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    Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
    3.
    发明申请
    Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach 有权
    通过血管内血管内途径进行脉冲电场神经调节的方法和装置

    公开(公告)号：US20070203549A1

    公开(公告)日：2007-08-30

    申请号：US11363867

    申请日：2006-02-27

    申请人： Denise Demarais ,  Benjamin Clark ,  Nicolas Zadno ,  Erik Thai ,  Hanson Gifford

    发明人： Denise Demarais ,  Benjamin Clark ,  Nicolas Zadno ,  Erik Thai ,  Hanson Gifford

    IPC分类号： A61N1/32

    CPC分类号： A61B18/1477 ,  A61B18/1206 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00613 ,  A61B2018/126 ,  A61M5/14 ,  A61M37/00 ,  A61N1/05 ,  A61N1/0514 ,  A61N1/0551 ,  A61N1/321 ,  A61N1/327 ,  A61N1/36007

    摘要： Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other conditions in target neural fibers. In some embodiments, the ITEV PEF system comprises an intravascular catheter having one or more electrodes configured for intra-to-extravascular placement across a wall of patient's vessel into proximity with target neural fibers. With the electrode(s) passing from an intravascular position to an extravascular position prior to delivery of the PEF, a magnitude of applied voltage or energy delivered via the electrode(s) and necessary to achieve desired neuromodulation may be reduced relative to an intravascular PEF system having one or more electrodes positioned solely intravascularly. The methods and apparatus of the present invention may, for example, be used to modulate one or more target neural fibers that contribute to renal function.

    摘要翻译： 提供了通过血管外途径进行脉冲电场神经调节的方法和装置，例如，以实现不可逆的电穿孔或电融合，坏死和/或诱导细胞凋亡，基因表达的改变，细胞因子上调的变化以及目标中的其他条件 神经纤维。 在一些实施方案中，ITEV PEF系统包括具有一个或多个电极的血管内导管，其配置用于穿过患者血管的壁进行血管外放置，使其与目标神经纤维接近。 随着电极在PEF递送之前从血管内位置传递到血管外位置，可以相对于血管内PEF减少施加的电压或通过电极传递并且达到所需神经调节所必需的能量的大小 系统具有仅位于血管内的一个或多个电极。 本发明的方法和装置可以例如用于调节一种或多种有助于肾功能的靶神经纤维。

    Methods and apparatus for intravascularly-induced neuromodulation
    6.
    发明申请
    Methods and apparatus for intravascularly-induced neuromodulation 有权
    血管内诱导神经调节的方法和装置

    公开(公告)号：US20060142801A1

    公开(公告)日：2006-06-29

    申请号：US11266993

    申请日：2005-11-04

    申请人： Denise Demarais ,  Nicolas Zadno ,  Benjamin Clark ,  Erik Thai

    发明人： Denise Demarais ,  Nicolas Zadno ,  Benjamin Clark ,  Erik Thai

    IPC分类号： A61N1/00

    CPC分类号： A61B18/1492 ,  A61B17/12136 ,  A61B2018/00083 ,  A61B2018/00285 ,  A61B2018/00434 ,  A61B2018/00613 ,  A61M25/0108 ,  A61M25/10 ,  A61N1/327 ,  A61N1/36007 ,  A61N1/36121 ,  A61N1/36182 ,  A61N1/37205 ,  A61N1/40

    摘要： Methods and apparatus are provided for intravascularly-induced neuromodulation using a pulsed electric field, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation, etc., in target neural fibers. In some embodiments, the intravascular PEF system comprises a catheter having a pair of bipolar electrodes for delivering the PEF, with a first electrode positioned on a first side of an impedance-altering element and a second electrode positioned on an opposing side of the impedance-altering element. A length of the electrodes, as well as a separation distance between the first and second electrodes, may be specified such that, with the impedance-altering element deployed in a manner that locally increases impedance within a patient's vessel, e.g., with the impedance-altering element deployed into contact with the vessel wall at a treatment site within the patient's vasculature, a magnitude of applied voltage delivered across the bipolar electrodes necessary to achieve desired neuromodulation is reduced relative to an intravascular PEF system having similarly spaced electrodes but no (or an undeployed) impedance-altering element. In a preferred embodiment, the impedance-altering element comprises an inflatable balloon configured to locally increase impedance within a patient's vasculature. The methods and apparatus of the present invention may be used to modulate a neural fiber that contributes to renal function.

    摘要翻译： 提供了使用脉冲电场进行血管内诱导的神经调节的方法和装置，例如，在靶神经纤维中实现不可逆的电穿孔或电融合，坏死和/或诱导细胞凋亡，基因表达的改变，细胞因子上调的变化等 。 在一些实施例中，血管内PEF系统包括导管，其具有用于传送PEF的一对双极电极，第一电极位于阻抗改变元件的第一侧上，第二电极位于阻抗变换元件的相对侧上， 改变元素 可以规定电极的长度以及第一和第二电极之间的间隔距离，使得以阻抗变化元件部署的方式，其局部地增加患者血管内的阻抗，例如阻抗 - 改变元件被部署成与病人血管系统中的治疗部位处的血管壁接触，相对于具有类似间隔开的电极而没有（或一个或多个）的血管内PEF系统，减少了实现所需神经调节所需双极电极的施加电压的大小 未部署）阻抗变化元件。 在优选实施例中，阻抗改变元件包括构造成在患者的脉管系统内局部增加阻抗的可充气球囊。 本发明的方法和装置可用于调节有助于肾功能的神经纤维。

    Fluid ejector device
    8.
    发明授权
    Fluid ejector device 有权
    流体喷射装置

    公开(公告)号：US08042908B2

    公开(公告)日：2011-10-25

    申请号：US11829354

    申请日：2007-07-27

    申请人： Benjamin Clark ,  Jeremy Harlan Donaldson ,  Mark Sanders Taylor ,  Joe E. Stout

    发明人： Benjamin Clark ,  Jeremy Harlan Donaldson ,  Mark Sanders Taylor ,  Joe E. Stout

    IPC分类号： B41J2/135

    CPC分类号： B41J2/1606 ,  C09D163/00 ,  Y10T29/49401

    摘要： A fluid ejector device, including: a fluid nozzle layer defining an orifice therein; and at least one epoxy resin layer established on the nozzle layer, the at least one epoxy resin layer having first and second opposed surfaces with a thickness there between and a fluorine gradient formed therein such that the gradient extends into at least a portion of the thickness of the at least one epoxy resin layer, wherein an amount of a fluorinated species present in the at least one epoxy resin layer at the first opposed surface is greater than an amount of the fluorinated species present in the at least one epoxy resin layer at the second opposed surface that is adjacent the fluid nozzle layer.

    摘要翻译： 一种流体喷射器装置，包括：在其中限定孔口的流体喷嘴层; 以及至少一个环氧树脂层，其建立在所述喷嘴层上，所述至少一个环氧树脂层具有形成在其中的厚度的第一和第二相对表面和形成在其中的氟梯度，使得所述梯度延伸到所述厚度的至少一部分 的至少一个环氧树脂层，其中存在于所述第一相对表面的所述至少一个环氧树脂层中的氟化物质的量大于所述至少一个环氧树脂层中存在的氟化物质的量 与流体喷嘴层相邻的第二相对表面。