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11 条记录 (耗时 0.053 秒)

    ADAM10 and its uses related to infection
    2.
    发明授权
    ADAM10 and its uses related to infection 有权
    ADAM10及其与感染有关的用途

    公开(公告)号：US08247451B2

    公开(公告)日：2012-08-21

    申请号：US12160862

    申请日：2007-01-16

    申请人： Donald H. Rubin ,  Thomas Hodge ,  James Murray

    发明人： Donald H. Rubin ,  Thomas Hodge ,  James Murray

    IPC分类号： A61K31/19 ,  A61K31/18 ,  A61K31/155

    CPC分类号： C12N15/1137 ,  C12N2310/14

    摘要： The present invention relates to a protein, ADAM10, ADAM10 nucleic acid sequences and ADAM10 proteins encoded by these sequences that are involved in infection by one or more pathogen such as a virus, a parasite, a bacteria or a fungus or are otherwise associated with the life cycle of a pathogen.

    摘要翻译： 本发明涉及由这些序列编码的蛋白质，ADAM10，ADAM10核酸序列和ADAM10蛋白质，其涉及一种或多种病原体如病毒，寄生虫，细菌或真菌的感染，或者与 病原体的生命周期。

    Rab9 protein crystal structures and methods for identifying Rab9 modulators
    7.
    发明申请
    Rab9 protein crystal structures and methods for identifying Rab9 modulators 审中-公开
    Rab9蛋白晶体结构和鉴定Rab9调节剂的方法

    公开(公告)号：US20060073582A1

    公开(公告)日：2006-04-06

    申请号：US11154203

    申请日：2005-06-16

    申请人： Edward Meehan ,  Liqing Chen ,  Enrico DiGiammarino ,  Thomas Hodge

    发明人： Edward Meehan ,  Liqing Chen ,  Enrico DiGiammarino ,  Thomas Hodge

    IPC分类号： G01N33/48 ,  C12N9/12 ,  G06F19/00

    CPC分类号： C12N9/16 ,  C07K2299/00 ,  G01N2500/04

    摘要： The present invention relates to crystalline Rab9 in complex with either GDP or the GTP analog Guanosine 5′-(β,γ-imido) triphosphate (GppNHp), the three dimensional coordinates and structures of Rab9 in Rab9-GDP and Rab9-GppNHp complexes, and uses thereof for drug design. In particular, the present invention relates to methods for producing Rab9 crystals of sufficient quality to obtain a determination of the three dimensional structure of Rab9 to a high resolution in both its GTP-bound (on/active) and GDP-bound (off/inactive) conformations. The present invention also relates to a computer-readable medium encoded with the three dimensional coordinates of Rab9 in Rab9-GDP and Rab9-GppNHp complexes wherein, using a graphical display software program, the three dimensional coordinates create an electronic file that can be visualized on a computer capable of representing the electronic file as a three dimensional image.

    摘要翻译： 本发明涉及与GDP或GTP类似物鸟苷5' - （β，γ-亚氨基）三磷酸（GppNHp）复合的结晶Rab9，Rab9-GDP和Rab9-GppNHp复合物中Rab9的三维坐标和结构， 并将其用于药物设计。 特别地，本发明涉及用于生产足够质量的Rab9晶体的方法，以在其GTP结合（开/主动）和GDP-结合（关/非活性）两者中获得Rab9的三维结构确定为高分辨率 ）构象。 本发明还涉及用Rab9-GDP和Rab9-GppNHp复合物中的Rab9的三维坐标编码的计算机可读介质，其中使用图形显示软件程序，三维坐标创建可以在 能够将电子文件表示为三维图像的计算机。

    Heavy-load tires having a rubber composition that delays irregular wear
    8.
    发明授权
    Heavy-load tires having a rubber composition that delays irregular wear 有权
    具有延迟不规则磨损的橡胶组合物的重载轮胎

    公开(公告)号：US06903155B2

    公开(公告)日：2005-06-07

    申请号：US09778144

    申请日：2001-02-07

    申请人： Thomas Hodge

    发明人： Thomas Hodge

    IPC分类号： B60C1/00 ,  C08K3/36 ,  C08K5/5415 ,  C08K5/548 ,  C08L15/00 ,  C08L19/00 ,  C08L83/10 ,  C08K3/34

    CPC分类号： B60C1/0016 ,  C08L19/006

    摘要： The present invention relates to tires suitable for bearing heavy loads, and to the use of a rubber composition to form the treads of such tires which delays the appearance of irregular wear on the treads of such tires during travel. The invention applies to tires for motor vehicles, such as heavy vehicles, construction vehicles or aircraft. The rubber composition comprises: an elastomeric matrix comprising majoritarily at least one diene elastomer having at one or more of its chain ends a functional group which is active for coupling to a reinforcing white filler, a reinforcing filler comprising at least 50% by weight a reinforcing white filler, and a reinforcing white filler/functionalized diene elastomer bonding agent. The present invention relates to tires suitable for bearing heavy loads, and to the use of the rubber composition to delay the appearance of irregular wear on the treads of such tires during travel. The invention applies to tires for motor vehicles, such as heavy vehicles, construction vehicles or aircraft.

    摘要翻译： 本发明涉及适于承载重载荷的轮胎，以及使用橡胶组合物来形成这种轮胎的胎面，其在行驶期间延迟了这种轮胎的胎面上的不规则磨损的外观。 本发明适用于机动车辆的轮胎，例如重型车辆，工程车辆或飞行器。 橡胶组合物包括：弹性体基体，其包含主要至少一种二烯弹性体，其在其一个或多个末端具有活性物质以与加强白色填料偶联的增强填料，所述增强填料包含至少50重量％ 白色填料和增强白色填料/官能化二烯弹性体粘结剂。 本发明涉及适于承载重载荷的轮胎，以及使用该橡胶组合物来延迟行驶期间这种轮胎的胎面上的不规则磨损的外观。 本发明适用于机动车辆的轮胎，例如重型车辆，工程车辆或飞行器。

    Cell lines and host nucleic acid sequences related to infectious disease
    9.
    发明申请
    Cell lines and host nucleic acid sequences related to infectious disease 有权
    与感染性疾病相关的细胞系和宿主核酸序列

    公开(公告)号：US20060257872A1

    公开(公告)日：2006-11-16

    申请号：US10535523

    申请日：2003-11-18

    申请人： Thomas Hodge ,  Natalie McDonald ,  Michael Shaw ,  Donald Rubin ,  Anthony Sanchez

    发明人： Thomas Hodge ,  Natalie McDonald ,  Michael Shaw ,  Donald Rubin ,  Anthony Sanchez

    IPC分类号： C12Q1/68 ,  C12P21/06

    CPC分类号： C07K14/47 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/18 ,  G01N33/56983 ,  G01N2500/02

    摘要： Host nucleic acids and host proteins that participate in viral infection, such as human immunodeficiency virus (HIV), influenza A, and Ebola virus, have been identified. Interfering with or disrupting the interaction between a host nucleic acid or host protein and a virus or viral protein confers an inhibition of or resistance to infection. Thus, interfering with such an interaction in a host subject can confer a therapeutic or prophylactic effect against a virus. The sequences identified can be used to identify agents that reduce or inhibit viral infection.

    摘要翻译： 已经鉴定了参与病毒感染的宿主核酸和宿主蛋白，例如人类免疫缺陷病毒（HIV），甲型流感和埃博拉病毒。 干扰或破坏宿主核酸或宿主蛋白与病毒或病毒蛋白质之间的相互作用赋予对感染的抑制或抗性。 因此，干扰宿主受试者中的这种相互作用可以赋予针对病毒的治疗或预防效果。 鉴定的序列可用于鉴定减少或抑制病毒感染的试剂。

    MAMMALIAN GENES INVOLVED IN INFECTION
    10.
    发明申请
    MAMMALIAN GENES INVOLVED IN INFECTION 审中-公开
    涉及感染的MAMMALIAN基因

    公开(公告)号：US20140220690A1

    公开(公告)日：2014-08-07

    申请号：US13877247

    申请日：2010-10-28

    申请人： Donald Rubin ,  Thomas Hodge ,  Robert Jeffrey Hogan

    发明人： Donald Rubin ,  Thomas Hodge ,  Robert Jeffrey Hogan

    IPC分类号： C12N15/85

    CPC分类号： A61K31/40

    摘要： The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of one or more pathogens.

    摘要翻译： 本发明涉及由这些序列编码的涉及感染或以其它方式与一种或多种病原体的生命周期相关的核酸序列和细胞蛋白质。