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    Method of preparing a poorly crystalline calcium phosphate and methods of its use
    1.
    发明授权
    Method of preparing a poorly crystalline calcium phosphate and methods of its use 失效
    制备结晶不良的磷酸钙的方法及其使用方法

    公开(公告)号：US07517539B1

    公开(公告)日：2009-04-14

    申请号：US09284297

    申请日：1997-10-16

    申请人： Dosuk D. Lee ,  Christian Rey ,  Maria Aiolova ,  Aliassghar Tofighi

    发明人： Dosuk D. Lee ,  Christian Rey ,  Maria Aiolova ,  Aliassghar Tofighi

    IPC分类号： A61K47/04

    CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61F2002/30062 ,  A61F2002/30762 ,  A61F2002/4648 ,  A61F2210/0004 ,  A61F2310/00293 ,  A61K9/2009 ,  A61L24/02 ,  A61L27/12 ,  A61L27/38 ,  A61L27/42 ,  A61L27/425 ,  A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/256 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/44 ,  A61L2300/452 ,  A61L2400/06 ,  A61L2430/02 ,  C01B25/16 ,  C01B25/32 ,  C01B25/321 ,  C01B25/325 ,  Y02P30/48

    摘要： The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable. A method for treating a bone defect also is provided by identifying a bone site suitable for receiving an implant, and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant site. The implant site may be a variety of sites, such as a tooth socket, non-union bone, bone prosthesis, an osteoporotic bone, an intervertebral space, an alveolar ridge or a bone fracture.

    摘要翻译： 本发明提供了一种用于生产与吸热反应相关的以温度依赖的方式硬化的磷酸钙水泥或填料的新方法。 在反应中，将有限量的水与干燥的磷酸钙前体混合以产生水合前体浆料。 糊状物的硬化在体温下快速发生，伴随着一种或多种反应物转化为结晶不良的磷灰石磷酸钙。 本发明的硬化水泥，填料，生长基质，矫形和递送装置可快速吸收并刺激硬组织的生长和愈合。 提供了一种复合材料，其包括强生物可再吸收，结晶不良的磷灰石复合材料和补充材料。 补充材料与羟基磷灰石材料紧密接触，其量有效地赋予复合材料所选择的特性。 补充材料可以是生物相容的，生物可再吸收的或不可再吸收的。 通过鉴定适于接收植入物的骨部位，以及在植入部位引入强吸收不良结晶的磷灰石磷酸钙，从而在植入部位形成骨，提供了治疗骨缺损的方法。 植入部位可以是各种部位，例如牙槽，非联合骨，骨假体，骨质疏松的骨，椎间隙，牙槽嵴或骨折。

    Neutral self-setting calcium phosphate paste
    2.
    发明授权
    Neutral self-setting calcium phosphate paste 有权
    中性自制磷酸钙糊

    公开(公告)号：US07150879B1

    公开(公告)日：2006-12-19

    申请号：US09569081

    申请日：2000-05-11

    申请人： Dosuk D. Lee ,  Christian Rey ,  Maria Aiolova ,  Aliassghar Tofighi

    发明人： Dosuk D. Lee ,  Christian Rey ,  Maria Aiolova ,  Aliassghar Tofighi

    IPC分类号： A61F13/00

    CPC分类号： A61L27/46 ,  A61L27/58

    摘要： The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature an is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing.

    摘要翻译： 本发明提供了一种用于生产与吸热反应相关的以温度依赖的方式硬化的磷酸钙水泥或填料的新方法。 在反应中，将有限量的水与干燥的磷酸钙前体混合以产生水合前体浆料。 糊状物的硬化在体温下迅速发生，伴随着一种或多种反应物转化为结晶不良的磷灰石磷酸钙。 本发明的硬化水泥，填料，生长基质，矫形和递送装置可快速吸收并刺激硬组织的生长和愈合。

    Method of preparing a poorly crystalline calcium phosphate and methods of its use
    5.
    发明授权
    Method of preparing a poorly crystalline calcium phosphate and methods of its use 有权
    制备结晶不良的磷酸钙的方法及其使用方法

    公开(公告)号：US06953594B2

    公开(公告)日：2005-10-11

    申请号：US09993739

    申请日：2001-11-23

    申请人： Dosuk D. Lee ,  Christian Rey ,  Maria Aiolova ,  Aliassghar Tofighi

    发明人： Dosuk D. Lee ,  Christian Rey ,  Maria Aiolova ,  Aliassghar Tofighi

    IPC分类号： A61F2/00 ,  A61L27/12 ,  A61L27/42 ,  A61K33/42

    CPC分类号： A61L27/425 ,  A61F2310/00293 ,  A61L27/12 ,  A61L2430/02 ,  Y10T428/2991 ,  Y10T428/2993

    摘要： The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable. A method for treating a bone defect also is provided by identifying a bone site suitable for receiving an implant, and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant site. The implant site may be a variety of sites, such as a tooth socket, non-union bone, bone prosthesis, an osteoporotic bone, an intervertebral space, an alveolar ridge or a bone fracture.

    摘要翻译： 本发明提供了一种用于生产与吸热反应相关的以温度依赖的方式硬化的磷酸钙水泥或填料的新方法。 在反应中，将有限量的水与干燥的磷酸钙前体混合以产生水合前体浆料。 糊状物的硬化在体温下快速发生，伴随着一种或多种反应物转化为结晶不良的磷灰石磷酸钙。 本发明的硬化水泥，填料，生长基质，矫形和递送装置可快速吸收并刺激硬组织的生长和愈合。 提供了一种复合材料，其包括强生物可再吸收，结晶不良的磷灰石复合材料和补充材料。 补充材料与羟基磷灰石材料紧密接触，其量有效地赋予复合材料所选择的特性。 补充材料可以是生物相容的，生物可再吸收的或不可再吸收的。 通过鉴定适于接收植入物的骨部位，以及在植入部位引入强吸收不良结晶的磷灰石磷酸钙，从而在植入部位形成骨，提供了治疗骨缺损的方法。 植入部位可以是各种部位，例如牙槽，非联合骨，骨假体，骨质疏松的骨，椎间隙，牙槽嵴或骨折。