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    HYDROPHILIC MEMBRANES WITH A NON-IONIC SURFACTANT
    4.
    发明申请
    HYDROPHILIC MEMBRANES WITH A NON-IONIC SURFACTANT 有权
    具有非离子表面活性剂的亲水膜

    公开(公告)号：US20100320146A1

    公开(公告)日：2010-12-23

    申请号：US12680531

    申请日：2008-09-26

    申请人： Bernd Krause ,  Markus Hornung ,  Reinhold Deppisch ,  Doris Deppisch ,  Silvia Koch

    发明人： Bernd Krause ,  Markus Hornung ,  Reinhold Deppisch ,  Doris Deppisch ,  Silvia Koch

    IPC分类号： B01D71/06 ,  B01D71/68 ,  B01D69/08 ,  B01D61/24 ,  B01J20/00 ,  B01J20/26

    CPC分类号： B01D69/02 ,  A61M1/16 ,  A61M1/3496 ,  B01D67/0088

    摘要： The invention relates to hydrophilic membranes which are supplemented or treated with a non-ionic surfactant and processes for preparing such membranes. The membranes are particularly suitable for plasma separation or for haemodialysis and haemodiafiltration, but can also advantageously be used in other applications. Accordingly, the invention is further directed to the use of such membranes for plasma separation, plasma filtration, micro filtration, plasma therapy, haemodialysis and haemodiafiltration or cell filtration applications, respectively. The treated hydrophilic membranes show excellent biocompatibility, such as reduced platelet drop and decreased TAT levels.

    摘要翻译： 本发明涉及用非离子表面活性剂补充或处理的亲水膜及其制备方法。 该膜特别适用于血浆分离或用于血液透析和血液透析过滤，但也可有利地用于其它应用。 因此，本发明进一步涉及这种膜用于血浆分离，血浆过滤，微过滤，血浆治疗，血液透析和血液透析或细胞过滤应用。 经处理的亲水膜显示出优异的生物相容性，例如减少血小板降低和降低的TAT水平。

    Hydrophilic membranes with a non-ionic surfactant
    6.
    发明授权
    Hydrophilic membranes with a non-ionic surfactant 有权
    亲水膜与非离子表面活性剂

    公开(公告)号：US08528744B2

    公开(公告)日：2013-09-10

    申请号：US12680531

    申请日：2008-09-26

    申请人： Bernd Krause ,  Markus Hornung ,  Silvia Koch ,  Doris Deppisch

    发明人： Bernd Krause ,  Markus Hornung ,  Reinhold Deppisch ,  Silvia Koch

    IPC分类号： B01D71/00 ,  B01D69/00 ,  B01D69/08 ,  B01D67/00

    CPC分类号： B01D69/02 ,  A61M1/16 ,  A61M1/3496 ,  B01D67/0088

    摘要： The invention relates to hydrophilic membranes which are supplemented or treated with a non-ionic surfactant and processes for preparing such membranes. The membranes are particularly suitable for plasma separation or for haemodialysis and haemodiafiltration, but can also advantageously be used in other applications. Accordingly, the invention is further directed to the use of such membranes for plasma separation, plasma filtration, micro filtration, plasma therapy, haemodialysis and haemodiafiltration or cell filtration applications, respectively. The treated hydrophilic membranes show excellent biocompatibility, such as reduced platelet drop and decreased TAT levels.

    摘要翻译： 本发明涉及用非离子表面活性剂补充或处理的亲水膜及其制备方法。 该膜特别适用于血浆分离或用于血液透析和血液透析过滤，但也可有利地用于其它应用。 因此，本发明进一步涉及这种膜用于血浆分离，血浆过滤，微过滤，血浆治疗，血液透析和血液透析或细胞过滤应用。 经处理的亲水膜显示出优异的生物相容性，例如减少血小板降低和降低的TAT水平。

    IRRADIATED MEMBRANE FOR CELL EXPANSION
    7.
    发明申请
    IRRADIATED MEMBRANE FOR CELL EXPANSION 审中-公开
    用于细胞扩增的IRRADIATED MEMBRANE

    公开(公告)号：US20110263022A1

    公开(公告)日：2011-10-27

    申请号：US13120375

    申请日：2009-09-23

    申请人： Bernd Krause ,  Markus Neubauer ,  Joachim Loercher

    发明人： Bernd Krause ,  Markus Neubauer ,  Joachim Loercher

    IPC分类号： C12N5/071 ,  C12M1/00 ,  C12N5/0775 ,  C12M3/00

    CPC分类号： B01D67/009 ,  A61L2/022 ,  C12M25/02 ,  C12N5/0068 ,  C12N5/0663 ,  C12N2533/30 ,  C12N2533/52

    摘要： A membrane for cultivating adherent or suspension cells, in particular adherent cells. The membrane permits adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma or beta rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. A method for preparing such an irradiated membrane for cultivating adherent or suspension cells. Methods of using such a membrane for cultivating adherent or suspension cells.

    摘要翻译： 用于培养粘附或悬浮细胞，特别是贴壁细胞的膜。 由于在氧气存在下用γ射线或β射线或电子束以12.5至175kGy的剂量照射湿膜或干膜，所述膜允许细胞粘附和增殖。 所得到的膜可以在没有表面改性物质的预处理的情况下使用。 制备用于培养粘附或悬浮细胞的这种照射膜的方法。 使用这种膜来培养粘附或悬浮细胞的方法。

    Irradiated membrane for cell expansion
    8.
    发明授权
    Irradiated membrane for cell expansion 有权

    公开(公告)号：US10974201B2

    公开(公告)日：2021-04-13

    申请号：US13120375

    申请日：2009-09-23

    申请人： Bernd Krause ,  Markus Neubauer ,  Joachim Loercher

    发明人： Bernd Krause ,  Markus Neubauer ,  Joachim Loercher

    IPC分类号： C12M1/12 ,  B01D67/00 ,  C12N5/00 ,  C12N5/0775 ,  A61L2/02

    摘要： A membrane for cultivating adherent or suspension cells, in particular adherent cells. The membrane permits adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma or beta rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. A method for preparing such an irradiated membrane for cultivating adherent or suspension cells. Methods of using such a membrane for cultivating adherent or suspension cells.

    Membranes having improved performance
    9.
    发明授权
    Membranes having improved performance 有权
    具有改进性能的膜

    公开(公告)号：US08827087B2

    公开(公告)日：2014-09-09

    申请号：US13320679

    申请日：2010-05-19

    申请人： Bernd Krause ,  Carina Zweigart

    发明人： Bernd Krause ,  Carina Zweigart

    IPC分类号： B01D71/68 ,  B01D69/08 ,  B01D71/76 ,  B29C47/12 ,  B01D71/40 ,  B01D67/00

    CPC分类号： B01D69/08 ,  B01D67/0088 ,  B01D67/0093 ,  B01D71/40 ,  B01D71/68 ,  B01D71/76

    摘要： Permselective asymmetric membranes suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved sieving characteristics providing enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The membranes comprise polyethersulfone and polyvinylpyrrolidone and are coated with hyaluronic acid or copolymers of 2-methacryloyloxyethyl phosphoryl choline and other vinyl polymerizable monomers. Processes for the preparation of these membranes, devices comprising these membranes, and the use of these membranes in hemodialysis, hemodiafiltration and hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.

    摘要翻译： 选择性不对称膜适合于例如 用于血液透析，血液透析过滤和血液的血液滤过，并且具有改善的筛分特性，提供中等分子量物质的增强除去。 具有20至40kDa分子量的炎性介质。 膜包含聚醚砜和聚乙烯吡咯烷酮，并用透明质酸或2-甲基丙烯酰氧基乙基磷酰胆碱和其它乙烯基可聚合单体的共聚物涂覆。 用于制备这些膜的方法，包括这些膜的装置以及这些膜在血液透析，血液透析滤过和血液血液滤过以及生物处理，血浆分离和蛋白质溶液的制备中的用途。

    ENZYME-FUNCTIONALIZED SUPPORTS
    10.
    发明申请
    ENZYME-FUNCTIONALIZED SUPPORTS 审中-公开
    酶功能化支持

    公开(公告)号：US20120208256A1

    公开(公告)日：2012-08-16

    申请号：US13503204

    申请日：2010-10-20

    申请人： Ralf Flieg ,  Manuela Klotz ,  Markus Storr ,  Martin Rempfer ,  Wolfgang Freudemann ,  Cornelia Winz ,  Bernd Krause ,  Markus Hornung

    发明人： Ralf Flieg ,  Manuela Klotz ,  Markus Storr ,  Martin Rempfer ,  Wolfgang Freudemann ,  Cornelia Winz ,  Bernd Krause ,  Markus Hornung

    IPC分类号： C12N11/06 ,  C12N11/02

    CPC分类号： C12N9/18 ,  C09D133/14 ,  C12N9/80 ,  C12N11/06 ,  C12N11/08

    摘要： An immobilized enzyme comprises a solid support, an enzyme linked to the solid support and a spacer for coupling the enzyme to the solid support. A method for the production of immobilized enzymes comprises: providing a solid support having amino-functional groups coupled to the support surface; covalently coupling the amino-functional groups with a thermally labile radical initiator; and, contacting the support surface with a solution of polymerizable monomers. The polymerizable monomers comprise functional groups which do not take part in radical polymerization, under conditions where thermally initiated graft copolymerization of the monomers takes place, to form polymer chains on the surface of the support. If the polymer chains do not already comprise primary amino-functional groups, the method further comprises transforming the functional groups in the polymer chains into groups comprising primary amino-functional groups. The method further comprises coupling the enzyme to amino-functional groups of the polymer chains.

    摘要翻译： 固定化酶包括固体支持物，与固体支持物连接的酶和用于将酶偶联到固体支持物的间隔物。 制备固定化酶的方法包括：提供具有与支持表面偶联的氨基官能团的固体支持物; 将氨基官能团与热不稳定的自由基引发剂共价偶联; 并且使支撑体表面与可聚合单体的溶液接触。 可聚合单体包括在发生单体的热引发接枝共聚的条件下不参与自由基聚合的官能团，以在载体的表面上形成聚合物链。 如果聚合物链不包括伯氨基官能团，则该方法还包括将聚合物链中的官能团转化为包含伯氨基官能团的基团。 该方法还包括将酶偶联到聚合物链的氨基官能团。