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    Osteoinductive bone material
    1.
    发明授权
    Osteoinductive bone material 有权
    骨诱导骨材料

    公开(公告)号：US08221781B2

    公开(公告)日：2012-07-17

    申请号：US10822540

    申请日：2004-04-12

    申请人： Aron D. Rosenberg ,  Laurent D. Gilles de Pelichy ,  Daniel Egan ,  Aliassghar N. Tofighi ,  Dosuk D. Lee

    发明人： Aron D. Rosenberg ,  Laurent D. Gilles de Pelichy ,  Daniel Egan ,  Aliassghar N. Tofighi ,  Dosuk D. Lee

    IPC分类号： A61F2/28 ,  A61F2/26

    CPC分类号： A61L27/3608 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2310/00293 ,  A61F2310/00359 ,  A61L27/227 ,  A61L27/26 ,  A61L27/34 ,  A61L27/365 ,  A61L27/46 ,  A61L27/48 ,  A61L2430/02 ,  C08L89/00

    摘要： Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo. Methods for using these implant materials to repair damaged bone and a method of assaying the content of DBM particles, by weight, in a bone implant material are also provided.

    摘要翻译： 提供了近似天然骨骼化学成分的成骨骨植入组合物。 这些植入物组合物的有机组分是骨诱导的，尽管存在无机组分，并且还存在足以使植入物的再生能力最大化的量，而不损害其成形性和机械强度。 组合物可以是骨诱导性粉末，包括软化骨基质（DBM）颗粒，磷酸钙粉末和任选的生物相容性粘合剂。 粉末可以与生理上可接受的流体组合以产生可成形的骨诱导性浆料，其自硬化以形成具有显着抗压强度的不良结晶磷灰石（PCA）磷酸钙。 骨植入材料在植入部位引入时保持其内聚性，并在体内重塑成骨。 还提供了使用这些植入材料修复受损骨的方法以及测定骨植入材料中重量的DBM颗粒含量的方法。

    Method of preparing a poorly crystalline calcium phosphate and methods of its use
    4.
    发明授权
    Method of preparing a poorly crystalline calcium phosphate and methods of its use 失效
    制备结晶不良的磷酸钙的方法及其使用方法

    公开(公告)号：US07517539B1

    公开(公告)日：2009-04-14

    申请号：US09284297

    申请日：1997-10-16

    申请人： Dosuk D. Lee ,  Christian Rey ,  Maria Aiolova ,  Aliassghar Tofighi

    发明人： Dosuk D. Lee ,  Christian Rey ,  Maria Aiolova ,  Aliassghar Tofighi

    IPC分类号： A61K47/04

    CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61F2002/30062 ,  A61F2002/30762 ,  A61F2002/4648 ,  A61F2210/0004 ,  A61F2310/00293 ,  A61K9/2009 ,  A61L24/02 ,  A61L27/12 ,  A61L27/38 ,  A61L27/42 ,  A61L27/425 ,  A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/256 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/44 ,  A61L2300/452 ,  A61L2400/06 ,  A61L2430/02 ,  C01B25/16 ,  C01B25/32 ,  C01B25/321 ,  C01B25/325 ,  Y02P30/48

    摘要： The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable. A method for treating a bone defect also is provided by identifying a bone site suitable for receiving an implant, and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant site. The implant site may be a variety of sites, such as a tooth socket, non-union bone, bone prosthesis, an osteoporotic bone, an intervertebral space, an alveolar ridge or a bone fracture.

    摘要翻译： 本发明提供了一种用于生产与吸热反应相关的以温度依赖的方式硬化的磷酸钙水泥或填料的新方法。 在反应中，将有限量的水与干燥的磷酸钙前体混合以产生水合前体浆料。 糊状物的硬化在体温下快速发生，伴随着一种或多种反应物转化为结晶不良的磷灰石磷酸钙。 本发明的硬化水泥，填料，生长基质，矫形和递送装置可快速吸收并刺激硬组织的生长和愈合。 提供了一种复合材料，其包括强生物可再吸收，结晶不良的磷灰石复合材料和补充材料。 补充材料与羟基磷灰石材料紧密接触，其量有效地赋予复合材料所选择的特性。 补充材料可以是生物相容的，生物可再吸收的或不可再吸收的。 通过鉴定适于接收植入物的骨部位，以及在植入部位引入强吸收不良结晶的磷灰石磷酸钙，从而在植入部位形成骨，提供了治疗骨缺损的方法。 植入部位可以是各种部位，例如牙槽，非联合骨，骨假体，骨质疏松的骨，椎间隙，牙槽嵴或骨折。

    Osteoinductive bone material
    5.
    发明申请
    Osteoinductive bone material 有权
    骨诱导骨材料

    公开(公告)号：US20080188946A1

    公开(公告)日：2008-08-07

    申请号：US12009888

    申请日：2008-01-23

    申请人： Aron D. Rosenberg ,  Laurent D. Gilles de Pelichy ,  Daniel Egan ,  Aliassghar N. Tofighi ,  Dosuk D. Lee ,  Youngmi M. Lee

    发明人： Aron D. Rosenberg ,  Laurent D. Gilles de Pelichy ,  Daniel Egan ,  Aliassghar N. Tofighi ,  Dosuk D. Lee ,  Youngmi M. Lee

    IPC分类号： A61F2/28

    CPC分类号： A61L27/3608 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2310/00293 ,  A61F2310/00359 ,  A61L27/227 ,  A61L27/26 ,  A61L27/34 ,  A61L27/365 ,  A61L27/46 ,  A61L27/48 ,  A61L2430/02 ,  C08L89/00

    摘要： Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo. Methods for using these implant materials to repair damaged bone and a method of assaying the content of DBM particles, by weight, in a bone implant material are also provided.

    摘要翻译： 提供了近似天然骨骼化学成分的成骨骨植入组合物。 这些植入物组合物的有机组分是骨诱导的，尽管存在无机组分，并且还存在足以使植入物的再生能力最大化的量，而不损害其成形性和机械强度。 组合物可以是骨诱导性粉末，包括软化骨基质（DBM）颗粒，磷酸钙粉末和任选的生物相容性粘合剂。 粉末可以与生理上可接受的流体组合以产生可成形的骨诱导性浆料，其自硬化以形成具有显着抗压强度的不良结晶磷灰石（PCA）磷酸钙。 骨植入材料在植入部位引入时保持其内聚性，并在体内重塑成骨。 还提供了使用这些植入材料修复受损骨的方法以及测定骨植入材料中重量的DBM颗粒含量的方法。

    Neutral self-setting calcium phosphate paste
    9.
    发明授权
    Neutral self-setting calcium phosphate paste 有权
    中性自制磷酸钙糊

    公开(公告)号：US07150879B1

    公开(公告)日：2006-12-19

    申请号：US09569081

    申请日：2000-05-11

    申请人： Dosuk D. Lee ,  Christian Rey ,  Maria Aiolova ,  Aliassghar Tofighi

    发明人： Dosuk D. Lee ,  Christian Rey ,  Maria Aiolova ,  Aliassghar Tofighi

    IPC分类号： A61F13/00

    CPC分类号： A61L27/46 ,  A61L27/58

    摘要： The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature an is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing.

    摘要翻译： 本发明提供了一种用于生产与吸热反应相关的以温度依赖的方式硬化的磷酸钙水泥或填料的新方法。 在反应中，将有限量的水与干燥的磷酸钙前体混合以产生水合前体浆料。 糊状物的硬化在体温下迅速发生，伴随着一种或多种反应物转化为结晶不良的磷灰石磷酸钙。 本发明的硬化水泥，填料，生长基质，矫形和递送装置可快速吸收并刺激硬组织的生长和愈合。