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公开(公告)号：US20180017586A1
公开(公告)日：2018-01-18
申请号：US15648182
申请日：2017-07-12
Applicant: Emulate Inc. , Janssen Biotech, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Va der Meer , Monica Otieno , David Conegliano
CPC classification number: G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20180017585A1
公开(公告)日：2018-01-18
申请号：US15648162
申请日：2017-07-12
Applicant: Emulate Inc. , Janssen Biotech. Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC classification number: G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20180015462A1
公开(公告)日：2018-01-18
申请号：US15648085
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC classification number: G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20180017584A1
公开(公告)日：2018-01-18
申请号：US15648104
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc.
Inventor： Daniel Levner , Christopher David Hinojosa , Noeman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC classification number: G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20180017583A1
公开(公告)日：2018-01-18
申请号：US15648029
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC classification number: G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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Patent Agency Ranking
公开(公告)号：US20180017582A1
公开(公告)日：2018-01-18
申请号：US15648000
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, INC.
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC classification number: G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20180015455A1
公开(公告)日：2018-01-18
申请号：US15648049
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC classification number: G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US10852311B2
公开(公告)日：2020-12-01
申请号：US15648029
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US10228381B2
公开(公告)日：2019-03-12
申请号：US15648085
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
IPC: B01L3/00 , G01N33/50 , G01N33/569 , C12M1/00 , C12M3/00 , G01N33/86 , C12M3/06 , C12M1/42 , C12M1/34 , G01N33/543 , G01N35/08
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US11519903B2
公开(公告)日：2022-12-06
申请号：US15648319
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Kyung Jin Jang , Jacob Fraser , S. Jordan Kerns , Antonio Varone , Dongeun Huh
IPC: C12N5/00 , C12N5/02 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , G01N33/50 , C07K14/78 , C12N5/071 , C12M3/06 , C12M1/00 , C12M1/12 , C12N5/077
Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.
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