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    ELUTION OF METAL IONS FROM CHELATING RESIN USING AMINO ACID ELUANT
    2.
    发明申请
    ELUTION OF METAL IONS FROM CHELATING RESIN USING AMINO ACID ELUANT 有权
    使用氨基酸溶液从粘合树脂中提取金属离​​子

    公开(公告)号：US20150175728A1

    公开(公告)日：2015-06-25

    申请号：US14414815

    申请日：2013-08-13

    申请人： Dow Global Technologies LLC ,  Rohm and Haas Company

    发明人： Charles R. Marston ,  Stephen M. Smith ,  Matthew L. Rodgers ,  Karen S. Eastman

    IPC分类号： C08F212/36 ,  C08F212/08 ,  B01D15/38

    CPC分类号： C08F212/36 ,  B01D15/3828 ,  B01J45/00 ,  B01J49/50 ,  C08F212/08 ,  C22B3/42 ,  Y02P10/234

    摘要： A method of eluting metal ions from a bed of metal-loaded chelating resin wherein the resin includes a crosslinked styrene-divinylbenzene copolymer matrix with pendent methyleneaminopyridine or phosphonic acid groups and the method includes the step of passing an eluant through the bed to at least partially remove the metal ions from the chelating resin and create a metal-rich eluate, wherein the eluant includes an aqueous solution comprising an amino acid compound having a molecular weight less than 500 Daltons.

    摘要翻译： 一种从金属负载的螯合树脂床中洗脱金属离子的方法，其中树脂包括具有侧链亚甲基氨基吡啶或膦酸基团的交联的苯乙烯 - 二乙烯基苯共聚物基质，并且该方法包括使洗脱剂通过床至少部分地 从螯合树脂中除去金属离子并产生富含金属的洗脱液，其中洗脱剂包括含有分子量小于500道尔顿的氨基酸化合物的水溶液。

    Methods and systems for conducting pari-mutuel wagers
    3.
    发明授权
    Methods and systems for conducting pari-mutuel wagers 有权
    进行同伴投注的方法和制度

    公开(公告)号：US08033911B2

    公开(公告)日：2011-10-11

    申请号：US10982546

    申请日：2004-11-05

    申请人： Kenneth A. Vlazny ,  Joseph J. Tracy ,  Victor I. Harrison ,  Stephen M. Smith ,  Mark G. Meyer

    发明人： Kenneth A. Vlazny ,  Joseph J. Tracy ,  Victor I. Harrison ,  Stephen M. Smith ,  Mark G. Meyer

    IPC分类号： A63F9/24 ,  A63F13/00 ,  G06F17/00 ,  G06F19/00

    CPC分类号： G06Q50/34 ,  G06Q40/025 ,  G06Q40/04 ,  G07F17/32 ,  G07F17/3288

    摘要： The present invention provides methods and systems of conducting wagers, such as pari-mutuel wagers. In one exemplary embodiment, an event, such as a horse race, dog race, a combination of races, etc., is identified for which a plurality of bettors may each place at least one wager. Each bettor of the plurality is enabled to provide input regarding at least one portion of their respective at least one wager prior to the event. At least one other portion of each bettor's at least one wager is randomized prior to the event. The wager then comprises the combination of the bettor selected portion and randomized portion. In one exemplary embodiment, the player selected portion may include selecting bettor-preferred participants of the event while the randomly selected portion may include the randomly assigning a finishing order to the player selected participants.

    摘要翻译： 本发明提供了进行投注的方法和系统，例如同时投注。 在一个示例性实施例中，识别诸如赛马，狗赛，种族的组合等的事件，其中多个投注者可以各自放置至少一个下注。 在事件之前，多个的每个下注者能够提供关于它们各自的至少一个下注的至少一部分的输入。 每个投注者的至少一个赌注的至少一个其他部分在事件之前被随机化。 赌注然后包括投注者选择部分和随机化部分的组合。 在一个示例性实施例中，玩家选择的部分可以包括选择事件的优先参与者，而随机选择的部分可以包括随机地向玩家选择的参与者分配完成顺序。

    Methods and systems for conducting parimutuel wagers
    4.
    发明授权
    Methods and systems for conducting parimutuel wagers 有权
    进行对妇女投注的方法和制度

    公开(公告)号：US07883411B2

    公开(公告)日：2011-02-08

    申请号：US10704533

    申请日：2003-11-07

    申请人： Kenneth A. Vlazny ,  Joseph J. Tracy ,  Victor I. Harrison ,  Jeffery B. Murphy ,  Stephen M. Smith

    发明人： Kenneth A. Vlazny ,  Joseph J. Tracy ,  Victor I. Harrison ,  Jeffery B. Murphy ,  Stephen M. Smith

    IPC分类号： A63F9/24 ,  A63F13/00 ,  G06F17/00 ,  G06F19/00

    CPC分类号： G06Q50/34 ,  G06Q40/025 ,  G06Q40/04 ,  G07F17/32 ,  G07F17/3288

    摘要： The present invention contemplates methods and systems of conducting wagers, such as parimutuel wagers. In one exemplary embodiment an event, such as a horse race, dog race, a combination of races, etc., is identified for which a plurality of bettors may each place at least one wager. Each bettor of the plurality is enabled to provide input regarding at least one portion of their respective at least one wager prior to the event. At least one other portion of each bettor's at least one wager is randomized prior to the event. The wager then comprises the combination of the bettor-selected portion and randomized portion. In one exemplary embodiment, the player-selected portion may include selecting bettor-preferred participants of the event while the randomly selected portion may include randomly assigning a finishing order to the player-selected participants.

    摘要翻译： 本发明考虑了进行下注的方法和系统，例如parimutuel投注。 在一个示例性实施例中，识别诸如赛马，狗赛，种族的组合等的事件，其中多个投注者可以各自投放至少一个下注。 在事件之前，多个的每个下注者能够提供关于它们各自的至少一个下注的至少一部分的输入。 每个投注者的至少一个赌注的至少一个其他部分在事件之前被随机化。 赌注然后包括下注者选择部分和随机化部分的组合。 在一个示例性实施例中，玩家选择的部分可以包括选择事件的优先参与者，而随机选择的部分可以包括向玩家选择的参与者随机分配完成顺序。

    Methods and systems for presenting pari-mutuel betting options and constructing wagers
    5.
    发明授权
    Methods and systems for presenting pari-mutuel betting options and constructing wagers 有权
    提供同盟投注选择和建立投注的方法和系统

    公开(公告)号：US08292729B2

    公开(公告)日：2012-10-23

    申请号：US10727154

    申请日：2003-12-02

    申请人： Kenneth A. Vlazny ,  Scott B. Pfennighausen ,  Stephen M. Smith ,  Joseph J. Tracy ,  Victor I. Harrison

    发明人： Kenneth A. Vlazny ,  Scott B. Pfennighausen ,  Stephen M. Smith ,  Joseph J. Tracy ,  Victor I. Harrison

    IPC分类号： A63F9/24

    CPC分类号： G07F17/32 ,  G07F17/3288

    摘要： Methods and systems of pari-mutuel wagering are disclosed to facilitate the wager construction process. In one method, patrons select runners, and betting options of selected runners are presented. In another method, a first wager is placed and other wagers are presented, wherein the additional wagers may include a runner of the first wager. Another method allows patrons to wager on a runner, wherein an area representing the runner is marked to indicate that this runner was selected on a previous wager or in the current wager. In another method, a portion of a wager is patron selected and a portion of the wager is suggested by the betting interface. In another method, patrons may construct wager(s) for single or future races, or specify criteria for those wagers. In another method, runners are displayed in a table and patrons may select or deselect runner combinations by selecting cells within the table. Methods and systems of pari-mutuel wagering that enable an organization to set rules to display the gaming activity, and an embodiment where players make subscription as well as programmed bets are described.

    摘要翻译： 公开了同时投注的方法和系统，以便于下注建设过程。 在一种方法中，顾客选择跑步者，并且呈现所选跑步者的投注选项。 在另一种方法中，放置第一投注和呈现其他投注，其中附加投注可以包括第一投注者的转牌。 另一种方法允许顾客在跑步者上投注，其中代表跑步者的区域被标记以指示在以前的下注或当前下注中选择了该选手。 在另一种方法中，投注的一部分被选中，并且投注的一部分由投注界面建议。 在另一种方法中，顾客可以为单一或未来的种族构建投注，或者为这些投注规定标准。 在另一种方法中，跑步者显示在表中，顾客可以通过选择表中的单元格来选择或取消选择赛跑者组合。 描述了使组织能够设置显示游戏活动的规则的同步赌注的方法和系统，以及玩家进行订阅以及编程赌注的实施例。

    DEVICE, SYSTEM AND METHOD FOR LOAD TRANSPORT
    6.
    发明申请
    DEVICE, SYSTEM AND METHOD FOR LOAD TRANSPORT 审中-公开
    装载，系统和负载运输方法

    公开(公告)号：US20090028679A1

    公开(公告)日：2009-01-29

    申请号：US12171522

    申请日：2008-07-11

    申请人： Stephen M. Smith

    发明人： Stephen M. Smith

    IPC分类号： B60P9/00

    CPC分类号： B60P1/4421 ,  B60R9/06 ,  B66F9/06 ,  B66F9/075 ,  B66F9/12

    摘要： A load transport device that mounts to a vehicle mounted trailer hitch. The load transport system comprises a channel portion fitted with a pinion gear, and the channel portion is rigidly attached to a mounting bar that slideably engages a receiver portion of a vehicle's trailer hitch. The device also comprises an invertible shaft with an optionally-motorized rack gear system. The invertible shaft has a channel portion insertion end and a load lifting end. The invertible shaft slideably engages in either a load-low or load-high orientation depending on which end, the insertion end or the load lifting end first engages with the channel portion. The pinion gear and the rack gear system are functionally engaged. The load transport device further comprises a load support member attached to the load lifting end and comprising one or more bars that support a load.

    摘要翻译： 一种装载到车辆挂车挂车上的装载运输装置。 负载传送系统包括配有小齿轮的通道部分，并且通道部分刚性地附接到可滑动地接合车辆拖车挂钩的接收器部分的安装杆。 该装置还包括具有任选地机动的齿条系统的可逆轴。 可逆轴具有通道部分插入端和负载提升端。 可逆轴可滑动地接合负载低或负载高的方向，取决于该端，插入端或负载提升端首先与通道部分接合。 小齿轮和齿条系统功能接合。 负载传送装置还包括附接到负载提升端并且包括支撑负载的一个或多个杆的负载支撑构件。

    Methods for making and implementing fluid delivery ring
    7.
    发明授权
    Methods for making and implementing fluid delivery ring 有权
    制造和实施流体输送环的方法

    公开(公告)号：US07040017B2

    公开(公告)日：2006-05-09

    申请号：US10251483

    申请日：2002-09-19

    申请人： Stephen M. Smith ,  Randolph E. Treur

    发明人： Stephen M. Smith ,  Randolph E. Treur

    IPC分类号： B21K21/08 ,  B05B1/14

    CPC分类号： H01L21/67051 ,  B08B3/02 ,  Y10S134/902 ,  Y10T29/49432 ,  Y10T29/49433

    摘要： A fluid delivery module for use in preparing a substrate is provided. The fluid delivery module includes a process bowl designed to contain a substrate to be prepared. The process bowl has a bottom wall and a sidewall. The fluid delivery module further includes a fluid delivery ring configured to be attached to the sidewall of the process bowl. The fluid delivery ring includes a plurality of inlet and outlet pairs. Each of the plurality of inlet and outlet pairs is defined in the fluid ring and is designed to receive a respective supply tube. Each respective supply tube has an end that terminates at each of the outlets of the fluid delivery ring and is configured to direct fluid onto a surface of the substrate.

    摘要翻译： 提供了一种用于制备基板的流体输送模块。 流体输送模块包括设计成容纳要制备的基底的处理碗。 处理碗具有底壁和侧壁。 流体输送模块还包括流体输送环，该流体输送环被配置为附接到处理碗的侧壁。 流体输送环包括多个入口和出口对。 多个入口和出口对中的每一个限定在流体环中并且被设计成容纳相应的供给管。 每个相应的供应管具有终止于流体输送环的每个出口处的端部，并且构造成将流体引导到基板的表面上。

    Conditionally controlled, attenuated HIV vaccine
    8.
    发明授权
    Conditionally controlled, attenuated HIV vaccine 失效
    减毒多西环素诱导型人类免疫缺陷病毒原病毒分子克隆

    公开(公告)号：US06541003B1

    公开(公告)日：2003-04-01

    申请号：US09624964

    申请日：2000-07-25

    申请人： Stephen M. Smith

    发明人： Stephen M. Smith

    IPC分类号： A61K3921

    CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5254 ,  C12N7/00 ,  C12N15/85 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16043 ,  C12N2740/16051 ,  C12N2830/003

    摘要： A live attenuated human immunodeficiency virus type 1 (HIV-1) whose replication is not constitutive but is instead conditionally regulated (such that rounds of reverse transcription with accompanying potential for error are strictly limited) might yield a paradigm that minimizes evolution to virulence and facilitate vaccine development. We have broached the concept of conditional control of HIV-1 through gain-of-function. Here, we describe the design of constitutively inactive HIV-1 genomes (HIV-DoxT and HIV-DoxSp) which can be conditionally resuscitated to an active state by tetracycline or related analogues. The HIV-DoxT construct comprises an inactivating mutation engineered into TAR, thereby rendering the virus non-responsive to Tat, a 302-bp DNA fragment (TetopT) which contains the tet-operator ligated into a position upstream of the HIV TATAA box, in both the 5′ and 3′ LTRs, and a reverse tetracycline-controlled activator (RTTA) coding sequence in place of the nef coding region. The HIV-DoxSp construct contains three additional Sp1 sites in the TetopT promoter upstream of the TATAA box thereby generating the promoter TetopSp. Genotypically, HIVDoxT is tat(+)tar(−)nef(−)Sp1(−) and HIVDoxSp is tat(+)tar(−)nef(−)Sp1(+). Since both genomes are genetically tar(−), they would ordinarily be expected to be wholly defective in producing viral proteins and/or particles. However, following transfection into an appropriate cell target, both proviruses, in a doxycycline-dependent fashion, capably released Gag and RT from cells. In the absence of doxycycline, no replication competent virus could be recovered. These findings suggest that the heterologous RTTA+Dox mechanism substituted effectively for Tat/TAR. These constructs should prove useful in the development of HIV-specific immunological and diagnostic reagents.

    摘要翻译： 一种减毒的人类免疫缺陷病毒1型（HIV-1），其复制不是组成型的，而是有条件地调节（使得具有伴随的误差潜力的逆转录循环被严格限制）可能产生使进化为毒力最小化的方式 疫苗开发。 我们通过功能增强来阐述了有条件地控制艾滋病毒1的概念。 在这里，我们描述了组成型无活性的HIV-1基因组（HIV-DoxT和HIV-DoxSp）的设计，其可以通过四环素或相关类似物有条件地复苏为活性状态。 HIV-DoxT构建体包含工程化成TAR的失活突变体，从而使病毒对Tat具有不敏感性，Tat是一种302bp的DNA片段（TetopT），其包含连接到HIV TATAA盒上游位置的tet操纵子， 5'和3'LTR以及反向四环素控制的激活子（RTTA）编码序列代替nef编码区。 HIV-DoxSp构建体在TATAA盒上游的TetopT启动子中含有三个额外的Sp1位点，从而产生启动子TetopSp。 基因型，HIVDoxT是tat（+）焦油（ - ）nef（ - ）Sp1（ - ）和HIVDoxSp是tat（+）焦油（ - ）nef（ - ）Sp1（+）。 由于两种基因组都是基因型焦油（ - ），因此通常预计在产生病毒蛋白和/或颗粒方面完全缺陷。 然而，在转染到合适的细胞靶之后，两种前病毒以强力霉素依赖的方式从细胞中有效释放Gag和RT。 在没有多西环素的情况下，不能恢复可复制的病毒。 这些发现表明异源RTTA + Dox机制有效地替代了Tat / TAR。 这些构建体在HIV特异性免疫和诊断试剂的开发中应该是有用的。