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    Irradiated membrane for cell expansion
    7.
    发明授权
    Irradiated membrane for cell expansion 有权

    公开(公告)号：US10974201B2

    公开(公告)日：2021-04-13

    申请号：US13120375

    申请日：2009-09-23

    申请人： Bernd Krause ,  Markus Neubauer ,  Joachim Loercher

    发明人： Bernd Krause ,  Markus Neubauer ,  Joachim Loercher

    IPC分类号： C12M1/12 ,  B01D67/00 ,  C12N5/00 ,  C12N5/0775 ,  A61L2/02

    摘要： A membrane for cultivating adherent or suspension cells, in particular adherent cells. The membrane permits adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma or beta rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. A method for preparing such an irradiated membrane for cultivating adherent or suspension cells. Methods of using such a membrane for cultivating adherent or suspension cells.

    IRRADIATED MEMBRANE FOR CELL EXPANSION
    8.
    发明申请
    IRRADIATED MEMBRANE FOR CELL EXPANSION 审中-公开
    用于细胞扩增的IRRADIATED MEMBRANE

    公开(公告)号：US20110263022A1

    公开(公告)日：2011-10-27

    申请号：US13120375

    申请日：2009-09-23

    申请人： Bernd Krause ,  Markus Neubauer ,  Joachim Loercher

    发明人： Bernd Krause ,  Markus Neubauer ,  Joachim Loercher

    IPC分类号： C12N5/071 ,  C12M1/00 ,  C12N5/0775 ,  C12M3/00

    CPC分类号： B01D67/009 ,  A61L2/022 ,  C12M25/02 ,  C12N5/0068 ,  C12N5/0663 ,  C12N2533/30 ,  C12N2533/52

    摘要： A membrane for cultivating adherent or suspension cells, in particular adherent cells. The membrane permits adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma or beta rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. A method for preparing such an irradiated membrane for cultivating adherent or suspension cells. Methods of using such a membrane for cultivating adherent or suspension cells.

    摘要翻译： 用于培养粘附或悬浮细胞，特别是贴壁细胞的膜。 由于在氧气存在下用γ射线或β射线或电子束以12.5至175kGy的剂量照射湿膜或干膜，所述膜允许细胞粘附和增殖。 所得到的膜可以在没有表面改性物质的预处理的情况下使用。 制备用于培养粘附或悬浮细胞的这种照射膜的方法。 使用这种膜来培养粘附或悬浮细胞的方法。

    BIOMIMETIC MEMBRANE FOR CELL EXPANSION
    9.
    发明申请
    BIOMIMETIC MEMBRANE FOR CELL EXPANSION 审中-公开
    用于细胞扩增的生物膜

    公开(公告)号：US20120028275A1

    公开(公告)日：2012-02-02

    申请号：US13186609

    申请日：2011-07-20

    申请人： Verena Kieferle ,  Markus Neubauer

    发明人： Verena Kieferle ,  Markus Neubauer

    IPC分类号： G01N33/53 ,  C12M1/00 ,  C12N5/0775 ,  C12M3/00 ,  C12N5/071 ,  C12Q1/06

    CPC分类号： C12N5/0068 ,  C12M25/10 ,  C12M25/12 ,  C12N5/0663 ,  C12N2533/30 ,  C12N2533/52 ,  C12N2533/70

    摘要： The invention relates to a membrane which can be used for cultivating adherent or suspension cells, in particular adherent cells, wherein said membrane allows for the adhesion and proliferation of the cells due to modification of the membrane surface with a combination of at least one extracellular matrix protein, at least one extracellular matrix (proteo-) glycan, and at least one heparin-binding growth factor. The invention further relates to a method for preparing said modified or coated membrane which can be used for the cultivation of cells, in particular adherent cells, and to methods of using such membrane for the cultivation of cells, in particular adherent cells.

    摘要翻译： 本发明涉及一种可用于培养粘附或悬浮细胞，特别是贴壁细胞的膜，其中所述膜允许由于膜表面的修饰而使细胞的粘附和增殖，所述膜表面与至少一种细胞外基质 蛋白质，至少一种细胞外基质（蛋白质 - ）聚糖，以及至少一种肝素结合生长因子。 本发明进一步涉及可用于培养细胞，特别是贴壁细胞的所述修饰或包被的膜的制备方法，以及使用这种膜来培养细胞，特别是贴壁细胞的方法。

    Bottom bracket unit for a bicycle
    10.
    发明授权
    Bottom bracket unit for a bicycle 有权
    自行车底托单元

    公开(公告)号：US09403577B2

    公开(公告)日：2016-08-02

    申请号：US14113656

    申请日：2012-04-17

    申请人： Markus Neubauer ,  Stefan Gluck ,  Frank Benkert

    发明人： Markus Neubauer ,  Stefan Gluck ,  Frank Benkert

    IPC分类号： G01P3/36 ,  B62M6/50 ,  B62M3/00

    CPC分类号： B62M6/50 ,  B62M3/003 ,  G01P3/36 ,  Y10S482/901

    摘要： A bottom bracket unit including a bottom bracket axle (1), at least one bearing (2, 3) that receives the bottom bracket axle (1) in a rotatable manner, and an optical detection unit (11), by which a rotational speed of the bottom bracket axle (1) can be detected. The optical detection unit (11) measures at least one signaling device (12) that is rotationally fixed to the bottom bracket axle (1). The aim of the invention is to provide a bottom bracket unit that can also detect the rotational direction of the bottom bracket axle in addition to the rotational speed of the axle. This is achieved in that the optical detection unit (11) has two optical sensors (17), with one of these sensors (17) providing a signal that is phase-shifted with respect to the other sensor (24) having a fixed phase difference, in particular with a phase difference of 90°.

    摘要翻译： 一种底托单元，包括一个底托架轴（1），至少一个轴承（2,3），可转动地容纳底托架轴（1），以及一光学检测单元（11） 可以检测到底托架轴（1）。 光学检测单元（11）测量至少一个旋转地固定到底托架轴（1）的信号装置（12）。 本发明的目的是提供一种底托架单元，其还可以检测除了轴的转速之外的底托架轴的旋转方向。 这是通过光学检测单元（11）具有两个光学传感器（17）实现的，其中这些传感器（17）中的一个提供相对于具有固定相位差的另一传感器（24）相移的信号 ，特别是相位差为90°。