摘要:
The transosseous spinal core approach (TOSCA) represents a novel approach to the interior of the spine or disc space by removing a core from a first bone and performing a procedure, and/or making further enlargements and cuts in the first bone and performing a procedure, and/or making another cut into an adjacent disc space from the first bone hole and performing a procedure and/or continuing by cutting into another second bone and performing a procedure. The process can be further extended into additional spine levels by extending the cutting process. A core can be made at more than one level. The preferred surgical approach is a posterior lateral approach. An anterior surgical approach can be used as well. Any practical surgical approach or any combination of surgical approaches can be utilized to gain access to the first bone. Once the surgical soft tissue access to the first bone is completed TOSCA can be used to gain access to the interior of a vertebral body or disc space. After the procedure is completed in a vertebral body or disc space, usually at least a portion of the bone core is replaced to fill in the core hole.
摘要:
Aging, injury and/or other pathologies of joints, especially weight bearing joints, contribute to changes in natural biomechanics. Deviations from optimal biomechanics lead to acceleration of the natural history of joint pathology and ultimately osteoarthritis. A Magnetic Vector Control System made up of an assembly of magnetic field sources can be disposed at or near a joint typically on or in adjacent bones of the joint, on one side of a first mechanical axis that creates a torque or moment about a second different axis of the joint, that intersects the first mechanical axis, to decrease the joint reactive force at the joint surface or equivalently substantially shift the first mechanical axis to a new or preferred position.
摘要:
The Annulus Fibrosus Stent (AFS) is a platform of barriers used in the intervertebral disc. The barrier can be inserted into an intervertebral disc to act to reinforce and/or supplement the disc. The AFS can be inserted at any of the many different stages of disc pathology. The AFS can be inserted to prevent pressure and dissection of disc material which in and of itself can decrease and/or eliminate pain from damaged AF fibers. The AFS can be inserted before disc pathology progresses to a substantial event such as a disc herniation. It can be inserted at any time in the progression of the natural history of disc disease. It can even be inserted when substantially the entire intervertebral disc has been removed. It can be inserted in conjunction with another procedure such as a Nucleus Pulposus Replacement (NPR) or Total Disc Replacement (TDR), etc. The various shapes and material of the AFS in this patent are designed to address particular clinical situations, particular anatomy and particular stages of disc degeneration. The AFS can be inserted directly through the AF, or by a technique of detaching part of the AF with bone without actually cutting a substantial part of AF fibers or layers of fibers or by the Transosseous approach.
摘要:
A method, instrumentation and implants for a minimally invasive bone and joint treatments allow cuts in bones to be made simultaneously. This method produces a simple precise alignment of cuts on opposite sides of a joint or bone part. It eliminates many steps need to align the numerous cuts used in current joint replacement and bone treatments. In some cases only one cut will be needed. The cuts can also easily be adapted to different anatomical variation and allows implants to be implanted in a fashion where the implants oriented individually in several different planes. The method and instruments allows for other joint and bone treatments besides joint replacement.
摘要:
The use of a compound of formula (I): in a method of manufacturing a medicament for the treatment or prophylaxis of a condition wherein inhibition of carboxypeptidase U is beneficial; specified compounds of formula (I) and compositions comprising a compound of formula (I) and a pharmaceutically acceptable adjuvant, diluent or carrier.
摘要:
Natural joint interfaces wear out and/or are damaged causing pain and disability. They can be currently replaced by artificial surfaces made of materials or in the near future by magnetic fields. They would benefit from a PVES (paramagnetic visco-viscoelastic supplement) that can replace or augment natural joint interfaces or augment total joint replacements. Joint replacement components can be modular and would benefit from a PVES to decrease wear and damp impact between modular parts of a single component. The PVES is a dynamic interface allowing components to be less rigid. Energy transmission is reduced. PVES can act as an interface between natural damaged joint surfaces obviating the need for classic total joint replacement or between the surfaces of artificial joint components to improve or supplement their function. These PVES can be controlled by magnetic fields with respect to their location, physical properties, loads, etc. PVES are typically made of paramagnetic ions and a substrate molecule. One such PVES can be made of gadolinium ions and hyaluronic acid to form gadolinium hyaluronate.
摘要:
A method and instrumentation is disclosed for gaining access to areas in and around joints for treatment and to provide new implants and instrumentation adapted for the new method. In a transosseous core approach, the joint is entered through a pathway provided in a portion of a joint bone. Such pathway is preferably made by removing a bone core from the bone in or adjacent to the joint, wherever possible without substantially compromising physical integrity and physiological viability of the joint. A route for the transosseous core approach traverses through a more-accessible bone of the joint which can be aligned with a less-accessible bone in order to facilitate treatment of articular surfaces and/or other structures in the joint. Implant modules are provided which can be inserted into the joint through the transosseous pathway and assembled in situ inside the joint to form an implant assembly.