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31 条记录 (耗时 0.025 秒)

    Genetic constructs and compositions comprising pre and cte and uses thereof
    4.
    发明申请
    Genetic constructs and compositions comprising pre and cte and uses thereof 有权
    遗传构建体和组合物，其包含前和后者及其用途

    公开(公告)号：US20060140978A1

    公开(公告)日：2006-06-29

    申请号：US10535326

    申请日：2003-11-19

    申请人： David Weiner ,  Karuppiah Muthumani

    发明人： David Weiner ,  Karuppiah Muthumani

    IPC分类号： A61K48/00 ,  A61K39/21 ,  C12N15/867

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16322 ,  C12N2740/16334

    摘要： Genetic constructs that comprise a coding sequence for HIV-1 Rev, and a coding sequence for a desired protein are disclosed. Compositions that comprise at least two nucleic acid molecules in which at least one nucleic acid molecule comprises a coding sequence for HIV-1 Rev, and at least one nucleic acid molecule comprises a coding sequence for a desired protein are disclosed. In such genetic constructs and compositions comprising nucleic acid molecules, the coding sequence for the desired protein comprises at least a portion of coding sequence for an HIV structural protein that includes an RRE and at least one CTE. Methods of inducing an immune response against an immunogen in an individual, methods of delivering proteins to an individual and methods of producing proteins are also disclosed.

    摘要翻译： 公开了包含HIV-1 Rev编码序列的遗传构建体和所需蛋白质的编码序列。 包含至少两个核酸分子的组合物，其中至少一个核酸分子包含HIV-1 Rev的编码序列，并且至少一个核酸分子包含所需蛋白质的编码序列。 在包含核酸分子的这种遗传构建体和组合物中，所需蛋白质的编码序列包含HIV结构蛋白的编码序列的至少一部分，其包括RRE和至少一种CTE。 还公开了诱导针对个体免疫原的免疫应答的方法，将蛋白递送给个体的方法和生产蛋白质的方法。

    P38 kinase inhibitor compositions and methods of using the same
    9.
    发明申请
    P38 kinase inhibitor compositions and methods of using the same 审中-公开
    P38激酶抑制剂组合物及其使用方法

    公开(公告)号：US20060241150A1

    公开(公告)日：2006-10-26

    申请号：US10559227

    申请日：2004-06-04

    申请人： David Weiner ,  Karuppiah Muthumani

    发明人： David Weiner ,  Karuppiah Muthumani

    IPC分类号： A61K31/4439 ,  A61K31/551 ,  A61K31/522 ,  A61K31/513 ,  C12Q1/70

    CPC分类号： A61K31/415 ,  A61K31/44 ,  C12Q1/18 ,  C12Q1/703 ,  G01N33/5023 ,  G01N33/56988 ,  G01N33/6872 ,  G01N2333/163 ,  C12Q2527/125

    摘要： Methods of treating an individual who has been identified as having been infected with HIV are disclosed. Methods of treating an individual who is suspected of having been exposed to HIV are disclosed. Some methods disclosed comprise the step of administering to the individual an amount of a p38 inhibitor effective to inhibit FasL expression. Some methods disclosed comprise the step of administering to the individual an amount of a p38 inhibitor effective to inhibit HIV replication. Some methods disclosed comprise the step of administering to the individual an amount of a p38 inhibitor effective to inhibit HIV replication without inhibiting T cell activation. Some methods disclosed comprise administering to the individual one or more other anti-HIV compounds in combination with a p38 inhibitor. Methods of identifying compounds that inhibit Nef mediated upregulation of FasL expression are disclosed. Methods of identifying compounds that inhibit the p38 pathway are disclosed.

    摘要翻译： 公开了已经鉴定为感染了HIV的个体的治疗方法。 披露了怀疑患有艾滋病毒的个体治疗方法。 公开的一些方法包括向个体施用一定量的有效抑制FasL表达的p38抑制剂的步骤。 公开的一些方法包括向个体施用一定量的有效抑制HIV复制的p38抑制剂的步骤。 公开的一些方法包括向个体施用一定量的有效抑制HIV复制而不抑制T细胞活化的量的p38抑制剂的步骤。 所公开的一些方法包括给予个体一种或多种其它抗HIV化合物与p38抑制剂的组合。 公开了鉴定抑制Nef介导的FasL表达上调的化合物的方法。 公开了鉴定抑制p38途径的化合物的方法。