy ,  Matthew Sangyup Lee ,  Grace Mann ,  Brian Hugh Ridgway ,  Craig Stacy Takeuchi ,  Peiwen Zhou

IPC分类号： A61K31/5377 ,  A61K31/4439 ,  A61K31/4184 ,  C07D413/14 ,  C07D401/14 ,  C07D403/12

CPC分类号： C07D405/14 ,  C07D233/90 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

摘要： This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.

摘要翻译： 本发明涉及蛋白酪氨酸激酶及其抑制剂的领域。 特别地，本发明涉及JAK-2抑制剂，用于抑制JAK-2的化合物的药物组合物，抑制细胞中JAK-2的方法，包括使需要JAK-2抑制的细胞与化合物 或包含根据本发明的化合物的药物组合物。 还包括治疗涉及JAK-2的疾病或病症的方法，包括向患者施用包含本发明化合物的药物组合物。

公开(公告)号：US20090298830A1

公开(公告)日：2009-12-03

申请号：US11992224

申请日：2007-01-30

申请人： Grace Mann ,  Naing Aay ,  Arlyn Arcalas ,  S. David Brown ,  Wai Ki Vicky Chan ,  Jeff Chen ,  Hongwang Du ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Adam A. Galan ,  Tai Phat Huynh ,  Mohamed Abdulkader Ibrahim ,  Henry William Beecroft Johnson ,  Brian Kane ,  Patrick Kearney ,  Byung Gyu Kim ,  Elena S. Koltun ,  James W. Leahy ,  Matthew Sangyup Lee ,  Gary L. Lewis ,  Lisa E. Meyr ,  Robin Tammie Noguchi ,  Michael Pack ,  Brian Hugh Ridgway ,  Xian Shi ,  John Woolfrey ,  Peiwen Zhou

发明人： Grace Mann ,  Naing Aay ,  Arlyn Arcalas ,  S. David Brown ,  Wai Ki Vicky Chan ,  Jeff Chen ,  Hongwang Du ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Adam A. Galan ,  Tai Phat Huynh ,  Mohamed Abdulkader Ibrahim ,  Henry William Beecroft Johnson ,  Brian Kane ,  Patrick Kearney ,  Byung Gyu Kim ,  Elena S. Koltun ,  James W. Leahy ,  Matthew Sangyup Lee ,  Gary L. Lewis ,  Lisa E. Meyr ,  Robin Tammie Noguchi ,  Michael Pack ,  Brian Hugh Ridgway ,  Xian Shi ,  John Woolfrey ,  Peiwen Zhou

IPC分类号： A61K31/5377 ,  C07D413/14 ,  A61P7/00

CPC分类号： C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D453/02 ,  C07D487/04

摘要： This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.

摘要翻译： 本发明涉及具有式（I）的JAK-2的某些嘧啶衍生物抑制剂：其中D，E，L，Z，R 1，R 2，R 25和n 1如说明书中所定义，其药学上可接受的盐，药物组合物 及其使用方法。

公开(公告)号：US08211929B2

公开(公告)日：2012-07-03

申请号：US11722719

申请日：2005-12-28

申请人： Jeff Chen ,  Lisa Esther Dalrymple Meyr ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Mohamed Abdulkader Ibrahim ,  James W. Leahy ,  Gary Lee Lewis ,  Grace Mann ,  Larry W. Mann ,  Robin Tammie Noguchi ,  Brian Hugh Ridgway ,  Joan Cruz Sangalang ,  Kevin Luke Schnepp ,  Xian Shi ,  Craig Stacy Takeuchi ,  Matthew Alan Williams ,  John Nuss ,  Atwood K. Cheung

发明人： Jeff Chen ,  Lisa Esther Dalrymple Meyr ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Mohamed Abdulkader Ibrahim ,  James W. Leahy ,  Gary Lee Lewis ,  Grace Mann ,  Larry W. Mann ,  Robin Tammie Noguchi ,  Brian Hugh Ridgway ,  Joan Cruz Sangalang ,  Kevin Luke Schnepp ,  Xian Shi ,  Craig Stacy Takeuchi ,  Matthew Alan Williams ,  John Nuss ,  Atwood K. Cheung

IPC分类号： A01N43/56 ,  A61K31/415 ,  C07D239/02 ,  C07D231/00

CPC分类号： C07D413/14 ,  C07D239/48 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/12 ,  C07D417/14 ,  C07D487/04

摘要： The invention provides compounds and methods for inhibition of kinases, more specifically IGF 1 R kinases. The invention also provides compounds and methods for inhibition of wildtype Abl. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, wherein, V is NR1R1a, or O—R1, wherein X is H, halo, C1-C6 alkyl, NO2, mono-, di-, or tri-halo substituted methyl, NR13R,14. C(O)O—C1-C6 alkyl, or N(R13)—C(O)—C1-C6 alkyl; Y is H, halo, OH, C1-C6 alkyl, C0-C6alkyl-NR,15R16, NR15R,6, C1-C6 alkoxy, —N(R13)—(CH2)n-NR15R16, —C(O)O—C1-C6 alkyl, —O—(CH2)n—NR15R16, —C(O)—C1-C6 alkyl, —C0-C6-alkyl-R21, —O—R21, —C(O)—R21, —O—(CH2)n—R21, —C(O)—NR13R14, —C(O)—N(R13)-aryl, —C(O)—N(R13)(CH2)n—NR15R16, —C(O)—N(R13)—(CH2)n-aryl —C(O)—N(R13)—(CH2)n-heterocyclyl; or X and Y together with the atoms to which they are attached form a 4-7 membered heterocyclyl or heteroaryl group containing one or two heteroatoms independently selected from O, N, and S. Z is H, NR2R3, —S—R2a, or —O—R2a

公开(公告)号：US08754092B2

公开(公告)日：2014-06-17

申请号：US13487594

申请日：2012-06-04

申请人： Suleyman Bahceci ,  William Bajjalieh ,  Jeff Chen ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Byung Gyu Kim ,  James W. Leahy ,  Matthew Sangyup Lee ,  Gary L. Lewis ,  Morrison B. Mac ,  Grace Mann ,  Charles K. Marlowe ,  Brian Hugh Ridgway ,  Joan C. Sangalang ,  Xian Shi ,  Craig Stacy Takeuchi ,  Yong Wang

发明人： Suleyman Bahceci ,  William Bajjalieh ,  Jeff Chen ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Byung Gyu Kim ,  James W. Leahy ,  Matthew Sangyup Lee ,  Gary L. Lewis ,  Morrison B. Mac ,  Grace Mann ,  Charles K. Marlowe ,  Brian Hugh Ridgway ,  Joan C. Sangalang ,  Xian Shi ,  Craig Stacy Takeuchi ,  Yong Wang

IPC分类号： A01N43/54 ,  A61K31/517 ,  C07D239/72 ,  C07D401/00

CPC分类号： C07D239/42 ,  C07D239/70 ,  C07D239/84 ,  C07D239/95 ,  C07D401/04 ,  C07D403/12

摘要： The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

公开(公告)号：US20090105211A1

公开(公告)日：2009-04-23

申请号：US12049225

申请日：2008-03-14

申请人： Suleyman Bahceci ,  William Bajjalieh ,  Jeff Chen ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Byung Gyu Kim ,  James W. Leahy ,  Matthew Sangyup Lee ,  Gary L. Lewis ,  Morrison B. Mac ,  Grace Mann ,  Charles K. Marlowe ,  Brian Hugh Ridgway ,  Joan C. Sangalang ,  Xian Shi ,  Craig Stacy Takeuchi ,  Yong Wang

发明人： Suleyman Bahceci ,  William Bajjalieh ,  Jeff Chen ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Byung Gyu Kim ,  James W. Leahy ,  Matthew Sangyup Lee ,  Gary L. Lewis ,  Morrison B. Mac ,  Grace Mann ,  Charles K. Marlowe ,  Brian Hugh Ridgway ,  Joan C. Sangalang ,  Xian Shi ,  Craig Stacy Takeuchi ,  Yong Wang

IPC分类号： C07D239/84 ,  C07D413/12 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/553 ,  A61K31/55 ,  C07D401/12 ,  C07D403/12 ,  A61P35/00 ,  C07D401/14

CPC分类号： C07D239/42 ,  C07D239/70 ,  C07D239/84 ,  C07D239/95 ,  C07D401/04 ,  C07D403/12

摘要： The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

摘要翻译： 本发明涉及式I化合物或其单一异构体; 其中除了制备式I化合物的方法之外，化合物任选为其药学上可接受的盐，水合物，溶剂合物或其组合，以及使用式I化合物治疗癌症的方法。