Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
    3.
    发明申请
    Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach 有权
    通过血管内血管内途径进行脉冲电场神经调节的方法和装置

    公开(公告)号:US20070203549A1

    公开(公告)日:2007-08-30

    申请号:US11363867

    申请日:2006-02-27

    IPC分类号: A61N1/32

    摘要: Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other conditions in target neural fibers. In some embodiments, the ITEV PEF system comprises an intravascular catheter having one or more electrodes configured for intra-to-extravascular placement across a wall of patient's vessel into proximity with target neural fibers. With the electrode(s) passing from an intravascular position to an extravascular position prior to delivery of the PEF, a magnitude of applied voltage or energy delivered via the electrode(s) and necessary to achieve desired neuromodulation may be reduced relative to an intravascular PEF system having one or more electrodes positioned solely intravascularly. The methods and apparatus of the present invention may, for example, be used to modulate one or more target neural fibers that contribute to renal function.

    摘要翻译: 提供了通过血管外途径进行脉冲电场神经调节的方法和装置,例如,以实现不可逆的电穿孔或电融合,坏死和/或诱导细胞凋亡,基因表达的改变,细胞因子上调的变化以及目标中的其他条件 神经纤维。 在一些实施方案中,ITEV PEF系统包括具有一个或多个电极的血管内导管,其配置用于穿过患者血管的壁进行血管外放置,使其与目标神经纤维接近。 随着电极在PEF递送之前从血管内位置传递到血管外位置,可以相对于血管内PEF减少施加的电压或通过电极传递并且达到所需神经调节所必需的能量的大小 系统具有仅位于血管内的一个或多个电极。 本发明的方法和装置可以例如用于调节一种或多种有助于肾功能的靶神经纤维。