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公开(公告)号：US20200061495A1
公开(公告)日：2020-02-27
申请号：US16610595
申请日：2018-04-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , John Caulmare , Melissa Holstein , Kristen Cotoni , Christopher Gillespie
Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
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2.发明申请公开(公告)号：US20200172568A1
公开(公告)日：2020-06-04
申请号：US16610616
申请日：2018-04-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , John Caulmare , Luc Messier , Melissa Holstein , Christopher Gillespie , Roger Hill
Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
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Patent Agency Ranking
公开(公告)号：US11547957B2
公开(公告)日：2023-01-10
申请号：US16610595
申请日：2018-04-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , John Caulmare , Melissa Holstein , Kristen Cotoni , Christopher Gillespie
Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
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4.发明授权公开(公告)号：US11732003B2
公开(公告)日：2023-08-22
申请号：US16610616
申请日：2018-04-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , John Caulmare , Luc Messier , Melissa Holstein , Christopher Gillespie , Roger Hill
CPC classification number: C07K1/22 , A61L2/0088 , A61L2/26 , B01D15/245 , B01D15/361 , B01D15/3809 , B01L3/502 , C12N7/00 , A61L2202/21 , B01L2400/0481 , B01L2400/082 , C12N2740/10063 , C12N2740/10064 , C12N2795/00063 , C12N2795/00064
Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
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公开(公告)号：US20210047430A1
公开(公告)日：2021-02-18
申请号：US17088659
申请日：2020-11-04
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Chia-Yun Sun , Melissa Holstein , Kristen Cotoni , Matthew T. Stone , Santosh Rahane
IPC: C07K16/34 , C07K1/22 , B01D15/38 , B01D15/42 , B01D15/20 , B01J20/289 , B01J20/285 , B01J20/32
Abstract: Embodiments described herein relate to novel chromatography media for removing anti-A and/or anti-B antibodies from a sample, as well as methods of using the same. The media described herein have several advantages over previously described media including, acid and alkaline stability.
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公开(公告)号：US10472389B2
公开(公告)日：2019-11-12
申请号：US14768254
申请日：2014-03-07
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Melissa Holstein
Abstract: The present invention provides methods for increasing purity of an Fc-containing protein by removing protein aggregates during the Protein A chromatography step used during the purification of the Fc-containing protein.
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7.发明申请METHODS OF INCREASING PROTEIN PURITY USING PROTEIN A BASED CHROMATOGRAPHY 审中-公开使用基于蛋白质的色谱法增加蛋白质纯度的方法公开(公告)号：US20160122385A1
公开(公告)日：2016-05-05
申请号：US14768254
申请日：2014-03-07
Applicant: EMD MILLIPORE CORPORATION
Inventor： Nanying Bian , Melissa Holstein
Abstract: The present invention provides methods for increasing purity of an Fc-containing protein by removing protein aggregates during the Protein A chromatography step used during the purification of the Fc-containing protein.
Abstract translation: 本发明提供了在纯化含Fc蛋白质期间使用的蛋白A色谱步骤期间通过除去蛋白质聚集体来提高含Fc蛋白质的纯度的方法。
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