Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species
    4.
    发明授权
    Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species 失效
    重组浣熊病毒及其在哺乳动物和禽类物种中作为疫苗的用途

    公开(公告)号:US06294176B1

    公开(公告)日:2001-09-25

    申请号:US09113750

    申请日:1998-07-10

    IPC分类号: A61K3912

    CPC分类号: C12N15/86 C12N2710/24143

    摘要: The present invention provides a recombinant raccoonpox virus comprising a raccoonpox virus viral genome which contains a foreign DNA sequence inserted into a non-essential region within the HindIII “U” genomic region, the HindIII “M” genomic region, or HindIII “N” genomic region of the raccoonpox virus genome. The present invention provides a recombinant raccoonpox virus comprising a raccoonpox virus viral genome which contains a deletion in a raccoonpox virus host range gene of the viral genome. The present invention provides a homology vector for producing a recombinant raccoonpox virus by inserting a foreign DNA sequence into the raccoonpox virus genome. The present invention provides a recombinant raccoonpox virus which is useful as a vaccine in mammalian and avian species.

    摘要翻译: 本发明提供了包含浣熊病毒病毒基因组的重组浣熊病毒,其包含插入到HindIII“U”基因组区域内的非必需区域,HindIII“M”基因组区域或HindIII“N”基因组中的外来DNA序列 浣熊病毒基因组的区域。 本发明提供了包含痘痘病毒病毒基因组的重组浣熊病毒,其在病毒基因组的浣熊病毒宿主范围基因中含有缺失。 本发明提供了通过将外来DNA序列插入浣熊病毒基因组来产生重组浣熊病毒的同源载体。 本发明提供了可用作哺乳动物和鸟类物种中的疫苗的重组浣熊病毒。

    NUCLEIC ACIDS ENCODING NEUTRALIZING GDF8 EPITOPE-BASED PEPTIDES AND FUSION PROTEINS
    7.
    发明申请
    NUCLEIC ACIDS ENCODING NEUTRALIZING GDF8 EPITOPE-BASED PEPTIDES AND FUSION PROTEINS 失效
    核苷酸编码中和GDF8基于EPITOPE的肽和融合蛋白

    公开(公告)号:US20080227156A1

    公开(公告)日:2008-09-18

    申请号:US12061012

    申请日:2008-04-02

    摘要: The invention provides new, specific antigenic peptides from the protein GDF8. The invention also provides fusion proteins comprising the new peptides, immunogens and vaccines based on the new peptides and/or fusion proteins, antibodies that specifically bind to the new peptides of GDF8, and methods of treating animals in order to modulate the activity of GDF8, employing vaccines or antibodies according to the invention.

    摘要翻译: 本发明提供来自蛋白GDF8的新的特异性抗原肽。 本发明还提供了包含新肽,基于新肽和/或融合蛋白的免疫原和疫苗的融合蛋白,特异性结合GDF8的新肽的抗体以及治疗动物以调节GDF8活性的方法, 使用根据本发明的疫苗或抗体。

    Neutralizing GDF8 epitope-based growth enhancing vaccine
    8.
    发明授权
    Neutralizing GDF8 epitope-based growth enhancing vaccine 失效
    中和GDF8表位生长增强疫苗

    公开(公告)号:US07371726B2

    公开(公告)日:2008-05-13

    申请号:US11019001

    申请日:2004-12-21

    摘要: The invention provides new, specific antigenic peptides from the protein GDF8. The invention also provides fusion proteins comprising the new peptides, immunogens and vaccines based on the new peptides and/or fusion proteins, antibodies that specifically bind to the new peptides of GDF8, and methods of treating animals in order to modulate the activity of GDF8, employing vaccines or antibodies according to the invention.

    摘要翻译: 本发明提供来自蛋白GDF8的新的特异性抗原肽。 本发明还提供了包含新肽,基于新肽和/或融合蛋白的免疫原和疫苗的融合蛋白,特异性结合GDF8的新肽的抗体以及治疗动物以调节GDF8活性的方法, 使用根据本发明的疫苗或抗体。