公开(公告)号：US06650757B1

公开(公告)日：2003-11-18

申请号：US09405020

申请日：1999-09-27

申请人： David Zhou ,  Francois Charette ,  Keng D. Hsueh ,  Vy Tran ,  Hsiao-An Hsieh

发明人： David Zhou ,  Francois Charette ,  Keng D. Hsueh ,  Vy Tran ,  Hsiao-An Hsieh

IPC分类号： A61F1106

CPC分类号： G01H3/08 ,  G01H1/00 ,  G01M13/028 ,  G01M17/04

摘要： An apparatus for detecting unwanted noise includes a reference sensor that generates a reference signal in response to stimulation by a source. A combined noise detector picks up a combined noise signal, which includes both background noise and the unwanted noise generated by the source. A noise separation synthesis device filters both signals to generate a coherent unwanted noise signal from the combined noise signal as a function of the reference signal generated by the reference sensor. A comparator determines the presence of unwanted noise by calculating the Kurtosis value of the coherent unwanted noise signal.

摘要翻译： 用于检测不需要的噪声的装置包括参考传感器，其响应于源的刺激而产生参考信号。 组合噪声检测器拾取组合噪声信号，其包括背景噪声和源产生的不需要的噪声。 噪声分离合成装置对两个信号进行滤波，以根据由参考传感器产生的参考信号的组合噪声信号产生相干不需要的噪声信号。 比较器通过计算相干不需要的噪声信号的峰度值来确定存在不想要的噪声。

公开(公告)号：US20070269906A1

公开(公告)日：2007-11-22

申请号：US11881455

申请日：2007-07-27

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： G01N33/536 ,  G01N33/00

CPC分类号： G01N33/54386 ,  G01N33/536 ,  G01N33/558 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A device and method for enhancing rapid confirmatory immunological testing (“RCIT”) in chromatography strip-type rapid IVD devices useful in, for example, clinical, point-of-care, laboratory or over-the-counter settings. The device drives a flow fluid, primarily under the force of gravity alone, through a first chamber having a porous dam structure to enhance and substantially complete the first affinity binding reaction between a source of mobilizable labeled binding members and an analyte in the fluid. Flow through the dam causes a delay, mixing and trapping of the typically chemically disuniform initial fluid front so that fluid exiting the dam exhibits a more uniformly high degree of first affinity binding and decreased non-affinity binding. Afterward, and without further human interaction, the fluid then flows under the combined, turbulence creating forces of gravity, siphoning, and capillarity, through a second chamber containing a chromatographic strip which captures the labeled analytes in a second affinity binding reaction. By separating the two affinity binding reactions, competition for analytes during each reaction is reduced, and thus accuracy improved.

摘要翻译： 用于例如在临床，护理点，实验室或非处方设置中有用的色谱条带型快速IVD装置中的快速确认免疫测试（“RCIT”）的装置和方法。 该装置主要在重力作用下驱动流体流体通过具有多孔坝结构的第一室，以增强并基本上完成可移动标记的结合构件的源和流体中的分析物之间的第一亲和结合反应。 通过大坝的流动导致典型的化学不均匀初始流体前沿的延迟，混合和捕获，使得离开坝的流体表现出更均匀的高度的第一亲和力结合和减少的非亲和力结合。 之后，并且在没有进一步的人类相互作用的情况下，流体在组合的湍流之下通过包含在第二亲和力结合反应中捕获标记分析物的色谱条的第二室产生重力，虹吸和毛细作用力。 通过分离两种亲和力结合反应，减少了每次反应期间对分析物的竞争，从而提高了精确度。

公开(公告)号：US20060292700A1

公开(公告)日：2006-12-28

申请号：US11158547

申请日：2005-06-22

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： G01N33/558

CPC分类号： G01N33/558 ,  G01N33/54386

摘要： A lateral flow chromatographic immunoassay rapid test device having an additional interrupting, porous, diffusive pad pretreated with a surfactant interposed between the conjugate pad and the reaction membrane. The diffusive pad causes improved mixing of the fluid to provide a more mixture of molecules in the fluid and a more uniformly dispersed fluid flow having a more uniformly high degree of first affinity binding and a more even fluid front to cross into the reaction membrane, thereby increasing the sensitivity and specificity of the second affinity binding at both test and control lines, and thereby providing an important advancement of the existing lateral flow rapid test technology.

摘要翻译： 一种侧流色谱免疫测定快速测试装置，其具有预先用表面活性剂预处理的另外的中断，多孔扩散垫，所述表面活性剂插入在所述共轭垫和所述反应膜之间。 扩散垫引起改善的流体混合以在流体中提供更多的分子混合物，以及更均匀地分散的流体流，其具有更均匀的高度的第一亲和力结合和更均匀的流体前沿以穿过反应膜，由此 增加了测试和对照线上第二亲和力结合的灵敏度和特异性，从而提供了现有侧流快速测试技术的重要进步。

公开(公告)号：US20070184492A1

公开(公告)日：2007-08-09

申请号：US11738356

申请日：2007-04-20

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： G01N33/53 ,  C12M3/00

CPC分类号： G01N33/5302 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/084 ,  G01N33/558

摘要： A self-contained apparatus using a gravitationally encouraged, interrupted, downward, diffusive and programmed flow of fluid to provide for rapid confirmatory immunological testing (“RCIT”) in, for example, a clinical, point-of-care setting. A fluid specimen such as blood, saliva or urine is deposited into a first chamber carrying a source of conjugate having mobilizable binding members such as immunographic antigens or antibodies specific to the condition being tested conjugated to a detectable label such as colloidal gold. The specimen is premixed with a first measured, reactive mix buffer solution carried within an openable tank. The specimen and solution are temporarily held within an incubation reservoir formed behind a dam made from porous, diffusive material. The delay and flow through the diffusive dam causes mixing of the specimen and solution to form a premixture which exhibits a more uniformly high degree of first affinity binding before flowing out of the first chamber toward one or more chromatographic test strips in a second chamber. In one embodiment, after a waiting period, a bladder containing a stop-wash buffer solution is opened to flow onto the strips. Additional embodiments provide one or more diffusive structures that can be pretreated with mixture enhancing chemicals such as surfactants. It is a rapid confirmatory immunological test apparatus having an analytical panel which can provide profile diagnostic results.

公开(公告)号：US08696917B2

公开(公告)日：2014-04-15

申请号：US12699302

申请日：2010-02-03

申请人： James R. Petisce ,  David Zhou ,  Mena Valiket

发明人： James R. Petisce ,  David Zhou ,  Mena Valiket

IPC分类号： H01B13/00

CPC分类号： G01N27/3272 ,  A61B5/0006 ,  A61B5/415 ,  A61B2562/0209 ,  A61B2562/028 ,  A61B2562/043 ,  A61B2562/12 ,  A61B2562/125 ,  B32B37/025 ,  B32B2309/105 ,  B32B2311/02 ,  B32B2457/00 ,  B32B2535/00 ,  B81C1/00539

摘要： Methods for fabricating analyte sensor components using IC- or MEMs-based fabrication techniques and sensors prepared therefrom. Fabrication of the analyte sensor component comprises providing an inorganic substrate having deposited thereon a release layer, a first flexible dielectric layer and a second flexible dielectric layer insulating there between electrodes, contact pads and traces connecting the electrodes and the contact pads of a plurality of sensors. Openings are provided in one of the dielectric layers over one or more of the electrodes to receive an analyte sensing membrane for the detection of an analyte of interest and for electrical connection with external electronics. The plurality of fabricated sensor components are lifted off the inorganic substrate.

摘要翻译： 使用基于IC或MEM的制造技术和由其制备的传感器来制造分析物传感器部件的方法。 分析物传感器部件的制造包括提供其上沉积有释放层的无机基材，在电极之间绝缘的第一柔性介电层和绝缘的第二柔性介电层，连接多个传感器的电极和接触焊盘的接触焊盘和迹线 。 在一个或多个电极中的一个电介质层中提供开口，以接收用于检测感兴趣分析物并与外部电子器件电连接的分析物感测膜。 将多个制造的传感器部件从无机基板上提起。

公开(公告)号：US20100200538A1

公开(公告)日：2010-08-12

申请号：US12699302

申请日：2010-02-03

申请人： James R. Petisce ,  David Zhou ,  Mena Valiket

发明人： James R. Petisce ,  David Zhou ,  Mena Valiket

IPC分类号： B32B38/10

CPC分类号： G01N27/3272 ,  A61B5/0006 ,  A61B5/415 ,  A61B2562/0209 ,  A61B2562/028 ,  A61B2562/043 ,  A61B2562/12 ,  A61B2562/125 ,  B32B37/025 ,  B32B2309/105 ,  B32B2311/02 ,  B32B2457/00 ,  B32B2535/00 ,  B81C1/00539

摘要： Methods for fabricating analyte sensor components using IC- or MEMs-based fabrication techniques and sensors prepared therefrom. Fabrication of the analyte sensor component comprises providing an inorganic substrate having deposited thereon a release layer, a first flexible dielectric layer and a second flexible dielectric layer insulating there between electrodes, contact pads and traces connecting the electrodes and the contact pads of a plurality of sensors. Openings are provided in one of the dielectric layers over one or more of the electrodes to receive an analyte sensing membrane for the detection of an analyte of interest and for electrical connection with external electronics. The plurality of fabricated sensor components are lifted off the inorganic substrate.

摘要翻译： 使用基于IC或MEM的制造技术和由其制备的传感器来制造分析物传感器部件的方法。 分析物传感器部件的制造包括提供其上沉积有释放层的无机基材，在电极之间绝缘的第一柔性介电层和绝缘的第二柔性介电层，连接多个传感器的电极和接触焊盘的接触焊盘和迹线 。 在一个或多个电极中的一个电介质层中提供开口，以接收用于检测感兴趣分析物并与外部电子器件电连接的分析物感测膜。 将多个制造的传感器部件从无机基板上提起。

公开(公告)号：US20060210448A1

公开(公告)日：2006-09-21

申请号：US11078876

申请日：2005-03-10

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： B01L3/00

CPC分类号： A61B10/0038 ,  B01L1/52 ,  B01L3/502 ,  B01L3/5029 ,  B01L2200/185 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/087

摘要： A device for quantitively collecting, preserving, storing and mailing a fresh and wet specimen of fecal or other biological matter for later analysis comprises a simple tubular vessel double sealed at one end by a machine manipulable plug having breakable hollow nib and cover, and that is engaged at the opposite end by a machine manipulable stopper from which a specimen carrying stick axially projects into the vessel through an internal sealable septum spanning a median section of the vessel. The cross-sectional profile of the stick is shaped to form a widened shoulder carrying a resilient washer. The shoulder matingly engages a correspondingly shaped passageway in the septum when the stopper engages the vessel which restricts the amount of specimen passing therethrough. The amount of specimen and preserving fluid are quantitatively balanced and remain so until part or all of the fluid is extracted for analysis either manually by breaking of the sealing nib or automatedly by machine removal of the plug or stopper. Collection by a patient or unskilled person is enhanced by providing the tubular vessel as part of a sample collection and return kit which further contains a disposable paper catch web which is made to be temporarily secured to a toilet droopingly spanning the seat to catch the feces for sampling. The kit also provides a sealable plastic bag and a crush resistant mailing carton. The above components of the kit are carried within a sterile bag until used.

摘要翻译： 一种用于定量收集，保存，储存和邮寄新鲜和潮湿的粪便或其他生物物质样品用于后续分析的装置包括简单的管状容器，其一端由具有可破坏的空心笔尖和盖的机器可操作的插塞双重密封， 在另一端通过机器可操纵的塞子接合，样品携带杆通过穿过容器的中间部分的内部可密封的隔膜轴向地突出到容器中。 棒的横截面轮廓成形为形成承载弹性垫圈的加宽肩部。 当止动器接合容器时，肩部配合地接合在隔膜中的相应形状的通道，其限制样本通过的量。 样品和保存液体的量定量平衡，并保持一致，直到部分或全部流体通过破坏密封笔尖手动或通过机械移除塞子或塞子自动分析来进行分析。 通过提供管状容器作为样品收集和返回试剂盒的一部分来增强病人或非熟练人的收集，所述样品收集和返回试剂盒进一步包含一次性纸吸收片，其被暂时固定到垂直于座位的马桶上以捕获粪便 采样。 该套件还提供了一个可密封的塑料袋和一个抗压邮寄箱。 将试剂盒的上述组分携带在无菌袋中直至使用。

公开(公告)号：US20060101725A1

公开(公告)日：2006-05-18

申请号：US11218890

申请日：2005-09-02

申请人： David Zhou

发明人： David Zhou

IPC分类号： E04F19/00 ,  E04H1/00

CPC分类号： F24B1/198 ,  E04F19/005

摘要： A master bracket system is provided to install a modular fireplace mantel at a fireplace opening. The bracket is generally C-shaped having a base plain and a number of planar extensions with predetermined angles to one another. Each of the plain surfaces of the bracket has an eyelet at the mounting point to receive a bolt that secures the corresponding marble member to the bracket. The base plain provides a retaining base for a main bolt to hold the entire mantel assembly to the wall. A number of brackets are used for each of the opposite sides of the mantel structure against the structure wall. The bracket has bolts each threaded through the eyelets into connection with a machined metal insert, which is embedded within the mantel members and held in place by adhesive. The metal inserts have a fastening means such as screw thread receiving the screw thread of the bolts. Once bolted together with the bolts tightened, the gaps between the separate mantel members will come in close proximity so that the mantel exterior in general appears continuous for a streamlined look. The main bolt that secures the master bracket to the structure wall pass through the preferably unthreaded aperture formed in the bracket.

摘要翻译： 提供主支架系统，在壁炉开口处安装模块化壁炉壁炉。 支架大致为C形，具有基部平面和多个彼此具有预定角度的平面延伸部。 支架的每个平坦表面在安装点处具有孔眼以接收将相应的大理石构件固定到支架的螺栓。 基座平面为主螺栓提供一个保持底座，用于将整个壁架组件固定在墙壁上。 对于壁架结构的相对于结构壁的相对侧中使用多个托架。 支架具有螺栓，每个螺栓穿过孔眼，与加工的金属插入件相连接，该金属插入件嵌入在壁架构件内并通过粘合剂保持在适当位置。 金属插件具有紧固装置，例如接收螺栓的螺纹的螺纹。 一旦用螺栓拧紧螺栓连接在一起，分开的壁架构件之间的间隙就会紧密接近，这样一来，壁架外观看起来是连续的，以便流线型的外观。 将主支架固定到结构壁上的主螺栓穿过形成在支架中的优选非螺纹孔。

公开(公告)号：US20050036910A1

公开(公告)日：2005-02-17

申请号：US10913899

申请日：2004-08-05

申请人： David Zhou ,  Nai Wang ,  Claudia Shen ,  Angela Shen

发明人： David Zhou ,  Nai Wang ,  Claudia Shen ,  Angela Shen

IPC分类号： A61B10/00 ,  G01N1/00

CPC分类号： A61B10/0096 ,  A61B10/0038 ,  Y10T436/25

摘要： A device for quantitively collecting, preserving and mailing a fresh and wet specimen of fecal or other biological matter for later analysis comprises a tubular vessel defining a chamber closed at one axial end by a plug and restricted at the opposite end by a narrow aperture. A stopper for closing the open end of the vessel extends into a stick whose distal portion comprises indentations capable of retaining a portion of the biological matter when the stick is dipped into it. The distal portion of the stick is shaped and dimensioned to intimately and circumferentially contact the edge of the aperture so that the amount of matter introduced into the chamber is limited to the part having penetrated into the indentations. The shank of the stick is dimensioned to seal the aperture once the stopper has been screwed upon the open end of the vessel. The plug mounts a breakable hollow nib and is installed after introduction into the chamber of a metered volume of preserving solution. A cover caps the plug and nib to provide additional sealing of that end of the vessel during transportation.

摘要翻译： 一种用于定量收集，保存和邮寄新鲜和潮湿的粪便或其他生物物质样品用于稍后分析的装置包括管状容器，该管状容器限定在一个轴向端部处由塞子封闭并且在相对端通过窄孔限制的腔室。 用于封闭容器的开口端的塞子延伸成棒，其远端部分包括当棒浸入其中时能够保留生物物质的一部分的凹痕。 棒的远端部分的形状和尺寸被设计成紧密地和圆周地接触孔的边缘，使得引入腔室的物质的数量被限制在已经穿入凹口的部分上。 一旦塞子已经拧紧在容器的开口端，则该杆的柄的尺寸被设计成密封孔。 插头安装了可破碎的空心笔尖，并在导入计量体积的保存溶液的腔室后安装。 盖子盖住塞子和笔尖，以便在运输过程中提供该容器端部的额外密封。

公开(公告)号：US06780160B2

公开(公告)日：2004-08-24

申请号：US10205712

申请日：2002-07-25

申请人： David Zhou ,  Nai Shu Sue Wang ,  Claudia J. R. Shen ,  Angela J. Q. Shen

发明人： David Zhou ,  Nai Shu Sue Wang ,  Claudia J. R. Shen ,  Angela J. Q. Shen

IPC分类号： A61B1000

CPC分类号： A61B10/0096 ,  A61B10/0038 ,  Y10T436/25

摘要： A device for quantitively collecting, preserving and mailing a specimen of fecal or other biological matter for later analysis comprises a tubular vessel defining a chamber closed at one end by a plug and restricted at the opposite end by a narrow aperture. A stopper for closing the open end of the vessel extends into a stick having indentations capable of retaining some of the biological matter. The stick intimately engages the aperture so that the amount of matter introduced into the chamber is limited to what is carried in the indentations. The shank of the stick seals the aperture once the stopper has been screwed into place. The plug mounts a breakable hollow nib and is installed after introduction into the chamber of a metered volume of preserving solution. A cover caps the plug and nib to provide additional sealing of that end of the vessel.

摘要翻译： 用于定量收集，保存和邮寄粪便或其他生物物质样本以用于以后分析的装置包括管状容器，其限定了一端通过塞子封闭的腔室，并在另一端通过窄孔限制。 用于封闭容器的开口端的塞子延伸成具有能够保留一些生物物质的压痕的棒。 杆与密封件紧密接合，使得引入腔室的物质的数量被限制在压痕中承载的物质的量。 一旦止动器拧入就位，棒的柄就会密封孔。 插头安装了可破碎的空心笔尖，并在导入计量体积的保存溶液的腔室后安装。 盖子盖住塞子和笔尖以提供该容器端部的额外密封。